JP4926056B2 - バイオサーファクタントを含有するスキンケア化粧料および肌荒れ改善剤 - Google Patents
バイオサーファクタントを含有するスキンケア化粧料および肌荒れ改善剤 Download PDFInfo
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- JP4926056B2 JP4926056B2 JP2007522859A JP2007522859A JP4926056B2 JP 4926056 B2 JP4926056 B2 JP 4926056B2 JP 2007522859 A JP2007522859 A JP 2007522859A JP 2007522859 A JP2007522859 A JP 2007522859A JP 4926056 B2 JP4926056 B2 JP 4926056B2
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Description
1. 少なくとも1種のバイオサーファクタントを含むスキンケア化粧料。
2. 肌荒れの改善のための項1に記載のスキンケア化粧料。
3. 界面活性剤の作用による肌荒れの改善のための項1に記載のスキンケア化粧料。
4. バイオサーファクタントがマンノシルエリスリトールリピッド(MEL)及び/又はマンノ
シルマンニトールリピッド(MML)であることを特徴とする項1に記載のスキンケア化粧料。
5. バイオサーファクタントがマンノシルエリスリトールリピッドA(MEL-A)、マンノシルエリスリトールリピッドB(MEL-B)、マンノシルエリスリトールリピッドC(MEL-C)からなる群から選ばれる少なくとも1種である、項1に記載のスキンケア化粧料。
6. バイオサーファクタントがマンノシルエリスリトールリピッドB(MEL-B)である、項1に記載のスキンケア化粧料。
7. バイオサーファクタントがマンノシルエリスリトールリピッドC(MEL-C)である、項1に記載のスキンケア化粧料。
8. バイオサーファクタントがマンノシルエリスリトールリピッドA(MEL-A)である、項1に記載のスキンケア化粧料。
9. 少なくとも1種のバイオサーファクタントからなる肌荒れ改善剤。
同様に、R1、R2がC2〜C19アルケニル基、C5〜C19アルカジエニル基もしくはC8〜C19アルカトリエニル基である式(I)、(II)、(III)のMEL、式(IV)のMMLは、原料として二重結合を2個以上有するリノール酸、リノレン酸、アラキドン酸、EPA、DHAまたはそのエステル(モノアルキルエステル、モノ−、ジ−、トリ−グリセライド、或いはこれらの高度不飽和脂肪酸を含む油脂等)などの原料を培地に添加することにより得ることができる。例えば、原料としてリノール酸を使用した場合にはR1、R2としてアルケニル基が主成分、アルカジエニル基がマイナー成分となり、原料としてリノレン酸を使用した場合にはR1、R2としてアルカジエニル基が主成分、アルケニル基またはアルカトリエニル基がマイナー成分となる。
バイオサーファクタントの製造方法は特に制限されるものはないが、微生物を用いた発酵方法を任意に選択して行えば良い。例えばMEL (MEL-A, MEL-B, MEL-C)の培養生産は常法に従って、Pseudozyma antarctica NBRC 10736により生産することができ、微生物としてはPseudozyma antarctica、Pseudozyma sp.、等を用いることができる。いずれの微生物でも容易にMEL混合物が得られることは周知の事実である。MEL混合物をシリカゲルカラムクロマトグラフィーを用いて精製し、
MEL−A、MEL−B及びMEL−Cを単離することが出来る。また、MEL−Bを生産する菌としては、Pseudozyma antarctica 、およびPseudozyma tsukubaensisが知られており、その菌を用いてもよい。MEL−Cを生産する菌としては、Pseudozyma hubeiensisが知られており、その菌を用いてもよい。MELを生産する能力を有する微生物としては特に限定するものではなく、目的に応じて適宜使用することができる。
(肌荒れ改善作用評価方法)
テストスキン(東洋紡績株式会社製)LSE−002または003キット付属の取り扱い説明の要領に沿って組織を取り出す。薬剤暴露部位を確保するリングをLSE組織表面に接着させ、ドデシル硫酸ナトリウム(SDS)0.1%水溶液をリング内に添加し5分間室温で静置する。その後、SDSをアスピレーターで除去し、アッセイ培地3mlをピペットで吹きかけ洗浄。この操作にて、角層の保湿成分が溶出し、乾燥肌が作成された。
種菌培養はPseudozyma antarctica NBRC 10736を種培地(20ml/500ml坂口フラスコ)に1 loop植菌して実施した。30℃にて一晩培養した。得られた培養液を種菌とした。種培地組成は4% Glucose、0.3% NaNO3、0.02% MgSO4・H2O、0.02% KH2PO4、0.1% yeast extractであった。培養は上記種菌75mlを生産培地1.5L(5L-jar)に植菌し、30℃、300rpm(攪拌回転)、0.5L/min0(Air)の条件で5L-jarを用いて培養した。生産培地組成は、3% ダイズ油、0.02% MgSO4・H2O、0.02% KH2PO4、0.1% yeast extractであった。培養液250mlを遠心(6500rpm、30min)し、上清を取り除き、沈殿(菌体)を回収した。沈殿に、50mlの酢酸エチルを加え、十分攪拌後、遠心(8500rpm、30min)し、沈殿と上清に分け、上清をエバポーレーターで濃縮した。シリカゲルを用いて、ヘキサン:アセトン=5:1、ヘキサン:アセトン=1:2で溶出しMEL画分(MEL-A、MEL-B、MEL-C)を得た。
0.2mlのP.tsukubaensisフローズンストックを20mlのYM種培地/500ml容坂口フラスコに植菌し、26℃、180rpm、1晩培養させ、種種菌とした。0.2mlの種種菌を再度、20mlのYM種培地/500ml容坂口フラスコに植菌し、26℃、180rpm、1晩培養させ、種菌とした。20mlの種菌を2LのYM培地/5L Jarに植菌し、26℃ 300rpm(1/4VVM、0.5L air /min)で8日間培養した。培養液を7,900rpm 60min 4℃で遠心し、菌体(MEL-Bを含む)と上清に分離した。菌体画分にそれぞれ80mlの酢酸エチルを加え、菌体が十分懸濁するように上下に攪拌した後、7,900rpm 30min 4℃で遠心した。得られた上清に等量の飽和食塩水を加え攪拌し酢酸エチル層を得た。酢酸エチル層に無水硫酸Naを適量加え、30分間精置させた後、エバポレートしMEL-B粗精製品を得た。得られたMEL-B粗精製品(20g)をシリカゲルカラム(200g)を用いて、ヘキサン:アセトンで溶出しMEL−B精製品を得た。
実施例1におけるMELの製造では、生産原料にダイズ油を用いたが、その代わりにオリーブ油を用いて実施例1と同様の方法で培養しMEL-A、MEL-B、MEL-Cを単離精製する。この時得られるMEL画分を、実施例1のMELと区別するためMEL-A(OL)、MEL-B(OL)、MEL-C(OL)と呼ぶ。
実施例1におけるMELの製造では、生産培地組成にダイズ油を用いたが、その代わりにミリスチン酸メチルを生産原料に用いて実施例1と同様の方法で培養しMEL-A、MEL-B、MEL-Cを単離精製する。この時得られるMEL画分を、実施例1のMELと区別するためMEL-A(MY)、MEL-B(MY)、MEL-C(MY)と呼ぶ。
皮膚三次元モデルを用いた肌荒れモデルを以下の通り実施し作成した。テストスキン(東洋紡LSE-002または003)を1%SDSで処理することにより、角質層脂質成分を除去した肌荒れモデルを作成した。MEL-Aを溶かしたオリーブ油を細胞上に添加し、一晩放置後、市販のMTTキットを用いて細胞生存率を算出することにより、肌荒れ防止効果を調べた。図1に示したようにMEL-Aの濃度依存的に細胞生存数が増加し、MEL-Aがセラミドの代替として働くことが確認された。一方、オリーブ油のみではそのような効果はまったく見られなかった。
皮膚三次元モデルを用いた肌荒れモデルは以下の通り実施し作成した。テストスキン(東洋紡LSE-003)を1%SDSで処理することにより、角質層脂質成分を除去した肌荒れモデルを作成した。実施例1A で得たMEL−Bを溶かしたオリーブ油を細胞上に添加し、一晩放置後、市販のMTTキットを用いて細胞生存率を算出することにより、肌荒れ防止効果を調べた。図4に示したようにMEL−Bの濃度依存的に細胞生存数が増加し、MEL−Bがセラミドの代替として働くことが確認された。一方、オリーブ油のみではそのような効果はまったく見られなかった。
皮膚三次元モデルを用いた肌荒れモデルは以下の通り実施し作成した。テストスキン(東洋紡LSE-003)を1%SDSで処理することにより、角質層脂質成分を除去した肌荒れモデルを作成した。実施例1で得たMEL-Cを溶かしたオリーブ油を細胞上に添加し、一晩放置後、市販のMTTキットを用いて細胞生存率を算出することにより、肌荒れ防止効果を調べた。図4に示したようにMEL-Cの濃度依存的に細胞生存数が増加し、MEL-Cがセラミドの代替として働くことが確認された。一方、オリーブ油のみではそのような効果はまったく見られなかった。
実施例4と同様に、皮膚三次元モデルを用いた肌荒れモデルを以下の通り実施し作成した。テストスキン(東洋紡LSE-002または003)を1%SDSで処理することにより、角質層脂質成分を除去した肌荒れモデルを作成した。MEL-A(実施例1)、MEL-A(OL)(実施例2)及びMEL-A(MY)(実施例3)を溶かしたオリーブ油を細胞上に添加し、一晩放置後、市販のMTTキットを用いて細胞生存率を算出することにより、肌荒れ防止効果を調べた。図3に示したようにMEL-Aの濃度依存的に細胞生存数が増加し、MEL-Aがセラミドの代替として働くことが確認された。一方、オリーブ油のみではそのような効果はまったく見られなかった。
ヒト上腕内部に1%SDS溶液を10分間接触させて肌荒れを作成した。直ちに5%MEL-Aを含む上記クリームを塗布し、3時間後に温水で皮膚を洗浄した。キムタオルで油分を拭き取り後、スキコンで皮膚角質水分量を測定した。図2に示したようにMEL-Aを添加したクリームに水分含量の回復が見られた。
ヒト上腕内部に1%SDS溶液を10分間接触させて肌荒れを作成した。直ちに5%MELを含む上記クリームを塗布し、3時間後に温水で皮膚を洗浄した。キムタオルで油分を拭き取り後、スキコンで皮膚角質水分量を測定した。図5に示したようにMEL-BあるいはMEL-Cを添加したクリームに水分含量の回復が見られた。
実施例10 MEL-B及びMEL-Cの分散安定性試験
エタノール注入法によるMEL−Bリポソーム溶液の調製は次の通りに行った。すなわち、MEL−B10mgをエタノール0.5mlに溶解し、あらかじめ70℃前後に温めておいた蒸留水1mLを加え、軽く振り混ぜた後、残存しているエタノールをロータリーエバポレーターで留去した。これを水浴型超音波装置(W-220R、本多電子株式会社)を用い約5分間超音波処理した後、蒸留水で1mlにメスアップした。
以下に示す組成の美容液を常法により製造した。コントロールとして、MELを含まない美容液も常法により製造した。
(組成) (重量%)
ソルビット 4.0
ジプロピレングリコール 6.0
ポリエチレングリコール1500 5.0
POE(20)オレイルアルコールエーテル 0.5
ショ糖脂肪酸エステル 0.2
メチルセルロース 0.2
MEL−B 5.0
精製水 全体で100となる量
以下に示す組成の乳液を常法により製造した。コントロールとして、MELを含まない乳液も常法により製造した。
(組成) (重量%)
グリセリルエーテル 1.5
ショ糖脂肪酸エステル 1.5
モノステアリン酸ソルビタン 1.0
スクワラン 7.5
ジプロピレングリコール 5.0
MEL−B 5.0
精製水 全体で100となる量
以下に示す組成のクリームを常法により製造した。コントロールとして、MELを含まないクリームも常法により製造した。
(組成) (重量%)
プロピレングリコール 6.0
フタル酸ジブチル 19.0
ステアリン酸 5.0
モノステアリン酸グリセリン 5.0
モノステアリン酸ソルビタン 12.0
モノステアリン酸ポリエチレンソルビタン 38.0
エデト酸ナトリウム 0.03
MEL−B 5.0
精製水 全体で100となる量
(組成) (重量%)
オリーブ油 90
MEL−A 10
実施例16 スキンケアオイル
(組成) (重量%)
オリーブ油 50%
MEL−C 30%
スクワラン 10%
ゴマ油 10%
(組成) (重量%)
オリーブ油 39
MEL−C 59
ゴマ油 1
ラベンダー油 0.4
ローズマリー油 0.4
セージ油 0.1
δ−トコフェロール 0.1
(組成) (重量%)
オリーブ油 40
MEL−B 28
メチルフェニルポリシロキサン 2
エタノール 0.3
イソステアリン酸 0.1
2−エチルヘキサン酸セチル 20
ジイソステアリン酸ポリエチレングリコール 2
ヤシ油脂肪酸ジエタノールアミド 0.1
モノイソステアリン酸ポリエチレングリコール 2
δ−トコフェロール 0.1
精製水 1
香料 適 量
(組成) (重量%)
オリーブ油 25
MEL−A 25
流動パラフィン 25
ジカプリル酸ネオペンチルグリコール 10
ポリオキシエチレンオレイルエーテル 10
精製水 0.5
δ−トコフェロール 0.1
香料 適 量
Claims (7)
- マンノシルエリスリトールリピッド及び/又はマンノシルマンニトールリピッドであるバイオサーファクタントを含む、角質細胞の剥離現象が認められる肌荒れの改善剤。
- 肌荒れが界面活性剤の作用によって生じる肌荒れである、請求項1に記載の改善剤。
- バイオサーファクタントが、マンノシルエリスリトールリピッドA(MEL-A)、マンノシルエリスリトールリピッドB(MEL-B)、マンノシルエリスリトールリピッドC(MEL-C)からなる群から選ばれる少なくとも1種である、請求項1又は2のいずれかに記載の改善剤。
- バイオサーファクタントが、マンノシルエリスリトールリピッドB(MEL-B)である、請求項1〜3のいずれかに記載の改善剤。
- バイオサーファクタントが、マンノシルエリスリトールリピッドC(MEL-C)である、請求項1〜3のいずれかに記載の改善剤。
- バイオサーファクタントが、マンノシルエリスリトールリピッドA(MEL-A)である、請求項1〜3のいずれかに記載の改善剤。
- 請求項1〜6のいずれかに記載の改善剤を含む洗浄用化粧料。
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WO2017003092A1 (ko) * | 2015-06-30 | 2017-01-05 | (주)아모레퍼시픽 | 높은 제형 안정성을 갖는 화장료 조성물 |
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FR3048852B1 (fr) | 2016-03-17 | 2019-09-06 | Oleon Nv | Concentre comprenant un mel et un ester d'acide gras et de polyethylene glycol de hlb superieur ou egal a 12 |
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WO2018052084A1 (ja) | 2016-09-14 | 2018-03-22 | 株式会社カネカ | ゲル状組成物、並びにそれを用いた皮膚外用剤及び化粧料 |
WO2018208530A1 (en) | 2017-05-07 | 2018-11-15 | Locus Ip Company, Llc | Cosmetic compositions for skin health and methods of using same |
JP7005981B2 (ja) * | 2017-07-20 | 2022-01-24 | 東洋紡株式会社 | セラミド合成促進剤及び皮膚外用剤 |
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WO2019227034A1 (en) | 2018-05-25 | 2019-11-28 | Locus Ip Company, Llc | Therapeutic compositions for enhanced healing of wounds and scars |
EP4046620A1 (en) | 2021-02-23 | 2022-08-24 | Beiersdorf AG | Emulsions comprising mannosylerythritol lipid (mel) |
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JP2005522859A (ja) * | 2002-04-11 | 2005-07-28 | 株式会社アドバンテスト | Asic/soc製造におけるプロトタイプホールドを回避するための製造方法と装置 |
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DE19802450A1 (de) * | 1998-01-23 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Ustilipide, Verfahren zu deren Herstellung sowie deren Verwendung |
JP2002101847A (ja) * | 2000-09-29 | 2002-04-09 | Higashimaru Shoyu Co Ltd | しょうゆ油の処理方法 |
JP3772190B2 (ja) * | 2002-03-05 | 2006-05-10 | 一丸ファルコス株式会社 | 養毛・育毛剤 |
GB0219825D0 (en) * | 2002-08-24 | 2002-10-02 | Cerestar Holding Bv | Process for producing and recovering mannosylerythritol lipidsfrom culture medium containing the same |
JP4675033B2 (ja) * | 2003-08-21 | 2011-04-20 | 広島県 | 血小板凝集抑制剤及びヒスタミン遊離抑制剤 |
JP4722386B2 (ja) * | 2003-08-22 | 2011-07-13 | 広島県 | 糖脂質及びその製造方法 |
US7042274B2 (en) * | 2003-09-29 | 2006-05-09 | Intel Corporation | Regulated sleep transistor apparatus, method, and system |
KR100588013B1 (ko) * | 2003-11-17 | 2006-06-09 | 엘지.필립스 엘시디 주식회사 | 액정표시장치의 구동방법 및 구동장치 |
WO2008018448A1 (fr) * | 2006-08-11 | 2008-02-14 | Toyo Boseki Kabushiki Kaisha | Activateur comprenant un bio-tensioactif comme ingrédient actif, un mannosyl érythritol lipide et son procédé de préparation |
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US20100004472A1 (en) | 2010-01-07 |
KR20080072743A (ko) | 2008-08-06 |
JPWO2007060956A1 (ja) | 2009-05-07 |
KR101225267B1 (ko) | 2013-01-22 |
WO2007060956A1 (ja) | 2007-05-31 |
CN102973418A (zh) | 2013-03-20 |
EP1964546A1 (en) | 2008-09-03 |
EP1964546B1 (en) | 2016-10-26 |
EP1964546A4 (en) | 2013-11-27 |
US20110257116A1 (en) | 2011-10-20 |
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