JP4388602B2 - マトリクスを含まない骨形成デバイス、移植片、およびその使用方法 - Google Patents

マトリクスを含まない骨形成デバイス、移植片、およびその使用方法 Download PDF

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Publication number
JP4388602B2
JP4388602B2 JP53487098A JP53487098A JP4388602B2 JP 4388602 B2 JP4388602 B2 JP 4388602B2 JP 53487098 A JP53487098 A JP 53487098A JP 53487098 A JP53487098 A JP 53487098A JP 4388602 B2 JP4388602 B2 JP 4388602B2
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Prior art keywords
matrix
bone
defect
gdf
bmp
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Expired - Fee Related
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JP53487098A
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Japanese (ja)
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JP2001511042A5 (enExample
JP2001511042A (ja
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シー． ルエガー，デイビッド
エム． タッカー，マージョリー
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Stryker Corp
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Stryker Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP53487098A 1997-02-07 1998-02-05 マトリクスを含まない骨形成デバイス、移植片、およびその使用方法 Expired - Fee Related JP4388602B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3732797P 1997-02-07 1997-02-07
US60/037,327 1997-02-07
US4790997P 1997-05-29 1997-05-29
US60/047,909 1997-05-29
PCT/US1998/002159 WO1998034655A1 (en) 1997-02-07 1998-02-05 Matrix-free osteogenic devices, implants and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009011457A Division JP5124495B2 (ja) 1997-02-07 2009-01-21 マトリクスを含まない骨形成デバイス、移植片、およびその使用方法

Publications (3)

Publication Number Publication Date
JP2001511042A JP2001511042A (ja) 2001-08-07
JP2001511042A5 JP2001511042A5 (enExample) 2005-10-06
JP4388602B2 true JP4388602B2 (ja) 2009-12-24

Family

ID=26714038

Family Applications (4)

Application Number Title Priority Date Filing Date
JP53487098A Expired - Fee Related JP4388602B2 (ja) 1997-02-07 1998-02-05 マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
JP2009011457A Expired - Fee Related JP5124495B2 (ja) 1997-02-07 2009-01-21 マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
JP2012025783A Withdrawn JP2012102145A (ja) 1997-02-07 2012-02-09 マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
JP2015155698A Pending JP2015227366A (ja) 1997-02-07 2015-08-06 マトリクスを含まない骨形成デバイス、移植片、およびその使用方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2009011457A Expired - Fee Related JP5124495B2 (ja) 1997-02-07 2009-01-21 マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
JP2012025783A Withdrawn JP2012102145A (ja) 1997-02-07 2012-02-09 マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
JP2015155698A Pending JP2015227366A (ja) 1997-02-07 2015-08-06 マトリクスを含まない骨形成デバイス、移植片、およびその使用方法

Country Status (8)

Country Link
US (2) US6281195B1 (enExample)
EP (3) EP2332564A1 (enExample)
JP (4) JP4388602B2 (enExample)
AT (1) ATE239514T1 (enExample)
AU (1) AU6267798A (enExample)
CA (1) CA2280931C (enExample)
DE (1) DE69814352T3 (enExample)
WO (1) WO1998034655A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009102393A (ja) * 1997-02-07 2009-05-14 Stryker Corp マトリクスを含まない骨形成デバイス、移植片、およびその使用方法

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE134647T1 (de) * 1988-04-08 1996-03-15 Stryker Corp Osteogene vorrichtungen
US6919308B2 (en) * 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US6586388B2 (en) * 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
US6495513B1 (en) * 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US7056882B2 (en) * 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
US6221854B1 (en) * 1996-03-05 2001-04-24 Orquest, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US8083745B2 (en) 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
US7618451B2 (en) * 2001-05-25 2009-11-17 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools facilitating increased accuracy, speed and simplicity in performing total and partial joint arthroplasty
US7534263B2 (en) 2001-05-25 2009-05-19 Conformis, Inc. Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
WO1999028341A2 (en) * 1997-12-04 1999-06-10 Creative Biomolecules, Inc. Maintenance of smooth muscle integrity by morphogenic proteins
US7239908B1 (en) 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
ATE439806T1 (de) 1998-09-14 2009-09-15 Univ Leland Stanford Junior Zustandsbestimmung eines gelenks und schadenvorsorge
US7067144B2 (en) * 1998-10-20 2006-06-27 Omeros Corporation Compositions and methods for systemic inhibition of cartilage degradation
JP3786533B2 (ja) * 1998-11-12 2006-06-14 善彦 西村 ペプチド及び骨形成促進剤
AU770933B2 (en) * 1998-12-01 2004-03-11 N.V. Organon Improvement of folliculogenesis
JP4732587B2 (ja) * 1999-02-04 2011-07-27 ウォーソー・オーソペディック・インコーポレーテッド 骨形成ペースト組成物およびその用途
ATE271886T1 (de) * 1999-10-15 2004-08-15 Inst Genetics Llc Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
CA2425120A1 (en) 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
AU2001290887B2 (en) 2000-09-14 2006-06-08 The Board Of Trustees Of The Leland Stanford Junior University Assessing condition of a joint and cartilage loss
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
CA2447694A1 (en) 2001-05-25 2002-12-05 Imaging Therapeutics, Inc. Methods and compositions for articular resurfacing
US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US7132110B2 (en) * 2001-08-30 2006-11-07 Isotis Orthobiologics, Inc. Tissue repair compositions and methods for their manufacture and use
JP4473576B2 (ja) 2001-11-19 2010-06-02 スキール テヒノロギー ゲーエムベーハー 骨誘導性および骨伝導特性を有するデバイス
AU2002365969A1 (en) * 2001-11-20 2003-06-10 Scott Bruder Flowable osteogenic and chondrogenic compositions
DE60209795T2 (de) * 2001-12-21 2006-10-05 IsoTis Orthobiologics, Inc., Irvine Zusammensetzungen enthaltend endgruppen-verkappte polyalkylenglykole
US7205337B2 (en) * 2001-12-21 2007-04-17 Isotis Orthobiologics, Inc. End-capped polymers and compositions containing such compounds
IL149562A0 (en) * 2002-05-09 2002-11-10 Prochon Ltd Fgf variants and methods for use thereof
MXPA04011337A (es) * 2002-05-17 2005-07-01 Wyeth Corp Portadores de acido hialuronico solidos y susceptibles de ser inyectados para la liberacion de proteinas osteogenicas.
US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
JP4358741B2 (ja) 2002-09-10 2009-11-04 スキール テヒノロギー ゲーエムベーハー 低酸素濃度下において骨誘導性タンパク質で被覆された金属インプラント
US7074425B2 (en) * 2002-09-26 2006-07-11 Bonewax, Llc Hemostatic compositions and methods
TWI231755B (en) * 2002-10-07 2005-05-01 Conformis Inc An interpositional articular implant and the method for making the same
WO2004043305A1 (en) 2002-11-07 2004-05-27 Conformis, Inc. Methods for determing meniscal size and shape and for devising treatment
BE1015258A5 (fr) 2002-12-18 2004-12-07 Dricot Roland Implant osseux.
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20050020506A1 (en) * 2003-07-25 2005-01-27 Drapeau Susan J. Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use
US7955616B2 (en) * 2003-09-23 2011-06-07 Orthocon, Inc. Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
ATE482228T1 (de) 2004-02-20 2010-10-15 Biosurface Eng Tech Inc Positiver modulator des knochenmorphogenetisches protein-2 (bmp-2)
CA2567405A1 (en) * 2004-05-25 2005-12-08 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
US20120077743A1 (en) * 2004-05-25 2012-03-29 Rueger David C Methods of treating cartilage defects
US20060194726A1 (en) * 2004-05-25 2006-08-31 Rueger David C Methods of treating cartilage defects
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
KR100912307B1 (ko) * 2004-10-21 2009-08-14 유니버시티 오브 아이오와 리써치 파운데이션 동일계내 제어된 방출 약물 전달 시스템
US7951880B2 (en) * 2004-12-10 2011-05-31 University Of Iowa Research Foundation Compositions for breast implant filling and methods of use
US7270655B2 (en) * 2005-01-14 2007-09-18 Haidukewych George J Autologous material delivery apparatus and method
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material
US7621963B2 (en) * 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
WO2007001624A2 (en) * 2005-06-28 2007-01-04 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
EP1926459B1 (en) 2005-09-19 2015-01-07 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
KR20080084808A (ko) * 2005-11-17 2008-09-19 바이오미메틱 세라퓨틱스, 인크. ｒｈＰＤＧＦ-ＢＢ 및 생체적합성 매트릭스를 사용하는상악안면골 보강
EP1951158A4 (en) 2005-11-21 2010-03-31 Vertegen Inc DEVICES AND METHODS FOR TREATMENT OF FACE CHAINS, UNCOVERTEBRAL JOINTS, COSTOVERTEBRUSK JOINTS AND OTHER JOINTS
CN105030297A (zh) 2006-02-06 2015-11-11 康复米斯公司 患者可选择的关节成形术装置和手术器具
US8623026B2 (en) 2006-02-06 2014-01-07 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief
EP2311505B1 (en) 2006-02-09 2013-11-06 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
US20100209470A1 (en) * 2006-05-01 2010-08-19 Warsaw Orthopedic, Inc. An Indiana Corporation Demineralized bone matrix devices
US7771741B2 (en) * 2006-05-01 2010-08-10 Warsaw Orthopedic, Inc Demineralized bone matrix devices
US8506983B2 (en) * 2006-05-01 2013-08-13 Warsaw Orthopedic, Inc. Bone filler material
US7838022B2 (en) 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
WO2007142818A2 (en) * 2006-05-17 2007-12-13 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
WO2007150053A2 (en) 2006-06-22 2007-12-27 Biosurface Engineering Technologies, Inc. Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
EP3381463A1 (en) 2006-06-30 2018-10-03 BioMimetic Therapeutics, LLC Pdgf-biomatrix compositions and methods for treating rotator cuff injuries
AU2007275580C1 (en) * 2006-07-21 2012-07-19 University of Zagreb School of Medicine BMP-1 procollagen C-proteinase for diagnosis and treatment of bone and soft tissue defects and disorders
US20060287654A1 (en) * 2006-08-11 2006-12-21 Jeffrey Posnick Implant securing device and method
CN101522164B (zh) * 2006-09-13 2014-03-26 提升肤质产品公司 用于治疗皮肤的化妆品组合物及其方法
CA2668189C (en) 2006-11-03 2016-01-26 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures comprising a solution of platelet derived growth factor (pdgf) incorporated in a biocompatible matrix
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
EP2120859B1 (en) * 2006-12-21 2013-11-20 Stryker Corporation Sustained-release formulations comprising bmp-7 crystals
EP2144613B1 (en) 2006-12-29 2018-03-21 OstéoQC Inc. Methods of altering bone growth by administration of sost or wise antagonist or agonist
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
EP2591756A1 (en) 2007-02-14 2013-05-15 Conformis, Inc. Implant device and method for manufacture
WO2008101300A1 (en) 2007-02-23 2008-08-28 Cellixe Pty Ltd Composition and method for the treatment or prevention of spinal disorders
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008255016B2 (en) * 2007-05-15 2013-05-09 Stryker Corporation Concentrated protein preparations of bone morphogenetic proteins and methods of use thereof
WO2008157412A2 (en) 2007-06-13 2008-12-24 Conformis, Inc. Surgical cutting guide
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
CN101801405A (zh) 2007-08-07 2010-08-11 先进科技及再生医学有限责任公司 包含于酸性水溶液中的gdf-5的蛋白质配方
US9056150B2 (en) * 2007-12-04 2015-06-16 Warsaw Orthopedic, Inc. Compositions for treating bone defects
CN102014977B (zh) 2008-02-07 2015-09-02 生物模拟治疗有限责任公司 用于牵引成骨术的组合物和方法
US8682052B2 (en) 2008-03-05 2014-03-25 Conformis, Inc. Implants for altering wear patterns of articular surfaces
CN102006841A (zh) * 2008-03-05 2011-04-06 肯弗默斯股份有限公司 边缘匹配的关节植入物
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US8840913B2 (en) * 2008-03-27 2014-09-23 Warsaw Orthopedic, Inc. Malleable multi-component implants and materials therefor
US7947649B2 (en) * 2008-04-14 2011-05-24 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered GDF-5 formulations
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
AU2009246474B2 (en) 2008-05-12 2015-04-16 Conformis, Inc. Devices and methods for treatment of facet and other joints
DK2297319T3 (en) * 2008-06-03 2015-10-19 Viacyte Inc GROWTH FACTORS FOR PREPARING DEFINITIVE ENDODERM
US20090298178A1 (en) * 2008-06-03 2009-12-03 D Amour Kevin Allen Growth factors for production of definitive endoderm
CN102231992B (zh) 2008-09-09 2015-05-20 生物模拟治疗公司 用于治疗肌腱和韧带损伤的血小板衍生生长因子的组合物和方法
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
US8808303B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
EP2405865B1 (en) 2009-02-24 2019-04-17 ConforMIS, Inc. Automated systems for manufacturing patient-specific orthopedic implants and instrumentation
US12383287B2 (en) 2009-02-24 2025-08-12 Microport Orthopedics Holdings, Inc. Systems and methods for installing an orthopedic implant
US8808297B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
JP2012523897A (ja) 2009-04-16 2012-10-11 コンフォーミス・インコーポレイテッド 靭帯修復のための患者固有の関節置換術の装置
US20120294868A1 (en) 2009-04-24 2012-11-22 Edwards James R Anti-tgf-beta induction of bone cell function and bone growth
CA2782137A1 (en) 2009-12-11 2011-06-16 Conformis, Inc. Patient-specific and patient-engineered orthopedic implants
NZ601559A (en) 2010-02-22 2014-10-31 Biomimetic Therapeutics Llc Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
CA2817584C (en) 2010-11-15 2018-01-02 Zimmer Orthobiologics, Inc. Bone void fillers
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
WO2012112694A2 (en) 2011-02-15 2012-08-23 Conformis, Inc. Medeling, analyzing and using anatomical data for patient-adapted implants. designs, tools and surgical procedures
US9675670B2 (en) 2011-04-11 2017-06-13 Induce Biologics Inc. System and method for multiphasic release of growth factors
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
US8992949B1 (en) 2011-11-17 2015-03-31 Unicare Biomedical, Inc. Biocompatible polymeric compositions having microcrystalline and amorphous components and methods for their manufacture
US9486226B2 (en) 2012-04-18 2016-11-08 Conformis, Inc. Tibial guides, tools, and techniques for resecting the tibial plateau
US9675471B2 (en) 2012-06-11 2017-06-13 Conformis, Inc. Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components
CN113416187B (zh) 2013-03-14 2024-07-19 奥斯菲治疗有限公司 促进骨生长的烷基胺骆驼蓬碱衍生物
AU2014244369A1 (en) * 2013-03-14 2015-11-05 Genzyme Corporation Thermo-sensitive bone growth compositions
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
EP3198006B1 (en) 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
EP3240563B1 (en) 2014-12-29 2020-12-09 Bioventus LLC Systems and methods for improved delivery of osteoinductive molecules in bone repair
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
EP3285792B1 (en) 2015-04-20 2020-11-04 The Board of Regents of The University of Texas System Clec11a is a bone growth agent
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CN109415696A (zh) 2016-05-25 2019-03-01 泰尔茂比司特公司 细胞扩增
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
PL3409301T3 (pl) * 2017-05-30 2021-09-20 Aqpha Ip B.V. Resorbująca biodegradowalna kompozycja medyczna i kosmetyczna
US10947236B2 (en) 2018-08-14 2021-03-16 Osteoqc Inc. Pyrrolo-dipyridine compounds
KR20210075971A (ko) 2018-08-14 2021-06-23 오스테오큐씨 인코포레이티드 플루오로 β-카볼린 화합물
US11324806B2 (en) 2018-10-19 2022-05-10 Warsaw Orthopedic, Inc. Sustained delivery of a growth differentiation factor
US12428484B2 (en) 2018-12-06 2025-09-30 Alexion Pharmaceuticals, Inc. Anti-ALK2 antibodies and uses thereof
JP2022531871A (ja) 2019-05-29 2022-07-12 ライト メディカル テクノロジー インコーポレイテッド 置換足関節の脛骨インプラント部品を受容するための脛骨の準備
WO2021146015A1 (en) 2020-01-17 2021-07-22 Wright Medical Technology, Inc. Guidance tools, systems, and methods
US12440227B2 (en) 2021-02-24 2025-10-14 Wright Medical Technology, Inc. Preparing a tibia for receiving tibial implant component of a replacement ankle
JP7705950B2 (ja) 2021-03-23 2025-07-10 テルモ ビーシーティー、インコーポレーテッド 細胞を増殖する方法
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60253455A (ja) * 1984-05-28 1985-12-14 京セラ株式会社 骨形成因子を含有する生体材料とその製造方法
US4620327A (en) * 1984-07-05 1986-11-04 Caplan Arnold I Process of adapting soluble bone protein for use in stimulating osteoinduction
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US6432919B1 (en) † 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
NZ226170A (en) * 1987-09-18 1990-07-26 Ethicon Inc Stable freeze-dried pharmaceutical composition containing epidermal growth factor
US4863732A (en) * 1987-12-16 1989-09-05 Collagen Corporation Injectable composition for inductive bone repair
US5344654A (en) * 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US4968590A (en) 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5011691A (en) 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
EP0429570B1 (en) † 1989-03-28 1998-01-14 Genetics Institute, Inc. Osteoinductive compositions
US5158934A (en) * 1989-09-01 1992-10-27 Genentech, Inc. Method of inducing bone growth using TGF-β
US5290558A (en) * 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5290271A (en) * 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
ATE209251T1 (de) 1990-05-16 2001-12-15 Genetics Inst Knochen- und knorpel-bildung hervorrufende proteine
ATE184052T1 (de) 1990-06-15 1999-09-15 Carnegie Inst Of Washington Gdf-1 und uog1 proteine
US5853746A (en) * 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
EP0587751A1 (en) * 1991-06-05 1994-03-23 The Procter & Gamble Company Therapeutic compositions for osteoinduction
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
CA2108770C (en) 1991-06-25 2007-04-03 John M. Wozney Bmp-9 compositions
ATE308336T1 (de) † 1991-08-30 2005-11-15 Curis Inc Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten
US5192743A (en) † 1992-01-16 1993-03-09 Genentech, Inc. Reconstitutable lyophilized protein formulation
IL106278A0 (en) † 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
CA2144513C (en) † 1992-09-15 1998-12-15 Thangavel Kuberasampath Morphogen-induced periodontal tissue regeneration
JPH08503198A (ja) † 1992-11-03 1996-04-09 クリエイティブ バイオモレキュルズ，インコーポレイテッド Ｏｐ−３誘導形態形成
DE4240621A1 (de) 1992-12-03 1994-06-09 Zahnradfabrik Friedrichshafen Verfahren zur Steuerung und Regelung der Lastübernahme bei einem automatischen Schaltgetriebe
JPH08505771A (ja) 1993-01-12 1996-06-25 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−３
ES2105641T3 (es) † 1993-01-12 1997-10-16 Genentech Inc Formulacion del factor de crecimiento de transformacion beta que provoca el crecimiento de los huesos.
JPH09501305A (ja) 1993-05-12 1997-02-10 ジェネティックス・インスティテュート・インコーポレイテッド Ｂｍｐ−１０組成物
CA2165778A1 (en) 1993-07-09 1995-01-19 Se-Jin Lee Growth differentiation factor-7
US5531791A (en) * 1993-07-23 1996-07-02 Bioscience Consultants Composition for repair of defects in osseous tissues, method of making, and prosthesis
AU7605394A (en) † 1993-09-03 1995-03-22 Regents Of The University Of California, The Neural tissue affecting factor and compositions
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6204047B1 (en) 1993-10-08 2001-03-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-10
JP3717930B2 (ja) 1993-12-07 2005-11-16 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Ｂｍｐ−１２、ｂｍｐ−１３およびそれらの腱誘導組成物
JPH09506675A (ja) † 1993-12-14 1997-06-30 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 使用済み触媒の回収
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
EP0812207B1 (en) † 1995-03-01 2000-11-02 Stryker Corporation Morphogen-induced dentine regeneration
UA46767C2 (uk) † 1995-04-19 2002-06-17 Біофарм Гезельшафт Цур Біотехнологішен Ентвіклунг Фон Фармака Мбх Білок, фармацевтична композиція для лікування захворювань хрящів і кісток, спосіб отримання білка, спосіб отримання гомодимерного білка, спосіб лікування захворювань хрящів і кісток
FI952196A0 (fi) 1995-05-08 1995-05-08 Suomen Punainen Risti Veripalv Framstaellning av immunoglobulin
KR100440645B1 (ko) * 1995-06-05 2004-09-18 뉴욕 쏘사이어티 포 더 릴리프 어브 더 럽쳐드 앤드 크리플드 메인테이닝 더 하스피틀 포 스페셜 설져리 결합조직부착의치료및치유를위한방법및조성물
US5902785A (en) † 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
US5674292A (en) * 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
JPH09143093A (ja) † 1995-11-17 1997-06-03 Hoechst Japan Ltd 軟骨・骨誘導性修復用材料
US6048964A (en) 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US5752974A (en) † 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
JP2002504083A (ja) † 1996-03-05 2002-02-05 オーケスト インコーポレイテッド ヒアルロン酸および増殖因子による骨の増殖を促進する方法
DE19647853A1 (de) † 1996-11-19 1998-05-20 Bioph Biotech Entw Pharm Gmbh Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität
HU226554B1 (en) † 1997-01-30 2009-03-30 Bioph Biotech Entw Pharm Gmbh Freeze-dried composition of bone morphogenetic protein human mp52
EP2332564A1 (en) * 1997-02-07 2011-06-15 Stryker Corporation Matrix-free osteogenic devices, implants and methods thereof
AU2002236558A1 (en) † 2000-12-01 2002-06-11 Regents Of The University Of California Method and composition for modulating bone growth

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009102393A (ja) * 1997-02-07 2009-05-14 Stryker Corp マトリクスを含まない骨形成デバイス、移植片、およびその使用方法

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