KR20060070543A - 알파-１-항트립신 용액의 제조 방법 - Google Patents

알파-１-항트립신 용액의 제조 방법 Download PDF

Info

Publication number
KR20060070543A
KR20060070543A KR1020067002718A KR20067002718A KR20060070543A KR 20060070543 A KR20060070543 A KR 20060070543A KR 1020067002718 A KR1020067002718 A KR 1020067002718A KR 20067002718 A KR20067002718 A KR 20067002718A KR 20060070543 A KR20060070543 A KR 20060070543A
Authority
KR
South Korea
Prior art keywords
a1at
solution
chromatography
virus
alat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020067002718A
Other languages
English (en)
Korean (ko)
Inventor
페트라 슐쯔
유르겐 뢰미쉬
Original Assignee
옥타파르마 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 옥타파르마 아게 filed Critical 옥타파르마 아게
Publication of KR20060070543A publication Critical patent/KR20060070543A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/022—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020067002718A 2003-08-12 2004-08-12 알파-１-항트립신 용액의 제조 방법 Ceased KR20060070543A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49409703P 2003-08-12 2003-08-12
US60/494,097 2003-08-12

Publications (1)

Publication Number Publication Date
KR20060070543A true KR20060070543A (ko) 2006-06-23

Family

ID=34135316

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067002718A Ceased KR20060070543A (ko) 2003-08-12 2004-08-12 알파-１-항트립신 용액의 제조 방법

Country Status (22)

Country Link
US (1) US20060194300A1 (https=)
EP (1) EP1654284B1 (https=)
JP (1) JP4668904B2 (https=)
KR (1) KR20060070543A (https=)
CN (1) CN1867582B (https=)
AT (1) ATE428730T1 (https=)
AU (1) AU2004262578B2 (https=)
BR (1) BRPI0412835A (https=)
CA (1) CA2534900A1 (https=)
DE (1) DE602004020632D1 (https=)
DK (1) DK1654284T3 (https=)
ES (1) ES2324168T3 (https=)
IL (1) IL172868A0 (https=)
NO (1) NO20060109L (https=)
PL (1) PL1654284T3 (https=)
PT (1) PT1654284E (https=)
RS (1) RS20060077A (https=)
RU (1) RU2370500C2 (https=)
SI (1) SI1654284T1 (https=)
UA (1) UA86775C2 (https=)
WO (1) WO2005014648A1 (https=)
ZA (1) ZA200601206B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005027821A2 (en) * 2003-09-22 2005-03-31 Kamada Ltd. Large scale preparation of alpha-1 proteinase inhibitor and use thereof
ES2246694B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
ES2246695B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
CN100354301C (zh) * 2005-10-13 2007-12-12 南京工业大学 化学合成多肽的新型大规模分离制备技术
CN100562523C (zh) * 2006-07-26 2009-11-25 河北大安制药有限公司 α1-抗胰蛋白酶的制备方法
HUE030205T2 (en) * 2007-11-02 2017-05-29 Grifols Therapeutics Inc A method, composition, and product for providing alpha-1-antitrypsin
CN102127165B (zh) * 2010-01-15 2013-09-04 上海莱士血液制品股份有限公司 一种从血浆组分四沉淀中制备高纯ApoA-I的生产工艺
CN102731642B (zh) * 2011-04-14 2014-01-29 上海莱士血液制品股份有限公司 从人血浆组分四沉淀制备高纯Apoa-I的生产工艺
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
AU2013205138B2 (en) 2012-08-09 2015-06-25 Grifols, S.A. Caprylate Viral Deactivation
WO2016207353A1 (en) * 2015-06-26 2016-12-29 Ferring B.V. Methods of purification and/or viral inactivation
CA3012694A1 (en) * 2016-02-03 2017-08-10 Plasma Technologies, Llc Methods for extracting proteins from a blood-based material
MX2020004151A (es) 2017-10-30 2020-08-13 Takeda Pharmaceuticals Co Detergentes compatibles con el medio ambiente para la inactivacion de virus envueltos en lipidos.
CN111991571B (zh) * 2020-08-12 2022-04-05 湖州师范学院 一种柱上低pH病毒灭活的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS584728A (ja) * 1981-05-01 1983-01-11 メデイカル・リサ−チ・インステイチユ−ト・オブ・サンフランシスコ・コ−ポレ−シヨン α−１−抗トリプシンの精製
US4379087A (en) * 1982-06-17 1983-04-05 Cutter Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4684723A (en) * 1985-09-11 1987-08-04 Miles Laboratories, Inc. Method of separating proteins from aqueous solutions
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
EP0288841B1 (en) * 1987-04-27 1992-12-30 Miles Inc. Method of preparing highly purified alpha-1-proteinase inhibitor
KR920005689B1 (ko) * 1989-12-21 1992-07-13 국제약품공업주식회사 혈청으로부터 알파-1-안티트립신의 분리 정제 및 혈중 알파-1-안티트립신 양의 검정키트
DE4125625C2 (de) * 1991-08-02 1999-12-02 Octapharma Ag Glarus Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
SE9301582D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Purification of plasma proteins
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
US6284874B1 (en) * 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
WO1997009350A1 (en) * 1995-09-07 1997-03-13 Ppl Therapeutics (Scotland) Ltd. Purification of alpha-1 proteinase inhibitor
JP4105249B2 (ja) * 1996-08-09 2008-06-25 財団法人化学及血清療法研究所 α２プラスミンインヒビターの製造方法
AT407114B (de) * 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
JP2007523883A (ja) 2007-08-23
CN1867582A (zh) 2006-11-22
US20060194300A1 (en) 2006-08-31
UA86775C2 (ru) 2009-05-25
AU2004262578B2 (en) 2010-05-06
ES2324168T3 (es) 2009-07-31
EP1654284B1 (en) 2009-04-15
CN1867582B (zh) 2010-06-16
PT1654284E (pt) 2009-07-06
EP1654284A1 (en) 2006-05-10
NO20060109L (no) 2006-02-15
IL172868A0 (en) 2006-06-11
CA2534900A1 (en) 2005-02-17
BRPI0412835A (pt) 2006-09-26
ZA200601206B (en) 2007-05-30
PL1654284T3 (pl) 2009-09-30
DK1654284T3 (da) 2009-07-20
SI1654284T1 (sl) 2009-10-31
DE602004020632D1 (de) 2009-05-28
ATE428730T1 (de) 2009-05-15
RS20060077A (sr) 2008-08-07
JP4668904B2 (ja) 2011-04-13
RU2370500C2 (ru) 2009-10-20
AU2004262578A1 (en) 2005-02-17
RU2006107533A (ru) 2006-07-27
WO2005014648A1 (en) 2005-02-17

Similar Documents

Publication Publication Date Title
JP4588770B2 (ja) タンパク質溶液からアポリポタンパク質を除去する方法
US10335467B2 (en) Methods of treatment using alpha-1-antitrypsin compositions
JP5600061B2 (ja) α−１−抗トリプシンおよびアポリポタンパク質Ａ−Ｉを精製する方法
JP2008120822A6 (ja) タンパク質溶液からアポリポタンパク質を除去する方法
EP1519944B1 (en) Processes for the preparation of fibrinogen
CN1867582B (zh) 制备α-1-抗胰蛋白酶溶液的方法
JP2002510294A (ja) アルファ １−抗トリプシン調製物およびその製造方法
JP2018528249A (ja) ヒト血漿由来ｂ型肝炎免疫グロブリン製剤の製造方法
MXPA06001112A (en) Process for preparing an alpha-1-antitrypsin solution
AU743904B2 (en) Purification of proteins

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20060208

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20080711

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20100910

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20110929

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20100910

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I