JP4740452B2 - 移植で免疫応答の予防と処置のための間葉幹細胞を利用する方法、組成物およびその使用法 - Google Patents

移植で免疫応答の予防と処置のための間葉幹細胞を利用する方法、組成物およびその使用法 Download PDF

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JP4740452B2
JP4740452B2 JP2000536402A JP2000536402A JP4740452B2 JP 4740452 B2 JP4740452 B2 JP 4740452B2 JP 2000536402 A JP2000536402 A JP 2000536402A JP 2000536402 A JP2000536402 A JP 2000536402A JP 4740452 B2 JP4740452 B2 JP 4740452B2
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mesenchymal stem
stem cells
graft
cells
isolated
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マッキントッシュ，ケビン，アール．
モスカ，ジョゼフ，ディー．
クリュシュネンコバ，エレナ，エヌ．
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オシリス セラピューティクス，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]

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  • Transplantation (AREA)
  • General Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2000536402A 1998-03-18 1999-03-12 移植で免疫応答の予防と処置のための間葉幹細胞を利用する方法、組成物およびその使用法 Expired - Lifetime JP4740452B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7846398P 1998-03-18 1998-03-18
US60/078,463 1998-03-18
US8996498P 1998-06-19 1998-06-19
US60/089,964 1998-06-19
PCT/US1999/005548 WO1999047163A2 (en) 1998-03-18 1999-03-12 Mesenchymal stem cells for prevention and treatment of immune responses in transplantation

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JP2002506831A JP2002506831A (ja) 2002-03-05
JP2002506831A5 JP2002506831A5 (https=) 2010-05-13
JP4740452B2 true JP4740452B2 (ja) 2011-08-03

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JP2000536402A Expired - Lifetime JP4740452B2 (ja) 1998-03-18 1999-03-12 移植で免疫応答の予防と処置のための間葉幹細胞を利用する方法、組成物およびその使用法

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US (1) US6328960B1 (https=)
EP (1) EP1066052B1 (https=)
JP (1) JP4740452B2 (https=)
AT (1) ATE316795T1 (https=)
AU (1) AU755888B2 (https=)
CA (1) CA2320040C (https=)
DE (1) DE69929681T2 (https=)
DK (1) DK1066052T3 (https=)
ES (1) ES2258329T3 (https=)
PT (1) PT1066052E (https=)
WO (1) WO1999047163A2 (https=)

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