JP4932735B2 - アミノピリミジン化合物および使用方法 - Google Patents

アミノピリミジン化合物および使用方法 Download PDF

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Publication number
JP4932735B2
JP4932735B2 JP2007546989A JP2007546989A JP4932735B2 JP 4932735 B2 JP4932735 B2 JP 4932735B2 JP 2007546989 A JP2007546989 A JP 2007546989A JP 2007546989 A JP2007546989 A JP 2007546989A JP 4932735 B2 JP4932735 B2 JP 4932735B2
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Japan
Prior art keywords
ethyl
pyrimidin
ylamino
dione
dimethyl
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Expired - Lifetime
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JP2007546989A
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Japanese (ja)
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JP2008524248A (ja
JP2008524248A5 (enExample
Inventor
スミス，エイドリアン・レオナード
ブレナン，ポール・エドワード
デモリン，フレネル・フイルス
リウ，カン
パラス，ニツク・エイ
レツツ，ダニエル・マーテイン
レインボー，エリザベス
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007546989A 2004-12-17 2005-12-16 アミノピリミジン化合物および使用方法 Expired - Lifetime JP4932735B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63660404P 2004-12-17 2004-12-17
US60/636,604 2004-12-17
PCT/US2005/045863 WO2006066172A1 (en) 2004-12-17 2005-12-16 Aminopyrimidine compounds and methods of use

Publications (3)

Publication Number Publication Date
JP2008524248A JP2008524248A (ja) 2008-07-10
JP2008524248A5 JP2008524248A5 (enExample) 2008-11-13
JP4932735B2 true JP4932735B2 (ja) 2012-05-16

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ID=36588221

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007546989A Expired - Lifetime JP4932735B2 (ja) 2004-12-17 2005-12-16 アミノピリミジン化合物および使用方法

Country Status (9)

Country Link
US (2) US7786132B2 (enExample)
EP (1) EP1831207B1 (enExample)
JP (1) JP4932735B2 (enExample)
CN (1) CN101115749B (enExample)
AU (1) AU2005316312B2 (enExample)
CA (1) CA2590939C (enExample)
ES (1) ES2397362T3 (enExample)
MX (1) MX2007007032A (enExample)
WO (1) WO2006066172A1 (enExample)

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AU2007267986A1 (en) 2006-05-23 2007-12-06 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
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WO2008011557A2 (en) * 2006-07-20 2008-01-24 Borchardt Allen J Heteroaryl inhibitors of rho kinase
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AU2007334039B2 (en) 2006-12-21 2012-02-16 Eli Lilly And Company Imidazolidinonyl aminopyrimidine compounds for the treatment' of cancer
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BRPI0811433A2 (pt) * 2007-05-16 2016-03-22 Lilly Co Eli compostos do tipo triazolil aminopirimidina
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US8334292B1 (en) 2010-06-14 2012-12-18 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
JP6250561B2 (ja) 2012-02-08 2017-12-20 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ヘテロアリール化合物およびそれらの使用方法
US9566280B2 (en) 2014-01-28 2017-02-14 Massachusetts Institute Of Technology Combination therapies and methods of use thereof for treating cancer
CN104860900A (zh) * 2014-02-25 2015-08-26 中国药科大学 噻唑类化合物、其制备方法及其在制药中的用途
CN105884711A (zh) * 2014-12-16 2016-08-24 中国药科大学 噻唑类化合物、其制备方法及其在制药中的用途
SI3319939T1 (sl) * 2015-07-08 2025-04-30 Cv6 Therapeutics (Ni) Limited Zaviralci deoksiuridin trifosfataze, ki vsebujejo hidantoin
EP3325623B3 (en) 2015-07-23 2021-01-20 Institut Curie Use of a combination of dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
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CA3032302A1 (en) 2016-07-29 2018-02-01 Taleen G. Hanania Compounds and compositions and uses thereof
CN110087687A (zh) 2016-07-29 2019-08-02 赛诺维信制药公司 化合物、组合物及其用途
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
CN111183138A (zh) 2017-08-02 2020-05-19 赛诺维信制药公司 异色满化合物以及用途
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MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
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CN112125879A (zh) * 2020-09-29 2020-12-25 浙江永太科技股份有限公司 一种卡格列净中间体2-(4-氟苯基)噻吩的制备方法
CN114133337A (zh) * 2020-12-14 2022-03-04 成都泰蓉生物科技有限公司 一种2-取代的赖氨酸的制备方法
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CN117050051A (zh) * 2023-08-14 2023-11-14 上海药坦药物研究开发有限公司 一种2-溴-1-（5-碘噻吩-2-基）-乙酮的纯化方法

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Also Published As

Publication number Publication date
US20070185133A1 (en) 2007-08-09
MX2007007032A (es) 2007-07-04
CN101115749A (zh) 2008-01-30
AU2005316312A1 (en) 2006-06-22
JP2008524248A (ja) 2008-07-10
EP1831207B1 (en) 2012-11-14
CN101115749B (zh) 2011-06-22
US7858785B2 (en) 2010-12-28
EP1831207A4 (en) 2010-09-15
CA2590939A1 (en) 2006-06-22
US20100010014A1 (en) 2010-01-14
CA2590939C (en) 2011-10-18
US7786132B2 (en) 2010-08-31
ES2397362T3 (es) 2013-03-06
EP1831207A1 (en) 2007-09-12
WO2006066172A1 (en) 2006-06-22
AU2005316312B2 (en) 2009-10-22

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