JP5322996B2 - 試料の自動分析のための遠心力式マイクロ流体システムおよび方法 - Google Patents

試料の自動分析のための遠心力式マイクロ流体システムおよび方法 Download PDF

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JP5322996B2
JP5322996B2 JP2010110646A JP2010110646A JP5322996B2 JP 5322996 B2 JP5322996 B2 JP 5322996B2 JP 2010110646 A JP2010110646 A JP 2010110646A JP 2010110646 A JP2010110646 A JP 2010110646A JP 5322996 B2 JP5322996 B2 JP 5322996B2
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reaction chamber
magnetically responsive
responsive particles
magnet
microfluidic
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JP2011007778A (ja
JP2011007778A5 (enExample
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クルキオ マリオ
コルナー シュテファン
ブリギッテ、ニーダーベルガー
オースターブレーク エドヴィン
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エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP2010110646A 2009-05-18 2010-05-12 試料の自動分析のための遠心力式マイクロ流体システムおよび方法 Active JP5322996B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09160558.4A EP2253958B1 (en) 2009-05-18 2009-05-18 Centrifugal force based microfluidic system and method for the automated analysis of samples
EP09160558.4 2009-05-18

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JP2011007778A JP2011007778A (ja) 2011-01-13
JP2011007778A5 JP2011007778A5 (enExample) 2011-11-24
JP5322996B2 true JP5322996B2 (ja) 2013-10-23

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US (1) US9442109B2 (enExample)
EP (1) EP2253958B1 (enExample)
JP (1) JP5322996B2 (enExample)
CN (1) CN101893640B (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104297506B (zh) 2007-10-02 2017-05-03 赛拉诺斯股份有限公司 模块化现场护理装置及其应用
CN103477197B (zh) 2011-01-21 2016-08-17 提拉诺斯公司 样品使用最大化的系统和方法
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
JP2014530358A (ja) * 2011-09-25 2014-11-17 セラノス， インコーポレイテッド 多重分析のためのシステム及び方法
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US8597882B2 (en) * 2012-02-03 2013-12-03 Pyrobett Pte. Ltd. Method and apparatus for conducting an assay
TWI456196B (zh) * 2012-04-24 2014-10-11 Ind Tech Res Inst 檢體免疫分析檢測裝置
CN103376312B (zh) * 2012-04-24 2015-01-28 财团法人工业技术研究院 检体免疫分析检测装置
TWD157676S (zh) * 2012-06-01 2013-12-01 三星電子股份有限公司 體液檢查盤的底盤之部分
TWD161734S (zh) * 2012-06-01 2014-07-11 三星電子股份有限公司 體液檢查盤
KR20140009607A (ko) * 2012-07-11 2014-01-23 삼성전자주식회사 검사장치 및 그 제어방법
DE102012107651A1 (de) * 2012-08-21 2014-02-27 Astrium Gmbh Verfahren zur Durchführung einer biochemischen Analyse, insbesondere im Weltraum
FR2998057B1 (fr) 2012-11-09 2016-12-30 Alain Rousseau-Techniques & Innovations (Arteion) Dispositif d’analyse pour diagnostic in vitro
TWI477321B (zh) * 2012-12-28 2015-03-21 Ind Tech Res Inst 微流體混合裝置及其方法
CN103212488B (zh) * 2013-03-29 2014-07-09 东南大学 一种用于制备纳米流体的离心装置及制备纳米流体的方法
USD746999S1 (en) * 2014-06-27 2016-01-05 Hemocue Ab Analyzer
US10309976B2 (en) 2014-06-30 2019-06-04 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
US10520521B2 (en) 2014-06-30 2019-12-31 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
WO2016002731A1 (ja) * 2014-06-30 2016-01-07 パナソニックヘルスケアホールディングス株式会社 試料分析用基板および試料分析装置
US10539582B2 (en) 2014-06-30 2020-01-21 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and method for removing liquid from liquid that contains magnetic particles
WO2016093332A1 (ja) 2014-12-12 2016-06-16 パナソニックヘルスケアホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
JP6030676B2 (ja) * 2015-01-30 2016-11-24 シャープ株式会社 試料分析装置及び試料分析方法
EP3294372B1 (en) 2015-05-08 2021-08-25 Biomagnetic Solutions LLC Apparatus and method for immunomagnetic cell separation
CN108449996A (zh) * 2015-08-07 2018-08-24 Poc医疗系统有限公司 微流体装置及其使用方法
WO2017085766A1 (ja) * 2015-11-16 2017-05-26 日立化成株式会社 遠心分析装置及び遠心分析用チップ
JP6768002B2 (ja) * 2015-12-28 2020-10-14 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
CA3051051A1 (en) 2016-06-08 2017-12-14 The Regents Of The University Of California Method and device for processing tissues and cells
JP6956166B2 (ja) * 2016-08-30 2021-10-27 シスメックス株式会社 試料分析用カートリッジ及びその製造方法、並びにその利用
GB201711804D0 (en) * 2017-07-21 2017-09-06 Mast Group Ltd Apparatus for conducting an assay
US11413378B2 (en) 2018-05-08 2022-08-16 Biomagnetic Solutions Llc Rigid chamber for cell separation from a flexible disposable bag
CN111007243B (zh) * 2018-10-08 2025-05-02 苏州国科均豪生物科技有限公司 磁场切换回转件、磁场切换装置、光检测装置、保温装置
WO2020076659A1 (en) * 2018-10-08 2020-04-16 Accure Health Inc. Automated assay processing methods and systems
KR102155587B1 (ko) * 2018-11-15 2020-09-14 재단법인대구경북과학기술원 미세 유동 장치 및 이를 이용한 표적 세포 분리 방법
CN112033953B (zh) * 2019-06-03 2024-04-19 利多(香港)有限公司 一种微流控芯片及应用
CN110237775A (zh) * 2019-06-18 2019-09-17 金华职业技术学院 一种微量液体混合反应方法
CN110420604B (zh) * 2019-08-30 2024-08-23 东莞东阳光医疗智能器件研发有限公司 圆盘芯片磁性微粒移动装置及检测装置及其移动控制方法
WO2021037099A1 (zh) * 2019-08-30 2021-03-04 东莞东阳光医疗智能器件研发有限公司 圆盘芯片磁性微粒移动装置及检测装置及其移动控制方法
WO2021045684A1 (en) * 2019-09-02 2021-03-11 Tan Tock Seng Hospital Pte Ltd A magnetic digital microfluidic system and method of performing an assay
KR20260116298A (ko) 2020-05-11 2026-07-28 신틀 헬스 테크놀로지스 인코포레이티드 조직 및 세포 처리 방법 및 장치
CN111548929A (zh) * 2020-05-29 2020-08-18 天津诺迈科技有限公司 一种用于细胞裂解和样本均质化的离心式微流控芯片
WO2022115981A1 (zh) * 2020-12-01 2022-06-09 王锦弘 离心式反应装置和离心式反应方法
JP7482257B2 (ja) * 2020-12-11 2024-05-13 株式会社堀場製作所 検査装置、情報処理方法およびプログラム
CN113588957B (zh) * 2021-07-16 2023-06-30 中国农业大学 微生物分离检测系统及检测方法
CN114509575B (zh) * 2022-04-19 2022-06-14 天津德祥生物技术有限公司 微流控检测装置
EP4541460A1 (en) * 2023-10-20 2025-04-23 Direct Analysis Machine and method for lysing a micro-organism

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627041A (en) * 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US20060068409A1 (en) 2000-11-27 2006-03-30 Phan Brigitte C Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets
US7015780B2 (en) * 2002-06-25 2006-03-21 Corning Incorporated Apparatus, device and method for generating magnetic field gradient
EP1728062A4 (en) * 2004-03-26 2012-12-26 Univ Laval REMOVABLE MICROFLUID FLOW CELL
JP2006010529A (ja) 2004-06-25 2006-01-12 Canon Inc 磁性粒子分離装置および分離方法
EP1885883A4 (en) * 2005-04-30 2009-09-23 Jae Chern Yoo BIO DISC, BIOT DRIVER DEVICE AND TEST METHOD USING THEREOF
EP2004541A1 (en) 2006-03-13 2008-12-24 Gyros Patent Ab Enhanced magnetic particle steering
EP1939629A3 (en) 2006-08-11 2011-03-09 Samsung Electronics Co., Ltd. Centrifugal Force Based Magnet Position Control Device and Disk-Shaped Micro Fluidic System
US8273310B2 (en) * 2006-09-05 2012-09-25 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device
KR100818274B1 (ko) * 2006-09-05 2008-04-01 삼성전자주식회사 미세유동 시스템 제어장치 및 그 방법, 및 미세유동 시스템
KR101343034B1 (ko) * 2006-09-05 2013-12-18 삼성전자 주식회사 원심력 기반의 단백질 검출용 미세유동 장치 및 이를포함하는 미세유동 시스템
KR101422572B1 (ko) * 2006-09-05 2014-07-30 삼성전자주식회사 핵산 검출을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
JP2008161649A (ja) 2007-01-04 2008-07-17 Hiroshi Nobori 簡易圧感覚検査器

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JP2011007778A (ja) 2011-01-13
EP2253958A1 (en) 2010-11-24
US9442109B2 (en) 2016-09-13
CN101893640A (zh) 2010-11-24
EP2253958B1 (en) 2013-04-17
US20110124128A1 (en) 2011-05-26
CN101893640B (zh) 2014-04-30

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