JP5306203B2 - Ｃ型肝炎ウイルス阻害剤 - Google Patents

Ｃ型肝炎ウイルス阻害剤 Download PDF

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Publication number
JP5306203B2
JP5306203B2 JP2009524737A JP2009524737A JP5306203B2 JP 5306203 B2 JP5306203 B2 JP 5306203B2 JP 2009524737 A JP2009524737 A JP 2009524737A JP 2009524737 A JP2009524737 A JP 2009524737A JP 5306203 B2 JP5306203 B2 JP 5306203B2
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JP
Japan
Prior art keywords
imidazol
pyrrolidinyl
phenyl
alkyl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009524737A
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English (en)
Japanese (ja)
Other versions
JP2010500414A (ja
JP2010500414A5 (cg-RX-API-DMAC7.html
Inventor
キャロル・バシャン
マコネン・ベレマ
ダニエル・エイチ・ディーオン
アンドリュー・シー・グッド
ジェイソン・グッドリッチ
クリント・エイ・ジェイムズ
リコ・ラヴォワ
オマール・デ・ロペス
アラン・マルテル
ニコラス・エイ・ミーンウェル
バン・エヌ・ヌグイェン
ジェフリー・リー・ロマイン
エドワード・エイチ・リュ−ディガー
ローレンス・ビー・スナイダー
デニス・アール・サン・ローラン
ヤン・フカン
デイビッド・アール・ラングリー
ローレンス・ジー・ハマン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
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Filing date
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Publication of JP2010500414A publication Critical patent/JP2010500414A/ja
Publication of JP2010500414A5 publication Critical patent/JP2010500414A5/ja
Application granted granted Critical
Publication of JP5306203B2 publication Critical patent/JP5306203B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2009524737A 2006-08-11 2007-08-09 Ｃ型肝炎ウイルス阻害剤 Expired - Fee Related JP5306203B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83699906P 2006-08-11 2006-08-11
US60/836,999 2006-08-11
PCT/US2007/075545 WO2008021928A2 (en) 2006-08-11 2007-08-09 Hepatitis c virus inhibitors

Publications (3)

Publication Number Publication Date
JP2010500414A JP2010500414A (ja) 2010-01-07
JP2010500414A5 JP2010500414A5 (cg-RX-API-DMAC7.html) 2010-08-26
JP5306203B2 true JP5306203B2 (ja) 2013-10-02

Family

ID=38895921

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009524737A Expired - Fee Related JP5306203B2 (ja) 2006-08-11 2007-08-09 Ｃ型肝炎ウイルス阻害剤

Country Status (16)

Country Link
US (1) US7659270B2 (cg-RX-API-DMAC7.html)
EP (1) EP2049116B1 (cg-RX-API-DMAC7.html)
JP (1) JP5306203B2 (cg-RX-API-DMAC7.html)
KR (1) KR101438851B1 (cg-RX-API-DMAC7.html)
CN (1) CN101528232B (cg-RX-API-DMAC7.html)
AT (1) ATE547103T1 (cg-RX-API-DMAC7.html)
AU (1) AU2007286223B2 (cg-RX-API-DMAC7.html)
CA (1) CA2660628C (cg-RX-API-DMAC7.html)
EA (1) EA017348B1 (cg-RX-API-DMAC7.html)
ES (1) ES2382005T3 (cg-RX-API-DMAC7.html)
IL (1) IL196815A (cg-RX-API-DMAC7.html)
MX (1) MX2009001436A (cg-RX-API-DMAC7.html)
NO (1) NO20090453L (cg-RX-API-DMAC7.html)
NZ (1) NZ574769A (cg-RX-API-DMAC7.html)
WO (1) WO2008021928A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200900935B (cg-RX-API-DMAC7.html)

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