MX356006B - Proceso para obtener una molécula que sirve como elicitor de péptidos antimicrobianos. - Google Patents
Proceso para obtener una molécula que sirve como elicitor de péptidos antimicrobianos.Info
- Publication number
- MX356006B MX356006B MX2013012160A MX2013012160A MX356006B MX 356006 B MX356006 B MX 356006B MX 2013012160 A MX2013012160 A MX 2013012160A MX 2013012160 A MX2013012160 A MX 2013012160A MX 356006 B MX356006 B MX 356006B
- Authority
- MX
- Mexico
- Prior art keywords
- lithocholic acid
- antimicrobial peptide
- elicitor
- molecule
- antimicrobial
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención refiere un método para sintetizar enzimáticamente el litocoil oleato y purificarlo de manera eficiente. El litocoil oleato es una molécula que sirve como elicitor de péptidos antimicrobianos, el cual presenta actividad antimicrobiana indirecta e inmunomoduladora al inducir la expresión o sobrexpresión de péptidos antimicrobianos e interferón tipo II (interferón-?). El litocoil es un derivado del ácido litocólico esterificado con ácido oleico en la posición alfa 3-hidroxi. Es un líquido oleoso amarillento a temperatura ambiente con un peso molecular de 641 gr/mol y fórmula química C42H72O4. Esta molécula se puede utilizar sola o en combinación con ácido ascórbico y/o glucosa, los cuales se demuestra en esta invención que son elicitores de péptidos antimicrobianos, para el tratamiento de enfermedades infecciosas y crónico-degenerativas en el humano.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2013012160A MX356006B (es) | 2013-10-18 | 2013-10-18 | Proceso para obtener una molécula que sirve como elicitor de péptidos antimicrobianos. |
PCT/MX2014/000161 WO2015057047A1 (es) | 2013-10-18 | 2014-10-13 | Proceso para obtener una molécula que sirve como elicitor de péptidos antimicrobianos |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2013012160A MX356006B (es) | 2013-10-18 | 2013-10-18 | Proceso para obtener una molécula que sirve como elicitor de péptidos antimicrobianos. |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013012160A MX2013012160A (es) | 2015-04-17 |
MX356006B true MX356006B (es) | 2018-04-24 |
Family
ID=52828413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013012160A MX356006B (es) | 2013-10-18 | 2013-10-18 | Proceso para obtener una molécula que sirve como elicitor de péptidos antimicrobianos. |
Country Status (2)
Country | Link |
---|---|
MX (1) | MX356006B (es) |
WO (1) | WO2015057047A1 (es) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE375359T1 (de) * | 1998-08-12 | 2007-10-15 | Genaera Corp | Aminosterolderivate und ihre verwendungen |
EP2040713B1 (en) * | 2006-06-27 | 2014-06-18 | Intercept Pharmaceuticals Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
WO2008149563A1 (ja) * | 2007-06-04 | 2008-12-11 | Nihon University | 作用選択的ビタミンd受容体作用剤 |
-
2013
- 2013-10-18 MX MX2013012160A patent/MX356006B/es active IP Right Grant
-
2014
- 2014-10-13 WO PCT/MX2014/000161 patent/WO2015057047A1/es active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2015057047A9 (es) | 2015-07-02 |
MX2013012160A (es) | 2015-04-17 |
WO2015057047A1 (es) | 2015-04-23 |
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Legal Events
Date | Code | Title | Description |
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FG | Grant or registration |