CN1867582B - 制备α-1-抗胰蛋白酶溶液的方法 - Google Patents

制备α-1-抗胰蛋白酶溶液的方法 Download PDF

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Publication number
CN1867582B
CN1867582B CN2004800208911A CN200480020891A CN1867582B CN 1867582 B CN1867582 B CN 1867582B CN 2004800208911 A CN2004800208911 A CN 2004800208911A CN 200480020891 A CN200480020891 A CN 200480020891A CN 1867582 B CN1867582 B CN 1867582B
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a1at
triton
carried out
polysorbate
tnbp
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CN2004800208911A
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Chinese (zh)
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CN1867582A (zh
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彼得拉·舒尔茨
于尔根·勒米施
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Octapharma AG
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Octapharma AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/022—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2004800208911A 2003-08-12 2004-08-12 制备α-1-抗胰蛋白酶溶液的方法 Expired - Fee Related CN1867582B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49409703P 2003-08-12 2003-08-12
US60/494,097 2003-08-12
PCT/EP2004/009043 WO2005014648A1 (en) 2003-08-12 2004-08-12 Process for preparing an alpha-1-antitrypsin solution

Publications (2)

Publication Number Publication Date
CN1867582A CN1867582A (zh) 2006-11-22
CN1867582B true CN1867582B (zh) 2010-06-16

Family

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Family Applications (1)

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CN2004800208911A Expired - Fee Related CN1867582B (zh) 2003-08-12 2004-08-12 制备α-1-抗胰蛋白酶溶液的方法

Country Status (22)

Country Link
US (1) US20060194300A1 (https=)
EP (1) EP1654284B1 (https=)
JP (1) JP4668904B2 (https=)
KR (1) KR20060070543A (https=)
CN (1) CN1867582B (https=)
AT (1) ATE428730T1 (https=)
AU (1) AU2004262578B2 (https=)
BR (1) BRPI0412835A (https=)
CA (1) CA2534900A1 (https=)
DE (1) DE602004020632D1 (https=)
DK (1) DK1654284T3 (https=)
ES (1) ES2324168T3 (https=)
IL (1) IL172868A0 (https=)
NO (1) NO20060109L (https=)
PL (1) PL1654284T3 (https=)
PT (1) PT1654284E (https=)
RS (1) RS20060077A (https=)
RU (1) RU2370500C2 (https=)
SI (1) SI1654284T1 (https=)
UA (1) UA86775C2 (https=)
WO (1) WO2005014648A1 (https=)
ZA (1) ZA200601206B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005027821A2 (en) * 2003-09-22 2005-03-31 Kamada Ltd. Large scale preparation of alpha-1 proteinase inhibitor and use thereof
ES2246694B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
ES2246695B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
CN100354301C (zh) * 2005-10-13 2007-12-12 南京工业大学 化学合成多肽的新型大规模分离制备技术
CN100562523C (zh) * 2006-07-26 2009-11-25 河北大安制药有限公司 α1-抗胰蛋白酶的制备方法
HUE030205T2 (en) * 2007-11-02 2017-05-29 Grifols Therapeutics Inc A method, composition, and product for providing alpha-1-antitrypsin
CN102127165B (zh) * 2010-01-15 2013-09-04 上海莱士血液制品股份有限公司 一种从血浆组分四沉淀中制备高纯ApoA-I的生产工艺
CN102731642B (zh) * 2011-04-14 2014-01-29 上海莱士血液制品股份有限公司 从人血浆组分四沉淀制备高纯Apoa-I的生产工艺
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
AU2013205138B2 (en) 2012-08-09 2015-06-25 Grifols, S.A. Caprylate Viral Deactivation
WO2016207353A1 (en) * 2015-06-26 2016-12-29 Ferring B.V. Methods of purification and/or viral inactivation
CA3012694A1 (en) * 2016-02-03 2017-08-10 Plasma Technologies, Llc Methods for extracting proteins from a blood-based material
MX2020004151A (es) 2017-10-30 2020-08-13 Takeda Pharmaceuticals Co Detergentes compatibles con el medio ambiente para la inactivacion de virus envueltos en lipidos.
CN111991571B (zh) * 2020-08-12 2022-04-05 湖州师范学院 一种柱上低pH病毒灭活的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
EP0525502A1 (de) * 1991-08-02 1993-02-03 Octapharma Ag Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
WO1994026287A1 (en) * 1993-05-07 1994-11-24 Pharmacia Ab Purification of plasma proteins
US20020082214A1 (en) * 1997-06-10 2002-06-27 Erwin Mattes Alpha 1-antitrypsin preparation as well as a method for producing the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS584728A (ja) * 1981-05-01 1983-01-11 メデイカル・リサ−チ・インステイチユ−ト・オブ・サンフランシスコ・コ−ポレ−シヨン α−１−抗トリプシンの精製
US4379087A (en) * 1982-06-17 1983-04-05 Cutter Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4684723A (en) * 1985-09-11 1987-08-04 Miles Laboratories, Inc. Method of separating proteins from aqueous solutions
EP0288841B1 (en) * 1987-04-27 1992-12-30 Miles Inc. Method of preparing highly purified alpha-1-proteinase inhibitor
KR920005689B1 (ko) * 1989-12-21 1992-07-13 국제약품공업주식회사 혈청으로부터 알파-1-안티트립신의 분리 정제 및 혈중 알파-1-안티트립신 양의 검정키트
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
US6284874B1 (en) * 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
WO1997009350A1 (en) * 1995-09-07 1997-03-13 Ppl Therapeutics (Scotland) Ltd. Purification of alpha-1 proteinase inhibitor
JP4105249B2 (ja) * 1996-08-09 2008-06-25 財団法人化学及血清療法研究所 α２プラスミンインヒビターの製造方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
EP0525502A1 (de) * 1991-08-02 1993-02-03 Octapharma Ag Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
WO1994026287A1 (en) * 1993-05-07 1994-11-24 Pharmacia Ab Purification of plasma proteins
US20020082214A1 (en) * 1997-06-10 2002-06-27 Erwin Mattes Alpha 1-antitrypsin preparation as well as a method for producing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
揭志军等.α1-抗胰蛋白酶临床应用的前景.国外医学呼吸系统分册19 4.1999,19(4),192-193. *

Also Published As

Publication number Publication date
JP2007523883A (ja) 2007-08-23
CN1867582A (zh) 2006-11-22
US20060194300A1 (en) 2006-08-31
UA86775C2 (ru) 2009-05-25
AU2004262578B2 (en) 2010-05-06
ES2324168T3 (es) 2009-07-31
EP1654284B1 (en) 2009-04-15
PT1654284E (pt) 2009-07-06
EP1654284A1 (en) 2006-05-10
NO20060109L (no) 2006-02-15
IL172868A0 (en) 2006-06-11
CA2534900A1 (en) 2005-02-17
BRPI0412835A (pt) 2006-09-26
ZA200601206B (en) 2007-05-30
PL1654284T3 (pl) 2009-09-30
DK1654284T3 (da) 2009-07-20
SI1654284T1 (sl) 2009-10-31
DE602004020632D1 (de) 2009-05-28
ATE428730T1 (de) 2009-05-15
RS20060077A (sr) 2008-08-07
JP4668904B2 (ja) 2011-04-13
RU2370500C2 (ru) 2009-10-20
AU2004262578A1 (en) 2005-02-17
RU2006107533A (ru) 2006-07-27
WO2005014648A1 (en) 2005-02-17
KR20060070543A (ko) 2006-06-23

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Granted publication date: 20100616

Termination date: 20120812