JP4751557B2 - 抗菌キノロン薬のための有用な中間物としてのアルキル３−シクロプロピルアミノ−２−［２，４−ジブロモ−３−（ジフルオロメトキシ）ベンゾイル］−２−プロペノエートのワンポット合成法 - Google Patents

抗菌キノロン薬のための有用な中間物としてのアルキル３−シクロプロピルアミノ−２−［２，４−ジブロモ−３−（ジフルオロメトキシ）ベンゾイル］−２−プロペノエートのワンポット合成法 Download PDF

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JP4751557B2
JP4751557B2 JP2001565332A JP2001565332A JP4751557B2 JP 4751557 B2 JP4751557 B2 JP 4751557B2 JP 2001565332 A JP2001565332 A JP 2001565332A JP 2001565332 A JP2001565332 A JP 2001565332A JP 4751557 B2 JP4751557 B2 JP 4751557B2
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difluoromethoxy
dibromo
alkyl
formula
solvent
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Japanese (ja)
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JP2003534243A (ja
JP2003534243A5 (https=
Inventor
ボーズ，プロセンジット
クマール，ナレッシュ
キヨト，タロー
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Toyama Chemical Co Ltd
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Toyama Chemical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001565332A 2000-03-07 2001-03-07 抗菌キノロン薬のための有用な中間物としてのアルキル３−シクロプロピルアミノ−２−［２，４−ジブロモ−３−（ジフルオロメトキシ）ベンゾイル］−２−プロペノエートのワンポット合成法 Expired - Lifetime JP4751557B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN196DE2000 2000-03-07
IN196/DEL/2000 2000-03-07
PCT/IB2001/000316 WO2001066512A1 (en) 2000-03-07 2001-03-07 One-pot synthesis of alkyl 3-cyclopropylamino-2-[2,4-dibromo-3-(difluoromethoxy)benzoyl]-2-propenoate as a useful intermediate for antibacterial quinolone medicaments

Publications (3)

Publication Number Publication Date
JP2003534243A JP2003534243A (ja) 2003-11-18
JP2003534243A5 JP2003534243A5 (https=) 2011-05-19
JP4751557B2 true JP4751557B2 (ja) 2011-08-17

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JP2001565332A Expired - Lifetime JP4751557B2 (ja) 2000-03-07 2001-03-07 抗菌キノロン薬のための有用な中間物としてのアルキル３−シクロプロピルアミノ−２−［２，４−ジブロモ−３−（ジフルオロメトキシ）ベンゾイル］−２−プロペノエートのワンポット合成法

Country Status (9)

Country Link
US (1) US6835848B1 (https=)
EP (1) EP1278717B1 (https=)
JP (1) JP4751557B2 (https=)
KR (1) KR100763077B1 (https=)
CN (1) CN1202075C (https=)
AT (1) ATE364036T1 (https=)
AU (1) AU3590801A (https=)
DE (1) DE60128797D1 (https=)
WO (1) WO2001066512A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
US7759362B2 (en) * 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
KR200457934Y1 (ko) * 2010-10-26 2012-01-12 주식회사 삼진엘앤디 등기구 마운팅 구조
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
CN105801482B (zh) * 2016-04-18 2018-06-22 浙江中欣氟材股份有限公司 一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的制备方法
CN105777631B (zh) * 2016-04-18 2018-06-29 浙江中欣氟材股份有限公司 一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的合成方法
CN114716373B (zh) * 2022-04-14 2023-01-10 内蒙古源宏精细化工有限公司 一种加替沙星环合酯的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63316757A (ja) * 1987-06-18 1988-12-26 Ube Ind Ltd ３−アミノ−２−置換ベンゾイルアクリル酸誘導体
JPH05194336A (ja) * 1992-01-14 1993-08-03 Kyorin Pharmaceut Co Ltd アミノアクリル酸誘導体
JPH05320107A (ja) * 1992-05-15 1993-12-03 Ube Ind Ltd ３−ジアルキルアミノ−２−置換ベンゾイルアクリル酸誘導体
WO1999021849A1 (en) * 1997-10-27 1999-05-06 Toyama Chemical Co., Ltd. Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient
WO2000029369A1 (fr) * 1998-11-18 2000-05-25 Asahi Glass Company Ltd. Derives d'acide aminoacrylique et procede de production correspondant
WO2000055116A1 (en) * 1999-03-17 2000-09-21 Daiichi Pharmaceutical Co., Ltd. Process for producing 5-amino-8- alkylquinolo necarboxylic acid derivatives and intermediates in the production thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0616642A (ja) * 1992-07-02 1994-01-25 Katayama Seiyakushiyo:Kk キノリンカルボン酸誘導体の製造方法
US5935952A (en) * 1994-08-12 1999-08-10 Toyama Chemical Co., Ltd. Quinolone- or naphthylidone-carboxylic acid derivates or their salts

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63316757A (ja) * 1987-06-18 1988-12-26 Ube Ind Ltd ３−アミノ−２−置換ベンゾイルアクリル酸誘導体
JPH05194336A (ja) * 1992-01-14 1993-08-03 Kyorin Pharmaceut Co Ltd アミノアクリル酸誘導体
JPH05320107A (ja) * 1992-05-15 1993-12-03 Ube Ind Ltd ３−ジアルキルアミノ−２−置換ベンゾイルアクリル酸誘導体
WO1999021849A1 (en) * 1997-10-27 1999-05-06 Toyama Chemical Co., Ltd. Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient
WO2000029369A1 (fr) * 1998-11-18 2000-05-25 Asahi Glass Company Ltd. Derives d'acide aminoacrylique et procede de production correspondant
WO2000055116A1 (en) * 1999-03-17 2000-09-21 Daiichi Pharmaceutical Co., Ltd. Process for producing 5-amino-8- alkylquinolo necarboxylic acid derivatives and intermediates in the production thereof

Also Published As

Publication number Publication date
JP2003534243A (ja) 2003-11-18
US20040267019A1 (en) 2004-12-30
CN1202075C (zh) 2005-05-18
ATE364036T1 (de) 2007-06-15
CN1427815A (zh) 2003-07-02
EP1278717A1 (en) 2003-01-29
KR20030017473A (ko) 2003-03-03
EP1278717B1 (en) 2007-06-06
DE60128797D1 (de) 2007-07-19
KR100763077B1 (ko) 2007-10-04
EP1278717A4 (en) 2005-06-08
WO2001066512A1 (en) 2001-09-13
US6835848B1 (en) 2004-12-28
AU3590801A (en) 2001-09-17

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