JP5307398B2 - 錠剤製造用の脂肪族アミンポリマー塩 - Google Patents

錠剤製造用の脂肪族アミンポリマー塩 Download PDF

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Publication number
JP5307398B2
JP5307398B2 JP2007539273A JP2007539273A JP5307398B2 JP 5307398 B2 JP5307398 B2 JP 5307398B2 JP 2007539273 A JP2007539273 A JP 2007539273A JP 2007539273 A JP2007539273 A JP 2007539273A JP 5307398 B2 JP5307398 B2 JP 5307398B2
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Prior art keywords
composition
tablet
sevelamer
cellulose derivative
carbonate
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Expired - Lifetime
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JP2007539273A
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Japanese (ja)
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JP2008518950A (ja
JP2008518950A5 (enExample
Inventor
バガット，ヒテシュ
ゴールドバーグ，ジェフリー，マーク
ハリアナワラ，アビザー
ブレンナー，ルイス
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ジェンザイム コーポレーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
JP2007539273A 2004-11-01 2005-11-01 錠剤製造用の脂肪族アミンポリマー塩 Expired - Lifetime JP5307398B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62400104P 2004-11-01 2004-11-01
US60/624,001 2004-11-01
US62875204P 2004-11-17 2004-11-17
US60/628,752 2004-11-17
PCT/US2005/039366 WO2006050315A2 (en) 2004-11-01 2005-11-01 Aliphatic amine polymer salts for tableting

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013087963A Division JP5758945B2 (ja) 2004-11-01 2013-04-19 錠剤製造用の脂肪族アミンポリマー塩

Publications (3)

Publication Number Publication Date
JP2008518950A JP2008518950A (ja) 2008-06-05
JP2008518950A5 JP2008518950A5 (enExample) 2008-12-18
JP5307398B2 true JP5307398B2 (ja) 2013-10-02

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JP2007539273A Expired - Lifetime JP5307398B2 (ja) 2004-11-01 2005-11-01 錠剤製造用の脂肪族アミンポリマー塩
JP2013087963A Expired - Lifetime JP5758945B2 (ja) 2004-11-01 2013-04-19 錠剤製造用の脂肪族アミンポリマー塩

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Country Status (17)

Country Link
US (4) US7985418B2 (enExample)
EP (2) EP3167878B1 (enExample)
JP (2) JP5307398B2 (enExample)
CN (2) CN101043878B (enExample)
AU (1) AU2005302243B2 (enExample)
BR (1) BRPI0517916B8 (enExample)
CA (2) CA2762076C (enExample)
CY (1) CY1119155T1 (enExample)
DK (1) DK1807057T3 (enExample)
ES (2) ES2621553T3 (enExample)
HR (1) HRP20170505T1 (enExample)
HU (1) HUE033638T2 (enExample)
LT (1) LT1807057T (enExample)
MX (1) MX2007004939A (enExample)
PL (1) PL1807057T3 (enExample)
PT (1) PT1807057T (enExample)
WO (1) WO2006050315A2 (enExample)

Cited By (1)

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JP2013139480A (ja) * 2004-11-01 2013-07-18 Genzyme Corp 錠剤製造用の脂肪族アミンポリマー塩

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WO2006072054A1 (en) * 2004-12-30 2006-07-06 Genzyme Corporation Zinc-containing treatments for hyperphosphatemia
JP2009507019A (ja) 2005-09-02 2009-02-19 ジェンザイム・コーポレーション リン酸塩を除去する方法およびそれに使用される重合体
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WO2007056405A2 (en) * 2005-11-08 2007-05-18 Genzyme Corporation Magnesium-containing polymers for the treatment of hyperphosphatemia
EP2043627A2 (en) * 2006-07-05 2009-04-08 Genzyme Corporation Iron(ii)-containing treatments for hyperphosphatemia
US7964182B2 (en) * 2006-09-01 2011-06-21 USV, Ltd Pharmaceutical compositions comprising phosphate-binding polymer
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JP2011506449A (ja) * 2007-12-14 2011-03-03 ジェンザイム コーポレーション コーティング医薬組成物
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AU2010209293A1 (en) * 2009-01-22 2011-09-08 Usv Limited Pharmaceutical compositions comprising phosphate-binding polymer
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CN102641251B (zh) * 2012-04-19 2013-11-27 天津太平洋制药有限公司 一种碳酸司维拉姆的可以在水中分散的片剂
CN102895204B (zh) * 2012-11-08 2014-12-31 南京生命能科技开发有限公司 一种用于制备片剂的碳酸司维拉姆原料药及其制备方法和应用
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CN103393610B (zh) * 2013-07-05 2014-12-24 常州方圆制药有限公司 一种脂肪胺聚合物盐快速崩解制剂
IL322207A (en) 2014-12-10 2025-09-01 Tricida Inc Proton-binding polymers for oral administration
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CN109715142B (zh) * 2016-06-14 2021-10-12 苏州韬略生物科技有限公司 用于压片的碳酸司维拉姆
CN107157947A (zh) * 2017-05-04 2017-09-15 方达医药技术（苏州）有限公司 一种碳酸司维拉姆片及其制备方法
CN107397734B (zh) * 2017-08-24 2020-06-30 正大制药（青岛）有限公司 一种稳定的碳酸司维拉姆片剂及其制备方法
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