JP5068642B2 - ピロール−2−カルボニトリルの合成 - Google Patents
ピロール−2−カルボニトリルの合成 Download PDFInfo
- Publication number
- JP5068642B2 JP5068642B2 JP2007506458A JP2007506458A JP5068642B2 JP 5068642 B2 JP5068642 B2 JP 5068642B2 JP 2007506458 A JP2007506458 A JP 2007506458A JP 2007506458 A JP2007506458 A JP 2007506458A JP 5068642 B2 JP5068642 B2 JP 5068642B2
- Authority
- JP
- Japan
- Prior art keywords
- pyrrole
- carbonitrile
- solution phase
- chem
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Description
Claims (14)
- 1−メチル−ピロール−2−カルボニトリルの調製法であって:
(a)1−メチル−ピロールを溶媒の存在下でクロロスルホニルイソシアネートと反応させ;
(b)工程(a)の生成物をモル過剰量のN,N−ジアルキルホルムアミドまたはN−ホルミルモルホリンと接触させ;
(c)工程(b)の生成物をモル過剰量の有機塩基と接触させ、その結果、沈殿および溶液相が生成し;
(d)溶液相から沈殿を分離し;
(e)工程(d)の溶液相に水を添加し;
(f)工程(e)の溶液相から蒸留により1−メチル−ピロール−2−カルボニトリルを単離することを含む方法。 - 少なくとも2.0モル当量のN,N−ジアルキルホルムアミドまたはN−ホルミルモルホリンが工程(b)において使用される請求項1記載の方法。
- 前記有機塩基が、ターシャリーアミンまたは芳香族アミンである請求項1または2記載の方法。
- 少なくとも2.0モル当量のターシャリーアミンまたは芳香族アミンが工程(c)において使用される請求項3記載の方法。
- 溶媒がトルエンまたはアセトニトリルである請求項1〜4のいずれか1つに記載の方法。
- 溶媒がトルエンである請求項5記載の方法。
- ターシャリーアミンがトリエチルアミンである請求項3〜6のいずれか1つに記載の方法。
- 芳香族アミンがピリジンである請求項3〜6のいずれか1つに記載の方法。
- 工程(b)がN−ホルミルモルホリンを用いて行われる請求項1〜8のいずれか1つに記載の方法。
- N,N−ジアルキルホルムアミドがN,N−ジメチルホルムアミドである請求項1〜8のいずれか1つに記載の方法。
- 1−メチル−ピロールとクロロスルホニルイソシアネートのモル比が0.9:1〜1.1:1である請求項1〜10のいずれか1つに記載の方法。
- 溶媒1当量当たり0.1〜0.4モル当量の水が使用される請求項1〜11のいずれか1つに記載の方法。
- 工程(d)の溶液相が、工程(e)における水の添加の前に濃縮される請求項12記載の方法。
- 工程(a)が0℃以下の温度で行われる請求項1〜13のいずれか1つに記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55780704P | 2004-03-30 | 2004-03-30 | |
US60/557,807 | 2004-03-30 | ||
US11/086,061 | 2005-03-22 | ||
US11/086,061 US7399870B2 (en) | 2004-03-30 | 2005-03-22 | Synthesis of pyrrole-2-carbonitriles |
PCT/US2005/010468 WO2005097743A1 (en) | 2004-03-30 | 2005-03-28 | Synthesis of pyrrole-2-carbonitriles |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012101507A Division JP2012158599A (ja) | 2004-03-30 | 2012-04-26 | ピロール−2−カルボニトリルの合成 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007531748A JP2007531748A (ja) | 2007-11-08 |
JP5068642B2 true JP5068642B2 (ja) | 2012-11-07 |
Family
ID=34963600
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007506458A Expired - Fee Related JP5068642B2 (ja) | 2004-03-30 | 2005-03-28 | ピロール−2−カルボニトリルの合成 |
JP2012101507A Withdrawn JP2012158599A (ja) | 2004-03-30 | 2012-04-26 | ピロール−2−カルボニトリルの合成 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012101507A Withdrawn JP2012158599A (ja) | 2004-03-30 | 2012-04-26 | ピロール−2−カルボニトリルの合成 |
Country Status (22)
Country | Link |
---|---|
US (1) | US7399870B2 (ja) |
EP (1) | EP1730109B1 (ja) |
JP (2) | JP5068642B2 (ja) |
KR (1) | KR20070009654A (ja) |
AR (1) | AR049157A1 (ja) |
AT (1) | ATE402145T1 (ja) |
AU (1) | AU2005230896A1 (ja) |
BR (1) | BRPI0509317B1 (ja) |
CA (1) | CA2560964C (ja) |
CR (1) | CR8641A (ja) |
DE (1) | DE602005008408D1 (ja) |
DK (1) | DK1730109T3 (ja) |
EC (1) | ECSP066897A (ja) |
ES (1) | ES2310817T3 (ja) |
HN (1) | HN2005000134A (ja) |
IL (1) | IL178184A0 (ja) |
NO (1) | NO20064891L (ja) |
PE (1) | PE20060203A1 (ja) |
PL (1) | PL1730109T3 (ja) |
RU (1) | RU2006134013A (ja) |
TW (1) | TW200604166A (ja) |
WO (1) | WO2005097743A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009082478A1 (en) * | 2007-12-20 | 2009-07-02 | Duramed Pharmaceuticals, Inc. | Dosage regimens and pharmaceutical compositions and packages for emergency contraception |
JP5754768B2 (ja) * | 2011-03-10 | 2015-07-29 | 学校法人明治大学 | 芳香族へテロ環化合物のニトリル化物の製造方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3506642A1 (de) * | 1985-02-26 | 1986-08-28 | A. Nattermann & Cie GmbH, 5000 Köln | Neue pyrrolamidine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
US5204332A (en) * | 1988-12-05 | 1993-04-20 | American Cyanamid Company | Pyrrole carbonitrile and nitropyrrole insecticidal and acaricidal and molluscicidal agents |
KR20000047461A (ko) * | 1998-12-29 | 2000-07-25 | 성재갑 | 트롬빈 억제제 |
-
2005
- 2005-03-22 US US11/086,061 patent/US7399870B2/en not_active Expired - Fee Related
- 2005-03-28 EP EP05729200A patent/EP1730109B1/en active Active
- 2005-03-28 CA CA2560964A patent/CA2560964C/en not_active Expired - Fee Related
- 2005-03-28 DE DE602005008408T patent/DE602005008408D1/de active Active
- 2005-03-28 ES ES05729200T patent/ES2310817T3/es active Active
- 2005-03-28 AU AU2005230896A patent/AU2005230896A1/en not_active Withdrawn
- 2005-03-28 BR BRPI0509317-1A patent/BRPI0509317B1/pt not_active IP Right Cessation
- 2005-03-28 PL PL05729200T patent/PL1730109T3/pl unknown
- 2005-03-28 JP JP2007506458A patent/JP5068642B2/ja not_active Expired - Fee Related
- 2005-03-28 DK DK05729200T patent/DK1730109T3/da active
- 2005-03-28 WO PCT/US2005/010468 patent/WO2005097743A1/en active Application Filing
- 2005-03-28 KR KR1020067022663A patent/KR20070009654A/ko not_active Application Discontinuation
- 2005-03-28 RU RU2006134013/04A patent/RU2006134013A/ru not_active Application Discontinuation
- 2005-03-28 AT AT05729200T patent/ATE402145T1/de not_active IP Right Cessation
- 2005-03-30 TW TW094109918A patent/TW200604166A/zh unknown
- 2005-03-30 PE PE2005000364A patent/PE20060203A1/es not_active Application Discontinuation
- 2005-03-30 AR ARP050101206A patent/AR049157A1/es unknown
- 2005-03-30 HN HN2005000134A patent/HN2005000134A/es unknown
-
2006
- 2006-09-19 IL IL178184A patent/IL178184A0/en unknown
- 2006-09-20 CR CR8641A patent/CR8641A/es not_active Application Discontinuation
- 2006-09-29 EC EC2006006897A patent/ECSP066897A/es unknown
- 2006-10-26 NO NO20064891A patent/NO20064891L/no not_active Application Discontinuation
-
2012
- 2012-04-26 JP JP2012101507A patent/JP2012158599A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2007531748A (ja) | 2007-11-08 |
DK1730109T3 (da) | 2008-09-29 |
BRPI0509317B1 (pt) | 2014-04-29 |
US20050222432A1 (en) | 2005-10-06 |
WO2005097743A1 (en) | 2005-10-20 |
NO20064891L (no) | 2006-10-26 |
PL1730109T3 (pl) | 2008-10-31 |
RU2006134013A (ru) | 2008-05-10 |
PE20060203A1 (es) | 2006-03-30 |
EP1730109B1 (en) | 2008-07-23 |
ES2310817T3 (es) | 2009-01-16 |
HN2005000134A (es) | 2007-03-26 |
US7399870B2 (en) | 2008-07-15 |
CA2560964A1 (en) | 2005-10-20 |
AU2005230896A1 (en) | 2005-10-20 |
BRPI0509317A (pt) | 2007-09-04 |
CR8641A (es) | 2007-08-28 |
KR20070009654A (ko) | 2007-01-18 |
JP2012158599A (ja) | 2012-08-23 |
DE602005008408D1 (en) | 2008-09-04 |
EP1730109A1 (en) | 2006-12-13 |
ATE402145T1 (de) | 2008-08-15 |
CA2560964C (en) | 2012-10-30 |
IL178184A0 (en) | 2006-12-31 |
AR049157A1 (es) | 2006-07-05 |
TW200604166A (en) | 2006-02-01 |
ECSP066897A (es) | 2006-11-24 |
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