JP5306194B2 - ピロ［１，２−ｂ］ピリダジノン化合物 - Google Patents

ピロ［１，２−ｂ］ピリダジノン化合物 Download PDF

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Publication number
JP5306194B2
JP5306194B2 JP2009516735A JP2009516735A JP5306194B2 JP 5306194 B2 JP5306194 B2 JP 5306194B2 JP 2009516735 A JP2009516735 A JP 2009516735A JP 2009516735 A JP2009516735 A JP 2009516735A JP 5306194 B2 JP5306194 B2 JP 5306194B2
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JP
Japan
Prior art keywords
mmol
alkylene
alkyl
heterocyclyl
dihydro
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Expired - Fee Related
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JP2009516735A
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Japanese (ja)
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JP2009544575A (ja
Inventor
フランク リュプサム，
マーティン， ティー． トラン，
ステファン， イー． ウェバー，
ピーター， エス． ドラゴビック，
リャンシェン リ，
ダグラス， イー． マーフィー，
デービッド， ジョン クチェラ，
チョンシャン サン，
チン， ベト トラン，
Original Assignee
アナディス ファーマシューティカルズ インク
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009516735A 2006-06-22 2007-06-21 ピロ［１，２−ｂ］ピリダジノン化合物 Expired - Fee Related JP5306194B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81557806P 2006-06-22 2006-06-22
US60/815,578 2006-06-22
PCT/US2007/071826 WO2007150001A1 (en) 2006-06-22 2007-06-21 Pyrro[1,2-b]pyridazinone compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013018431A Division JP5670487B2 (ja) 2006-06-22 2013-02-01 ピロ［１，２−ｂ］ピリダジノン化合物

Publications (2)

Publication Number Publication Date
JP2009544575A JP2009544575A (ja) 2009-12-17
JP5306194B2 true JP5306194B2 (ja) 2013-10-02

Family

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Family Applications (2)

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JP2009516735A Expired - Fee Related JP5306194B2 (ja) 2006-06-22 2007-06-21 ピロ［１，２−ｂ］ピリダジノン化合物
JP2013018431A Expired - Fee Related JP5670487B2 (ja) 2006-06-22 2013-02-01 ピロ［１，２−ｂ］ピリダジノン化合物

Family Applications After (1)

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JP2013018431A Expired - Fee Related JP5670487B2 (ja) 2006-06-22 2013-02-01 ピロ［１，２−ｂ］ピリダジノン化合物

Country Status (14)

Country Link
US (3) US7462611B2 (de)
EP (1) EP2038286B1 (de)
JP (2) JP5306194B2 (de)
KR (1) KR101384266B1 (de)
CN (2) CN101501039B (de)
AR (1) AR061581A1 (de)
BR (1) BRPI0713684A2 (de)
CA (1) CA2656000C (de)
IL (1) IL196106A0 (de)
MX (1) MX2008016519A (de)
NZ (1) NZ573875A (de)
PA (1) PA8733401A1 (de)
TW (1) TWI395749B (de)
WO (1) WO2007150001A1 (de)

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UA100120C2 (en) 2007-04-03 2012-11-26 Анадис Фармасьютикалз, Инк. 5,6-dihydro-1h-pyridin-2-one compounds
MX2009011930A (es) 2007-05-04 2009-11-18 Vertex Pharma Terapia de combinacion para el tratamiento de infeccion de virus de hepatitis c.
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EP2283002A2 (de) * 2008-04-15 2011-02-16 Intermune, Inc. Neue replikationshemmer des hepatitis-c-virus
EP2346329B1 (de) 2008-10-09 2013-08-21 Anadys Pharmaceuticals, Inc. Verfahren zur hemmung des hepatitis-c-virus mittels kombination aus einem 5,6-dihydro-1h-pyridin-2-on und einer oder mehreren antiviralen verbindungen
CN102858344A (zh) 2009-10-28 2013-01-02 安那迪斯药品股份有限公司 氘化5,6-二氢-1h-吡啶-2-酮化合物
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US20120321590A1 (en) 2011-04-06 2012-12-20 Anadys Pharmaceuticals, Inc. Bridged polycyclic compounds
US8815847B2 (en) 2011-06-07 2014-08-26 Anadys Pharmaceuticals, Inc. [1,2,4]thiadiazine 1,1-dioxide compounds for lowering serum uric acid
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EA201591333A1 (ru) * 2013-01-14 2015-11-30 Ф. Хоффманн-Ля Рош Аг Новый способ получения метилового эфира n-(4-нитро-2-сульфамоилфенил)малонаминовой кислоты и метилового эфира n-(4-амино-2-сульфамоилфенил)малонаминовой кислоты
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Also Published As

Publication number Publication date
WO2007150001A8 (en) 2008-02-28
US20090105473A1 (en) 2009-04-23
CN102584649A (zh) 2012-07-18
US7842838B2 (en) 2010-11-30
US20090312570A1 (en) 2009-12-17
CN101501039B (zh) 2012-02-22
BRPI0713684A2 (pt) 2012-10-30
KR101384266B1 (ko) 2014-04-24
WO2007150001A1 (en) 2007-12-27
TWI395749B (zh) 2013-05-11
JP5670487B2 (ja) 2015-02-18
CN101501039A (zh) 2009-08-05
TW200817405A (en) 2008-04-16
US20080031852A1 (en) 2008-02-07
JP2009544575A (ja) 2009-12-17
PA8733401A1 (es) 2008-11-19
EP2038286A1 (de) 2009-03-25
NZ573875A (en) 2011-11-25
AU2007260827A1 (en) 2007-12-27
AR061581A1 (es) 2008-09-03
JP2013136599A (ja) 2013-07-11
US7462611B2 (en) 2008-12-09
CA2656000C (en) 2016-09-06
EP2038286B1 (de) 2017-03-08
US7582754B2 (en) 2009-09-01
CA2656000A1 (en) 2007-12-27
MX2008016519A (es) 2009-01-30
IL196106A0 (en) 2009-09-01
EP2038286A4 (de) 2010-05-12
KR20090063203A (ko) 2009-06-17

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