ES2397362T3 - Compuestos de aminopirimidina como inhibidores de PLK - Google Patents

Compuestos de aminopirimidina como inhibidores de PLK Download PDF

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Publication number
ES2397362T3
ES2397362T3 ES05854551T ES05854551T ES2397362T3 ES 2397362 T3 ES2397362 T3 ES 2397362T3 ES 05854551 T ES05854551 T ES 05854551T ES 05854551 T ES05854551 T ES 05854551T ES 2397362 T3 ES2397362 T3 ES 2397362T3
Authority
ES
Spain
Prior art keywords
ethyl
pyrimidin
ylamino
imidazolidin
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05854551T
Other languages
English (en)
Spanish (es)
Inventor
Adrian Leonard Smith
Paul Edward Brennan
Frenel Fils Demorin
Gang Liu
Nick A. Paras
Daniel Martin Retz
Elizabeth Rainbeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ES2397362T3 publication Critical patent/ES2397362T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES05854551T 2004-12-17 2005-12-16 Compuestos de aminopirimidina como inhibidores de PLK Expired - Lifetime ES2397362T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63660404P 2004-12-17 2004-12-17
US636604P 2004-12-17
PCT/US2005/045863 WO2006066172A1 (en) 2004-12-17 2005-12-16 Aminopyrimidine compounds and methods of use

Publications (1)

Publication Number Publication Date
ES2397362T3 true ES2397362T3 (es) 2013-03-06

Family

ID=36588221

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05854551T Expired - Lifetime ES2397362T3 (es) 2004-12-17 2005-12-16 Compuestos de aminopirimidina como inhibidores de PLK

Country Status (9)

Country Link
US (2) US7786132B2 (enExample)
EP (1) EP1831207B1 (enExample)
JP (1) JP4932735B2 (enExample)
CN (1) CN101115749B (enExample)
AU (1) AU2005316312B2 (enExample)
CA (1) CA2590939C (enExample)
ES (1) ES2397362T3 (enExample)
MX (1) MX2007007032A (enExample)
WO (1) WO2006066172A1 (enExample)

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US8334292B1 (en) 2010-06-14 2012-12-18 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
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EP3325623B3 (en) 2015-07-23 2021-01-20 Institut Curie Use of a combination of dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
WO2017106639A1 (en) * 2015-12-17 2017-06-22 Arqule, Inc. Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
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CN110087687A (zh) 2016-07-29 2019-08-02 赛诺维信制药公司 化合物、组合物及其用途
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WO2019025250A1 (en) 2017-08-04 2019-02-07 Basf Se SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
KR20200130856A (ko) 2018-03-13 2020-11-20 옹쎄오 암 치료에서 획득한 내성에 대한 디베이트 분자
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
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CN112125879A (zh) * 2020-09-29 2020-12-25 浙江永太科技股份有限公司 一种卡格列净中间体2-(4-氟苯基)噻吩的制备方法
CN114133337A (zh) * 2020-12-14 2022-03-04 成都泰蓉生物科技有限公司 一种2-取代的赖氨酸的制备方法
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Also Published As

Publication number Publication date
US20070185133A1 (en) 2007-08-09
MX2007007032A (es) 2007-07-04
CN101115749A (zh) 2008-01-30
AU2005316312A1 (en) 2006-06-22
JP2008524248A (ja) 2008-07-10
EP1831207B1 (en) 2012-11-14
CN101115749B (zh) 2011-06-22
US7858785B2 (en) 2010-12-28
JP4932735B2 (ja) 2012-05-16
EP1831207A4 (en) 2010-09-15
CA2590939A1 (en) 2006-06-22
US20100010014A1 (en) 2010-01-14
CA2590939C (en) 2011-10-18
US7786132B2 (en) 2010-08-31
EP1831207A1 (en) 2007-09-12
WO2006066172A1 (en) 2006-06-22
AU2005316312B2 (en) 2009-10-22

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