DE602004031115D1 - Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga - Google Patents

Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga

Info

Publication number
DE602004031115D1
DE602004031115D1 DE602004031115T DE602004031115T DE602004031115D1 DE 602004031115 D1 DE602004031115 D1 DE 602004031115D1 DE 602004031115 T DE602004031115 T DE 602004031115T DE 602004031115 T DE602004031115 T DE 602004031115T DE 602004031115 D1 DE602004031115 D1 DE 602004031115D1
Authority
DE
Germany
Prior art keywords
nucleotide analog
pyrimidine compounds
phosphonate groups
sub
antiviral nucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004031115T
Other languages
German (de)
English (en)
Inventor
Jan Marie Balzarini
Clercq Erik Desire De
Dana Hockova
Antonin Holy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Czech Academy of Sciences CAS
Institute of Organic Chemistry and Biochemistry CAS
Original Assignee
Katholieke Universiteit Leuven
Czech Academy of Sciences CAS
Institute of Organic Chemistry and Biochemistry CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Katholieke Universiteit Leuven, Czech Academy of Sciences CAS, Institute of Organic Chemistry and Biochemistry CAS filed Critical Katholieke Universiteit Leuven
Publication of DE602004031115D1 publication Critical patent/DE602004031115D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602004031115T 2003-06-16 2004-06-16 Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga Expired - Lifetime DE602004031115D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47889303P 2003-06-16 2003-06-16
PCT/CZ2004/000034 WO2004111064A1 (en) 2003-06-16 2004-06-16 Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs

Publications (1)

Publication Number Publication Date
DE602004031115D1 true DE602004031115D1 (de) 2011-03-03

Family

ID=33551859

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004031115T Expired - Lifetime DE602004031115D1 (de) 2003-06-16 2004-06-16 Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga

Country Status (15)

Country Link
US (2) US7115592B2 (enExample)
EP (1) EP1644389B1 (enExample)
JP (2) JP5280631B2 (enExample)
KR (1) KR101102815B1 (enExample)
CN (1) CN1805966B (enExample)
AT (1) ATE496056T1 (enExample)
AU (1) AU2004247305B2 (enExample)
CA (1) CA2527805C (enExample)
DE (1) DE602004031115D1 (enExample)
DK (1) DK1644389T3 (enExample)
EA (1) EA011948B1 (enExample)
IL (1) IL172015A (enExample)
NZ (1) NZ543864A (enExample)
SI (1) SI1644389T1 (enExample)
WO (1) WO2004111064A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1906971A2 (en) * 2005-07-27 2008-04-09 Gilead Sciences, Inc. Antiviral compounds
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
JP5988492B2 (ja) 2009-09-02 2016-09-07 ノバルティス アーゲー Ｔｌｒ活性モジュレーターを含む免疫原性組成物
AU2011239560B2 (en) * 2010-04-14 2016-11-03 The Regents Of The University Of California Phosphonates with reduced toxicity for treatment of viral infections
CA2809679C (en) * 2010-08-31 2018-03-20 Chimerix, Inc. Phosphonate ester derivatives and methods of synthesis thereof
CN105999275A (zh) 2010-09-01 2016-10-12 诺华有限公司 免疫增强剂吸附不溶性金属离子
CN104666315A (zh) 2010-12-10 2015-06-03 西格玛制药实验有限责任公司 口服活性核苷酸类似物或口服活性核苷酸类似物前药的高度稳定组合物
CA2828844C (en) 2011-03-02 2020-07-14 Novartis Ag Combination vaccines with lower doses of antigen and/or adjuvant
ES2874774T3 (es) 2011-12-22 2021-11-05 Geron Corp Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
AU2013229432A1 (en) 2012-03-08 2014-10-16 Novartis Ag Adjuvanted formulations of booster vaccines
CN103665043B (zh) * 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CN102796138B (zh) * 2012-09-07 2014-10-22 山东大学 (2-(3-甲硫基-1,2,4-噻二嗪)乙氧基)甲基膦酸酯类衍生物及其制备与应用
TWI642677B (zh) 2013-03-15 2018-12-01 美國加利福尼亞大學董事會 非環狀核苷膦酸二酯
EA036391B1 (ru) 2014-09-15 2020-11-05 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Нуклеотидные аналоги
EP3875462A1 (en) 2015-09-15 2021-09-08 The Regents of The University of California Nucleotide analogs
JP2025526212A (ja) 2022-07-21 2025-08-13 アンティバ バイオサイエンシズ インコーポレイテッド Ｈｐｖ感染症及びｈｐｖ誘発性新生物の治療用の組成物及び剤形

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
US4740365A (en) 1984-04-09 1988-04-26 Toyo Boseki Kabushiki Kaisha Sustained-release preparation applicable to mucous membrane in oral cavity
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
US4725233A (en) * 1985-10-30 1988-02-16 Jens Planert Device for removing crowns, bridges, and similar structures from the stumps of teeth
US5141752A (en) 1986-05-09 1992-08-25 Alza Corporation Delayed drug delivery device
CS264222B1 (en) 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
NZ222553A (en) 1986-11-18 1991-07-26 Bristol Myers Co Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
CA2001715C (en) 1988-11-14 1999-12-28 Muzammil M. Mansuri Carbocyclic nucleosides and nucleotides
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
CA2297294C (en) 1989-05-15 2005-11-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxymethylpurine/pyrimidine derivatives
MY104575A (en) 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5302585A (en) 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
SK280313B6 (sk) 1990-04-24 1999-11-08 �Stav Organick� Chemie A Biochemie Av �R N-(3-fluór-2-fosfonylmetoxypropyl)deriváty purínov
AU653542B2 (en) 1990-07-19 1994-10-06 Beecham Group Plc Antiviral phosphono-alken derivatives of purines
EP0468119A1 (en) 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
EP0481214B1 (en) 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US5208221A (en) 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
CZ284678B6 (cs) 1991-05-20 1999-01-13 Ústav Organické Chemie A Biochemie Avčr Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
AU661347B2 (en) 1991-10-11 1995-07-20 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
EP0618214A1 (en) 1993-04-01 1994-10-05 Merrell Dow Pharmaceuticals Inc. Unsaturated phosphonate derivatives of purines and pyrimidines
DE69435319D1 (de) 1993-09-17 2010-12-16 Gilead Sciences Inc Nukleotidanaloge
KR100447096B1 (ko) 1995-02-27 2005-10-11 갈리드사이언스인코오퍼레이티드 바이러스성또는세균성뉴라미니다제의신규한선택적저해제
US5977061A (en) 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
WO1998004569A1 (en) 1996-07-26 1998-02-05 Gilead Sciences, Inc. Nucleotide analogs
EA006020B1 (ru) * 2001-06-29 2005-08-25 Инститьют Оф Оргэник Кемистри Энд Байокемистри Оф Зе Экэдеми Оф Сайэнс Оф Зе Чек Рипаблик Производные 6-[2-(фосфонометокси)алкокси]пиримидинов, обладающие антивирусной активностью, способ их получения (варианты) и способ лечения вирусной инфекции

Also Published As

Publication number Publication date
US7115592B2 (en) 2006-10-03
AU2004247305A1 (en) 2004-12-23
KR101102815B1 (ko) 2012-01-05
WO2004111064A1 (en) 2004-12-23
NZ543864A (en) 2009-10-30
CA2527805A1 (en) 2004-12-23
IL172015A (en) 2016-07-31
CA2527805C (en) 2012-08-21
KR20060041182A (ko) 2006-05-11
EA011948B1 (ru) 2009-06-30
AU2004247305B2 (en) 2010-02-18
EP1644389B1 (en) 2011-01-19
US20050075318A1 (en) 2005-04-07
DK1644389T3 (da) 2011-05-09
US20060241081A1 (en) 2006-10-26
JP2012153731A (ja) 2012-08-16
EP1644389A1 (en) 2006-04-12
JP5280631B2 (ja) 2013-09-04
CN1805966B (zh) 2013-03-13
JP2006527702A (ja) 2006-12-07
IL172015A0 (en) 2009-02-11
CN1805966A (zh) 2006-07-19
HK1088013A1 (en) 2006-10-27
SI1644389T1 (sl) 2011-06-30
EA200600046A1 (ru) 2006-06-30
ATE496056T1 (de) 2011-02-15

Similar Documents

Publication Publication Date Title
DE602004031115D1 (de) Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
DK1501507T3 (da) Tetrahydropyranyl-cyclopentyl-tertrahydropyridopyrindin-modulatorer af kemokin-receptor-aktivitet
GT200200043A (es) Nuevos compuestos antiinflamatorios de bencimidazol
CA2492096A1 (en) Cis-alkoxy-substituted spirocyclic 1-h-pyrrolidine-2,4-dione derivatives serving as pesticides
EA200501333A1 (ru) 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
NO20062950L (no) 5,7-diaminopyrazolo `43-Dlpyrimidiner med PDE-5 inhiberende aktivitet
BR0305258A (pt) Inibidores de polimerase de ns5b de hcv
SE9904108D0 (sv) Nya föreningar
SE0004245D0 (sv) Novel compounds and their use
DE50209545D1 (de) Flüssigkristallines medium
DE60316984D1 (de) Benzoylsulfonamide als antitumor-mittel
SE0103710D0 (sv) Compounds
DE50310579D1 (de) Furancarboxamide
DE60311887D1 (de) Multifunktionelle kationische photoinitiatoren, deren herstellung und verwendung
BRPI0416678A (pt) pirazolpirimidinas
MXPA06003345A (es) Derivados de aminopiridina como inhibidores de la no-sintasa inducible.
DK1742950T3 (da) Pyrazolo-[4,3-D]-pyrimidiner
DE50311756D1 (de) Mikrobizide oxathiincarboxamide
ITMI20020933A1 (it) Procedimento per la sintesi di clopidogrel
GB0103240D0 (en) Organic compounds
EA200600092A1 (ru) Новые цитотоксические депсипептиды
WO2000043375A3 (de) Substituierte arylheterocyclen
GT200200250A (es) Compuestos hexaciclicos
DE50303586D1 (de) Methylthiophencarboxanilide
DE60328621D1 (de) Cyclooct-(en-)yl-derivate zur verwendung als duftstoffe