JP5280631B2 - 抗ウイルスヌクレオチド類似物としてのホスホネート基を有するピリミジン化合物 - Google Patents

抗ウイルスヌクレオチド類似物としてのホスホネート基を有するピリミジン化合物 Download PDF

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JP5280631B2
JP5280631B2 JP2006515644A JP2006515644A JP5280631B2 JP 5280631 B2 JP5280631 B2 JP 5280631B2 JP 2006515644 A JP2006515644 A JP 2006515644A JP 2006515644 A JP2006515644 A JP 2006515644A JP 5280631 B2 JP5280631 B2 JP 5280631B2
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compound
formula
alkyl
independently
hydroxy
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JP2006527702A5 (enExample
JP2006527702A (ja
Inventor
ジャン マリー レネ バルザリニ，
クレルク， エリック デザイア アリス デ
ダナ ホッコヴァ，
アントニン ホリー，
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Katholieke Universiteit Leuven
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Katholieke Universiteit Leuven
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2006515644A 2003-06-16 2004-06-16 抗ウイルスヌクレオチド類似物としてのホスホネート基を有するピリミジン化合物 Expired - Lifetime JP5280631B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47889303P 2003-06-16 2003-06-16
US60/478,893 2003-06-16
PCT/CZ2004/000034 WO2004111064A1 (en) 2003-06-16 2004-06-16 Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs

Related Child Applications (1)

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JP2012115602A Division JP2012153731A (ja) 2003-06-16 2012-05-21 抗ウイルスヌクレオチド類似物としてのホスホネート基を有するピリミジン化合物

Publications (3)

Publication Number Publication Date
JP2006527702A JP2006527702A (ja) 2006-12-07
JP2006527702A5 JP2006527702A5 (enExample) 2007-09-06
JP5280631B2 true JP5280631B2 (ja) 2013-09-04

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Family Applications (2)

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JP2006515644A Expired - Lifetime JP5280631B2 (ja) 2003-06-16 2004-06-16 抗ウイルスヌクレオチド類似物としてのホスホネート基を有するピリミジン化合物
JP2012115602A Pending JP2012153731A (ja) 2003-06-16 2012-05-21 抗ウイルスヌクレオチド類似物としてのホスホネート基を有するピリミジン化合物

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JP2012115602A Pending JP2012153731A (ja) 2003-06-16 2012-05-21 抗ウイルスヌクレオチド類似物としてのホスホネート基を有するピリミジン化合物

Country Status (15)

Country Link
US (2) US7115592B2 (enExample)
EP (1) EP1644389B1 (enExample)
JP (2) JP5280631B2 (enExample)
KR (1) KR101102815B1 (enExample)
CN (1) CN1805966B (enExample)
AT (1) ATE496056T1 (enExample)
AU (1) AU2004247305B2 (enExample)
CA (1) CA2527805C (enExample)
DE (1) DE602004031115D1 (enExample)
DK (1) DK1644389T3 (enExample)
EA (1) EA011948B1 (enExample)
IL (1) IL172015A (enExample)
NZ (1) NZ543864A (enExample)
SI (1) SI1644389T1 (enExample)
WO (1) WO2004111064A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2616314A1 (en) * 2005-07-27 2007-02-01 Gilead Sciences, Inc. Antiviral phosphonate conjugates for inhibition of hiv
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
ES2443952T3 (es) 2009-09-02 2014-02-21 Novartis Ag Composiciones inmunógenas que incluyen moduladores de la actividad de TLR
CN102939291B (zh) 2010-04-14 2016-09-07 加利福尼亚大学董事会 用于病毒感染治疗的具有降低的毒性的膦酸酯
CN103209985B (zh) * 2010-08-31 2016-08-24 奇默里克斯公司 膦酸酯衍生物及其合成方法
CN105999275A (zh) 2010-09-01 2016-10-12 诺华有限公司 免疫增强剂吸附不溶性金属离子
FI2648701T3 (fi) 2010-12-10 2023-06-12 Sigmapharm Laboratories Llc Hyvin stabiileja adefovirdipivoksiilin koostumuksia
US20140112950A1 (en) 2011-03-02 2014-04-24 Manmohan Singh Combination vaccines with lower doses of antigen and/or adjuvant
US9593137B2 (en) 2011-12-22 2017-03-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
US9375471B2 (en) 2012-03-08 2016-06-28 Glaxosmithkline Biologicals Sa Adjuvanted formulations of booster vaccines
CN103665043B (zh) * 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CN102796138B (zh) * 2012-09-07 2014-10-22 山东大学 (2-(3-甲硫基-1,2,4-噻二嗪)乙氧基)甲基膦酸酯类衍生物及其制备与应用
JP6462659B2 (ja) 2013-03-15 2019-01-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 非環式ヌクレオシドホスホン酸ジエステル
CN112898345A (zh) 2014-09-15 2021-06-04 加利福尼亚大学董事会 核苷酸类似物
EP3350191B9 (en) 2015-09-15 2021-12-22 The Regents of the University of California Nucleotide analogs
CA3262284A1 (en) 2022-07-21 2024-01-25 Antiva Biosciences Inc Pharmaceutical compositions and forms for the treatment of human papillomavirus (HPV) infection and HPV-induced neoplasm

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
DE3580384D1 (de) 1984-04-09 1990-12-13 Toyo Boseki Praeparat mit verzoegerter freigabe zum aufbringen auf die schleimhaeute der mundhoehle.
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
JPS63501194A (ja) * 1985-10-30 1988-05-12 プラネルト・イエンス 歯の残根から冠，ブリツジ等を除去するための装置
US5141752A (en) 1986-05-09 1992-08-25 Alza Corporation Delayed drug delivery device
CS264222B1 (en) 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
NZ222553A (en) 1986-11-18 1991-07-26 Bristol Myers Co Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
CA2001715C (en) 1988-11-14 1999-12-28 Muzammil M. Mansuri Carbocyclic nucleosides and nucleotides
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
CA2297294C (en) 1989-05-15 2005-11-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxymethylpurine/pyrimidine derivatives
MY104575A (en) 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5302585A (en) 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CZ285420B6 (cs) 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
WO1992001698A1 (en) 1990-07-19 1992-02-06 Beecham Group Plc Antiviral phosphono-alken derivatives of purines
EP0468119A1 (en) 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
DE10399025I2 (de) 1990-09-14 2007-11-08 Acad Of Science Czech Republic Wirkstoffvorläufer von Phosphonaten
US5208221A (en) 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
CZ284678B6 (cs) 1991-05-20 1999-01-13 Ústav Organické Chemie A Biochemie Avčr Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
DE69218968T2 (de) 1991-10-11 1997-10-09 Inst Of Organic Chemistry And Antivirale acyclische phosphonomethoxyalkyl substituierte, alkenyl und alkynyl purin und pyrimidin-derivate
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
EP0618214A1 (en) 1993-04-01 1994-10-05 Merrell Dow Pharmaceuticals Inc. Unsaturated phosphonate derivatives of purines and pyrimidines
CA2171743C (en) 1993-09-17 2007-11-20 Norbert W. Bischofberger Nucleotide analogs
SI9620042A (sl) 1995-02-27 1998-12-31 Gilead Sciences, Inc. Novi selektivni inhibitorji virusnih ali bakterijskih neuraminidaz
US5977061A (en) 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
JP4033494B2 (ja) 1996-07-26 2008-01-16 ギリヤド サイエンシーズ， インコーポレイテッド ヌクレオチドアナログ
MXPA04000138A (es) * 2001-06-29 2005-06-06 Acad Of Science Czech Republic Compuestos novedosos y metodos de trabajo.

Also Published As

Publication number Publication date
KR20060041182A (ko) 2006-05-11
NZ543864A (en) 2009-10-30
CA2527805C (en) 2012-08-21
CN1805966B (zh) 2013-03-13
US20050075318A1 (en) 2005-04-07
SI1644389T1 (sl) 2011-06-30
CN1805966A (zh) 2006-07-19
EP1644389A1 (en) 2006-04-12
US7115592B2 (en) 2006-10-03
AU2004247305A1 (en) 2004-12-23
IL172015A0 (en) 2009-02-11
DK1644389T3 (da) 2011-05-09
EP1644389B1 (en) 2011-01-19
DE602004031115D1 (de) 2011-03-03
EA200600046A1 (ru) 2006-06-30
KR101102815B1 (ko) 2012-01-05
JP2012153731A (ja) 2012-08-16
AU2004247305B2 (en) 2010-02-18
US20060241081A1 (en) 2006-10-26
WO2004111064A1 (en) 2004-12-23
JP2006527702A (ja) 2006-12-07
CA2527805A1 (en) 2004-12-23
IL172015A (en) 2016-07-31
EA011948B1 (ru) 2009-06-30
HK1088013A1 (en) 2006-10-27
ATE496056T1 (de) 2011-02-15

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