AU783684B2 - Increased lysine production by gene amplification - Google Patents
Increased lysine production by gene amplification Download PDFInfo
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- AU783684B2 AU783684B2 AU26088/01A AU2608801A AU783684B2 AU 783684 B2 AU783684 B2 AU 783684B2 AU 26088/01 A AU26088/01 A AU 26088/01A AU 2608801 A AU2608801 A AU 2608801A AU 783684 B2 AU783684 B2 AU 783684B2
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- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000005891 transamination reaction Methods 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 108010080629 tryptophan-leucine Proteins 0.000 description 1
- 108010084932 tryptophyl-proline Proteins 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/345—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Brevibacterium (G)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US17370799P | 1999-12-30 | 1999-12-30 | |
| US60/173707 | 1999-12-30 | ||
| US18413000P | 2000-02-22 | 2000-02-22 | |
| US60/184130 | 2000-02-22 | ||
| US09/722,441 US6927046B1 (en) | 1999-12-30 | 2000-11-28 | Increased lysine production by gene amplification using coryneform bacteria |
| US09/722441 | 2000-11-28 | ||
| PCT/US2000/035617 WO2001049854A2 (en) | 1999-12-30 | 2000-12-29 | Increased lysine production by gene amplification using coryneform bacteria |
Publications (2)
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| AU2608801A AU2608801A (en) | 2001-07-16 |
| AU783684B2 true AU783684B2 (en) | 2005-11-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU26088/01A Ceased AU783684B2 (en) | 1999-12-30 | 2000-12-29 | Increased lysine production by gene amplification |
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| US (5) | US6927046B1 (enExample) |
| EP (1) | EP1246921B1 (enExample) |
| JP (3) | JP4963152B2 (enExample) |
| KR (1) | KR100760222B1 (enExample) |
| CN (1) | CN1415014A (enExample) |
| AT (1) | ATE437230T1 (enExample) |
| AU (1) | AU783684B2 (enExample) |
| BR (1) | BR0016833A (enExample) |
| CA (2) | CA2396052C (enExample) |
| DE (1) | DE60042612D1 (enExample) |
| MX (1) | MXPA02006524A (enExample) |
| NZ (1) | NZ520390A (enExample) |
| WO (1) | WO2001049854A2 (enExample) |
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| US6927046B1 (en) * | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
| ATE411378T1 (de) * | 2000-01-21 | 2008-10-15 | Ajinomoto Kk | Verfahren zur herstellung von l-lysin |
| NZ527129A (en) * | 2001-02-08 | 2005-05-27 | Archer Daniels Midland Co | Polynucleotide constructs for increased lysine production |
| BR0304860A (pt) * | 2002-11-11 | 2004-08-31 | Ajinomoto Kk | Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia |
| US7723097B2 (en) * | 2005-03-11 | 2010-05-25 | Archer-Daniels-Midland Company | Escherichia coli strains that over-produce L-threonine and processes for their production |
| US20070244719A1 (en) * | 2006-04-13 | 2007-10-18 | David Peter R | Compositions and methods for producing fermentation products and residuals |
| US7309602B2 (en) | 2006-04-13 | 2007-12-18 | Ambrozea, Inc. | Compositions and methods for producing fermentation products and residuals |
| US20070243235A1 (en) * | 2006-04-13 | 2007-10-18 | David Peter R | Compositions and methods for producing fermentation products and residuals |
| DE102006032634A1 (de) | 2006-07-13 | 2008-01-17 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
| EP3170889A1 (en) * | 2006-09-15 | 2017-05-24 | CJ Cheiljedang Corporation | A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same |
| KR100830826B1 (ko) * | 2007-01-24 | 2008-05-19 | 씨제이제일제당 (주) | 코리네박테리아를 이용하여 글리세롤을 포함한탄소원으로부터 발효산물을 생산하는 방법 |
| KR100987281B1 (ko) * | 2008-01-31 | 2010-10-12 | 씨제이제일제당 (주) | 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법 |
| JP2011512823A (ja) | 2008-03-03 | 2011-04-28 | グローバル バイオ−ケム テクノロジー グループ カンパニー リミテッド | Ｌ−リシン製造のためのリコンビナント微生物および方法 |
| KR101126041B1 (ko) * | 2008-04-10 | 2012-03-19 | 씨제이제일제당 (주) | 트랜스포존을 이용한 형질전환용 벡터, 상기 벡터로형질전환된 미생물 및 이를 이용한 ｌ-라이신 생산방법 |
| US8932861B2 (en) | 2008-04-10 | 2015-01-13 | Cj Cheiljedang Corporation | Transformation vector comprising transposon, microorganisms transformed with the vector, and method for producing L-lysine using the microorganism |
| DE102008001874A1 (de) | 2008-05-20 | 2009-11-26 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
| EP2302066A4 (en) | 2008-07-09 | 2012-02-08 | Ajinomoto Kk | METHOD FOR PRODUCING AMINOHYDROXYBENZOIC ACID |
| KR20110035805A (ko) | 2009-09-30 | 2011-04-06 | 씨제이제일제당 (주) | 사이코스-에피머화 효소의 고정화 및 이를 이용한 사이코스의 제조방법 |
| US8839078B2 (en) * | 2010-03-05 | 2014-09-16 | Samsung Electronics Co., Ltd. | Application layer FEC framework for WiGig |
| WO2013179711A1 (ja) | 2012-05-29 | 2013-12-05 | 味の素株式会社 | ３－アセチルアミノ－４－ヒドロキシ安息香酸の製造方法 |
| DE102012016716A1 (de) | 2012-08-22 | 2014-02-27 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung von Vektoren enthaltend ein für in seiner feedback-Inhibierung gemindertes oder ausgeschaltetes Enzym kodierendes Gen und deren Verwendung für die Herstellung von Aminosäuren und Nukleotiden |
| KR101594156B1 (ko) * | 2013-06-25 | 2016-02-15 | 씨제이제일제당 주식회사 | Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법 |
| EP2940144A1 (de) | 2014-04-30 | 2015-11-04 | Evonik Degussa GmbH | Verfahren zur Produktion von L-Lysin unter Verwendung eines alkaliphilen Bakteriums |
| KR20200026874A (ko) * | 2017-06-06 | 2020-03-11 | 지머젠 인코포레이티드 | 대장균 개량을 위한 htp 게놈 공학 플랫폼 |
| CN107916246A (zh) * | 2017-11-17 | 2018-04-17 | 江南大学 | 遗传改造谷氨酸棒杆菌中dhdpr提高赖氨酸产量的方法 |
| WO2019118548A1 (en) * | 2017-12-15 | 2019-06-20 | Archer Daniels Midland Company | Engineered strains of corynebacteria |
| US20240254526A1 (en) | 2018-09-07 | 2024-08-01 | Archer Daniels Midland Company | Engineered strains of corynebacteria |
| KR102126951B1 (ko) * | 2019-09-26 | 2020-06-26 | 씨제이제일제당 주식회사 | 디하이드로디피콜린산 리덕타제 변이형 폴리펩티드 및 이를 이용한 l-쓰레오닌 생산방법 |
| CN110951662B (zh) * | 2019-12-26 | 2024-03-12 | 新疆梅花氨基酸有限责任公司 | 一种高产赖氨酸的棒状细菌及其构建方法与应用 |
| CN111411092B (zh) * | 2020-03-08 | 2022-07-05 | 安徽丰原发酵技术工程研究有限公司 | 高产l-赖氨酸的谷氨酸棒状杆菌及其应用 |
| MX2023010588A (es) * | 2021-03-09 | 2023-12-08 | Cj Cheiljedang Corp | Variante de corynebacterium glutamicum que tiene capacidad de producción mejorada de l-lisina, y procedimiento para la producción de l-lisina mediante el uso de la misma. |
| US20240175064A1 (en) * | 2021-03-09 | 2024-05-30 | Daesang Corporation | Mutant of corynebacterium glutamicum with enhanced l-lysine productivity and method for preparing l-lysine using the same |
| KR102668767B1 (ko) * | 2021-04-30 | 2024-05-24 | 씨제이제일제당 주식회사 | L-라이신 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-라이신의 생산 방법 |
| EP4525843A1 (en) | 2022-05-18 | 2025-03-26 | Evonik Operations GmbH | Biotechnological production of monomers of bisucaberins, desferrioxamines and analogs thereof |
| EP4525842A1 (en) | 2022-05-18 | 2025-03-26 | Evonik Operations GmbH | Biotechnological production of bisucaberins, desferrioxamines and analogs thereof |
| CN119301244A (zh) | 2022-05-18 | 2025-01-10 | 赢创运营有限公司 | 去铁胺及其类似物的生物技术生产 |
| CN116042416B (zh) * | 2023-01-09 | 2024-09-27 | 天津科技大学 | 高产ε-聚赖氨酸的多基因过表达链霉菌工程菌株及方法与应用 |
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- 2000-12-29 CN CN00817929A patent/CN1415014A/zh active Pending
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- 2000-12-29 CA CA002396052A patent/CA2396052C/en not_active Expired - Fee Related
- 2000-12-29 NZ NZ520390A patent/NZ520390A/en not_active IP Right Cessation
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- 2000-12-29 BR BR0016833-5A patent/BR0016833A/pt not_active Application Discontinuation
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- 2000-12-29 MX MXPA02006524A patent/MXPA02006524A/es active IP Right Grant
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Also Published As
| Publication number | Publication date |
|---|---|
| US20110045549A1 (en) | 2011-02-24 |
| JP2011062217A (ja) | 2011-03-31 |
| JP2012120536A (ja) | 2012-06-28 |
| ATE437230T1 (de) | 2009-08-15 |
| US20060286645A1 (en) | 2006-12-21 |
| WO2001049854A2 (en) | 2001-07-12 |
| JP2004500072A (ja) | 2004-01-08 |
| CA2396052A1 (en) | 2001-07-12 |
| US7368276B2 (en) | 2008-05-06 |
| EP1246921B1 (en) | 2009-07-22 |
| JP5486029B2 (ja) | 2014-05-07 |
| KR100760222B1 (ko) | 2007-10-04 |
| US20040126854A1 (en) | 2004-07-01 |
| US6927046B1 (en) | 2005-08-09 |
| US20030055232A1 (en) | 2003-03-20 |
| JP5091330B2 (ja) | 2012-12-05 |
| JP4963152B2 (ja) | 2012-06-27 |
| MXPA02006524A (es) | 2003-02-12 |
| US8067210B2 (en) | 2011-11-29 |
| AU2608801A (en) | 2001-07-16 |
| CA2654770C (en) | 2013-07-30 |
| US20050250937A9 (en) | 2005-11-10 |
| CA2654770A1 (en) | 2001-07-12 |
| DE60042612D1 (de) | 2009-09-03 |
| CA2396052C (en) | 2009-05-12 |
| NZ520390A (en) | 2004-02-27 |
| CN1415014A (zh) | 2003-04-30 |
| WO2001049854A3 (en) | 2002-06-13 |
| US8685719B2 (en) | 2014-04-01 |
| EP1246921A2 (en) | 2002-10-09 |
| KR20020089320A (ko) | 2002-11-29 |
| BR0016833A (pt) | 2002-10-01 |
| US7741460B2 (en) | 2010-06-22 |
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