JP4668904B2 - α１−アンチトリプシン溶液の製造方法 - Google Patents

α１−アンチトリプシン溶液の製造方法 Download PDF

Info

Publication number
JP4668904B2
JP4668904B2 JP2006522987A JP2006522987A JP4668904B2 JP 4668904 B2 JP4668904 B2 JP 4668904B2 JP 2006522987 A JP2006522987 A JP 2006522987A JP 2006522987 A JP2006522987 A JP 2006522987A JP 4668904 B2 JP4668904 B2 JP 4668904B2
Authority
JP
Japan
Prior art keywords
a1at
virus
solution
containing solution
exchange chromatography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006522987A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007523883A (ja
JP2007523883A5 (https=
Inventor
ペートラ シュルツ
ユルゲン レーミッシュ
Original Assignee
オクタファルマ アクチェン ゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オクタファルマ アクチェン ゲゼルシャフト filed Critical オクタファルマ アクチェン ゲゼルシャフト
Publication of JP2007523883A publication Critical patent/JP2007523883A/ja
Publication of JP2007523883A5 publication Critical patent/JP2007523883A5/ja
Application granted granted Critical
Publication of JP4668904B2 publication Critical patent/JP4668904B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/022—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2006522987A 2003-08-12 2004-08-12 α１−アンチトリプシン溶液の製造方法 Expired - Fee Related JP4668904B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49409703P 2003-08-12 2003-08-12
PCT/EP2004/009043 WO2005014648A1 (en) 2003-08-12 2004-08-12 Process for preparing an alpha-1-antitrypsin solution

Publications (3)

Publication Number Publication Date
JP2007523883A JP2007523883A (ja) 2007-08-23
JP2007523883A5 JP2007523883A5 (https=) 2010-11-11
JP4668904B2 true JP4668904B2 (ja) 2011-04-13

Family

ID=34135316

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006522987A Expired - Fee Related JP4668904B2 (ja) 2003-08-12 2004-08-12 α１−アンチトリプシン溶液の製造方法

Country Status (22)

Country Link
US (1) US20060194300A1 (https=)
EP (1) EP1654284B1 (https=)
JP (1) JP4668904B2 (https=)
KR (1) KR20060070543A (https=)
CN (1) CN1867582B (https=)
AT (1) ATE428730T1 (https=)
AU (1) AU2004262578B2 (https=)
BR (1) BRPI0412835A (https=)
CA (1) CA2534900A1 (https=)
DE (1) DE602004020632D1 (https=)
DK (1) DK1654284T3 (https=)
ES (1) ES2324168T3 (https=)
IL (1) IL172868A0 (https=)
NO (1) NO20060109L (https=)
PL (1) PL1654284T3 (https=)
PT (1) PT1654284E (https=)
RS (1) RS20060077A (https=)
RU (1) RU2370500C2 (https=)
SI (1) SI1654284T1 (https=)
UA (1) UA86775C2 (https=)
WO (1) WO2005014648A1 (https=)
ZA (1) ZA200601206B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005027821A2 (en) * 2003-09-22 2005-03-31 Kamada Ltd. Large scale preparation of alpha-1 proteinase inhibitor and use thereof
ES2246694B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
ES2246695B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
CN100354301C (zh) * 2005-10-13 2007-12-12 南京工业大学 化学合成多肽的新型大规模分离制备技术
CN100562523C (zh) * 2006-07-26 2009-11-25 河北大安制药有限公司 α1-抗胰蛋白酶的制备方法
HUE030205T2 (en) * 2007-11-02 2017-05-29 Grifols Therapeutics Inc A method, composition, and product for providing alpha-1-antitrypsin
CN102127165B (zh) * 2010-01-15 2013-09-04 上海莱士血液制品股份有限公司 一种从血浆组分四沉淀中制备高纯ApoA-I的生产工艺
CN102731642B (zh) * 2011-04-14 2014-01-29 上海莱士血液制品股份有限公司 从人血浆组分四沉淀制备高纯Apoa-I的生产工艺
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
AU2013205138B2 (en) 2012-08-09 2015-06-25 Grifols, S.A. Caprylate Viral Deactivation
WO2016207353A1 (en) * 2015-06-26 2016-12-29 Ferring B.V. Methods of purification and/or viral inactivation
CA3012694A1 (en) * 2016-02-03 2017-08-10 Plasma Technologies, Llc Methods for extracting proteins from a blood-based material
MX2020004151A (es) 2017-10-30 2020-08-13 Takeda Pharmaceuticals Co Detergentes compatibles con el medio ambiente para la inactivacion de virus envueltos en lipidos.
CN111991571B (zh) * 2020-08-12 2022-04-05 湖州师范学院 一种柱上低pH病毒灭活的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS584728A (ja) * 1981-05-01 1983-01-11 メデイカル・リサ−チ・インステイチユ−ト・オブ・サンフランシスコ・コ−ポレ−シヨン α−１−抗トリプシンの精製
US4379087A (en) * 1982-06-17 1983-04-05 Cutter Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4684723A (en) * 1985-09-11 1987-08-04 Miles Laboratories, Inc. Method of separating proteins from aqueous solutions
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
EP0288841B1 (en) * 1987-04-27 1992-12-30 Miles Inc. Method of preparing highly purified alpha-1-proteinase inhibitor
KR920005689B1 (ko) * 1989-12-21 1992-07-13 국제약품공업주식회사 혈청으로부터 알파-1-안티트립신의 분리 정제 및 혈중 알파-1-안티트립신 양의 검정키트
DE4125625C2 (de) * 1991-08-02 1999-12-02 Octapharma Ag Glarus Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
SE9301582D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Purification of plasma proteins
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
US6284874B1 (en) * 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
WO1997009350A1 (en) * 1995-09-07 1997-03-13 Ppl Therapeutics (Scotland) Ltd. Purification of alpha-1 proteinase inhibitor
JP4105249B2 (ja) * 1996-08-09 2008-06-25 財団法人化学及血清療法研究所 α２プラスミンインヒビターの製造方法
AT407114B (de) * 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
JP2007523883A (ja) 2007-08-23
CN1867582A (zh) 2006-11-22
US20060194300A1 (en) 2006-08-31
UA86775C2 (ru) 2009-05-25
AU2004262578B2 (en) 2010-05-06
ES2324168T3 (es) 2009-07-31
EP1654284B1 (en) 2009-04-15
CN1867582B (zh) 2010-06-16
PT1654284E (pt) 2009-07-06
EP1654284A1 (en) 2006-05-10
NO20060109L (no) 2006-02-15
IL172868A0 (en) 2006-06-11
CA2534900A1 (en) 2005-02-17
BRPI0412835A (pt) 2006-09-26
ZA200601206B (en) 2007-05-30
PL1654284T3 (pl) 2009-09-30
DK1654284T3 (da) 2009-07-20
SI1654284T1 (sl) 2009-10-31
DE602004020632D1 (de) 2009-05-28
ATE428730T1 (de) 2009-05-15
RS20060077A (sr) 2008-08-07
RU2370500C2 (ru) 2009-10-20
AU2004262578A1 (en) 2005-02-17
RU2006107533A (ru) 2006-07-27
WO2005014648A1 (en) 2005-02-17
KR20060070543A (ko) 2006-06-23

Similar Documents

Publication Publication Date Title
JP4588770B2 (ja) タンパク質溶液からアポリポタンパク質を除去する方法
US11224643B2 (en) Methods of treatment using alpha-1-antitrypsin compositions
JP2008120822A6 (ja) タンパク質溶液からアポリポタンパク質を除去する方法
KR100451266B1 (ko) 새로운크로마토그래피분리조건을이용한α-1프로테이나제억제제의정제방법
JP4668904B2 (ja) α１−アンチトリプシン溶液の製造方法
EP1519944B1 (en) Processes for the preparation of fibrinogen
JP2002510294A (ja) アルファ １−抗トリプシン調製物およびその製造方法
CN101134776A (zh) 制备α1－抗胰蛋白酶的方法
MXPA06001112A (en) Process for preparing an alpha-1-antitrypsin solution
WO2000043412A1 (en) Compositions containing highly purified heparin cofactor ii and method for separating the same

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070724

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100420

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100720

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100727

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20100921

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101019

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101214

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20110111

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20110113

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140121

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees