JP4963152B2 - 遺伝子増幅によるリジン産生の増加 - Google Patents

遺伝子増幅によるリジン産生の増加 Download PDF

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JP4963152B2
JP4963152B2 JP2001550382A JP2001550382A JP4963152B2 JP 4963152 B2 JP4963152 B2 JP 4963152B2 JP 2001550382 A JP2001550382 A JP 2001550382A JP 2001550382 A JP2001550382 A JP 2001550382A JP 4963152 B2 JP4963152 B2 JP 4963152B2
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amino acid
nucleic acid
acid sequence
molecule encoding
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JP2004500072A (ja
JP2004500072A5 (enExample
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ポール ディー． ハンク，
リン−ユー リ−デリア，
ピー． ジョン ラヤパチ，
ホリー ジェイ． ウォルシュ，
コレイ エム． クラフトン，
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アーチャー・ダニエルズ・ミッドランド カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/345—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Brevibacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

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  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
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  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2001550382A 1999-12-30 2000-12-29 遺伝子増幅によるリジン産生の増加 Expired - Lifetime JP4963152B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17370799P 1999-12-30 1999-12-30
US60/173,707 1999-12-30
US18413000P 2000-02-22 2000-02-22
US60/184,130 2000-02-22
US09/722,441 2000-11-28
US09/722,441 US6927046B1 (en) 1999-12-30 2000-11-28 Increased lysine production by gene amplification using coryneform bacteria
PCT/US2000/035617 WO2001049854A2 (en) 1999-12-30 2000-12-29 Increased lysine production by gene amplification using coryneform bacteria

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JP2011001545A Division JP5091330B2 (ja) 1999-12-30 2011-01-06 遺伝子増幅によるリジン産生の増加

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JP2004500072A JP2004500072A (ja) 2004-01-08
JP2004500072A5 JP2004500072A5 (enExample) 2008-02-14
JP4963152B2 true JP4963152B2 (ja) 2012-06-27

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JP2001550382A Expired - Lifetime JP4963152B2 (ja) 1999-12-30 2000-12-29 遺伝子増幅によるリジン産生の増加
JP2011001545A Expired - Lifetime JP5091330B2 (ja) 1999-12-30 2011-01-06 遺伝子増幅によるリジン産生の増加
JP2012027445A Expired - Lifetime JP5486029B2 (ja) 1999-12-30 2012-02-10 遺伝子増幅によるリジン産生の増加

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JP2011001545A Expired - Lifetime JP5091330B2 (ja) 1999-12-30 2011-01-06 遺伝子増幅によるリジン産生の増加
JP2012027445A Expired - Lifetime JP5486029B2 (ja) 1999-12-30 2012-02-10 遺伝子増幅によるリジン産生の増加

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US (5) US6927046B1 (enExample)
EP (1) EP1246921B1 (enExample)
JP (3) JP4963152B2 (enExample)
KR (1) KR100760222B1 (enExample)
CN (1) CN1415014A (enExample)
AT (1) ATE437230T1 (enExample)
AU (1) AU783684B2 (enExample)
BR (1) BR0016833A (enExample)
CA (2) CA2396052C (enExample)
DE (1) DE60042612D1 (enExample)
MX (1) MXPA02006524A (enExample)
NZ (1) NZ520390A (enExample)
WO (1) WO2001049854A2 (enExample)

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NZ527129A (en) * 2001-02-08 2005-05-27 Archer Daniels Midland Co Polynucleotide constructs for increased lysine production
BR0304860A (pt) * 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
US7723097B2 (en) * 2005-03-11 2010-05-25 Archer-Daniels-Midland Company Escherichia coli strains that over-produce L-threonine and processes for their production
US20070244719A1 (en) * 2006-04-13 2007-10-18 David Peter R Compositions and methods for producing fermentation products and residuals
US7309602B2 (en) 2006-04-13 2007-12-18 Ambrozea, Inc. Compositions and methods for producing fermentation products and residuals
US20070243235A1 (en) * 2006-04-13 2007-10-18 David Peter R Compositions and methods for producing fermentation products and residuals
DE102006032634A1 (de) 2006-07-13 2008-01-17 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Aminosäuren
EP3170889A1 (en) * 2006-09-15 2017-05-24 CJ Cheiljedang Corporation A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same
KR100830826B1 (ko) * 2007-01-24 2008-05-19 씨제이제일제당 (주) 코리네박테리아를 이용하여 글리세롤을 포함한탄소원으로부터 발효산물을 생산하는 방법
KR100987281B1 (ko) * 2008-01-31 2010-10-12 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
JP2011512823A (ja) 2008-03-03 2011-04-28 グローバル バイオ−ケム テクノロジー グループ カンパニー リミテッド Ｌ−リシン製造のためのリコンビナント微生物および方法
KR101126041B1 (ko) * 2008-04-10 2012-03-19 씨제이제일제당 (주) 트랜스포존을 이용한 형질전환용 벡터, 상기 벡터로형질전환된 미생물 및 이를 이용한 ｌ-라이신 생산방법
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KR101594156B1 (ko) * 2013-06-25 2016-02-15 씨제이제일제당 주식회사 Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법
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CN110951662B (zh) * 2019-12-26 2024-03-12 新疆梅花氨基酸有限责任公司 一种高产赖氨酸的棒状细菌及其构建方法与应用
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CN116042416B (zh) * 2023-01-09 2024-09-27 天津科技大学 高产ε-聚赖氨酸的多基因过表达链霉菌工程菌株及方法与应用

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US20060286645A1 (en) 2006-12-21
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US20040126854A1 (en) 2004-07-01
US6927046B1 (en) 2005-08-09
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