JP5222846B2 - Fxr媒介疾患または状態の予防または治療のためのfxrリガンドとしての胆汁酸誘導体 - Google Patents
Fxr媒介疾患または状態の予防または治療のためのfxrリガンドとしての胆汁酸誘導体 Download PDFInfo
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- JP5222846B2 JP5222846B2 JP2009518230A JP2009518230A JP5222846B2 JP 5222846 B2 JP5222846 B2 JP 5222846B2 JP 2009518230 A JP2009518230 A JP 2009518230A JP 2009518230 A JP2009518230 A JP 2009518230A JP 5222846 B2 JP5222846 B2 JP 5222846B2
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/12—Antidiarrhoeals
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Virology (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81663506P | 2006-06-27 | 2006-06-27 | |
| US60/816,635 | 2006-06-27 | ||
| PCT/US2007/014829 WO2008002573A2 (en) | 2006-06-27 | 2007-06-27 | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010500285A JP2010500285A (ja) | 2010-01-07 |
| JP2010500285A5 JP2010500285A5 (enExample) | 2010-09-02 |
| JP5222846B2 true JP5222846B2 (ja) | 2013-06-26 |
Family
ID=38846269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518230A Expired - Fee Related JP5222846B2 (ja) | 2006-06-27 | 2007-06-27 | Fxr媒介疾患または状態の予防または治療のためのfxrリガンドとしての胆汁酸誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US7932244B2 (enExample) |
| EP (1) | EP2040713B1 (enExample) |
| JP (1) | JP5222846B2 (enExample) |
| CN (1) | CN101522703B (enExample) |
| AU (1) | AU2007265457C1 (enExample) |
| CA (1) | CA2656320C (enExample) |
| CY (1) | CY1115533T1 (enExample) |
| DK (1) | DK2040713T3 (enExample) |
| ES (1) | ES2523591T3 (enExample) |
| IL (2) | IL196169A (enExample) |
| PL (1) | PL2040713T3 (enExample) |
| PT (1) | PT2040713E (enExample) |
| SI (1) | SI2040713T1 (enExample) |
| WO (1) | WO2008002573A2 (enExample) |
Families Citing this family (98)
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|---|---|---|---|---|
| DE60205891T2 (de) | 2001-03-12 | 2006-06-22 | Intercept Pharmaceuticals, Inc. | Steroide als agonisten für fxr |
| ES2609395T5 (es) | 2004-03-12 | 2021-08-06 | Intercept Pharmaceuticals Inc | Tratamiento de la fibrosis usando ligandos de Fxr |
| US10987362B2 (en) | 2004-03-12 | 2021-04-27 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using FXR ligands |
| ITMI20050912A1 (it) | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
| EP2040713B1 (en) | 2006-06-27 | 2014-06-18 | Intercept Pharmaceuticals Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
| CN101679476B (zh) | 2007-01-19 | 2014-05-07 | 英特塞普特医药品公司 | 23取代的胆汁酸作为tgr5调节剂及其使用方法 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2009276507B2 (en) * | 2008-07-30 | 2015-11-19 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| CN102325784B (zh) | 2008-11-19 | 2014-11-19 | 英特塞普特医药品公司 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
| CN102316889B (zh) | 2008-11-26 | 2014-11-26 | 萨蒂奥根制药公司 | 组合物及使用方法 |
| JP2012509891A (ja) | 2008-11-26 | 2012-04-26 | サティオゲン ファーマシューティカルズ,インク. | 肥満症及び糖尿病を治療するための胆汁酸再循環阻害剤 |
| US20110257139A1 (en) | 2008-12-19 | 2011-10-20 | Royal College Of Surgeons In Ireland | Treatment of diarrhoea |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
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| CA2920017C (en) * | 2013-08-01 | 2021-11-23 | Frank J. Gonzalez | Inhibitors of the farnesoid x receptor and uses in medicine |
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