CN1202075C - 作为抗菌剂喹诺酮药物的有用中间体的3－环丙基氨基－2－[2,4－二溴－3－(二氟甲氧基 )苯甲酰基]－2－丙烯酸烷酯的－锅合成 - Google Patents

作为抗菌剂喹诺酮药物的有用中间体的3－环丙基氨基－2－[2,4－二溴－3－(二氟甲氧基 )苯甲酰基]－2－丙烯酸烷酯的－锅合成 Download PDF

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Publication number
CN1202075C
CN1202075C CNB018090362A CN01809036A CN1202075C CN 1202075 C CN1202075 C CN 1202075C CN B018090362 A CNB018090362 A CN B018090362A CN 01809036 A CN01809036 A CN 01809036A CN 1202075 C CN1202075 C CN 1202075C
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CN
China
Prior art keywords
formula
methyl
methoxy
ethyl
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CNB018090362A
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English (en)
Chinese (zh)
Other versions
CN1427815A (zh
Inventor
P·鲍斯
N·库马
清都太郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Toyama Chemical Co Ltd
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Publication date
Application filed by Ranbaxy Laboratories Ltd, Toyama Chemical Co Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of CN1427815A publication Critical patent/CN1427815A/zh
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Publication of CN1202075C publication Critical patent/CN1202075C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB018090362A 2000-03-07 2001-03-07 作为抗菌剂喹诺酮药物的有用中间体的3－环丙基氨基－2－[2,4－二溴－3－(二氟甲氧基 )苯甲酰基]－2－丙烯酸烷酯的－锅合成 Expired - Lifetime CN1202075C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN196DE2000 2000-03-07
IN196/DEL/2000 2000-03-07

Publications (2)

Publication Number Publication Date
CN1427815A CN1427815A (zh) 2003-07-02
CN1202075C true CN1202075C (zh) 2005-05-18

Family

ID=11097039

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018090362A Expired - Lifetime CN1202075C (zh) 2000-03-07 2001-03-07 作为抗菌剂喹诺酮药物的有用中间体的3－环丙基氨基－2－[2,4－二溴－3－(二氟甲氧基 )苯甲酰基]－2－丙烯酸烷酯的－锅合成

Country Status (9)

Country Link
US (1) US6835848B1 (https=)
EP (1) EP1278717B1 (https=)
JP (1) JP4751557B2 (https=)
KR (1) KR100763077B1 (https=)
CN (1) CN1202075C (https=)
AT (1) ATE364036T1 (https=)
AU (1) AU3590801A (https=)
DE (1) DE60128797D1 (https=)
WO (1) WO2001066512A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
US7759362B2 (en) * 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
KR200457934Y1 (ko) * 2010-10-26 2012-01-12 주식회사 삼진엘앤디 등기구 마운팅 구조
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
CN105801482B (zh) * 2016-04-18 2018-06-22 浙江中欣氟材股份有限公司 一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的制备方法
CN105777631B (zh) * 2016-04-18 2018-06-29 浙江中欣氟材股份有限公司 一种1-环丙基-4-氧代-7-溴-8-二氟甲氧基-1,4-二氢喹啉-3-羧酸乙酯的合成方法
CN114716373B (zh) * 2022-04-14 2023-01-10 内蒙古源宏精细化工有限公司 一种加替沙星环合酯的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0784423B2 (ja) * 1987-06-18 1995-09-13 宇部興産株式会社 ３−アミノ−２−置換ベンゾイルアクリル酸誘導体
JPH05194336A (ja) * 1992-01-14 1993-08-03 Kyorin Pharmaceut Co Ltd アミノアクリル酸誘導体
JP2918134B2 (ja) * 1992-05-15 1999-07-12 宇部興産株式会社 ３−ジアルキルアミノ−２−置換ベンゾイルアクリル酸誘導体
JPH0616642A (ja) * 1992-07-02 1994-01-25 Katayama Seiyakushiyo:Kk キノリンカルボン酸誘導体の製造方法
US5935952A (en) * 1994-08-12 1999-08-10 Toyama Chemical Co., Ltd. Quinolone- or naphthylidone-carboxylic acid derivates or their salts
AU750760B2 (en) * 1997-10-27 2002-07-25 Toyama Chemical Co. Ltd. Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient
ATE245140T1 (de) * 1998-11-18 2003-08-15 Asahi Glass Co Ltd Derivate der aminoacryl-säure und ein verfahren zur herstellung derselben
AU3191700A (en) * 1999-03-17 2000-10-04 Daiichi Pharmaceutical Co., Ltd. Process for producing 5-amino-8- alkylquinolo necarboxylic acid derivatives and intermediates in the production thereof

Also Published As

Publication number Publication date
JP2003534243A (ja) 2003-11-18
US20040267019A1 (en) 2004-12-30
JP4751557B2 (ja) 2011-08-17
ATE364036T1 (de) 2007-06-15
CN1427815A (zh) 2003-07-02
EP1278717A1 (en) 2003-01-29
KR20030017473A (ko) 2003-03-03
EP1278717B1 (en) 2007-06-06
DE60128797D1 (de) 2007-07-19
KR100763077B1 (ko) 2007-10-04
EP1278717A4 (en) 2005-06-08
WO2001066512A1 (en) 2001-09-13
US6835848B1 (en) 2004-12-28
AU3590801A (en) 2001-09-17

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