JP4982337B2 - ヘリコバクター・ピロリに関連する疾患を治療する際の、生姜の根茎から抽出された有効産物の使用 - Google Patents
ヘリコバクター・ピロリに関連する疾患を治療する際の、生姜の根茎から抽出された有効産物の使用 Download PDFInfo
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- JP4982337B2 JP4982337B2 JP2007301916A JP2007301916A JP4982337B2 JP 4982337 B2 JP4982337 B2 JP 4982337B2 JP 2007301916 A JP2007301916 A JP 2007301916A JP 2007301916 A JP2007301916 A JP 2007301916A JP 4982337 B2 JP4982337 B2 JP 4982337B2
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- 235000006886 Zingiber officinale Nutrition 0.000 title claims description 35
- 235000008397 ginger Nutrition 0.000 title claims description 35
- 241000234314 Zingiber Species 0.000 title claims description 33
- 201000010099 disease Diseases 0.000 title claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 9
- 229940037467 helicobacter pylori Drugs 0.000 title description 16
- 241000590002 Helicobacter pylori Species 0.000 title description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 142
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 72
- 239000003480 eluent Substances 0.000 claims description 72
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 66
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 66
- 239000000203 mixture Substances 0.000 claims description 59
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 47
- 239000008194 pharmaceutical composition Substances 0.000 claims description 46
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 31
- 239000000706 filtrate Substances 0.000 claims description 28
- 239000003960 organic solvent Substances 0.000 claims description 27
- OQWKEEOHDMUXEO-UHFFFAOYSA-N (6)-shogaol Natural products CCCCCC=CC(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-UHFFFAOYSA-N 0.000 claims description 23
- OQWKEEOHDMUXEO-BQYQJAHWSA-N [6]-Shogaol Chemical compound CCCCC\C=C\C(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-BQYQJAHWSA-N 0.000 claims description 23
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims description 20
- 239000000047 product Substances 0.000 claims description 19
- 239000000287 crude extract Substances 0.000 claims description 18
- 238000001704 evaporation Methods 0.000 claims description 15
- 208000007107 Stomach Ulcer Diseases 0.000 claims description 12
- 238000010828 elution Methods 0.000 claims description 12
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- 238000004587 chromatography analysis Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 8
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- 230000008020 evaporation Effects 0.000 claims description 7
- 238000011282 treatment Methods 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 208000007882 Gastritis Diseases 0.000 claims description 4
- 208000000718 duodenal ulcer Diseases 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 244000273928 Zingiber officinale Species 0.000 claims description 2
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- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 16
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 16
- 239000000243 solution Substances 0.000 description 13
- 239000012141 concentrate Substances 0.000 description 12
- 238000010992 reflux Methods 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 235000002780 gingerol Nutrition 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
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- OJYLAHXKWMRDGS-UHFFFAOYSA-N zingerone Chemical compound COC1=CC(CCC(C)=O)=CC=C1O OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 description 3
- 240000002234 Allium sativum Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
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- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
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- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 238000001604 Rao's score test Methods 0.000 description 1
- 240000004482 Withania somnifera Species 0.000 description 1
- 235000001978 Withania somnifera Nutrition 0.000 description 1
- 244000131415 Zanthoxylum piperitum Species 0.000 description 1
- 235000008853 Zanthoxylum piperitum Nutrition 0.000 description 1
- 238000002814 agar dilution Methods 0.000 description 1
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- 230000002776 aggregation Effects 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002790 anti-mutagenic effect Effects 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
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- 210000004369 blood Anatomy 0.000 description 1
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- 210000004556 brain Anatomy 0.000 description 1
- 230000003177 cardiotonic effect Effects 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 description 1
- 229960002626 clarithromycin Drugs 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
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- IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
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- 201000009240 nasopharyngitis Diseases 0.000 description 1
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- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
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- 230000036269 ulceration Effects 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000001243 zingiber officinale rosc. root absolute Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/121—Ketones acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0720144.5 | 2007-10-16 | ||
GB0720144A GB2453728B (en) | 2007-10-16 | 2007-10-16 | Use of a potent product extracted from rhizomes of zingiber offcinale in preparation of a medicament for treatment gastritis, gastric ulcer and duodenal ulcer |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009096789A JP2009096789A (ja) | 2009-05-07 |
JP4982337B2 true JP4982337B2 (ja) | 2012-07-25 |
Family
ID=38813849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007301916A Active JP4982337B2 (ja) | 2007-10-16 | 2007-11-21 | ヘリコバクター・ピロリに関連する疾患を治療する際の、生姜の根茎から抽出された有効産物の使用 |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP4982337B2 (fr) |
DE (1) | DE102007057231A1 (fr) |
FR (1) | FR2922110B1 (fr) |
GB (1) | GB2453728B (fr) |
TW (1) | TWI336624B (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120232040A1 (en) | 2011-03-07 | 2012-09-13 | Yen-Hsu Chen | Medication for clinical extensively-drug resistant acinetobacter baumannii |
CA3121536A1 (fr) * | 2018-11-28 | 2020-06-04 | Locus Ip Company, Llc | Compositions et methodes de traitement et de prevention des infections a helicobacter pylori |
CN110878014B (zh) * | 2019-12-18 | 2022-06-24 | 保定冀中药业有限公司 | 一种姜辣素的快速提取方法 |
KR102652214B1 (ko) * | 2021-05-12 | 2024-04-01 | 주식회사 코시스바이오 | 면역기능 증진 활성이 있는 생약 유래 다당 분획물 및 이를 포함하는 조성물 |
KR102488117B1 (ko) * | 2021-12-15 | 2023-01-13 | (주)에스디생명공학 | 증숙 생강 추출물을 유효성분으로 함유하는 헬리코박터 파일로리 감염에 의해 유발된 감염성 위염의 치료 또는 예방용 조성물 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5804603A (en) | 1993-11-26 | 1998-09-08 | National Science Council | Synthesized β-adrenergic blockers derivatives of guaiacol |
JP3547782B2 (ja) * | 1993-12-28 | 2004-07-28 | ロート製薬株式会社 | 抗ヘリコバクター・ピロリ活性剤 |
JP3593357B2 (ja) * | 1994-02-28 | 2004-11-24 | エーザイ株式会社 | 抗菌剤 |
JPH08119872A (ja) * | 1994-10-18 | 1996-05-14 | Otsuka Pharmaceut Co Ltd | ヘリコバクター・ピロリに対する生薬組成物 |
DE19716660C2 (de) * | 1997-04-22 | 2002-11-14 | Schwabe Willmar Gmbh & Co | Zubereitungen, insbesondere pharmazeutische, und Arzneiformen auf pflanzlicher Basis zur Bekämpfung von Helicobacter pylori-Infektionen |
TWI290469B (en) * | 2000-07-12 | 2007-12-01 | Medical & Pharm Ind Tech & Dev | Method for manufacturing product with component capable of efficiently preventing inflammation and platelets agglutination form ginger and medical composition with the efficient component |
US6855347B2 (en) | 2002-03-25 | 2005-02-15 | Council Of Scientific And Industrial Research | Composition for treating gastric ulcer and a process for preparing the same |
JP2004115536A (ja) | 2003-11-27 | 2004-04-15 | Rohto Pharmaceut Co Ltd | 抗ヘリコバクター・ピロリ活性剤 |
US8158608B2 (en) * | 2006-03-30 | 2012-04-17 | Council Of Scientific And Industrial Research | Bioactive fraction from Zingier officinale and a process for the preparation thereof |
-
2007
- 2007-10-16 GB GB0720144A patent/GB2453728B/en active Active
- 2007-11-21 JP JP2007301916A patent/JP4982337B2/ja active Active
- 2007-11-26 TW TW096144861A patent/TWI336624B/zh active
- 2007-11-28 DE DE102007057231A patent/DE102007057231A1/de not_active Withdrawn
- 2007-11-30 FR FR0708384A patent/FR2922110B1/fr active Active
Also Published As
Publication number | Publication date |
---|---|
JP2009096789A (ja) | 2009-05-07 |
TWI336624B (en) | 2011-02-01 |
GB2453728A (en) | 2009-04-22 |
GB0720144D0 (en) | 2007-11-28 |
GB2453728B (en) | 2009-11-04 |
FR2922110B1 (fr) | 2010-05-28 |
FR2922110A1 (fr) | 2009-04-17 |
DE102007057231A1 (de) | 2009-04-30 |
TW200918085A (en) | 2009-05-01 |
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