BRPI0509317A - sìntese de pirrol-2-carbonitrilas - Google Patents

sìntese de pirrol-2-carbonitrilas

Info

Publication number
BRPI0509317A
BRPI0509317A BRPI0509317-1A BRPI0509317A BRPI0509317A BR PI0509317 A BRPI0509317 A BR PI0509317A BR PI0509317 A BRPI0509317 A BR PI0509317A BR PI0509317 A BRPI0509317 A BR PI0509317A
Authority
BR
Brazil
Prior art keywords
pyrrol
solution phase
carbonitrile
precipitate
molar excess
Prior art date
Application number
BRPI0509317-1A
Other languages
English (en)
Inventor
Jean Louise Helom
Arkadiy Zinoviy Rubezhov
Anthony Scott Pilcher
Bogdan Kazimierz Wilk
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0509317A publication Critical patent/BRPI0509317A/pt
Publication of BRPI0509317B1 publication Critical patent/BRPI0509317B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Abstract

"SìNTESE DE PIRROL-2-CARBONITRILAS". A presente invenção refere-se a processos para a produção de pirrol-2-carbonitrilas tal como 1-metilpirrol-2-carbonitrila. Tais processos compreendem preferivelmente as etapas de reagir um pirrol com isocianato de clorosulfonilaa na presença de um solvente e colocar em contato o produto resultante com um excesso molar de uma amida tal como N,N- dialquilformamida. O produto dessa etapa de contato é então colocado em contato com um excesso molar de uma base orgânica para produzir um precipitado e uma fase de solução. O precipitado é então separado da fase de solução e a pirrol-2-carbonitrila correspondente é isolada a partir da fase de solução resultante.
BRPI0509317-1A 2004-03-30 2005-03-28 Processo para preparar uma pirrol-2-carbonitrila e produto BRPI0509317B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US55780704P 2004-03-30 2004-03-30
US60/557,807 2004-03-30
US11/086,061 US7399870B2 (en) 2004-03-30 2005-03-22 Synthesis of pyrrole-2-carbonitriles
US11/086,061 2005-03-22
PCT/US2005/010468 WO2005097743A1 (en) 2004-03-30 2005-03-28 Synthesis of pyrrole-2-carbonitriles

Publications (2)

Publication Number Publication Date
BRPI0509317A true BRPI0509317A (pt) 2007-09-04
BRPI0509317B1 BRPI0509317B1 (pt) 2014-04-29

Family

ID=34963600

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509317-1A BRPI0509317B1 (pt) 2004-03-30 2005-03-28 Processo para preparar uma pirrol-2-carbonitrila e produto

Country Status (22)

Country Link
US (1) US7399870B2 (pt)
EP (1) EP1730109B1 (pt)
JP (2) JP5068642B2 (pt)
KR (1) KR20070009654A (pt)
AR (1) AR049157A1 (pt)
AT (1) ATE402145T1 (pt)
AU (1) AU2005230896A1 (pt)
BR (1) BRPI0509317B1 (pt)
CA (1) CA2560964C (pt)
CR (1) CR8641A (pt)
DE (1) DE602005008408D1 (pt)
DK (1) DK1730109T3 (pt)
EC (1) ECSP066897A (pt)
ES (1) ES2310817T3 (pt)
HN (1) HN2005000134A (pt)
IL (1) IL178184A0 (pt)
NO (1) NO20064891L (pt)
PE (1) PE20060203A1 (pt)
PL (1) PL1730109T3 (pt)
RU (1) RU2006134013A (pt)
TW (1) TW200604166A (pt)
WO (1) WO2005097743A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2710293A1 (en) * 2007-12-20 2009-07-02 Teva Women's Health, Inc. Dosage regimens and pharmaceutical compositions and packages for emergency contraception
JP5754768B2 (ja) * 2011-03-10 2015-07-29 学校法人明治大学 芳香族へテロ環化合物のニトリル化物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3506642A1 (de) * 1985-02-26 1986-08-28 A. Nattermann & Cie GmbH, 5000 Köln Neue pyrrolamidine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US5204332A (en) * 1988-12-05 1993-04-20 American Cyanamid Company Pyrrole carbonitrile and nitropyrrole insecticidal and acaricidal and molluscicidal agents
KR20000047461A (ko) * 1998-12-29 2000-07-25 성재갑 트롬빈 억제제

Also Published As

Publication number Publication date
CA2560964C (en) 2012-10-30
RU2006134013A (ru) 2008-05-10
DE602005008408D1 (en) 2008-09-04
US7399870B2 (en) 2008-07-15
ECSP066897A (es) 2006-11-24
EP1730109B1 (en) 2008-07-23
CR8641A (es) 2007-08-28
KR20070009654A (ko) 2007-01-18
PL1730109T3 (pl) 2008-10-31
IL178184A0 (en) 2006-12-31
DK1730109T3 (da) 2008-09-29
PE20060203A1 (es) 2006-03-30
JP2007531748A (ja) 2007-11-08
US20050222432A1 (en) 2005-10-06
WO2005097743A1 (en) 2005-10-20
HN2005000134A (es) 2007-03-26
NO20064891L (no) 2006-10-26
JP5068642B2 (ja) 2012-11-07
TW200604166A (en) 2006-02-01
EP1730109A1 (en) 2006-12-13
AR049157A1 (es) 2006-07-05
CA2560964A1 (en) 2005-10-20
AU2005230896A1 (en) 2005-10-20
BRPI0509317B1 (pt) 2014-04-29
JP2012158599A (ja) 2012-08-23
ES2310817T3 (es) 2009-01-16
ATE402145T1 (de) 2008-08-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/03/2005, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 11A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.