JP4829205B2 - 血球を再循環洗浄するのに用いる方法、バッグおよび使い捨てセット - Google Patents
血球を再循環洗浄するのに用いる方法、バッグおよび使い捨てセット Download PDFInfo
- Publication number
- JP4829205B2 JP4829205B2 JP2007297162A JP2007297162A JP4829205B2 JP 4829205 B2 JP4829205 B2 JP 4829205B2 JP 2007297162 A JP2007297162 A JP 2007297162A JP 2007297162 A JP2007297162 A JP 2007297162A JP 4829205 B2 JP4829205 B2 JP 4829205B2
- Authority
- JP
- Japan
- Prior art keywords
- bag
- blood cells
- buffer solution
- port
- blood cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
- A61M1/262—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
- A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3618—Magnetic separation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3692—Washing or rinsing blood or blood constituents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- External Artificial Organs (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
上記の米国特許および国際特許願公開公報は各々、本願に援用するものである。
本発明には、血球を再循環洗浄するのに用いる方法、バッグおよび使い捨てセットが含まれている。本発明は、磁気血球選択器機で血球を洗浄するのに使用できるが、全血または他の血球製品を洗浄するのに使用することもできる。
本発明の再循環洗浄バッグは、頂部ポートと底部ポートを有する可撓性プラスチック製バッグである。一実施態様で、半剛性プラスチックメッシュのチューブからなる一体の粗いフィルターが、頂部ポートからバッグ内中に延びている。このフィルターは、より大きな血球凝集体に対し、ゆるやかな抵抗を与える。
本発明の他の実施態様では、再循環洗浄法を開始する際に、再循環洗浄バッグに、磁気血球選択法で選択された血球、および選択された血球を、血球/磁気ビーズ接合体から解放させるのに使用したペプチド解放剤が入っており、濾液は緩衝溶液によるペプチド解放剤の溶液を含有し、そして血球の濃縮懸濁液のペプチド解放剤の含有量が、所望のレベルまで減少するまで再循環洗浄が続けられる。
IsoFlow (商標)再循環洗浄バッグ
図1に、IsoFlow (商標)バッグ全体を番号5で示してある。そのバッグは例えば可撓性プラスチックで製造され、底部ポート1と頂部ポート2を備えている。半剛性のプラスチック製メッシュで製造されたチューブ3からなる一体の目の粗いフィルターが、頂部ポートからバッグ内に、バッグの底部から約0.5〜3インチ以内、好ましくは約1インチまで延びている。
図2に示す本発明の使い捨てセットは、IsoFlow バッグ5、および回転膜濾過器6と緩衝溶液が入っているバッグを接続するための配管を含む関連配管を備えている。回転膜濾過器6(時には、単に、“回転膜”または“スピナー(spinner )”と呼ぶ)は、Duffの米国特許第5,234,608 号の図2に示す構造を有している。その膜は、公称4ミクロンのポリカーボネート製膜である。
図3は、独立型血球洗浄装置、すなわち、Isolex300i器機の磁気血球選択機能のような血球選択機能をもっていない装置に使用するように構成された本発明の使い捨てセットを示す。
その使い捨てセットは、頂部ポート2と底部ポート1を有するIsoflow バッグ5;血球の希釈懸濁液用の入口ポート11、血球の濃縮懸濁液用の出口ポート14および濾液用の出口ポート24を有する回転膜濾過器6;ならびに入口ポート29を有する濾液バッグ30を具備している。
本発明の再循環洗浄法を実施する場合、濾液流量(f)は一般に、約70ml/min に固定される。血球を洗浄回路内に移送中、再循環流量(r)によって、一次圧力調整が(以下に述べる濃度比を利用して)行われ、その流量は14ml/min から70ml/min まで変動する。再循環段階において、再循環流量は約24〜70ml/min の範囲内である。緩衝溶液の流量(b)は、0〜70ml/min の範囲内であり、最小スケールの容積を、二次圧力調整機構として維持する。回転膜濾過器のローターは、通常の処理を行っている間、最高3700RPM と最低約2340RPM で作動する。
式中、i=個別の時間間隔
FSRi=時間ti における出発残留物のフラクション
FSRi-1=時間 ti-1における出発残留物のフラクション
Fi=時間間隔 i-1〜i で測定された流量f(単位:ml)で移動した濾液の容積
Bi=時間間隔 i-1〜i で測定された流量b(単位:ml)で移動した緩衝溶液の容積
Ci=IsoFlow バッグ5からの流量、および未洗浄血球の追加流量(追加された場合)を含む時間間隔iで測定された流量e(単位:ml)で移動した血球原料
Vi=時間間隔iにおける血球生成物の容積(ml)
TA=目標アドミタンス(Target Admittance )
抗体および解放剤を洗浄する場合の目標アドミタンスは、 0.7〜1.2 であり、好ましい設定値は1であることが見出された。Isolex300iでCD34+ を選択するのに利用される抗体の最適レベルは、50〜150 μgの範囲内であることが見出された。
血球のサイクル数 Si= ∫(Rj+Fj+Bj)/Vj= ∫Cj/Vj
式中、
Rj=時間間隔jで測定された流量rで移動した再循環容積(単位:ml)、および
血球のサイクル数Si=血球生成物が時間間隔iで経験した、回転膜装置を通過するサイクル数。
Claims (2)
- 頂部出口ポートと底部入口ポート、当該頂部出口ポートからバッグ中に延びて底部末端が閉鎖されている半剛性プラスチック性メッシュのチューブを有する一体のフィルター、および前記頂部出口ポートから前記バッグ中に、前記メッシュチューブの内側に延びるプラスチック製配管を有し頂部に位置する泡トラップ、を有する血球の再循環洗浄用の可撓性プラスチック製バッグ。
- 前記メッシュチューブが十分剛性であって、前記バッグに減圧がかかって、バッグをしぼむ場合、当該メッシュチューブがバッグ内に開放経路を保持し、前記底部ポートに入る緩衝溶液中の血球が頂部ポートまで移動できる請求項1に記載のバッグ。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/004,344 | 1998-01-08 | ||
US09/004,344 US6251295B1 (en) | 1998-01-08 | 1998-01-08 | Method for recirculation washing of blood cells |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000527295A Division JP4307714B2 (ja) | 1998-01-08 | 1999-01-07 | 血球を再循環洗浄するのに用いる方法、バッグおよび使い捨てセット |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008119474A JP2008119474A (ja) | 2008-05-29 |
JP4829205B2 true JP4829205B2 (ja) | 2011-12-07 |
Family
ID=21710308
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000527295A Expired - Fee Related JP4307714B2 (ja) | 1998-01-08 | 1999-01-07 | 血球を再循環洗浄するのに用いる方法、バッグおよび使い捨てセット |
JP2007297162A Expired - Lifetime JP4829205B2 (ja) | 1998-01-08 | 2007-11-15 | 血球を再循環洗浄するのに用いる方法、バッグおよび使い捨てセット |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000527295A Expired - Fee Related JP4307714B2 (ja) | 1998-01-08 | 1999-01-07 | 血球を再循環洗浄するのに用いる方法、バッグおよび使い捨てセット |
Country Status (9)
Country | Link |
---|---|
US (2) | US6251295B1 (ja) |
EP (1) | EP1058564B1 (ja) |
JP (2) | JP4307714B2 (ja) |
AT (1) | ATE314869T1 (ja) |
AU (1) | AU744878B2 (ja) |
CA (3) | CA2569912C (ja) |
DE (1) | DE69929303T2 (ja) |
ES (1) | ES2257028T3 (ja) |
WO (1) | WO1999034848A1 (ja) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020131958A1 (en) * | 2001-01-22 | 2002-09-19 | John Chapman | Method for purifying a biological composition |
DE10127068A1 (de) * | 2001-05-23 | 2002-11-28 | Bio Medical Apherese Systeme G | Vorrichtung und Verfahren zum Inkubieren und Wiederabtrennen von Magnetteilchen in und von flüssige biologische Dispersionen |
US7771716B2 (en) * | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
CA2469370C (en) | 2001-12-07 | 2014-07-08 | Macropore Biosurgery, Inc. | Adipose-derived cell processing unit |
US7651684B2 (en) | 2001-12-07 | 2010-01-26 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in augmenting autologous fat transfer |
US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
EP1525400B1 (en) * | 2002-07-09 | 2006-08-02 | Gambro Lundia AB | A support element for an extracorporeal fluid transport line |
FR2848224B1 (fr) * | 2002-12-05 | 2006-12-08 | Indicia Biotechnology | Procede de detection de microorganismes a l'aide d'un dispositif de filtration par flux tangentiel |
MXPA05009044A (es) | 2003-02-20 | 2006-03-17 | Macropore Biosurgery Inc | Metodos para utilizar celulas derivadas de tejido adiposo en el tratamiento de condiciones cardiovasculares. |
US7326355B2 (en) * | 2004-03-31 | 2008-02-05 | Hyclone Laboratories, Inc. | Mobile filtration facility and methods of use |
US8603805B2 (en) | 2005-04-22 | 2013-12-10 | Hyclone Laboratories, Inc. | Gas spargers and related container systems |
ES2485387T3 (es) | 2005-11-07 | 2014-08-13 | Amorcyte, Inc. | Composiciones y métodos de reparación de lesiones vasculares |
EP2465922B1 (en) | 2006-01-13 | 2018-08-01 | Mesoblast International Sàrl | Mesenchymal stem cells expressing tnf-alpha receptor |
US20090304644A1 (en) * | 2006-05-30 | 2009-12-10 | Cytori Therapeutics, Inc. | Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue |
US20100015104A1 (en) * | 2006-07-26 | 2010-01-21 | Cytori Therapeutics, Inc | Generation of adipose tissue and adipocytes |
WO2009044221A1 (en) | 2007-10-04 | 2009-04-09 | Gambro Lundia Ab | An infusion apparatus |
US20100028311A1 (en) * | 2008-07-09 | 2010-02-04 | Baxter International Inc. | Using of scaffold comprising fibrin for delivery of stem cells |
US8123713B2 (en) * | 2008-08-12 | 2012-02-28 | Caridian Bct, Inc. | System and method for collecting plasma protein fractions from separated blood components |
MX362512B (es) | 2008-08-14 | 2019-01-22 | Mesoblast Int Sarl | Composiciones purificadas de celulas madre mesenquimales y metodos para purificar composiciones de celulas madre mesenquimales. |
WO2010021993A1 (en) * | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
ES2625893T3 (es) * | 2009-05-01 | 2017-07-20 | Bimini Technologies Llc | Sistemas, procedimientos y composiciones para optimizar injertos enriquecidos con tejido y células |
SG178548A1 (en) | 2009-08-26 | 2012-03-29 | Xcellerex Inc | Continuous recovery harvest bag |
EP3170891B1 (en) | 2009-10-23 | 2020-11-25 | Caladrius Biosciences, Inc. | Compositions and uses for treating progressive myocardial injury due to a vascular insufficiency |
US8512566B2 (en) * | 2009-12-11 | 2013-08-20 | General Electric Company | Disposable fluid path systems and methods for processing complex biological materials |
US20120087868A1 (en) | 2010-10-08 | 2012-04-12 | Gabriele Todd | Nanoparticle-loaded cells |
BR112013022568B1 (pt) * | 2011-03-11 | 2021-01-12 | Fenwal, Inc. | método para umedecer uma membrana em um separador de membrana |
US10130751B2 (en) * | 2011-03-11 | 2018-11-20 | Fenwal, Inc. | Membrane separation and washing devices, systems and methods employing same, and data management systems and methods |
US10934519B2 (en) * | 2011-07-29 | 2021-03-02 | Global Life Sciences Solutions Usa Llc | Systems, methods and control laws for cell harvesting |
US9376655B2 (en) | 2011-09-29 | 2016-06-28 | Life Technologies Corporation | Filter systems for separating microcarriers from cell culture solutions |
JP6101698B2 (ja) | 2011-09-30 | 2017-03-22 | ライフ テクノロジーズ コーポレイション | フィルムスパージャを有する容器 |
US9533010B2 (en) | 2011-10-31 | 2017-01-03 | Amorcyte, Llc | Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency |
EP2817014A2 (en) | 2012-02-21 | 2014-12-31 | Baxter International Inc | Pharmaceutical composition comprising cd34+ cells |
CN105408467A (zh) | 2013-07-23 | 2016-03-16 | 株式会社钟化 | 细胞浓缩液的制造方法以及细胞悬浊液处理系统 |
US8945376B1 (en) | 2013-08-02 | 2015-02-03 | All Cell Recovery LLC | Systems, methods, and apparatus for resuspending cells in solution |
US9452021B2 (en) | 2013-08-02 | 2016-09-27 | All Cell Recovery LLC | Systems, methods, and apparatus for resuspending cells from surgical laundry |
US10159980B2 (en) | 2013-08-02 | 2018-12-25 | All Cell Recovery LLC | Systems and methods for recovering blood cells, in a controlled environment, for storage |
TWI585202B (zh) * | 2013-09-13 | 2017-06-01 | Medinet Co Ltd | A cell suspension filter apparatus and a method for preparing a dot drop solution containing a cell suspension |
CN105531363A (zh) * | 2013-09-13 | 2016-04-27 | 美迪奈特股份有限公司 | 细胞悬浮液过滤器具以及包含细胞悬浮液的点滴用溶液的制备方法 |
ES2641547T3 (es) | 2013-09-19 | 2017-11-10 | Cytori Therapeutics, Inc. | Métodos de uso de células derivadas de tejido adiposo en el tratamiento del fenómeno de Raynaud asociado con esclerodermia |
WO2015124235A1 (en) * | 2014-02-24 | 2015-08-27 | Fresenius Kabi Deutschland Gmbh | Apparatus and method for determining the liquid level of salvaged blood in a blood collection reservoir of an autologous blood transfusion system |
WO2015131087A1 (en) * | 2014-02-28 | 2015-09-03 | Cytovera Inc. | A system for tissu manipulation |
CA3159833A1 (en) * | 2014-05-21 | 2015-11-26 | Unchained Labs | Systems and methods for exchange of buffer solutions |
US9079690B1 (en) | 2014-06-26 | 2015-07-14 | Advanced Scientifics, Inc. | Freezer bag, storage system, and method of freezing |
EP3998335A3 (en) | 2015-05-08 | 2022-07-27 | Biomagnetic Solutions LLC | Apparatus and method for immunomagnetic cell separation |
TWI821751B (zh) * | 2015-06-05 | 2023-11-11 | 瑞士商諾華公司 | 流通式磁性分離/去除卷邊模組及磁性顆粒結合細胞處理方法 |
CN105675864B (zh) * | 2016-02-29 | 2017-11-07 | 董玉俊 | 一种基于免疫方法的细菌自动分选标记装置 |
US10449283B2 (en) | 2016-04-29 | 2019-10-22 | Fenwal, Inc. | System and method for selecting and culturing cells |
US10251990B2 (en) | 2016-04-29 | 2019-04-09 | Fenwal, Inc. | System and method for processing, incubating, and/or selecting biological cells |
US10654000B2 (en) * | 2016-07-13 | 2020-05-19 | Fenwal, Inc. | Cell processing system and method with centralized data management, monitoring and/or control |
US10729829B2 (en) * | 2016-11-11 | 2020-08-04 | Fenwal, Inc. | Systems and methods for platelet concentration with a spinning membrane separator |
CN115232745A (zh) | 2016-12-01 | 2022-10-25 | 生命科技股份有限公司 | 微载体过滤袋总成和使用方法 |
US10274495B2 (en) | 2016-12-21 | 2019-04-30 | Fenwal, Inc. | System and method for separating cells incorporating magnetic separation |
JP7260985B2 (ja) * | 2017-09-29 | 2023-04-19 | フェンウォール、インコーポレイテッド | 大容量の生物学的流体を処理するためのシステムおよび方法 |
US11583615B2 (en) | 2017-12-28 | 2023-02-21 | I-Sep | System and method for treating haemorrhagic fluid for autotransfusion |
US11413378B2 (en) | 2018-05-08 | 2022-08-16 | Biomagnetic Solutions Llc | Rigid chamber for cell separation from a flexible disposable bag |
WO2020174005A1 (en) | 2019-02-28 | 2020-09-03 | The Regenerative Group Ltd. | Regenerative combination of plasma and adipose tissue |
AU2020325825A1 (en) | 2019-08-05 | 2022-03-17 | Mesoblast International Sarl | Cellular compositions comprising viral vectors and methods of treatment |
BR112022016448A2 (pt) | 2020-02-19 | 2022-11-29 | Mesoblast Int Sarl | Método para tratamento de doença do enxerto contra hospedeiro crônica |
EP4114418A1 (en) | 2020-03-05 | 2023-01-11 | Mesoblast International Sàrl | Method for treating inflammatory lung diseases using mesenchymal lineage precursor or stem cells |
EP4117691A1 (en) | 2020-03-11 | 2023-01-18 | Mesoblast International Sàrl | Method for treating inflammatory bowel disease i |
CA3170918A1 (en) | 2020-03-11 | 2021-09-16 | Mesoblast International Sarl | Method for treating inflammatory bowel disease ii |
EP4125957A1 (en) | 2020-04-03 | 2023-02-08 | Mesoblast International Sàrl | Method for treating hyperinflammation using mesenchymal lineage precursor or stem cells |
AU2021289205A1 (en) | 2020-06-11 | 2023-02-02 | Mesoblast International Sarl | 3D culture of mesenchymal lineage precursor or stem cells |
WO2022034467A1 (en) | 2020-08-10 | 2022-02-17 | Mesoblast International Sarl | A composition comprising mesenchymal precursor or stem cells and their use |
US20230293590A1 (en) | 2020-08-10 | 2023-09-21 | Mesoblast International Sárl | Cellular compositions and methods of treatment |
CA3202153A1 (en) | 2020-12-15 | 2022-06-23 | Silviu Itescu | Method of treating progressive heart failure in subjects with class ii heart failure |
JP2024503211A (ja) * | 2020-12-15 | 2024-01-25 | グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー | 細胞洗浄、磁気単離および投与調整のための使い捨てキット |
BR112023021825A2 (pt) | 2021-04-23 | 2024-02-06 | Mesoblast Int Sarl | Método para tratar síndrome da angústia respiratória aguda (sara) em pacientes específicos utilizando precursores de linhagem mesenquimal ou células tronco |
WO2023092043A1 (en) | 2021-11-17 | 2023-05-25 | Silviu Itescu | Method of treating progressive heart failure in subjects at high risk of poor outcomes |
WO2023119239A1 (en) | 2021-12-23 | 2023-06-29 | Mesoblast International Sarl | Method of treating severe graft versus host disease |
WO2023228153A1 (en) | 2022-05-26 | 2023-11-30 | Mesoblast International Sàrl | High flow filter and method of use |
WO2023238074A1 (en) | 2022-06-08 | 2023-12-14 | Mesoblast International Sarl | Mesenchymal progenitor cells for enhancing partial reprogramming of target cells |
WO2024009226A1 (en) | 2022-07-05 | 2024-01-11 | Mesoblast International Sarl | Cryopreserved intermediate and potency assay for same |
WO2024121818A1 (en) | 2022-12-09 | 2024-06-13 | Mesoblast International Sarl | Method of treating heart failure in subjects with persistent inflammation |
WO2024121821A1 (en) | 2022-12-09 | 2024-06-13 | Mesoblast International Sarl | Conditioned media and use of the same |
WO2024121819A1 (en) | 2022-12-09 | 2024-06-13 | Mesoblast International Sarl | Method of treating inflammation with cellular compositions |
WO2024121820A1 (en) | 2022-12-09 | 2024-06-13 | Mesoblast International Sarl | Pre-licensed composition and cell culture methods |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US595489A (en) * | 1897-12-14 | Gas-engine | ||
US2704544A (en) | 1954-07-02 | 1955-03-22 | Venoclysis equipment | |
USRE26006E (en) | 1959-12-23 | 1966-04-26 | Transfusion set | |
US4102655A (en) | 1977-05-02 | 1978-07-25 | Cobe Laboratories, Inc. | Bubble trap |
JPS5759551A (en) * | 1980-09-26 | 1982-04-09 | Terumo Corp | Continuous flow type serum separating method |
DD206626A3 (de) | 1981-12-15 | 1984-02-01 | Christoph Drechsler | Blutstroemungsbahn in einem blutwaermebeutel |
US4443220A (en) * | 1982-03-16 | 1984-04-17 | Hauer Jerome Maurice | Blood collection and transfer apparatus |
US5034135A (en) | 1982-12-13 | 1991-07-23 | William F. McLaughlin | Blood fractionation system and method |
US4980054A (en) * | 1983-08-15 | 1990-12-25 | Lavender Ardis R | System and method for mass transfer between fluids |
ATE50156T1 (de) | 1984-03-21 | 1990-02-15 | Mclaughlin William F | Verfahren und vorrichtung zur filtration. |
US4675106A (en) | 1985-04-12 | 1987-06-23 | Hemascience Laboratories, Inc. | Pivot pin bearing for biomedical systems |
US4816151A (en) | 1985-04-26 | 1989-03-28 | Baxter International Inc. | Rotor drive for medical disposables |
US4753729A (en) | 1985-04-26 | 1988-06-28 | Baxter Travenol Laboratories, Inc. | Rotor drive for medical disposables |
US4675100A (en) * | 1985-05-30 | 1987-06-23 | Merichem Company | Treatment of sour hydrocarbon distillate |
SE453360B (sv) * | 1985-11-18 | 1988-02-01 | Gambro Lundia Ab | Autotransfusionssystem for uppsamling, behandling och aterforing av en patients blod |
JP2881305B2 (ja) | 1986-08-11 | 1999-04-12 | バクスター、インターナショナル、インコーポレイテッド | 血球洗浄システムおよび方法 |
US4943288A (en) * | 1988-02-25 | 1990-07-24 | Bioresearch, Inc. | Liquid reinfusion bag system |
US4976707A (en) | 1988-05-04 | 1990-12-11 | Sherwood Medical Company | Fluid collection, storage and infusion apparatus |
US5536475A (en) | 1988-10-11 | 1996-07-16 | Baxter International Inc. | Apparatus for magnetic cell separation |
US5215519A (en) * | 1990-03-07 | 1993-06-01 | Shettigar U Ramakrishna | Autotransfusion membrane system with means for providing reverse filtration |
US5055198A (en) * | 1990-03-07 | 1991-10-08 | Shettigar U Ramakrishna | Autologous blood recovery membrane system and method |
US5234608A (en) | 1990-12-11 | 1993-08-10 | Baxter International Inc. | Systems and methods for processing cellular rich suspensions |
US5695489A (en) | 1991-09-30 | 1997-12-09 | Baxter International Inc. | Blood filtering container |
US5298016A (en) | 1992-03-02 | 1994-03-29 | Advanced Haemotechnologies | Apparatus for separating plasma and other wastes from blood |
US5403272A (en) * | 1992-05-29 | 1995-04-04 | Baxter International Inc. | Apparatus and methods for generating leukocyte free platelet concentrate |
US5580349A (en) * | 1993-09-17 | 1996-12-03 | Avecor Cardiovascular, Inc. | Blood reservoir |
US5460493A (en) * | 1993-11-17 | 1995-10-24 | Baxter International Inc. | Organizer frame for holding an array of flexible tubing in alignment with one or more peristaltic pump rotors |
US5762791A (en) * | 1995-08-09 | 1998-06-09 | Baxter International Inc. | Systems for separating high hematocrit red blood cell concentrations |
US5876611A (en) * | 1997-06-16 | 1999-03-02 | Shettigar; U. Ramakrishna | Intraoperative blood salvaging system and method |
-
1998
- 1998-01-08 US US09/004,344 patent/US6251295B1/en not_active Expired - Lifetime
-
1999
- 1999-01-07 AU AU21110/99A patent/AU744878B2/en not_active Ceased
- 1999-01-07 EP EP99901408A patent/EP1058564B1/en not_active Expired - Lifetime
- 1999-01-07 CA CA002569912A patent/CA2569912C/en not_active Expired - Fee Related
- 1999-01-07 CA CA002644322A patent/CA2644322A1/en not_active Abandoned
- 1999-01-07 DE DE69929303T patent/DE69929303T2/de not_active Expired - Lifetime
- 1999-01-07 WO PCT/US1999/000535 patent/WO1999034848A1/en active IP Right Grant
- 1999-01-07 AT AT99901408T patent/ATE314869T1/de not_active IP Right Cessation
- 1999-01-07 ES ES99901408T patent/ES2257028T3/es not_active Expired - Lifetime
- 1999-01-07 CA CA002317756A patent/CA2317756C/en not_active Expired - Fee Related
- 1999-01-07 JP JP2000527295A patent/JP4307714B2/ja not_active Expired - Fee Related
-
2001
- 2001-05-23 US US09/863,485 patent/US20010035377A1/en not_active Abandoned
-
2007
- 2007-11-15 JP JP2007297162A patent/JP4829205B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2008119474A (ja) | 2008-05-29 |
JP4307714B2 (ja) | 2009-08-05 |
CA2644322A1 (en) | 1999-07-15 |
CA2569912A1 (en) | 1999-07-15 |
AU744878B2 (en) | 2002-03-07 |
DE69929303T2 (de) | 2006-09-14 |
EP1058564B1 (en) | 2006-01-04 |
US20010035377A1 (en) | 2001-11-01 |
US6251295B1 (en) | 2001-06-26 |
WO1999034848A1 (en) | 1999-07-15 |
CA2317756C (en) | 2007-10-16 |
ATE314869T1 (de) | 2006-02-15 |
ES2257028T3 (es) | 2006-07-16 |
EP1058564A1 (en) | 2000-12-13 |
AU2111099A (en) | 1999-07-26 |
CA2317756A1 (en) | 1999-07-15 |
DE69929303D1 (de) | 2006-03-30 |
JP2002500071A (ja) | 2002-01-08 |
CA2569912C (en) | 2009-03-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4829205B2 (ja) | 血球を再循環洗浄するのに用いる方法、バッグおよび使い捨てセット | |
JP4050477B2 (ja) | 血液成分採取装置 | |
JP4395204B2 (ja) | 血液透析における限外濾過装置 | |
JP5723026B2 (ja) | 血小板を収集し、かつ血漿の返血を予測するためのシステムおよび方法 | |
CN101678161B (zh) | 用于对体外血液回路进行预充的方法和设备 | |
EP3238760B1 (en) | System and method for selecting and culturing cells | |
JPH02168960A (ja) | 細胞懸濁液に含まれる細胞の処理装置 | |
EP3238759B1 (en) | System and method for processing, incubating and/or selecting biological cells | |
JPH0216455A (ja) | 低密度リポ蛋白質の選択的体外沈澱法 | |
JP2005509497A (ja) | 透析装置の運転方法 | |
JP2002500932A (ja) | 透析機械の安全装置およびその安全装置の作動方法 | |
JP2002537907A (ja) | 血液の体外浄化用の管および管の用途 | |
CN112251333B (zh) | 一种细胞外泌体提纯装置及方法 | |
EP3199617B1 (en) | Systems and methods for the separation of cells from microcarriers using a spinning membrane | |
US5589389A (en) | Apparatus for causing medicinal products to penetrate into red blood cells | |
JP2015536719A (ja) | 全血の連続分離のためのシステム及び方法 | |
JP7260985B2 (ja) | 大容量の生物学的流体を処理するためのシステムおよび方法 | |
CN116555006B (zh) | 一种包括外泌体在内的细胞外囊泡连续浓缩纯化提取系统及方法 | |
CN210331253U (zh) | 一种循环肿瘤细胞在体闭环提取设备 | |
CN209485830U (zh) | 医院及家庭用均可使的富集尿液细胞外囊泡的装置 | |
WO2008021623A1 (en) | Method and apparatus for recirculating elutriation fluids | |
WO2023246851A1 (zh) | 便携式体外血液细胞基因编辑或修饰系统 | |
CN110456033A (zh) | 用于调整含有细胞的液体样品的密度和或体积的系统 | |
JP2008061968A (ja) | 血液成分採取装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20100723 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100727 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20101027 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20101101 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110124 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20110816 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20110915 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140922 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |