CN101893640B - 用于自动分析样本的基于离心力的微流体系统和方法 - Google Patents

用于自动分析样本的基于离心力的微流体系统和方法 Download PDF

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Publication number
CN101893640B
CN101893640B CN201010179492.7A CN201010179492A CN101893640B CN 101893640 B CN101893640 B CN 101893640B CN 201010179492 A CN201010179492 A CN 201010179492A CN 101893640 B CN101893640 B CN 101893640B
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reaction chamber
magnet
magnetically responsive
responsive particles
microfluidic
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Chinese (zh)
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CN101893640A (zh
Inventor
M·库尔西奥
S·科纳
B·尼德伯格
E·乌斯特布罗克
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201010179492.7A 2009-05-18 2010-05-17 用于自动分析样本的基于离心力的微流体系统和方法 Active CN101893640B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09160558.4A EP2253958B1 (en) 2009-05-18 2009-05-18 Centrifugal force based microfluidic system and method for the automated analysis of samples
EP09160558.4 2009-05-18

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Publication Number Publication Date
CN101893640A CN101893640A (zh) 2010-11-24
CN101893640B true CN101893640B (zh) 2014-04-30

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US (1) US9442109B2 (enExample)
EP (1) EP2253958B1 (enExample)
JP (1) JP5322996B2 (enExample)
CN (1) CN101893640B (enExample)

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CN108449996A (zh) * 2015-08-07 2018-08-24 Poc医疗系统有限公司 微流体装置及其使用方法
WO2017085766A1 (ja) * 2015-11-16 2017-05-26 日立化成株式会社 遠心分析装置及び遠心分析用チップ
JP6768002B2 (ja) * 2015-12-28 2020-10-14 Ｐｈｃホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
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CN112033953B (zh) * 2019-06-03 2024-04-19 利多(香港)有限公司 一种微流控芯片及应用
CN110237775A (zh) * 2019-06-18 2019-09-17 金华职业技术学院 一种微量液体混合反应方法
CN110420604B (zh) * 2019-08-30 2024-08-23 东莞东阳光医疗智能器件研发有限公司 圆盘芯片磁性微粒移动装置及检测装置及其移动控制方法
WO2021037099A1 (zh) * 2019-08-30 2021-03-04 东莞东阳光医疗智能器件研发有限公司 圆盘芯片磁性微粒移动装置及检测装置及其移动控制方法
WO2021045684A1 (en) * 2019-09-02 2021-03-11 Tan Tock Seng Hospital Pte Ltd A magnetic digital microfluidic system and method of performing an assay
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CN111548929A (zh) * 2020-05-29 2020-08-18 天津诺迈科技有限公司 一种用于细胞裂解和样本均质化的离心式微流控芯片
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Publication number Publication date
JP2011007778A (ja) 2011-01-13
EP2253958A1 (en) 2010-11-24
US9442109B2 (en) 2016-09-13
CN101893640A (zh) 2010-11-24
EP2253958B1 (en) 2013-04-17
US20110124128A1 (en) 2011-05-26
JP5322996B2 (ja) 2013-10-23

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