AU755888B2 - Mesenchymal stem cells for prevention and treatment of immune responses in transplantation - Google Patents

Mesenchymal stem cells for prevention and treatment of immune responses in transplantation Download PDF

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Publication number
AU755888B2
AU755888B2 AU31856/99A AU3185699A AU755888B2 AU 755888 B2 AU755888 B2 AU 755888B2 AU 31856/99 A AU31856/99 A AU 31856/99A AU 3185699 A AU3185699 A AU 3185699A AU 755888 B2 AU755888 B2 AU 755888B2
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AU
Australia
Prior art keywords
cells
recipient
mesenchymal stem
transplant
stem cells
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Expired
Application number
AU31856/99A
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English (en)
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AU3185699A (en
Inventor
Elena N. Klyushnenkova
Kevin R. Mcintosh
Joseph D. Mosca
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Mesoblast International SARL
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Osiris Therapeutics Inc
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Publication of AU3185699A publication Critical patent/AU3185699A/en
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Publication of AU755888B2 publication Critical patent/AU755888B2/en
Assigned to Mesoblast International Sarl reassignment Mesoblast International Sarl Alteration of Name(s) in Register under S187 Assignors: OSIRIS THERAPEUTICS, INC.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/001Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5158Antigen-pulsed cells, e.g. T-cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/24Interferons [IFN]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU31856/99A 1998-03-18 1999-03-12 Mesenchymal stem cells for prevention and treatment of immune responses in transplantation Expired AU755888B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7846398P 1998-03-18 1998-03-18
US60/078463 1998-03-18
US8996498P 1998-06-19 1998-06-19
US60/089964 1998-06-19
PCT/US1999/005548 WO1999047163A2 (en) 1998-03-18 1999-03-12 Mesenchymal stem cells for prevention and treatment of immune responses in transplantation

Publications (2)

Publication Number Publication Date
AU3185699A AU3185699A (en) 1999-10-11
AU755888B2 true AU755888B2 (en) 2003-01-02

Family

ID=26760560

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31856/99A Expired AU755888B2 (en) 1998-03-18 1999-03-12 Mesenchymal stem cells for prevention and treatment of immune responses in transplantation

Country Status (11)

Country Link
US (1) US6328960B1 (https=)
EP (1) EP1066052B1 (https=)
JP (1) JP4740452B2 (https=)
AT (1) ATE316795T1 (https=)
AU (1) AU755888B2 (https=)
CA (1) CA2320040C (https=)
DE (1) DE69929681T2 (https=)
DK (1) DK1066052T3 (https=)
ES (1) ES2258329T3 (https=)
PT (1) PT1066052E (https=)
WO (1) WO1999047163A2 (https=)

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ES2258329T3 (es) 2006-08-16
WO1999047163A3 (en) 1999-11-18
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AU3185699A (en) 1999-10-11
JP2002506831A (ja) 2002-03-05
CA2320040A1 (en) 1999-09-23
DE69929681T2 (de) 2006-10-26
WO1999047163A2 (en) 1999-09-23
JP4740452B2 (ja) 2011-08-03
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