EA201390639A1 - Производные 2-пиперазин-1-ил-4н-1,3-бензотиазин-4-она и их применение для лечения инфекций у млекопитающих - Google Patents

Производные 2-пиперазин-1-ил-4н-1,3-бензотиазин-4-она и их применение для лечения инфекций у млекопитающих

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Publication number
EA201390639A1
EA201390639A1 EA201390639A EA201390639A EA201390639A1 EA 201390639 A1 EA201390639 A1 EA 201390639A1 EA 201390639 A EA201390639 A EA 201390639A EA 201390639 A EA201390639 A EA 201390639A EA 201390639 A1 EA201390639 A1 EA 201390639A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzothiazin
piperazin
infections
treatment
mammals
Prior art date
Application number
EA201390639A
Other languages
English (en)
Other versions
EA023879B1 (ru
Inventor
Вадим Макаров
Стюарт Коул
Original Assignee
Эколь Политекник Федераль Де Лозанна (Эпфл)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Эколь Политекник Федераль Де Лозанна (Эпфл) filed Critical Эколь Политекник Федераль Де Лозанна (Эпфл)
Publication of EA201390639A1 publication Critical patent/EA201390639A1/ru
Publication of EA023879B1 publication Critical patent/EA023879B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым производным 2-пиперазин-1-ил-4H-1,3-бензотиазин-4-она и их применению для лечения инфекций у млекопитающих, вызванных бактериями, в частности таких заболеваний, как туберкулез (ТБ), язва Бурули и проказа, которые возникают в результате инфицирования близкородственными микобактериями.
EA201390639A 2010-11-19 2011-11-21 Производные 2-пиперазин-1-ил-4н-1,3-бензотиазин-4-она и их применение для лечения инфекций у млекопитающих EA023879B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2010000688 2010-11-19
PCT/IB2011/055209 WO2012066518A1 (en) 2010-11-19 2011-11-21 2-piperazin-1-yl-4h-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections

Publications (2)

Publication Number Publication Date
EA201390639A1 true EA201390639A1 (ru) 2013-09-30
EA023879B1 EA023879B1 (ru) 2016-07-29

Family

ID=45349249

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390639A EA023879B1 (ru) 2010-11-19 2011-11-21 Производные 2-пиперазин-1-ил-4н-1,3-бензотиазин-4-она и их применение для лечения инфекций у млекопитающих

Country Status (19)

Country Link
US (1) US8796264B2 (ru)
EP (1) EP2640712B1 (ru)
JP (1) JP6061346B2 (ru)
KR (2) KR101851774B1 (ru)
CN (2) CN107011287A (ru)
AU (1) AU2011330742B2 (ru)
BR (1) BR112013012280B1 (ru)
CA (1) CA2817931C (ru)
EA (1) EA023879B1 (ru)
ES (1) ES2690728T3 (ru)
GE (1) GEP201606545B (ru)
HU (1) HUE040152T2 (ru)
IL (1) IL226289A (ru)
LT (1) LT2640712T (ru)
PL (1) PL2640712T3 (ru)
TR (1) TR201815010T4 (ru)
UA (1) UA109557C2 (ru)
WO (1) WO2012066518A1 (ru)
ZA (1) ZA201303829B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103508980B (zh) * 2012-06-14 2016-07-06 四川大学 苯并噻嗪-4-酮衍生物及其制备方法和用途
CN104211708B (zh) * 2013-05-29 2018-08-24 中国医学科学院药物研究所 苯并噁嗪酮衍生物及其作为抗菌剂的应用
RU2016134406A (ru) * 2014-01-24 2018-03-01 Лэм Терапьютикс, Инк. Композиции апилимода и способы их применения
DE102014012546A1 (de) * 2014-09-26 2016-03-31 Martin-Luther-Universität Halle-Wittenberg Antimykobakteriell wirksame Substanzen, Verfahren zu ihrer Herstellung und deren Verwendung
CN107249638B (zh) 2014-11-07 2021-05-14 人工智能治疗公司 阿匹莫德用于治疗肾癌
EP3072889A1 (en) * 2015-03-23 2016-09-28 Ecole Polytechnique Federale De Lausanne (Epfl) 2-Homopiperazine-1-yl-4H-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides
US11155542B2 (en) 2016-09-22 2021-10-26 University Of Notre Dame Du Lac Antimicrobial compounds, their use for the treatment of mammalian infections and a new metabolic mechanism
CN108929329B (zh) * 2017-05-24 2020-12-11 中国医学科学院药物研究所 2-氮杂环-5-三氟甲基-8-硝基苯并(硫代)吡喃-4-酮类化合物
RU2751163C9 (ru) * 2020-04-06 2021-10-20 Общество С Ограниченной Ответственностью "Ниармедик Плюс" Фармацевтическая композиция на основе макозинона для лечения туберкулеза, включая его формы с множественной и широкой лекарственной устойчивостью.
CN111303075A (zh) * 2020-04-08 2020-06-19 苏州大学 苯并噻嗪酮衍生物及其制备方法与作为抗结核药物的应用
KR102409518B1 (ko) 2020-06-22 2022-06-17 조은바이오주식회사 대량의 하천수를 저장하여 인공양어장을 조성함과 동시에 미세먼지 발생량을 줄여주도록 유도시켜서 대기중의 오염된 공기를 개선시킴과 동시에 비중이 무거운 깨끗한 물 분자를 우선적으로 배출하여 오염된 하천수를 깨끗한 하천수로 정화시키도록 구성되는 자연친화적인 친환경 저수시스템을 이용하여 대량의 전기를 생산하면서 저수지, 호수,댐, 석호,하천,강의 수질을 자연정화시키는 자연친화적인 수질정화 친환경공법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470168A (en) * 1967-03-31 1969-09-30 American Home Prod 2-substituted-4h-1,3-benzothiazin-4-one derivatives
US3522247A (en) 1967-11-07 1970-07-28 Pfizer & Co C 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators
EA015910B1 (ru) 2006-05-24 2011-12-30 Ляйбниц Инститьют Фор Нэчерал Продакт Ресерч Энд Инфекшн Байолоджи Э. Ф. Ханс-Кнелль-Институт (Хки) Производные бензотиазинона и их применение в качестве антибактериальных средств
EP2020406A1 (en) 2007-07-16 2009-02-04 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knöll-Institut New antimicrobial compounds, their synthesis and their use for treatment of mammalian infection
EP2380886A1 (en) * 2010-04-23 2011-10-26 Vadim A. Makarov Process for the preparation of 2-aminosubstituted 1,3-benzothiazine-4-ones
CN102367239B (zh) * 2011-07-20 2015-10-28 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途

Also Published As

Publication number Publication date
WO2012066518A1 (en) 2012-05-24
CN107011287A (zh) 2017-08-04
EA023879B1 (ru) 2016-07-29
EP2640712A1 (en) 2013-09-25
ES2690728T3 (es) 2018-11-22
TR201815010T4 (tr) 2018-11-21
IL226289A (en) 2016-07-31
BR112013012280B1 (pt) 2022-01-04
KR101871970B1 (ko) 2018-08-02
AU2011330742A1 (en) 2013-06-27
CA2817931A1 (en) 2012-05-24
HUE040152T2 (hu) 2019-02-28
JP6061346B2 (ja) 2017-01-18
IL226289A0 (en) 2013-07-31
CA2817931C (en) 2017-10-31
ZA201303829B (en) 2014-01-29
UA109557C2 (uk) 2015-09-10
AU2011330742B2 (en) 2016-10-13
KR101851774B1 (ko) 2018-04-25
GEP201606545B (en) 2016-09-26
EP2640712B1 (en) 2018-07-11
LT2640712T (lt) 2018-11-12
BR112013012280A2 (pt) 2020-09-01
KR20140012956A (ko) 2014-02-04
JP2013542980A (ja) 2013-11-28
KR20170137211A (ko) 2017-12-12
PL2640712T3 (pl) 2019-03-29
CN103221399A (zh) 2013-07-24
US20130245007A1 (en) 2013-09-19
US8796264B2 (en) 2014-08-05

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