JP4757024B2 - 神経保護鉄キレート剤及びそれを含む医薬組成物 - Google Patents

神経保護鉄キレート剤及びそれを含む医薬組成物 Download PDF

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JP4757024B2
JP4757024B2 JP2005502148A JP2005502148A JP4757024B2 JP 4757024 B2 JP4757024 B2 JP 4757024B2 JP 2005502148 A JP2005502148 A JP 2005502148A JP 2005502148 A JP2005502148 A JP 2005502148A JP 4757024 B2 JP4757024 B2 JP 4757024B2
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compound
iron
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JP2006515599A (ja
JP2006515599A5 (https=
Inventor
ヨウディム、ムサ、ビー.、エイチ.
フリドキン、マティティヤフ
チョン、ハイリン
ワルシャウスキー、リヴカ
ワルシャウスキー、アブラハム
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Yeda Research and Development Co Ltd
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JP2005502148A 2002-11-07 2003-11-07 神経保護鉄キレート剤及びそれを含む医薬組成物 Expired - Fee Related JP4757024B2 (ja)

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US42431302P 2002-11-07 2002-11-07
US60/424,313 2002-11-07
US50412603P 2003-09-22 2003-09-22
US60/504,126 2003-09-22
PCT/IL2003/000932 WO2004041151A2 (en) 2002-11-07 2003-11-07 Neuroprotective iron chelators and pharmaceutical compositions comprising them

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JP2006515599A JP2006515599A (ja) 2006-06-01
JP2006515599A5 JP2006515599A5 (https=) 2006-12-07
JP4757024B2 true JP4757024B2 (ja) 2011-08-24

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Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004020644A1 (de) * 2004-04-22 2005-11-17 Coty B.V. Verfahren zur Bestimmung eines UVA- und UVB-Strahlung erfassenden integralen Sonnenschutzfaktors
WO2007095728A1 (en) * 2006-02-22 2007-08-30 Arnold Munnich The use of deferiprone and methods to treat and/or prevent friedreich ataxia resulting from intracellular mishandling of iron
BRPI0715123A2 (pt) * 2006-08-04 2013-06-04 Novartis Ag tratamento de disfunÇço endàcrina usando quelantes de ferro
FR2913976B1 (fr) * 2007-03-23 2013-04-26 Biopharmed Derives de la classe des hydroxyquinoleines aminees pour le traitement de cancers.
CN101679263B (zh) 2007-03-28 2014-01-15 阿普泰克斯科技公司 去铁酮的氟化衍生物
EP2268282B1 (en) * 2008-04-25 2014-10-29 Apotex Technologies Inc. Liquid formulation for deferiprone with palatable taste
CN111808084A (zh) 2008-11-10 2020-10-23 阿布特斯生物制药公司 用于递送治疗剂的新型脂质和组合物
FR2940289B1 (fr) * 2008-12-23 2014-09-12 Biopharmed Derives de la classe des hydroxyquinoleines aminees pour le traitement du cancer du pancreas
CA2750599A1 (en) * 2009-01-26 2010-07-29 Michael Spino Use of deferiprone for treatment and prevention of iron-related eye disorders
CA2751033A1 (en) 2009-01-29 2010-08-05 Yeda Research And Development Co. Ltd. Neuroprotective multifunctional compounds and pharmaceutical compositions comprising them
WO2010092419A1 (en) * 2009-02-12 2010-08-19 Assistance Publique - Hopitaux De Paris Combined treatment of multiple sclerosis
WO2010147621A1 (en) * 2009-06-16 2010-12-23 The Trustees Of Columbia University In The City Of New York Methods for ameliorating adverse effects associated with transfusion of aged red blood cells
GEP20146008B (en) 2009-07-03 2014-01-10 Apotex Tech Inc Fluorinated derivatives of 3-hydroxypyridin-4-ones
US20140186280A1 (en) * 2010-08-13 2014-07-03 Varinel Inc Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof
CN103298790A (zh) * 2010-08-13 2013-09-11 维里奈奥公司 神经保护作用和神经修复作用的铁螯合剂和单胺氧化酶抑制剂及其用途
WO2012104204A1 (en) 2011-01-31 2012-08-09 Vifor (International) Ag Iron-carbohydrate complex compounds for the intravenous therapy of malaria
CA2826192A1 (en) * 2011-01-31 2012-08-09 The Government Of The United States, As Represented By The Secretary Of The Army Methods and compositions for treating bacterial infections with iron chelators
WO2013115793A1 (en) 2012-01-31 2013-08-08 Varinel, Inc. Iron chelators and uses thereof
EP2727916A1 (en) 2012-10-30 2014-05-07 Universitat Autònoma de Barcelona Neuroprotective multi-target directed drugs
WO2014179139A2 (en) * 2013-04-30 2014-11-06 Albert Einstein College Of Medicine Of Yeshiva University TREATMENT OF AGING EFFECTS BY GONADOTROPIN-RELEASING HORMONE, NEUROGENESIS OR BRAIN IKK-β/NF-κΒ INHIBITION
US20160271248A1 (en) * 2013-10-03 2016-09-22 Drexel University Cxcr4 up- and down-regulation for treatment of diseases or disorders
US11504346B2 (en) 2013-11-03 2022-11-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Redox-activated pro-chelators
US12383518B2 (en) 2013-11-03 2025-08-12 Arizona Board Of Regents On Behalf Of The University Of Arizona Disulfide-masked pro-chelator compositions and methods of use
JP6612131B2 (ja) 2014-01-17 2019-11-27 セルスペクト株式会社 鉄(ii)イオン検出剤及びそれを用いた検出方法
WO2016029158A2 (en) * 2014-08-21 2016-02-25 Collaborative Medicinal Development Llc Compositions and methods for extending lifespan
GB201420348D0 (en) * 2014-11-17 2014-12-31 Univ Northumbria Newcastle Compounds for treating neurodegenerative diseases
EP3377094B1 (en) * 2015-11-19 2021-04-28 Universität Basel Virulence attenuated bacteria for treatment of malignant solid tumors
CN106279582B (zh) * 2016-08-15 2018-04-17 浙江大学 铜离子响应性的两亲性聚合物和作为抗肿瘤药物和载体的应用
JP2018188419A (ja) * 2017-05-11 2018-11-29 株式会社ダステック 抗腫瘍活性、抗菌活性、および/または抗ウイルス活性を有し、副作用が低減された鉄キレート剤を含む医薬組成物
WO2018207852A1 (ja) * 2017-05-11 2018-11-15 株式会社ダステック 抗腫瘍活性、抗菌活性、および/または抗ウイルス活性を有し、副作用が低減された鉄キレート剤を含む医薬組成物
MD3684344T2 (ro) 2017-10-25 2025-09-30 Chiesi Farm Spa Comprimate de deferipronă cu eliberare întârziată și metode de utilizare a acestora
WO2020061474A1 (en) * 2018-09-20 2020-03-26 Tautona Group Ip Holding Company, L.L.C. Iron chelating compounds for treating aesthetic skin conditions
CN109761964B (zh) * 2018-12-29 2021-02-02 浙江工业大学 香豆素骈3-羟基吡啶-4-酮的衍生物及其制备方法与应用
US12150958B2 (en) * 2020-01-08 2024-11-26 The Sallie Astor Burdine Breast Foundation Compositions and methods for treatment of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, and associated methods for preparing said compositions
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WO2022015983A1 (en) * 2020-07-15 2022-01-20 Memorial Sloan-Kettering Cancer Center Methods of treating leptomeningeal metastasis
CN112521331B (zh) * 2020-12-16 2022-07-19 浙江工业大学 一种吡啶酮一位炔胺修饰衍生物及其制备方法与应用
CN112552232B (zh) * 2020-12-16 2022-11-25 浙江工业大学 一种吡啶酮六位炔胺修饰衍生物及其制备方法与应用
US12016850B2 (en) 2022-04-11 2024-06-25 Chiesi Farmaceutici S.P.A. Modified release pharmaceutical formulations comprising deferiprone
US12016851B2 (en) 2022-04-11 2024-06-25 Chiesi Farmaceutici S.P.A. Modified release pharmaceutical formulations comprising deferiprone
CN114716366B (zh) * 2022-04-13 2023-12-26 浙江大学 3-羟基吡啶-4-酮类衍生物及在抑制肾细胞铁死亡中的应用
CN117105853A (zh) * 2023-08-28 2023-11-24 浙江工业大学 3-羟基吡啶-4(h)-酮类衍生物及其制备方法与应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58174318A (ja) * 1982-03-24 1983-10-13 ブリティッシュ・テクノロジー・グループ・リミテッド 医薬用組成物
WO2000074664A2 (en) * 1999-06-07 2000-12-14 Yeda Research And Development Co. Ltd. Novel iron chelators and pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders
JP2001521924A (ja) * 1997-10-31 2001-11-13 バーナリス リサーチ リミテッド 鉄キレート化剤および酸化防止剤としてのオルト−ヒドロキシピリジノン誘導体
JP2002500663A (ja) * 1997-05-29 2002-01-08 ビーティージー・インターナショナル・リミテッド 新規な経口用で活性な鉄(iii)キレート化剤
WO2004007461A1 (en) * 2002-07-16 2004-01-22 Prana Biotechnology Limited 8-hydroxy quinoline derivatives

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297527A (en) 1963-10-09 1967-01-10 Parke Davis & Co Propargylamine as an anti-depressant
RO63861A2 (fr) 1974-09-26 1979-01-15 Medicamente Terapia Intreprind Derive du hydrazide d'acide isonicotinique et procede de preparation
US4861800A (en) 1987-08-18 1989-08-29 Buyske Donald A Method for administering the drug deprenyl so as to minimize the danger of side effects
HU208484B (en) 1988-08-17 1993-11-29 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical composition containing acid additional salt of selegilin as active component for treating schisofrenia
IL92952A (en) 1990-01-03 1994-06-24 Teva Pharma R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them
US5744500A (en) 1990-01-03 1998-04-28 Teva Pharmaceutical Industries, Ltd. Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof
US5151449A (en) 1990-08-31 1992-09-29 Deprenyl Animal Health, Inc. Use of L-deprenyl for retention of specific physiological functions
US5225446A (en) 1990-08-31 1993-07-06 Deprenyl Animal Health, Inc. Use of 1-deprenyl for retention of specific physiological functions
CA2039194C (en) 1990-08-31 1997-01-28 Norton W. Milgram Uses of l-deprenyl and compositions for same
US5192808A (en) 1990-08-31 1993-03-09 Deprenyl Animal Health, Inc. Therapeutic effect of L-deprenyl in the management of pituitary-dependent hyperadrenocorticism (cushing's disease)
US5169868A (en) 1991-03-01 1992-12-08 University Of Saskatchewan Aliphatic propargylamines as specific mao-b inhibitors
US5532416A (en) 1994-07-20 1996-07-02 Monsanto Company Benzoyl derivatives and synthesis thereof
US5242950A (en) 1992-04-23 1993-09-07 Somerset Pharmaceuticals, Inc. Treatment of macular degeneration
US5914349A (en) 1994-01-10 1999-06-22 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
IL118836A (en) 1996-07-11 2001-01-11 Teva Pharma Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan
US6251938B1 (en) 1996-12-18 2001-06-26 Teva Pharmaceutical Industries, Ltd., Phenylethylamine derivatives
DE69738275T2 (de) 1996-12-18 2008-08-28 Teva Pharmaceutical Industries Ltd. Aminoindanderivate
US5840979A (en) 1997-07-14 1998-11-24 University Of Saskatchewan Aliphatic propargylamines as cellular rescue agents
US20020137786A1 (en) 1998-02-12 2002-09-26 William G. Tatton Deprenyl compounds to treat viral infections and reduce tissue damage associated therewith
EP1006108A1 (en) * 1998-12-01 2000-06-07 Cerebrus Pharmaceuticals Limited 3-Hydroxy-2(1H)-pyridinone or 3-hydroxy-4(1H)-pyridinone derivatives useful as reactive oxygen species (ROS) scavengers
EP1185259A1 (en) 1999-04-29 2002-03-13 MERCK PATENT GmbH Glycine cleavage system inhibitors as potential antipsychotics
US20020019421A1 (en) 2000-07-05 2002-02-14 Roni Biberman Compositions and therapy for substance addiction

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58174318A (ja) * 1982-03-24 1983-10-13 ブリティッシュ・テクノロジー・グループ・リミテッド 医薬用組成物
JP2002500663A (ja) * 1997-05-29 2002-01-08 ビーティージー・インターナショナル・リミテッド 新規な経口用で活性な鉄(iii)キレート化剤
JP2001521924A (ja) * 1997-10-31 2001-11-13 バーナリス リサーチ リミテッド 鉄キレート化剤および酸化防止剤としてのオルト−ヒドロキシピリジノン誘導体
WO2000074664A2 (en) * 1999-06-07 2000-12-14 Yeda Research And Development Co. Ltd. Novel iron chelators and pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders
WO2004007461A1 (en) * 2002-07-16 2004-01-22 Prana Biotechnology Limited 8-hydroxy quinoline derivatives

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