CN1805966B - 作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物 - Google Patents

作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物 Download PDF

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Publication number
CN1805966B
CN1805966B CN2004800168859A CN200480016885A CN1805966B CN 1805966 B CN1805966 B CN 1805966B CN 2004800168859 A CN2004800168859 A CN 2004800168859A CN 200480016885 A CN200480016885 A CN 200480016885A CN 1805966 B CN1805966 B CN 1805966B
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compound
group
independently
amino
formula
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Expired - Lifetime
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CN2004800168859A
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Chinese (zh)
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CN1805966A (zh
Inventor
J·M·R·巴尔扎里尼
E·D·A·德克莱尔克
D·霍茨科娃
A·霍利
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KU Leuven
Czech Academy of Sciences
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KU Leuven
Czech Academy of Sciences
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2004800168859A 2003-06-16 2004-06-16 作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物 Expired - Lifetime CN1805966B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47889303P 2003-06-16 2003-06-16
US60/478,893 2003-06-16
PCT/CZ2004/000034 WO2004111064A1 (en) 2003-06-16 2004-06-16 Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs

Publications (2)

Publication Number Publication Date
CN1805966A CN1805966A (zh) 2006-07-19
CN1805966B true CN1805966B (zh) 2013-03-13

Family

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Family Applications (1)

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CN2004800168859A Expired - Lifetime CN1805966B (zh) 2003-06-16 2004-06-16 作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物

Country Status (15)

Country Link
US (2) US7115592B2 (enExample)
EP (1) EP1644389B1 (enExample)
JP (2) JP5280631B2 (enExample)
KR (1) KR101102815B1 (enExample)
CN (1) CN1805966B (enExample)
AT (1) ATE496056T1 (enExample)
AU (1) AU2004247305B2 (enExample)
CA (1) CA2527805C (enExample)
DE (1) DE602004031115D1 (enExample)
DK (1) DK1644389T3 (enExample)
EA (1) EA011948B1 (enExample)
IL (1) IL172015A (enExample)
NZ (1) NZ543864A (enExample)
SI (1) SI1644389T1 (enExample)
WO (1) WO2004111064A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006272521A1 (en) * 2005-07-27 2007-02-01 Gilead Sciences, Inc. Antiviral phosphonate conjugates for inhibition of HIV
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
US9950062B2 (en) 2009-09-02 2018-04-24 Glaxosmithkline Biologicals Sa Compounds and compositions as TLR activity modulators
CN102939291B (zh) * 2010-04-14 2016-09-07 加利福尼亚大学董事会 用于病毒感染治疗的具有降低的毒性的膦酸酯
CN105998039A (zh) * 2010-08-31 2016-10-12 奇默里克斯公司 膦酸酯衍生物及其合成方法
JP2013538217A (ja) 2010-09-01 2013-10-10 ノバルティス アーゲー 不溶性金属塩への免疫増強物質の吸着
WO2012079035A1 (en) 2010-12-10 2012-06-14 Sigmapharm Laboratories, Llc Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs
CN103533954B (zh) 2011-03-02 2015-09-09 诺华股份有限公司 含较低剂量的抗原和/或佐剂的联合疫苗
CA2857490C (en) 2011-12-22 2020-03-31 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
CA2866406A1 (en) 2012-03-08 2013-09-12 Novartis Ag Adjuvanted formulations of booster vaccines
CN107312039B (zh) * 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
CN102796138B (zh) * 2012-09-07 2014-10-22 山东大学 (2-(3-甲硫基-1,2,4-噻二嗪)乙氧基)甲基膦酸酯类衍生物及其制备与应用
KR20150130355A (ko) 2013-03-15 2015-11-23 더 리전트 오브 더 유니버시티 오브 캘리포니아 비환식 뉴클레오사이드 포스포네이트 디에스테르
MX377983B (es) 2014-09-15 2025-03-04 Univ California Análogos de nucleótidos.
EP3875462A1 (en) 2015-09-15 2021-09-08 The Regents of The University of California Nucleotide analogs
KR20250052378A (ko) 2022-07-21 2025-04-18 안티바 바이오사이언시즈, 인크. Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2003002580A1 (en) * 2001-06-29 2003-01-09 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity

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US4740365A (en) 1984-04-09 1988-04-26 Toyo Boseki Kabushiki Kaisha Sustained-release preparation applicable to mucous membrane in oral cavity
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
JPS63501194A (ja) * 1985-10-30 1988-05-12 プラネルト・イエンス 歯の残根から冠，ブリツジ等を除去するための装置
US5141752A (en) * 1986-05-09 1992-08-25 Alza Corporation Delayed drug delivery device
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
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US5098443A (en) * 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
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CZ285420B6 (cs) 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
JPH05509307A (ja) * 1990-07-19 1993-12-22 ビーチャム・グループ・パブリック・リミテッド・カンパニー プリンの抗ウイルス性ホスホノ―アルケン誘導体
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EP0630381B1 (en) 1991-10-11 1997-04-09 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives
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WO2003002580A1 (en) * 2001-06-29 2003-01-09 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity

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Publication number Publication date
JP2006527702A (ja) 2006-12-07
EA011948B1 (ru) 2009-06-30
DK1644389T3 (da) 2011-05-09
CA2527805A1 (en) 2004-12-23
AU2004247305A1 (en) 2004-12-23
IL172015A (en) 2016-07-31
KR101102815B1 (ko) 2012-01-05
NZ543864A (en) 2009-10-30
CN1805966A (zh) 2006-07-19
ATE496056T1 (de) 2011-02-15
EP1644389B1 (en) 2011-01-19
DE602004031115D1 (de) 2011-03-03
US7115592B2 (en) 2006-10-03
CA2527805C (en) 2012-08-21
EP1644389A1 (en) 2006-04-12
JP2012153731A (ja) 2012-08-16
KR20060041182A (ko) 2006-05-11
US20060241081A1 (en) 2006-10-26
US20050075318A1 (en) 2005-04-07
WO2004111064A1 (en) 2004-12-23
IL172015A0 (en) 2009-02-11
EA200600046A1 (ru) 2006-06-30
HK1088013A1 (en) 2006-10-27
AU2004247305B2 (en) 2010-02-18
SI1644389T1 (sl) 2011-06-30
JP5280631B2 (ja) 2013-09-04

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Granted publication date: 20130313