JP4467799B2 - ポリビニルアルコール微小球、ならびにその製造方法および治療用途 - Google Patents

ポリビニルアルコール微小球、ならびにその製造方法および治療用途 Download PDF

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Publication number
JP4467799B2
JP4467799B2 JP2000576829A JP2000576829A JP4467799B2 JP 4467799 B2 JP4467799 B2 JP 4467799B2 JP 2000576829 A JP2000576829 A JP 2000576829A JP 2000576829 A JP2000576829 A JP 2000576829A JP 4467799 B2 JP4467799 B2 JP 4467799B2
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Prior art keywords
polyvinyl alcohol
microsphere
microspheres
suspension
embolization
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Expired - Lifetime
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JP2000576829A
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Japanese (ja)
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JP2002527206A (ja
JP2002527206A5 (https=
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ボスチェッティ，エギスト
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バイオスフィア メディカル，ソシエテアノニム
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2000576829A 1998-10-16 1999-10-15 ポリビニルアルコール微小球、ならびにその製造方法および治療用途 Expired - Lifetime JP4467799B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9813019A FR2784580B1 (fr) 1998-10-16 1998-10-16 Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
FR98/13019 1998-10-16
PCT/EP1999/007846 WO2000023054A1 (en) 1998-10-16 1999-10-15 Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same

Publications (3)

Publication Number Publication Date
JP2002527206A JP2002527206A (ja) 2002-08-27
JP2002527206A5 JP2002527206A5 (https=) 2008-06-05
JP4467799B2 true JP4467799B2 (ja) 2010-05-26

Family

ID=33462605

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000576829A Expired - Lifetime JP4467799B2 (ja) 1998-10-16 1999-10-15 ポリビニルアルコール微小球、ならびにその製造方法および治療用途

Country Status (10)

Country Link
US (4) US6680046B1 (https=)
EP (1) EP1128816B1 (https=)
JP (1) JP4467799B2 (https=)
AT (1) ATE262319T1 (https=)
AU (1) AU1039600A (https=)
CA (1) CA2345205A1 (https=)
DE (1) DE69915858T2 (https=)
ES (1) ES2219072T3 (https=)
FR (1) FR2784580B1 (https=)
WO (1) WO2000023054A1 (https=)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
ES2525553T3 (es) * 1999-03-25 2014-12-26 Metabolix, Inc. Dispositivos y aplicaciones médicas de polímeros polihidroxialcanoato
DE60139112D1 (de) * 2000-03-06 2009-08-13 Boston Scient Ltd Unter ultralschall sichtbare embolisierende substanzen
AU4566001A (en) * 2000-03-13 2001-09-24 Biocure Inc Embolic compositions
EP1263801B1 (en) 2000-03-13 2006-05-24 BioCure, Inc. Tissue bulking and coating compositions
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
US7338657B2 (en) 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
WO2001070289A2 (en) 2000-03-20 2001-09-27 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
KR100872884B1 (ko) * 2000-03-24 2008-12-10 바이오스피어 메디칼 인코포레이티드 능동 색전화용 미소구
US20040266983A1 (en) * 2000-08-17 2004-12-30 Reeve Lorraine E Purified polyoxyalkylene block copolymers
US9080146B2 (en) * 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
RU2295329C2 (ru) 2001-09-12 2007-03-20 ВиРекс Медикал Корпорейшн Перекрывающее кровоток твердофазное средство с покрытием из иммобилизованного связывающего средства
US7462366B2 (en) * 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
WO2003105917A2 (en) 2002-06-12 2003-12-24 Scimed Life Systems, Inc. Bulking agents
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7883490B2 (en) * 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
WO2004040972A2 (en) * 2002-11-04 2004-05-21 Biosphere Medical Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same
WO2004073688A1 (en) * 2003-02-21 2004-09-02 Biocompatibles Uk Limited Drug delivery from embolic agents
JP4909071B2 (ja) * 2003-03-24 2012-04-04 プルーローメッド， インコーポレイテッド 逆感熱性ポリマーを使用する一時的な塞栓形成
JP2004313759A (ja) * 2003-03-31 2004-11-11 Toray Ind Inc 血管塞栓材料
EP2860292B1 (en) 2003-05-08 2020-07-22 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
ES2395077T3 (es) * 2003-07-08 2013-02-08 Tepha, Inc. Matrices poli-4-hidroxibutirato para una administración prolongada de medicamentos
JP2007503221A (ja) * 2003-08-22 2007-02-22 テファ， インコーポレイテッド ポリヒドロキシアルカノエート神経再生デバイス
WO2005018600A2 (en) * 2003-08-22 2005-03-03 Cube Medical A/S Method of treating a patient suffering from a solid tumour
US7976823B2 (en) * 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7901770B2 (en) * 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
WO2005046438A2 (en) * 2003-11-06 2005-05-26 Pluromed, Inc. Internal clamp for surgical procedures
US7736671B2 (en) * 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US20050238870A1 (en) * 2004-04-22 2005-10-27 Marcia Buiser Embolization
JP4655505B2 (ja) * 2004-04-28 2011-03-23 東レ株式会社 架橋生分解性粒子およびその製造方法
US7311861B2 (en) * 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
CA2572363A1 (en) 2004-06-29 2006-01-12 Biocure, Inc. Biomaterial
ES2362217T3 (es) * 2004-08-03 2011-06-29 Tepha, Inc. Suturas de polihidroxialcanoato no rizadas.
US20070258939A1 (en) * 2004-08-03 2007-11-08 Biocamparibles Uk Limited Drug Delivery from Embolic Agents
WO2006013376A2 (en) * 2004-08-04 2006-02-09 Biocompatibles Uk Limited Drug delivery of a cox inhibitor from embolic agents
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
JP4885866B2 (ja) 2004-10-25 2012-02-29 セロノヴァ バイオサイエンスィズ ジャーマニー ゲーエムベーハー 治療適用および／または診断適用のための充填可能なポリホスファゼン含有粒子、ならびにその調製方法および使用方法
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US8663225B2 (en) * 2004-11-12 2014-03-04 Medtronic, Inc. Hydrogel bone void filler
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7858183B2 (en) * 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7727555B2 (en) * 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
KR101429774B1 (ko) * 2005-05-09 2014-10-02 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및방법
US20070004973A1 (en) * 2005-06-15 2007-01-04 Tan Sharon M L Tissue treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8361454B2 (en) 2005-07-01 2013-01-29 The Nippon Synthetic Chemical Industry Co., Ltd. PVA particle for temporary embolic material and production process thereof, and temporary embolic material
US20070083219A1 (en) * 2005-10-12 2007-04-12 Buiser Marcia S Embolic coil introducer sheath locking mechanisms
US8007509B2 (en) * 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
WO2007050744A2 (en) * 2005-10-26 2007-05-03 Biocure, Inc. Hydrogel spinal disc implants with swellable articles
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US8152839B2 (en) * 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US20070142859A1 (en) * 2005-12-19 2007-06-21 Boston Scientific Scimed, Inc. Embolic coils
US20070142560A1 (en) * 2005-12-21 2007-06-21 Young-Ho Song Block copolymer particles
US7501179B2 (en) 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US7947368B2 (en) * 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US20080305176A1 (en) * 2006-01-24 2008-12-11 Biocompatibles Uk Limited Process For Loading Polymer Particles With Drug
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
ATE520427T1 (de) * 2006-01-30 2011-09-15 Biosphere Medical Inc Poröse intravaskuläre embolisierungsteilchen und verfahren zu deren herstellung
US8252339B2 (en) 2006-04-11 2012-08-28 Massachusetts Institute Of Technology Medical treatment applications of swellable and deformable microspheres
US8062673B2 (en) 2006-04-11 2011-11-22 E I Du Pont De Nemours And Company Process for embolization using swellable and deformable microspheres
US7838035B2 (en) 2006-04-11 2010-11-23 E. I. Du Pont De Nemours And Company Microsphere powder of high density, swellable, deformable, durable occlusion-forming microspheres
US7794755B2 (en) 2006-04-11 2010-09-14 E.I. Du Pont De Nemours And Company Process for preparation of swellable and deformable microspheres
US20070299461A1 (en) * 2006-06-21 2007-12-27 Boston Scientific Scimed, Inc. Embolic coils and related components, systems, and methods
US9481752B2 (en) * 2006-07-27 2016-11-01 Boston Scientific Scimed, Inc. Polymeric particles comprising vinyl formal, vinyl alcohol and vinyl acetate monomer units
US8414927B2 (en) * 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US20080145658A1 (en) * 2006-12-15 2008-06-19 Boston Scientific Scimed, Inc. Freeze Thaw Methods For Making Polymer Particles
US20090092547A1 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Injectable Particles
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
US8114436B2 (en) 2008-03-25 2012-02-14 Boston Scientific Scimed, Inc. Compositions and methods for delivery of embolics
CN102143996A (zh) * 2008-10-30 2011-08-03 大卫·刘 微球形多孔可生物相容支架及制造该支架的方法和装置
EP2485777B1 (en) 2009-10-06 2013-12-11 Regents of the University of Minnesota Bioresorbable embolization microspheres
CN102695501A (zh) 2009-11-09 2012-09-26 聚光灯技术合伙有限责任公司 碎裂水凝胶
EP2498763A4 (en) 2009-11-09 2015-10-07 Spotlight Technology Partners Llc HYDROGELE ON POLYSACCHARIDBASIS
GB201008843D0 (en) * 2010-05-27 2010-07-14 Aubin Ltd Method and composition
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
CN101885852B (zh) * 2010-07-07 2012-01-11 天津大学 表面光滑明胶微球与制备方法
KR20130124322A (ko) * 2010-09-29 2013-11-13 사이언 카디오-바스큘라, 인크. 미소구의 가공 방법, 이에 의해 가공된 미소구, 및 그의 용도
US9724421B2 (en) 2010-11-29 2017-08-08 Centre Hospitalier Universitaire Vaudois Chemoembolization composition comprising anti-angiogenic agents
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
IT1404015B1 (it) * 2011-02-04 2013-11-08 Hsd Holding Smart Device S R L Uso di un polimero di destrano reticolato come filtro contro l'inalazione di sostanze nocive per la salute
CN102492178B (zh) * 2011-11-29 2014-12-24 中国科学院过程工程研究所 一种尺寸均一的魔芋葡甘聚糖微球及其制备方法
EP3984556B8 (en) 2012-06-14 2025-07-09 Microvention, Inc. Polymeric treatment compositions
AU2013331439B2 (en) 2012-10-15 2016-05-12 Microvention, Inc. Polymeric treatment compositions
US8936795B2 (en) 2012-12-19 2015-01-20 Regents Of The University Of Minnesota Liquid embolic material including carboxymethyl chitosan crosslinked with carboxymethyl cellulose
WO2014159759A1 (en) 2013-03-13 2014-10-02 Biosphere Medical, Inc. Compositions and associated methods for radioisotope-binding microparticles
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
JP6641265B2 (ja) 2013-09-19 2020-02-05 マイクロベンション インコーポレイテッドＭｉｃｒｏｖｅｎｔｉｏｎ， Ｉｎｃ． ポリマーフィルム
EP3046952B1 (en) 2013-09-19 2021-05-12 Terumo Corporation Polymer particles
EP3065719A4 (en) 2013-11-08 2017-08-09 Terumo Corporation Polymer particles
WO2016025329A1 (en) 2014-08-15 2016-02-18 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
EP3230500B1 (en) 2014-12-11 2025-06-18 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
WO2016154592A1 (en) 2015-03-26 2016-09-29 Microvention, Inc. Embiolic particles
US10071181B1 (en) 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
CN108025056B (zh) * 2015-06-19 2022-01-14 新罗杰股份有限公司 用于病毒栓塞的组合物和方法
CN105148327B (zh) * 2015-07-29 2019-07-12 广东博与再生医学有限公司 一种多糖-聚乙烯醇栓塞微球的制备方法
US10182979B2 (en) 2016-03-22 2019-01-22 Regents Of The University Of Minnesota Biodegradable microspheres
JP2019518428A (ja) * 2016-04-12 2019-07-04 ユニシテ エーファウ アクチェンゲゼルシャフト 体液試料からの細胞外小胞（ｅｖ）の単離
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
EP4279139A3 (en) 2016-09-28 2024-01-24 Terumo Corporation Polymer particles
WO2018070894A1 (ru) * 2016-10-12 2018-04-19 Общество С Ограниченной Ответственностью "Технология Лекарств" Химиоэмболизирующие частицы, способ их получения и применения
WO2019074965A1 (en) 2017-10-09 2019-04-18 Microvention, Inc. EMBOLIC RADIOACTIVE LIQUID
CN108744020A (zh) * 2018-06-12 2018-11-06 杭州艾力康医药科技有限公司 一种离子交换型聚乙烯醇微球的制备方法
CN113272347B (zh) 2018-11-21 2024-05-14 株式会社可乐丽 单分散性水凝胶颗粒
EP4389148A3 (en) * 2019-06-19 2024-09-25 Zylo Therapeutics, Inc. Sulfur functionalized monoliths and particles derived from the same as nitric oxide carriers for pharmaceutical and cosmetic applications
WO2021166746A1 (ja) * 2020-02-18 2021-08-26 日産化学株式会社 液晶ナノカプセル及びその製造方法、並びに該液晶ナノカプセルを有する液晶ナノカプセル分散液及び液晶表示素子
CN114159554B (zh) * 2021-11-22 2022-12-13 广州优理氏生物科技有限公司 一种纤连蛋白-聚乙烯醇微球的制备方法及其应用
CN114642640B (zh) * 2022-05-23 2022-09-16 杭州旸顺医疗科技有限公司 微球及其制备方法、制备系统
CN120769874A (zh) 2023-02-22 2025-10-10 株式会社可乐丽 干燥水凝胶形成性物品、水凝胶、和干燥水凝胶形成性物品的制造方法
WO2024182477A2 (en) * 2023-02-28 2024-09-06 Medstar Health, Inc. Angiogenesis inhibitors coupled to embolic microparticles
CN116159178B (zh) * 2023-04-18 2023-07-04 上海汇禾医疗器械有限公司 一种小粒径栓塞微球及其制备方法

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US499188A (en) * 1893-06-06 Territory
US3919411A (en) 1972-01-31 1975-11-11 Bayvet Corp Injectable adjuvant and compositions including such adjuvant
JPS49108168A (https=) 1973-02-16 1974-10-15
JPS49108158A (https=) 1973-02-19 1974-10-15
JPS5350290A (en) 1976-10-18 1978-05-08 Sumitomo Chem Co Ltd Preparation f hydrogel
DE2935712A1 (de) 1978-09-07 1980-03-20 Sumitomo Chemical Co Verfahren zum herstellen von stark absorbierenden polymerisaten
US4314032A (en) 1978-10-26 1982-02-02 Kureha Kagaku Kogyo Kabushiki Kaisha Crosslinked polyvinyl alcohol gel
US4268495A (en) 1979-01-08 1981-05-19 Ethicon, Inc. Injectable embolization and occlusion solution
US4306031A (en) 1979-08-14 1981-12-15 Mitsubishi Chemical Industries Limited Weakly acidic cation exchange resin and process for producing same
GB2088392B (en) 1980-12-03 1984-05-02 Sumitomo Chemical Co Production of hydrogels
JPS57128709A (en) 1981-02-03 1982-08-10 Sumitomo Chem Co Ltd Preparation of hydrogel
CA1225585A (en) 1983-06-30 1987-08-18 Maria T. Litvinova Composition for embolization of blood vessels
GB8418772D0 (en) 1984-07-24 1984-08-30 Geistlich Soehne Ag Chemical substances
US4680171A (en) 1985-03-15 1987-07-14 William Shell Visualization of a bloodstream circulation with biodegradable microspheres
US5186922A (en) 1985-03-15 1993-02-16 See/Shell Biotechnology, Inc. Use of biodegradable microspheres labeled with imaging energy constrast materials
AU6129486A (en) 1985-07-02 1987-01-30 Target Therapeutics, Inc. Vaso-occlusive collagen composition and method
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
JPS6317904A (ja) 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd 多孔質架橋ポリビニルアルコ−ル粒子の製造法
CA1329800C (en) * 1987-12-29 1994-05-24 Hiroaki Takayanagi Composite separating agent
GB8813425D0 (en) 1988-06-07 1988-07-13 Hall L D Magnetic resonance imaging
JPH064713B2 (ja) 1988-07-22 1994-01-19 テルモ株式会社 生体適合性材料
JPH0286838A (ja) 1988-09-22 1990-03-27 Terumo Corp 水不溶性ヒドロゲルおよびその製造方法
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5258028A (en) 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US5092883A (en) 1988-12-28 1992-03-03 Eppley Barry L Method for promoting soft connective tissue growth and repair in mammals
GB8900376D0 (en) 1989-01-09 1989-03-08 Nycomed As Iodinated esters
US5007940A (en) 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
ATE130517T1 (de) 1990-08-08 1995-12-15 Takeda Chemical Industries Ltd Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff.
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
EP0526608B1 (fr) 1991-02-25 1996-12-18 Debiopharm S.A. Agents therapeutiques pour le traitement de la resistance multidrogue de cancers
FR2676927B1 (fr) 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
JP3356447B2 (ja) 1991-10-16 2002-12-16 テルモ株式会社 乾燥高分子ゲルからなる血管病変塞栓材料
KR100266912B1 (ko) 1992-02-28 2000-12-01 파라비 레이 조직접촉물질이며 방출조절운반체인 광중합성 생분해성 하이드로겔
JPH0656676A (ja) 1992-08-05 1994-03-01 Hori Shinichi 血管塞栓用懸濁液
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
ATE163230T1 (de) 1993-03-09 1998-02-15 Epic Therapeutics Inc Makromolekulare mikropartikel und verfahren zu ihrer herstellung
UA10911C2 (uk) 1994-08-10 1996-12-25 Мале Впроваджувальне Підприємство "Іhтерфалл" Біосумісhий гідрогель
US5955108A (en) 1994-12-16 1999-09-21 Quadrant Healthcare (Uk) Limited Cross-linked microparticles and their use as therapeutic vehicles
WO1996022736A1 (en) 1995-01-27 1996-08-01 Scimed Life Systems, Inc. Embolizing system
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
DE19601699A1 (de) * 1996-01-18 1997-07-24 Wacker Chemie Gmbh Redispergierbare Polymerisatpulver und daraus erhältliche wäßrige Polymerisat-Dispersionen
US5785977A (en) 1996-02-07 1998-07-28 Breithbarth; Richard Non-metallic microparticle carrier materials
US5803075A (en) * 1996-03-15 1998-09-08 Yaru Llc Surgical mask with adhesive strip to improve breathing
US5925683A (en) 1996-10-17 1999-07-20 Target Therapeutics, Inc. Liquid embolic agents
US6139963A (en) * 1996-11-28 2000-10-31 Kuraray Co., Ltd. Polyvinyl alcohol hydrogel and process for producing the same
AU9313298A (en) 1997-09-04 1999-03-22 Point Biomedical Corporation Injectable tissue reconstruction material
AU8877098A (en) * 1997-09-05 1999-03-29 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising contrast agent for chemoembolization
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
WO1999044643A1 (en) * 1998-03-06 1999-09-10 Biosepra Medical Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
US6660301B1 (en) * 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
US6165193A (en) 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6710126B1 (en) 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
KR100335866B1 (ko) 2000-01-06 2002-05-10 박호군 폴리아세트산비닐 코어/폴리비닐알코올 외피의 2중 구조를갖는 미세구형 색전재료 및 그의 제조방법
AU4566001A (en) 2000-03-13 2001-09-24 Biocure Inc Embolic compositions
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
US6436424B1 (en) * 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
WO2001070289A2 (en) * 2000-03-20 2001-09-27 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
KR100872884B1 (ko) * 2000-03-24 2008-12-10 바이오스피어 메디칼 인코포레이티드 능동 색전화용 미소구
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
US6537569B2 (en) 2001-02-14 2003-03-25 Microvention, Inc. Radiation cross-linked hydrogels
WO2002100444A1 (en) * 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
US6488952B1 (en) 2001-08-28 2002-12-03 John P. Kennedy Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system
US6911219B2 (en) * 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
KR101429774B1 (ko) * 2005-05-09 2014-10-02 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및방법
ATE520427T1 (de) * 2006-01-30 2011-09-15 Biosphere Medical Inc Poröse intravaskuläre embolisierungsteilchen und verfahren zu deren herstellung
WO2007090127A2 (en) * 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems

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JP2002527206A (ja) 2002-08-27
US20040091425A1 (en) 2004-05-13
FR2784580A1 (fr) 2000-04-21
FR2784580B1 (fr) 2004-06-25
US20090117196A1 (en) 2009-05-07
CA2345205A1 (en) 2000-04-27
ATE262319T1 (de) 2004-04-15
US7591993B2 (en) 2009-09-22
WO2000023054A1 (en) 2000-04-27
AU1039600A (en) 2000-05-08
ES2219072T3 (es) 2004-11-16
US8673266B2 (en) 2014-03-18
US20100119572A1 (en) 2010-05-13
EP1128816A1 (en) 2001-09-05
EP1128816B1 (en) 2004-03-24
US6680046B1 (en) 2004-01-20
US7670592B2 (en) 2010-03-02

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