JP4746856B2 - ピラゾロン系製剤 - Google Patents
ピラゾロン系製剤 Download PDFInfo
- Publication number
- JP4746856B2 JP4746856B2 JP2004235253A JP2004235253A JP4746856B2 JP 4746856 B2 JP4746856 B2 JP 4746856B2 JP 2004235253 A JP2004235253 A JP 2004235253A JP 2004235253 A JP2004235253 A JP 2004235253A JP 4746856 B2 JP4746856 B2 JP 4746856B2
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- preparation
- phenyl
- pyrazolin
- cyclodextrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000002360 preparation method Methods 0.000 title claims description 42
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical compound O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 title claims description 14
- QELUYTUMUWHWMC-UHFFFAOYSA-N edaravone Chemical compound O=C1CC(C)=NN1C1=CC=CC=C1 QELUYTUMUWHWMC-UHFFFAOYSA-N 0.000 claims description 31
- 229920000858 Cyclodextrin Polymers 0.000 claims description 23
- -1 hydroxypropyl derivatives of β- cyclodextrin Chemical class 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 19
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- 238000009472 formulation Methods 0.000 claims description 6
- 235000013336 milk Nutrition 0.000 claims description 6
- 239000008267 milk Substances 0.000 claims description 6
- 210000004080 milk Anatomy 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 3
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| JP2004235253A JP4746856B2 (ja) | 2004-08-12 | 2004-08-12 | ピラゾロン系製剤 |
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| JP2006052172A JP2006052172A (ja) | 2006-02-23 |
| JP2006052172A5 JP2006052172A5 (enExample) | 2007-09-27 |
| JP4746856B2 true JP4746856B2 (ja) | 2011-08-10 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE031463T2 (en) * | 2007-01-19 | 2017-07-28 | Hananja Ehf | Method and compositions for administering an active ingredient |
| WO2009041714A1 (ja) * | 2007-09-26 | 2009-04-02 | Mikasa Seiyaku Co., Ltd. | フリーラジカル性疾患用外用剤 |
| EP2230912A4 (en) * | 2007-11-21 | 2013-05-01 | Teikoku Pharma Usa Inc | EMULSION FORMULATIONS OF PYRAZOLON DERIVATIVES |
| CN101524352A (zh) | 2008-03-04 | 2009-09-09 | 江苏先声药物研究有限公司 | 一种含有3-甲基-1-苯基-2-吡唑啉-5-酮的组合物 |
| CN101953832B (zh) * | 2010-08-10 | 2012-02-15 | 南京师范大学 | β-环糊精包合依达拉奉的口服药物组合物及其制备方法 |
| JP2014518228A (ja) * | 2011-07-01 | 2014-07-28 | フオンダツイオーネ・イステイトウート・インスブリコ・デイ・リチエルカ・ペル・ラ・ビータ | 高速溶解速度を有する非晶質トモキシプロールとシクロデキストリンとの複合体およびこの調製方法 |
| ES2928785T3 (es) * | 2017-10-13 | 2022-11-22 | Treeway Tw001 B V | Sal de edaravona |
| GB202103807D0 (en) * | 2021-03-18 | 2021-05-05 | Johnson Matthey Plc | A crystalline salt of edaravone, processes for the preparation and use thereof |
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| JP2906512B2 (ja) * | 1990-01-16 | 1999-06-21 | 三菱化学株式会社 | 抗潰瘍剤 |
| JP3176716B2 (ja) * | 1991-06-21 | 2001-06-18 | 武田薬品工業株式会社 | 溶解性が向上した難水溶性薬物組成物 |
| DE4333598A1 (de) * | 1993-10-01 | 1995-04-06 | Consortium Elektrochem Ind | Verfahren zur Herstellung von alkylierten Cyclodextrin-Derivaten, nach dem Verfahren herstellbare methylierte Cyclodextrin-Derivate und die Verwendung der Produkte |
| JPH10279480A (ja) * | 1997-04-07 | 1998-10-20 | Mitsubishi Chem Corp | 皮膚組織障害の予防・治療剤 |
| CA2446837C (en) * | 2001-05-11 | 2012-01-03 | Mitsubishi Pharma Corporation | Stable high-concentration injection containing pyrazolone derivative |
| JP2003081830A (ja) * | 2001-09-12 | 2003-03-19 | Mitsubishi-Tokyo Pharmaceuticals Inc | 酸化ストレス抑制剤 |
| CN1232539C (zh) * | 2002-05-10 | 2005-12-21 | 刘云清 | 有机药物与倍他环糊精衍生物的配合物及其制备方法 |
| JP2004300153A (ja) * | 2003-03-20 | 2004-10-28 | Kiyoshi Kurokawa | 蛋白修飾物生成抑制剤 |
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