JP4919575B2 - ファルネシルトランスフェラーゼ阻害性１，２−環付加キノリン鏡像異性体 - Google Patents

ファルネシルトランスフェラーゼ阻害性１，２−環付加キノリン鏡像異性体 Download PDF

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Publication number
JP4919575B2
JP4919575B2 JP2002504258A JP2002504258A JP4919575B2 JP 4919575 B2 JP4919575 B2 JP 4919575B2 JP 2002504258 A JP2002504258 A JP 2002504258A JP 2002504258 A JP2002504258 A JP 2002504258A JP 4919575 B2 JP4919575 B2 JP 4919575B2
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JP
Japan
Prior art keywords
chlorophenyl
pharmaceutically acceptable
quinazoline
tetrazolo
imidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP2002504258A
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English (en)
Japanese (ja)
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JP2004501153A (ja
JP2004501153A5 (https=
Inventor
ブネ，マルク・ガストン
アンジボー，パトリク・ルネ
エンド，デイビツド・ウイリアム
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2002504258A 2000-06-22 2001-06-13 ファルネシルトランスフェラーゼ阻害性１，２−環付加キノリン鏡像異性体 Expired - Lifetime JP4919575B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00202181 2000-06-22
EP00202181.4 2000-06-22
PCT/EP2001/006747 WO2001098302A1 (en) 2000-06-22 2001-06-13 Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer

Publications (3)

Publication Number Publication Date
JP2004501153A JP2004501153A (ja) 2004-01-15
JP2004501153A5 JP2004501153A5 (https=) 2008-07-17
JP4919575B2 true JP4919575B2 (ja) 2012-04-18

Family

ID=8171675

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002504258A Expired - Lifetime JP4919575B2 (ja) 2000-06-22 2001-06-13 ファルネシルトランスフェラーゼ阻害性１，２−環付加キノリン鏡像異性体

Country Status (33)

Country Link
US (3) US20030114471A1 (https=)
EP (1) EP1296984B1 (https=)
JP (1) JP4919575B2 (https=)
KR (2) KR100846370B1 (https=)
CN (1) CN1207296C (https=)
AR (1) AR030704A1 (https=)
AT (1) ATE294804T1 (https=)
AU (3) AU6396201A (https=)
BG (1) BG65894B1 (https=)
BR (1) BRPI0111743B8 (https=)
CA (1) CA2410232C (https=)
CZ (1) CZ295278B6 (https=)
DE (1) DE60110592T2 (https=)
EA (1) EA005065B1 (https=)
EE (1) EE04966B1 (https=)
EG (1) EG24180A (https=)
ES (1) ES2241830T3 (https=)
HR (1) HRP20020989B1 (https=)
HU (1) HU229095B1 (https=)
IL (2) IL153560A0 (https=)
IS (1) IS2596B (https=)
JO (1) JO2361B1 (https=)
MX (1) MXPA02012845A (https=)
MY (1) MY127734A (https=)
NO (1) NO324494B1 (https=)
NZ (1) NZ522481A (https=)
PA (1) PA8519501A1 (https=)
PL (1) PL209521B1 (https=)
SA (1) SA01220349B1 (https=)
SK (1) SK285699B6 (https=)
UA (1) UA73572C2 (https=)
WO (1) WO2001098302A1 (https=)
ZA (1) ZA200210305B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003018135A1 (en) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation Method of using 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase
ATE336496T1 (de) 2002-04-15 2006-09-15 Janssen Pharmaceutica Nv Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen
US20050003422A1 (en) 2003-07-01 2005-01-06 Mitch Reponi Methods for assessing and treating cancer
US10076512B2 (en) 2014-05-01 2018-09-18 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
US20180338993A1 (en) * 2014-12-04 2018-11-29 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
WO2016172342A1 (en) 2015-04-21 2016-10-27 Eiger Biopharmaceuticals, Inc. Pharmaceutical compositions comprising lonafarnib and ritonavir
SMT202100712T1 (it) 2015-08-17 2022-01-10 Kura Oncology Inc Metodi di trattamento di pazienti di cancro con inibitori di farnesil trasferasi
TW201818965A (zh) 2016-11-03 2018-06-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶（ｆａｒｎｅｓｙｌ ｔｒａｎｓｆｅｒａｓｅ）抑制劑治療癌症病患之方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1519765A (en) * 1974-09-05 1978-08-02 Ici Ltd Pesticidal dihydrotetrazolo(1,5a) quinazolines compositions and processes
US4141979A (en) * 1976-12-23 1979-02-27 Pfizer Inc. Tetrazolo[a]quinazol-5-ones antiallergy and antiulcer agents
GB9513577D0 (en) * 1995-07-04 1995-09-06 Brotherwood Rodney J Improvements in passenger carrying vehicles
TW349948B (en) * 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
SK283335B6 (sk) * 1995-12-08 2003-06-03 Janssen Pharmaceutica N. V. (Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze
WO1997036876A1 (en) 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
TW591030B (en) * 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
RU2205831C2 (ru) * 1997-04-25 2003-06-10 Янссен Фармацевтика Н.В. Хиназолиноны, ингибирующие фарнезилтрансферазу
AU740603B2 (en) 1997-06-02 2001-11-08 Janssen Pharmaceutica N.V. (imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation
ID26987A (id) * 1998-07-06 2001-02-22 Janssen Pharmaceutica Nv Inhibitor-inhibitor transferase protein farnesil dengan sifat-sifat peka terhadap sinar radiasi in vivo
HRP20000904A2 (en) 1998-07-06 2001-12-31 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibitors for treating arthropathies
ES2237125T3 (es) * 1998-08-27 2005-07-16 Pfizer Products Inc. Derivados de quinolin-2-ona utiles como agentes anticancerigenos.
ID27562A (id) * 1998-08-27 2001-04-12 Pfizer Prod Inc Turunan-turunan kinolin-2-ona tersubstitusi alkunil yang berguna sebagai zat anti kanker
ID29241A (id) * 1998-12-23 2001-08-16 Janssen Pharmaceutica Nv Turunan-turunan kinolin teranelasi-1,2
US6462201B1 (en) * 1998-12-29 2002-10-08 Isp Investments Inc. Process for the production of N-vinyl-2-pyrrolidone by vinylation
PL349839A1 (en) * 1999-02-11 2002-09-23 Pfizer Prod Inc Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents
HN2000000266A (es) 2000-01-21 2001-05-21 Pfizer Prod Inc Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
US6838467B2 (en) * 2000-02-24 2005-01-04 Janssen Pharmaceutica N. V. Dosing regimen
WO2002024686A2 (en) 2000-09-25 2002-03-28 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
US7067531B2 (en) 2000-09-25 2006-06-27 Angibaud Patrick Rene Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives

Also Published As

Publication number Publication date
SK285699B6 (sk) 2007-06-07
PL209521B1 (pl) 2011-09-30
PL358918A1 (en) 2004-08-23
US20080114009A1 (en) 2008-05-15
HUP0300872A2 (hu) 2003-07-28
CA2410232C (en) 2008-10-07
EA200300048A1 (ru) 2003-04-24
EE04966B1 (et) 2008-02-15
HU229095B1 (en) 2013-07-29
DE60110592T2 (de) 2006-01-19
US20030114471A1 (en) 2003-06-19
IL153560A0 (en) 2003-07-06
IS6590A (is) 2002-10-25
AU2006220405A1 (en) 2006-10-12
NO324494B1 (no) 2007-10-29
BRPI0111743B1 (pt) 2019-03-26
KR20030009463A (ko) 2003-01-29
WO2001098302A1 (en) 2001-12-27
AU2001263962B2 (en) 2006-07-20
NZ522481A (en) 2004-09-24
SK502003A3 (en) 2003-05-02
BR0111743A (pt) 2003-07-08
NO20026032L (no) 2002-12-16
EG24180A (en) 2008-09-28
UA73572C2 (en) 2005-08-15
AU6396201A (en) 2002-01-02
EA005065B1 (ru) 2004-10-28
DE60110592D1 (de) 2005-06-09
JP2004501153A (ja) 2004-01-15
EP1296984A1 (en) 2003-04-02
CZ295278B6 (cs) 2005-06-15
MY127734A (en) 2006-12-29
NO20026032D0 (no) 2002-12-16
BRPI0111743B8 (pt) 2021-05-25
MXPA02012845A (es) 2003-05-15
BG65894B1 (bg) 2010-04-30
IS2596B (is) 2010-03-15
IL153560A (en) 2011-06-30
HRP20020989A2 (en) 2005-02-28
BG107310A (bg) 2003-07-31
CZ2003114A3 (cs) 2003-05-14
HUP0300872A3 (en) 2004-11-29
EP1296984B1 (en) 2005-05-04
HK1058363A1 (en) 2004-05-14
AR030704A1 (es) 2003-09-03
ES2241830T3 (es) 2005-11-01
PA8519501A1 (es) 2002-08-29
JO2361B1 (en) 2006-12-12
CA2410232A1 (en) 2001-12-27
AU2006220405B2 (en) 2009-05-21
ZA200210305B (en) 2004-03-19
US8329714B2 (en) 2012-12-11
KR100846370B1 (ko) 2008-07-15
KR20070121847A (ko) 2007-12-27
CN1437601A (zh) 2003-08-20
HRP20020989B1 (hr) 2011-05-31
EE200200695A (et) 2004-06-15
KR100831940B1 (ko) 2008-05-23
CN1207296C (zh) 2005-06-22
US8318753B2 (en) 2012-11-27
ATE294804T1 (de) 2005-05-15
US20070259902A1 (en) 2007-11-08
SA01220349B1 (ar) 2007-01-23

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