JP5119153B2 - イリノテカン塩酸塩の新規結晶形 - Google Patents

イリノテカン塩酸塩の新規結晶形 Download PDF

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Publication number
JP5119153B2
JP5119153B2 JP2008531427A JP2008531427A JP5119153B2 JP 5119153 B2 JP5119153 B2 JP 5119153B2 JP 2008531427 A JP2008531427 A JP 2008531427A JP 2008531427 A JP2008531427 A JP 2008531427A JP 5119153 B2 JP5119153 B2 JP 5119153B2
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Japan
Prior art keywords
irinotecan hydrochloride
irinotecan
iii
pxrd
infrared diffuse
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JP2008531427A
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English (en)
Japanese (ja)
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JP2009508874A (ja
JP2009508874A5 (https=
Inventor
チェン，シュー−ピン
ハーン，ピイン−ジー
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Scinopharm Singapore Pte Ltd
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Scinopharm Singapore Pte Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2008531427A 2005-09-20 2006-09-19 イリノテカン塩酸塩の新規結晶形 Expired - Fee Related JP5119153B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71882705P 2005-09-20 2005-09-20
US60/718,827 2005-09-20
PCT/US2006/036437 WO2007035709A2 (en) 2005-09-20 2006-09-19 Novel crystal forms of irinotecan hydrochloride

Publications (3)

Publication Number Publication Date
JP2009508874A JP2009508874A (ja) 2009-03-05
JP2009508874A5 JP2009508874A5 (https=) 2009-11-12
JP5119153B2 true JP5119153B2 (ja) 2013-01-16

Family

ID=37889452

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008531427A Expired - Fee Related JP5119153B2 (ja) 2005-09-20 2006-09-19 イリノテカン塩酸塩の新規結晶形

Country Status (14)

Country Link
US (1) US7435818B2 (https=)
EP (2) EP2082741A1 (https=)
JP (1) JP5119153B2 (https=)
KR (1) KR101150504B1 (https=)
CN (1) CN101277694B (https=)
AR (1) AR056082A1 (https=)
AT (1) ATE460162T1 (https=)
AU (1) AU2006292328B2 (https=)
BR (1) BRPI0616308A2 (https=)
CA (1) CA2623117C (https=)
DE (1) DE602006012871D1 (https=)
ES (1) ES2343204T3 (https=)
NZ (1) NZ566807A (https=)
WO (1) WO2007035709A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101318964B (zh) * 2007-06-07 2010-12-15 上海迪赛诺医药发展有限公司 盐酸伊立替康新晶型及其制备方法
US7572803B2 (en) * 2007-10-25 2009-08-11 The Christus Stehlin Foundation For Cancer Research Hydrated crystalline esters of camptothecin
IT1391757B1 (it) * 2008-11-11 2012-01-27 Antibioticos Spa Irinotecan cloridrato cristallino e metodi per la sua preparazione
US8546573B2 (en) 2009-11-18 2013-10-01 Cadila Healthcare Limited Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperdino] carbonyloxy-camptothecin hydrochloride trihydrate
WO2012007952A1 (en) * 2010-07-12 2012-01-19 Hetero Research Foundation Novel polymorph of irinotecan hydrochloride
CN102311443B (zh) * 2011-08-24 2014-07-16 上海北卡医药技术有限公司 盐酸伊立替康的新晶型及其制备方法
CN102617584B (zh) * 2012-03-14 2013-10-16 海南锦瑞制药股份有限公司 一种盐酸伊立替康化合物及其药物组合物
CN102850363B (zh) * 2012-09-18 2013-07-10 山东罗欣药业股份有限公司 盐酸伊立替康化合物及其药物组合物
MX2015014486A (es) * 2013-04-15 2016-07-21 Regeneron Pharma Marcadores de respuesta de células tumorales a la terapia.
CN105713004A (zh) * 2016-03-23 2016-06-29 杭州华东医药集团新药研究院有限公司 一种高品质盐酸伊立替康三水合物晶型的制备方法
US10919905B2 (en) * 2019-05-16 2021-02-16 Scinopharm Taiwan, Ltd. Polymorphism for irinotecan free base

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
AR015190A1 (es) * 1997-10-23 2001-04-18 Smithkline Beecham Corp Un polimorfo cristalino de 1,3-diciclopropilmetil-8-aminoxantina, procedimiento para su preparacion, composiciones farmaceuticas que lo contienen y su usopara la manufactura de un medicamento
EP1248869A2 (en) 2000-01-07 2002-10-16 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
JP2005525367A (ja) 2002-03-01 2005-08-25 フアルマシア・イタリア・エツセ・ピー・アー 塩酸イリノテカンの結晶多形
CZ20022250A3 (cs) * 2002-06-27 2004-02-18 Pliva-Lachema A. S. Způsob výroby irinotekanu
NZ541990A (en) 2003-02-25 2009-04-30 Yakult Honsha Kk Method for preparing polymorphism of irinotecan hydrochloride
JP2008509211A (ja) * 2004-08-09 2008-03-27 シルパ・メディケア・リミテッド 塩酸イリノテカン三水和物の改良された製造方法
US20060046993A1 (en) * 2004-09-01 2006-03-02 Pharmacia Italia S.P.A. Crystalline polymorphic form of irinotecan hydrochloride
WO2006082279A1 (en) * 2005-02-07 2006-08-10 Fermion Oy Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin
PL1928883T3 (pl) * 2005-02-08 2014-03-31 Fermion Oy Sposób otrzymywania chlorowodorku irynotekanu

Also Published As

Publication number Publication date
AU2006292328B2 (en) 2012-12-20
US7435818B2 (en) 2008-10-14
CN101277694B (zh) 2011-04-20
AR056082A1 (es) 2007-09-19
EP1951235A4 (en) 2008-10-29
ES2343204T3 (es) 2010-07-26
JP2009508874A (ja) 2009-03-05
AU2006292328A1 (en) 2007-03-29
CA2623117A1 (en) 2007-03-29
EP1951235B1 (en) 2010-03-10
EP1951235A2 (en) 2008-08-06
WO2007035709A2 (en) 2007-03-29
ATE460162T1 (de) 2010-03-15
KR20080059244A (ko) 2008-06-26
NZ566807A (en) 2011-05-27
DE602006012871D1 (de) 2010-04-22
KR101150504B1 (ko) 2012-07-09
CA2623117C (en) 2013-12-10
EP2082741A1 (en) 2009-07-29
CN101277694A (zh) 2008-10-01
WO2007035709A3 (en) 2007-10-25
US20070072890A1 (en) 2007-03-29
BRPI0616308A2 (pt) 2011-06-14

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