JP4757024B2 - 神経保護鉄キレート剤及びそれを含む医薬組成物 - Google Patents
神経保護鉄キレート剤及びそれを含む医薬組成物 Download PDFInfo
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- JP4757024B2 JP4757024B2 JP2005502148A JP2005502148A JP4757024B2 JP 4757024 B2 JP4757024 B2 JP 4757024B2 JP 2005502148 A JP2005502148 A JP 2005502148A JP 2005502148 A JP2005502148 A JP 2005502148A JP 4757024 B2 JP4757024 B2 JP 4757024B2
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
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- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
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- C—CHEMISTRY; METALLURGY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| PCT/IL2003/000932 WO2004041151A2 (en) | 2002-11-07 | 2003-11-07 | Neuroprotective iron chelators and pharmaceutical compositions comprising them |
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| DE102004020644A1 (de) * | 2004-04-22 | 2005-11-17 | Coty B.V. | Verfahren zur Bestimmung eines UVA- und UVB-Strahlung erfassenden integralen Sonnenschutzfaktors |
| WO2007095728A1 (en) * | 2006-02-22 | 2007-08-30 | Arnold Munnich | The use of deferiprone and methods to treat and/or prevent friedreich ataxia resulting from intracellular mishandling of iron |
| BRPI0715123A2 (pt) * | 2006-08-04 | 2013-06-04 | Novartis Ag | tratamento de disfunÇço endàcrina usando quelantes de ferro |
| FR2913976B1 (fr) * | 2007-03-23 | 2013-04-26 | Biopharmed | Derives de la classe des hydroxyquinoleines aminees pour le traitement de cancers. |
| CN101679263B (zh) | 2007-03-28 | 2014-01-15 | 阿普泰克斯科技公司 | 去铁酮的氟化衍生物 |
| EP2268282B1 (en) * | 2008-04-25 | 2014-10-29 | Apotex Technologies Inc. | Liquid formulation for deferiprone with palatable taste |
| CN111808084A (zh) | 2008-11-10 | 2020-10-23 | 阿布特斯生物制药公司 | 用于递送治疗剂的新型脂质和组合物 |
| FR2940289B1 (fr) * | 2008-12-23 | 2014-09-12 | Biopharmed | Derives de la classe des hydroxyquinoleines aminees pour le traitement du cancer du pancreas |
| CA2750599A1 (en) * | 2009-01-26 | 2010-07-29 | Michael Spino | Use of deferiprone for treatment and prevention of iron-related eye disorders |
| CA2751033A1 (en) | 2009-01-29 | 2010-08-05 | Yeda Research And Development Co. Ltd. | Neuroprotective multifunctional compounds and pharmaceutical compositions comprising them |
| WO2010092419A1 (en) * | 2009-02-12 | 2010-08-19 | Assistance Publique - Hopitaux De Paris | Combined treatment of multiple sclerosis |
| WO2010147621A1 (en) * | 2009-06-16 | 2010-12-23 | The Trustees Of Columbia University In The City Of New York | Methods for ameliorating adverse effects associated with transfusion of aged red blood cells |
| GEP20146008B (en) | 2009-07-03 | 2014-01-10 | Apotex Tech Inc | Fluorinated derivatives of 3-hydroxypyridin-4-ones |
| US20140186280A1 (en) * | 2010-08-13 | 2014-07-03 | Varinel Inc | Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof |
| CN103298790A (zh) * | 2010-08-13 | 2013-09-11 | 维里奈奥公司 | 神经保护作用和神经修复作用的铁螯合剂和单胺氧化酶抑制剂及其用途 |
| WO2012104204A1 (en) | 2011-01-31 | 2012-08-09 | Vifor (International) Ag | Iron-carbohydrate complex compounds for the intravenous therapy of malaria |
| CA2826192A1 (en) * | 2011-01-31 | 2012-08-09 | The Government Of The United States, As Represented By The Secretary Of The Army | Methods and compositions for treating bacterial infections with iron chelators |
| WO2013115793A1 (en) | 2012-01-31 | 2013-08-08 | Varinel, Inc. | Iron chelators and uses thereof |
| EP2727916A1 (en) | 2012-10-30 | 2014-05-07 | Universitat Autònoma de Barcelona | Neuroprotective multi-target directed drugs |
| WO2014179139A2 (en) * | 2013-04-30 | 2014-11-06 | Albert Einstein College Of Medicine Of Yeshiva University | TREATMENT OF AGING EFFECTS BY GONADOTROPIN-RELEASING HORMONE, NEUROGENESIS OR BRAIN IKK-β/NF-κΒ INHIBITION |
| US20160271248A1 (en) * | 2013-10-03 | 2016-09-22 | Drexel University | Cxcr4 up- and down-regulation for treatment of diseases or disorders |
| US11504346B2 (en) | 2013-11-03 | 2022-11-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redox-activated pro-chelators |
| US12383518B2 (en) | 2013-11-03 | 2025-08-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Disulfide-masked pro-chelator compositions and methods of use |
| JP6612131B2 (ja) | 2014-01-17 | 2019-11-27 | セルスペクト株式会社 | 鉄(ii)イオン検出剤及びそれを用いた検出方法 |
| WO2016029158A2 (en) * | 2014-08-21 | 2016-02-25 | Collaborative Medicinal Development Llc | Compositions and methods for extending lifespan |
| GB201420348D0 (en) * | 2014-11-17 | 2014-12-31 | Univ Northumbria Newcastle | Compounds for treating neurodegenerative diseases |
| EP3377094B1 (en) * | 2015-11-19 | 2021-04-28 | Universität Basel | Virulence attenuated bacteria for treatment of malignant solid tumors |
| CN106279582B (zh) * | 2016-08-15 | 2018-04-17 | 浙江大学 | 铜离子响应性的两亲性聚合物和作为抗肿瘤药物和载体的应用 |
| JP2018188419A (ja) * | 2017-05-11 | 2018-11-29 | 株式会社ダステック | 抗腫瘍活性、抗菌活性、および/または抗ウイルス活性を有し、副作用が低減された鉄キレート剤を含む医薬組成物 |
| WO2018207852A1 (ja) * | 2017-05-11 | 2018-11-15 | 株式会社ダステック | 抗腫瘍活性、抗菌活性、および/または抗ウイルス活性を有し、副作用が低減された鉄キレート剤を含む医薬組成物 |
| MD3684344T2 (ro) | 2017-10-25 | 2025-09-30 | Chiesi Farm Spa | Comprimate de deferipronă cu eliberare întârziată și metode de utilizare a acestora |
| WO2020061474A1 (en) * | 2018-09-20 | 2020-03-26 | Tautona Group Ip Holding Company, L.L.C. | Iron chelating compounds for treating aesthetic skin conditions |
| CN109761964B (zh) * | 2018-12-29 | 2021-02-02 | 浙江工业大学 | 香豆素骈3-羟基吡啶-4-酮的衍生物及其制备方法与应用 |
| US12150958B2 (en) * | 2020-01-08 | 2024-11-26 | The Sallie Astor Burdine Breast Foundation | Compositions and methods for treatment of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, and associated methods for preparing said compositions |
| CN111170936B (zh) * | 2020-01-19 | 2021-01-01 | 杭州泽德医药科技有限公司 | 3,4-二羟基-n-(1’-苄基-2’-羟乙基)-2-甲基吡啶氯化物及制备和应用 |
| WO2022015983A1 (en) * | 2020-07-15 | 2022-01-20 | Memorial Sloan-Kettering Cancer Center | Methods of treating leptomeningeal metastasis |
| CN112521331B (zh) * | 2020-12-16 | 2022-07-19 | 浙江工业大学 | 一种吡啶酮一位炔胺修饰衍生物及其制备方法与应用 |
| CN112552232B (zh) * | 2020-12-16 | 2022-11-25 | 浙江工业大学 | 一种吡啶酮六位炔胺修饰衍生物及其制备方法与应用 |
| US12016850B2 (en) | 2022-04-11 | 2024-06-25 | Chiesi Farmaceutici S.P.A. | Modified release pharmaceutical formulations comprising deferiprone |
| US12016851B2 (en) | 2022-04-11 | 2024-06-25 | Chiesi Farmaceutici S.P.A. | Modified release pharmaceutical formulations comprising deferiprone |
| CN114716366B (zh) * | 2022-04-13 | 2023-12-26 | 浙江大学 | 3-羟基吡啶-4-酮类衍生物及在抑制肾细胞铁死亡中的应用 |
| CN117105853A (zh) * | 2023-08-28 | 2023-11-24 | 浙江工业大学 | 3-羟基吡啶-4(h)-酮类衍生物及其制备方法与应用 |
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2011
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| JPS58174318A (ja) * | 1982-03-24 | 1983-10-13 | ブリティッシュ・テクノロジー・グループ・リミテッド | 医薬用組成物 |
| JP2002500663A (ja) * | 1997-05-29 | 2002-01-08 | ビーティージー・インターナショナル・リミテッド | 新規な経口用で活性な鉄(iii)キレート化剤 |
| JP2001521924A (ja) * | 1997-10-31 | 2001-11-13 | バーナリス リサーチ リミテッド | 鉄キレート化剤および酸化防止剤としてのオルト−ヒドロキシピリジノン誘導体 |
| WO2000074664A2 (en) * | 1999-06-07 | 2000-12-14 | Yeda Research And Development Co. Ltd. | Novel iron chelators and pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders |
| WO2004007461A1 (en) * | 2002-07-16 | 2004-01-22 | Prana Biotechnology Limited | 8-hydroxy quinoline derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011079834A (ja) | 2011-04-21 |
| US20060234927A1 (en) | 2006-10-19 |
| CA2505476A1 (en) | 2004-05-21 |
| US20120058945A1 (en) | 2012-03-08 |
| JP2006515599A (ja) | 2006-06-01 |
| US8058442B2 (en) | 2011-11-15 |
| CA2505476C (en) | 2015-05-26 |
| AU2003282337A1 (en) | 2004-06-07 |
| EP1565185A4 (en) | 2011-01-05 |
| WO2004041151A2 (en) | 2004-05-21 |
| WO2004041151A3 (en) | 2004-10-28 |
| EP1565185A2 (en) | 2005-08-24 |
| US8685955B2 (en) | 2014-04-01 |
| AU2003282337B2 (en) | 2009-07-16 |
| IL168419A (en) | 2017-01-31 |
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