JP5214436B2 - 置換された環状尿素誘導体及び医薬の製造へのその使用 - Google Patents

置換された環状尿素誘導体及び医薬の製造へのその使用 Download PDF

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JP5214436B2
JP5214436B2 JP2008506989A JP2008506989A JP5214436B2 JP 5214436 B2 JP5214436 B2 JP 5214436B2 JP 2008506989 A JP2008506989 A JP 2008506989A JP 2008506989 A JP2008506989 A JP 2008506989A JP 5214436 B2 JP5214436 B2 JP 5214436B2
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JP2008538366A5 (https=
JP2008538366A (ja
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フランク・ローベルト
ズンダーマン・ベルント
シック・ハンス
ゾンネンシャイン・ヘルムート
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グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
JP2008506989A 2005-04-19 2006-04-18 置換された環状尿素誘導体及び医薬の製造へのその使用 Expired - Fee Related JP5214436B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005018191.0 2005-04-19
DE102005018191A DE102005018191A1 (de) 2005-04-19 2005-04-19 Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
PCT/EP2006/003519 WO2006111346A1 (de) 2005-04-19 2006-04-18 Substituierte zyklische harnstoff-derivate und deren verwendung als vanilloid-rezeptor 1 modulatoren

Publications (3)

Publication Number Publication Date
JP2008538366A JP2008538366A (ja) 2008-10-23
JP2008538366A5 JP2008538366A5 (https=) 2013-02-14
JP5214436B2 true JP5214436B2 (ja) 2013-06-19

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JP2008506989A Expired - Fee Related JP5214436B2 (ja) 2005-04-19 2006-04-18 置換された環状尿素誘導体及び医薬の製造へのその使用

Country Status (8)

Country Link
US (1) US8207182B2 (https=)
EP (1) EP1874733B1 (https=)
JP (1) JP5214436B2 (https=)
CA (1) CA2605144C (https=)
DE (1) DE102005018191A1 (https=)
ES (1) ES2386796T3 (https=)
PL (1) PL1874733T3 (https=)
WO (1) WO2006111346A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008029168A2 (en) * 2006-09-08 2008-03-13 Summit Corporation Plc Treatment of duchenne muscular dystrophy
US8557872B2 (en) 2008-01-28 2013-10-15 Amorepacific Corporation Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
US8691855B2 (en) 2008-07-02 2014-04-08 Amorepacific Corporation Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same
WO2011018790A1 (en) * 2009-08-12 2011-02-17 Technion Research & Development Foundation Ltd. Polycyclic compounds, termed calixurenes, and uses thereof
US8815265B2 (en) 2010-06-30 2014-08-26 Avon Products, Inc. Cosmetic use of N-substituted sulfonyloxybenzylamines and related compounds
KR102505374B1 (ko) * 2016-10-06 2023-03-02 닛산 가가쿠 가부시키가이샤 디아민, 중합체, 액정 배향제, 액정 배향막 및 액정 표시 소자
US20240287019A1 (en) * 2021-06-07 2024-08-29 Kinki University T-type calcium channel blocker

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670368A1 (de) * 1966-07-16 1970-11-05 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung aralkylsubstituierter Lactame und Cyclischer Harnstoffe
JPS588503B2 (ja) * 1974-12-27 1983-02-16 富士写真フイルム株式会社 カラ−シヤシンカンコウザイリヨウ
JPS58203976A (ja) * 1982-05-24 1983-11-28 Sumitomo Chem Co Ltd ベンズイミダゾリン−２−チオン誘導体の製造法
JPS63170011A (ja) * 1987-01-07 1988-07-13 Mitsubishi Monsanto Chem Co アミド系樹脂成形品およびその製造法
GB8724912D0 (en) 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
DE4300912A1 (de) * 1993-01-15 1994-07-21 Merck Patent Gmbh Chinazolinderivate
FR2722190B1 (fr) * 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
US5612363A (en) * 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
WO1997008150A1 (en) * 1995-08-22 1997-03-06 The Du Pont Merck Pharmaceutical Company Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors
AU2001280229B2 (en) * 2000-08-21 2006-12-07 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
WO2004103281A2 (en) * 2003-05-16 2004-12-02 Georgetown University Vanilloid receptor antagonists, and methods of making and using them
US20090264650A1 (en) 2005-03-31 2009-10-22 Nobuo Cho Prophylactic/Therapeutic Agent for Diabetes

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Publication number Publication date
US20080090855A1 (en) 2008-04-17
DE102005018191A1 (de) 2006-10-26
CA2605144C (en) 2014-05-27
WO2006111346A1 (de) 2006-10-26
US8207182B2 (en) 2012-06-26
CA2605144A1 (en) 2006-10-26
PL1874733T3 (pl) 2012-09-28
EP1874733A1 (de) 2008-01-09
JP2008538366A (ja) 2008-10-23
ES2386796T3 (es) 2012-08-30
EP1874733B1 (de) 2012-06-20

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