JP4313435B2 - プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制 - Google Patents
プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制 Download PDFInfo
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- JP4313435B2 JP4313435B2 JP50696497A JP50696497A JP4313435B2 JP 4313435 B2 JP4313435 B2 JP 4313435B2 JP 50696497 A JP50696497 A JP 50696497A JP 50696497 A JP50696497 A JP 50696497A JP 4313435 B2 JP4313435 B2 JP 4313435B2
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| US143995P | 1995-07-24 | 1995-07-24 | |
| US60/001,439 | 1995-07-24 | ||
| US50775795A | 1995-07-26 | 1995-07-26 | |
| US08/507,757 | 1995-07-26 | ||
| US08/559,442 US5888996A (en) | 1995-07-26 | 1995-11-15 | Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity |
| US08/559,442 | 1995-11-15 | ||
| PCT/US1996/012198 WO1997003677A1 (en) | 1995-07-24 | 1996-07-24 | Inhibition of nmda receptor activity by pregnenolone sulfate derivatives |
Publications (3)
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| JPH11509844A JPH11509844A (ja) | 1999-08-31 |
| JPH11509844A5 JPH11509844A5 (https=) | 2009-05-07 |
| JP4313435B2 true JP4313435B2 (ja) | 2009-08-12 |
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| US (1) | US6083941A (https=) |
| EP (1) | EP0840612A1 (https=) |
| JP (1) | JP4313435B2 (https=) |
| WO (1) | WO1997003677A1 (https=) |
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| US20010051599A1 (en) * | 1997-05-02 | 2001-12-13 | Michael Z. Kagan | Pregnan-3-ol-20-ones |
| ATE360426T1 (de) | 1998-11-10 | 2007-05-15 | Curamentis Ltd | Verwendung von agonisten der corticosteroidrezeptoren und einer suchtdroge zur suchtbehandlung |
| FR2786102B1 (fr) * | 1998-11-20 | 2001-02-16 | Monique Vincens | Utilisation de sulfate de dehydroepiandrosterone pour augmenter le nombre de recepteurs nmda chez un mammifere |
| GB9917822D0 (en) * | 1999-07-29 | 1999-09-29 | Imperial College | Nmda antagonist |
| EP1212618B1 (en) * | 1999-08-31 | 2009-03-11 | Trustees Of Boston University | Effect of steroids on nmda receptors depends on subunit composition |
| US20040204490A1 (en) * | 1999-08-31 | 2004-10-14 | Farb David H. | Effect of steroids on NMDA receptors depends on subunit composition |
| GB0003524D0 (en) * | 2000-02-15 | 2000-04-05 | Btg Int Ltd | Cytoprotective steroids (II) |
| GB2363983A (en) | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 7-hydroxyepiandrosterone |
| AU2002217841A1 (en) * | 2000-11-06 | 2002-05-15 | Trustees Of Boston University | Neuroactive steroid derivatives and methods of use |
| US20030013692A1 (en) * | 2001-01-19 | 2003-01-16 | Gullans Steven R. | Methods of treating neurological disorders |
| EP1436258A4 (en) * | 2001-03-08 | 2005-03-23 | Univ Emory | PH VALVE DEPENDENT NMDA RECEPTOR ANTAGONISTS |
| DE60120104T2 (de) * | 2001-03-20 | 2006-09-21 | Schwarz Pharma Ag | Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz |
| DK1243263T3 (da) * | 2001-03-21 | 2003-03-17 | Sanol Arznei Schwarz Gmbh | Hidtil ukendt anvendelse af en klasse af peptidforbindelser til behandling af allodyni eller andre forskellige typer af kronisk- eller fantomsmerte |
| US7790404B2 (en) * | 2001-08-20 | 2010-09-07 | Sanford-Burnham Medical Research Institute | Excitatory glycine receptors and methods |
| AUPR731901A0 (en) * | 2001-08-28 | 2001-09-20 | Goodchild, Colin Stanley | Method of treatment |
| FR2850023B1 (fr) * | 2003-01-17 | 2007-04-06 | Mapreg | Medicaments pour le systeme nerveux |
| IL154318A (en) | 2003-02-06 | 2010-05-31 | Sarah Herzog Memorial Hospital | Pharmaceutical compositions for the treatment of movement disorders |
| EP2301549A1 (en) * | 2003-04-18 | 2011-03-30 | Advanced Medicine Research Institute | Remedies for diseases to be applied to eye |
| JP4664924B2 (ja) * | 2003-12-02 | 2011-04-06 | ウーツェーベー ファルマ ゲーエムベーハー | 中枢神経因性疼痛の治療のためのペプチド化合物の新規使用 |
| CN1906206A (zh) * | 2004-01-15 | 2007-01-31 | 沃纳奇尔科特公司 | 雌二醇的二－甾族前体药物 |
| CA2553816A1 (en) * | 2004-01-15 | 2005-08-04 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of ethinyl estradiol |
| US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
| US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
| AU2005232395B2 (en) | 2004-04-16 | 2010-09-09 | Schwarz Pharma Ag | Use of peptidic compounds for the prophylaxis and treatment of chronic headache |
| EP1604655A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| EP1604656A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
| EA014055B1 (ru) * | 2004-08-27 | 2010-08-30 | Шварц Фарма Аг | Применение пептидных соединений для лечения боли при раке кости, а также боли, вызванной химиотерапией и нуклеозидами |
| US20060252749A1 (en) * | 2005-01-28 | 2006-11-09 | Srz Properties, Inc. | Lacosamide for add-on therapy of psychosis |
| EP1910401A2 (en) * | 2005-07-12 | 2008-04-16 | Warner Chilcott Company, Inc. | 3-ester prodrugs of ethynylestradiol |
| CA2610481A1 (en) * | 2005-07-12 | 2007-01-18 | Warner Chilcott Company, Inc. | 3-ester prodrugs of estradiol |
| EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| JP4382735B2 (ja) * | 2005-10-06 | 2009-12-16 | 独立行政法人科学技術振興機構 | 神経因性疼痛治療剤 |
| WO2007049932A1 (en) * | 2005-10-28 | 2007-05-03 | Sun-Yeou Kim | Extract of the family dioscoreaceae and composition for preventing or treating peripheral neuropathy comprising the same |
| CN101466390B (zh) * | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
| EA019757B1 (ru) | 2006-06-15 | 2014-06-30 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая композиция с синергетическим противосудорожным эффектом |
| US20090203658A1 (en) * | 2007-01-08 | 2009-08-13 | Duke University | Neuroactive steroid compositions and methods of use therefor |
| KR20100045983A (ko) | 2007-06-29 | 2010-05-04 | 에모리 유니버시티 | 신경보호를 위한 ｎｍｄａ 수용체 길항물질 |
| WO2010077292A1 (en) * | 2008-12-09 | 2010-07-08 | King Faisal Specialist Hospital & Research Center | Pregnenolone sulfate for the treatment of neurologic disorders |
| HRP20230747T1 (hr) * | 2011-09-08 | 2024-01-05 | Sage Therapeutics, Inc. | Neuroaktivni steroidi, pripravci i njihova uporaba |
| US10478505B2 (en) | 2011-09-23 | 2019-11-19 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
| SG10201606063RA (en) | 2012-01-23 | 2016-09-29 | Sage Therapeutics Inc | Neuroactive steroid formulations and methods of treating cns disorders |
| FR2992645B1 (fr) * | 2012-07-02 | 2014-08-01 | Univ Claude Bernard Lyon | Nouveaux derives de pyrrolidine |
| MX2015002252A (es) | 2012-08-21 | 2015-07-21 | Sage Therapeutics Inc | Metodos para tratar epilepsia o estado de epilepsia. |
| DK2925327T3 (da) | 2012-11-30 | 2024-03-25 | Univ California | Allopregnanolon til behandling, reduktion eller lindring af symptomer på fødselsdepression |
| SMT201800657T1 (it) | 2013-03-13 | 2019-01-11 | Sage Therapeutics Inc | Steroidi neuroattivi e loro metodi di utilizzo |
| WO2015195967A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| CZ2014575A3 (cs) | 2014-08-26 | 2016-02-24 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | Amfifilní sloučeniny s neuroprotektivními účinky |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| PL3319611T3 (pl) | 2015-07-06 | 2021-07-12 | Sage Therapeutics, Inc. | Oksysterole i sposoby ich stosowania |
| MX382122B (es) | 2015-07-06 | 2025-03-13 | Sage Therapeutics Inc | Oxiesteroles y metodos de uso de los mismos. |
| HK1258616A1 (zh) | 2016-03-08 | 2019-11-15 | Sage Therapeutics, Inc. | 神经活性类固醇、组合物、及其用途 |
| EP3436022B1 (en) | 2016-04-01 | 2022-03-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2018009867A1 (en) * | 2016-07-07 | 2018-01-11 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| PT3519422T (pt) | 2016-09-30 | 2022-12-05 | Sage Therapeutics Inc | Oxisteróis substituídos em c7 e métodos como moduladores nmda |
| CA3041088C (en) | 2016-10-18 | 2024-05-21 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| DK4105223T3 (da) | 2016-10-18 | 2025-07-07 | Sage Therapeutics Inc | Oxysteroler og fremgangsmåder til anvendelse deraf |
| EP3988096A1 (en) * | 2020-10-26 | 2022-04-27 | Universidad Pablo de Olavide OTRI | Sulfated c19 steroid hormones to treat and/or prevent proteotoxicity in protein-aggregation diseases |
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| US5212167A (en) * | 1991-09-12 | 1993-05-18 | Trustees Of Boston University | Modulation of receptor-mediated ion transport |
| EP0603312A4 (en) * | 1991-09-13 | 1995-06-07 | Cocensys Inc | NEW GABA A RECEPTOR WITH STEROID BINDING POINTS. |
| AU698834B2 (en) * | 1993-05-24 | 1998-11-12 | Purdue Pharma Ltd. | Methods and compositions for inducing sleep |
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- 1996-07-24 EP EP96926768A patent/EP0840612A1/en not_active Withdrawn
- 1996-07-24 WO PCT/US1996/012198 patent/WO1997003677A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| JPH11509844A (ja) | 1999-08-31 |
| US6083941A (en) | 2000-07-04 |
| WO1997003677A1 (en) | 1997-02-06 |
| EP0840612A1 (en) | 1998-05-13 |
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