CN101893640B - 用于自动分析样本的基于离心力的微流体系统和方法 - Google Patents

用于自动分析样本的基于离心力的微流体系统和方法 Download PDF

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CN101893640B
CN101893640B CN201010179492.7A CN201010179492A CN101893640B CN 101893640 B CN101893640 B CN 101893640B CN 201010179492 A CN201010179492 A CN 201010179492A CN 101893640 B CN101893640 B CN 101893640B
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magnet
holding area
reaction chamber
magnetic
strutting arrangement
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CN101893640A (zh
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M·库尔西奥
S·科纳
B·尼德伯格
E·乌斯特布罗克
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201010179492.7A 2009-05-18 2010-05-17 用于自动分析样本的基于离心力的微流体系统和方法 Active CN101893640B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09160558.4 2009-05-18
EP09160558.4A EP2253958B1 (en) 2009-05-18 2009-05-18 Centrifugal force based microfluidic system and method for the automated analysis of samples

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CN101893640A CN101893640A (zh) 2010-11-24
CN101893640B true CN101893640B (zh) 2014-04-30

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US (1) US9442109B2 (enExample)
EP (1) EP2253958B1 (enExample)
JP (1) JP5322996B2 (enExample)
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Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3756767B1 (en) 2007-10-02 2024-05-01 Labrador Diagnostics LLC Modular point-of-care devices and uses thereof
CA3097861A1 (en) 2011-01-21 2012-07-26 Labrador Diagnostics Llc Systems and methods for sample use maximization
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
SG10201602141QA (en) * 2011-09-25 2016-04-28 Theranos Inc Systems And Methods For Multi-Analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US8597882B2 (en) * 2012-02-03 2013-12-03 Pyrobett Pte. Ltd. Method and apparatus for conducting an assay
TWI456196B (zh) * 2012-04-24 2014-10-11 Ind Tech Res Inst 檢體免疫分析檢測裝置
CN103376312B (zh) * 2012-04-24 2015-01-28 财团法人工业技术研究院 检体免疫分析检测装置
TWD161734S (zh) * 2012-06-01 2014-07-11 三星電子股份有限公司 體液檢查盤
TWD157676S (zh) * 2012-06-01 2013-12-01 三星電子股份有限公司 體液檢查盤的底盤之部分
KR20140009607A (ko) * 2012-07-11 2014-01-23 삼성전자주식회사 검사장치 및 그 제어방법
DE102012107651A1 (de) * 2012-08-21 2014-02-27 Astrium Gmbh Verfahren zur Durchführung einer biochemischen Analyse, insbesondere im Weltraum
FR2998057B1 (fr) 2012-11-09 2016-12-30 Alain Rousseau-Techniques & Innovations (Arteion) Dispositif d’analyse pour diagnostic in vitro
TWI477321B (zh) * 2012-12-28 2015-03-21 Ind Tech Res Inst 微流體混合裝置及其方法
CN103212488B (zh) * 2013-03-29 2014-07-09 东南大学 一种用于制备纳米流体的离心装置及制备纳米流体的方法
USD746999S1 (en) * 2014-06-27 2016-01-05 Hemocue Ab Analyzer
WO2016002729A1 (ja) * 2014-06-30 2016-01-07 パナソニックヘルスケアホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
JP6548645B2 (ja) * 2014-06-30 2019-07-24 Ｐｈｃホールディングス株式会社 試料分析用基板および試料分析装置
WO2016002727A1 (ja) 2014-06-30 2016-01-07 パナソニックヘルスケアホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
EP3163307B1 (en) * 2014-06-30 2021-03-03 PHC Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and method for removing liquid from liquid that contains magnetic particles
EP3232203B1 (en) 2014-12-12 2022-02-02 PHC Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
JP6030676B2 (ja) * 2015-01-30 2016-11-24 シャープ株式会社 試料分析装置及び試料分析方法
EP3998335A3 (en) 2015-05-08 2022-07-27 Biomagnetic Solutions LLC Apparatus and method for immunomagnetic cell separation
WO2017027384A1 (en) * 2015-08-07 2017-02-16 Poc Medical Systems, Inc. Microfluidic devices and methods of use thereof
WO2017085766A1 (ja) * 2015-11-16 2017-05-26 日立化成株式会社 遠心分析装置及び遠心分析用チップ
US11262356B2 (en) * 2015-12-28 2022-03-01 Phc Holdings Corporation Specimen analysis substrate, specimen analysis device, specimen analysis system, and program for specimen analysis system
KR102370343B1 (ko) * 2016-06-08 2022-03-03 더 리전트 오브 더 유니버시티 오브 캘리포니아 조직 및 세포를 프로세싱하기 위한 방법 및 장치
JP6956166B2 (ja) * 2016-08-30 2021-10-27 シスメックス株式会社 試料分析用カートリッジ及びその製造方法、並びにその利用
GB201711804D0 (en) * 2017-07-21 2017-09-06 Mast Group Ltd Apparatus for conducting an assay
US11413378B2 (en) 2018-05-08 2022-08-16 Biomagnetic Solutions Llc Rigid chamber for cell separation from a flexible disposable bag
WO2020076659A1 (en) * 2018-10-08 2020-04-16 Accure Health Inc. Automated assay processing methods and systems
CN111007243B (zh) * 2018-10-08 2025-05-02 苏州国科均豪生物科技有限公司 磁场切换回转件、磁场切换装置、光检测装置、保温装置
KR102155587B1 (ko) * 2018-11-15 2020-09-14 재단법인대구경북과학기술원 미세 유동 장치 및 이를 이용한 표적 세포 분리 방법
CN112033953B (zh) * 2019-06-03 2024-04-19 利多(香港)有限公司 一种微流控芯片及应用
CN110237775A (zh) * 2019-06-18 2019-09-17 金华职业技术学院 一种微量液体混合反应方法
WO2021037099A1 (zh) * 2019-08-30 2021-03-04 东莞东阳光医疗智能器件研发有限公司 圆盘芯片磁性微粒移动装置及检测装置及其移动控制方法
CN110420604B (zh) * 2019-08-30 2024-08-23 东莞东阳光医疗智能器件研发有限公司 圆盘芯片磁性微粒移动装置及检测装置及其移动控制方法
US20220266245A1 (en) * 2019-09-02 2022-08-25 Tan Tock Seng Hospital Pte Ltd A magnetic digital microfluidic system and method of performing an assay
CN111548929A (zh) * 2020-05-29 2020-08-18 天津诺迈科技有限公司 一种用于细胞裂解和样本均质化的离心式微流控芯片
CN115516311A (zh) * 2020-12-01 2022-12-23 王锦弘 离心式反应装置和离心式反应方法
US20240069050A1 (en) * 2020-12-11 2024-02-29 Horiba, Ltd. Testing device, and method and program for information processing
CN113588957B (zh) * 2021-07-16 2023-06-30 中国农业大学 微生物分离检测系统及检测方法
CN114509575B (zh) * 2022-04-19 2022-06-14 天津德祥生物技术有限公司 微流控检测装置
EP4541460A1 (en) * 2023-10-20 2025-04-23 Direct Analysis Machine and method for lysing a micro-organism

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101166834A (zh) * 2005-04-30 2008-04-23 柳在泉 生物盘、生物驱动器装置和使用该盘和装置的化验方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627041A (en) * 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US20060068409A1 (en) 2000-11-27 2006-03-30 Phan Brigitte C Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets
US7015780B2 (en) * 2002-06-25 2006-03-21 Corning Incorporated Apparatus, device and method for generating magnetic field gradient
JP2007536504A (ja) * 2004-03-26 2007-12-13 インフェクシオ・リシェルシェ・インコーポレーテッド 取り外し可能マイクロ流体フローセル
JP2006010529A (ja) * 2004-06-25 2006-01-12 Canon Inc 磁性粒子分離装置および分離方法
JP2009530606A (ja) * 2006-03-13 2009-08-27 ギロス パテント アーべー 増強型磁気粒子ステアリング
EP1939629A3 (en) 2006-08-11 2011-03-09 Samsung Electronics Co., Ltd. Centrifugal Force Based Magnet Position Control Device and Disk-Shaped Micro Fluidic System
KR101422572B1 (ko) * 2006-09-05 2014-07-30 삼성전자주식회사 핵산 검출을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
US8273310B2 (en) * 2006-09-05 2012-09-25 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device
KR100818274B1 (ko) * 2006-09-05 2008-04-01 삼성전자주식회사 미세유동 시스템 제어장치 및 그 방법, 및 미세유동 시스템
KR101343034B1 (ko) * 2006-09-05 2013-12-18 삼성전자 주식회사 원심력 기반의 단백질 검출용 미세유동 장치 및 이를포함하는 미세유동 시스템
JP2008161649A (ja) 2007-01-04 2008-07-17 Hiroshi Nobori 簡易圧感覚検査器

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101166834A (zh) * 2005-04-30 2008-04-23 柳在泉 生物盘、生物驱动器装置和使用该盘和装置的化验方法

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US9442109B2 (en) 2016-09-13
JP5322996B2 (ja) 2013-10-23
US20110124128A1 (en) 2011-05-26
EP2253958B1 (en) 2013-04-17
CN101893640A (zh) 2010-11-24
EP2253958A1 (en) 2010-11-24
JP2011007778A (ja) 2011-01-13

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