JP4313435B2 - プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制 - Google Patents
プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制 Download PDFInfo
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- JP4313435B2 JP4313435B2 JP50696497A JP50696497A JP4313435B2 JP 4313435 B2 JP4313435 B2 JP 4313435B2 JP 50696497 A JP50696497 A JP 50696497A JP 50696497 A JP50696497 A JP 50696497A JP 4313435 B2 JP4313435 B2 JP 4313435B2
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| US143995P | 1995-07-24 | 1995-07-24 | |
| US60/001,439 | 1995-07-24 | ||
| US50775795A | 1995-07-26 | 1995-07-26 | |
| US08/507,757 | 1995-07-26 | ||
| US08/559,442 | 1995-11-15 | ||
| US08/559,442 US5888996A (en) | 1995-07-26 | 1995-11-15 | Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity |
| PCT/US1996/012198 WO1997003677A1 (en) | 1995-07-24 | 1996-07-24 | Inhibition of nmda receptor activity by pregnenolone sulfate derivatives |
Publications (3)
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| JPH11509844A JPH11509844A (ja) | 1999-08-31 |
| JPH11509844A5 JPH11509844A5 (https=) | 2009-05-07 |
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| EP (1) | EP0840612A1 (https=) |
| JP (1) | JP4313435B2 (https=) |
| WO (1) | WO1997003677A1 (https=) |
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| US20010051599A1 (en) * | 1997-05-02 | 2001-12-13 | Michael Z. Kagan | Pregnan-3-ol-20-ones |
| JP2002529416A (ja) | 1998-11-10 | 2002-09-10 | メディモド・リサーチ・インスティチュート・ゲーエムベーハー | 嗜癖の治療のためのグルココルチコステロイド・レセプターおよび／またはミネラルコルチコステロイド・レセプターのアゴニスト、特にコルチコステロイドの使用 |
| FR2786102B1 (fr) * | 1998-11-20 | 2001-02-16 | Monique Vincens | Utilisation de sulfate de dehydroepiandrosterone pour augmenter le nombre de recepteurs nmda chez un mammifere |
| GB9917822D0 (en) * | 1999-07-29 | 1999-09-29 | Imperial College | Nmda antagonist |
| US20040204490A1 (en) * | 1999-08-31 | 2004-10-14 | Farb David H. | Effect of steroids on NMDA receptors depends on subunit composition |
| CA2383047A1 (en) | 1999-08-31 | 2001-03-08 | Trustees Of Boston University | Effect of steroids on nmda receptors depends on subunit composition |
| GB0003524D0 (en) * | 2000-02-15 | 2000-04-05 | Btg Int Ltd | Cytoprotective steroids (II) |
| GB2363983A (en) | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 7-hydroxyepiandrosterone |
| AU2002217841A1 (en) * | 2000-11-06 | 2002-05-15 | Trustees Of Boston University | Neuroactive steroid derivatives and methods of use |
| US20030013692A1 (en) * | 2001-01-19 | 2003-01-16 | Gullans Steven R. | Methods of treating neurological disorders |
| US7375136B2 (en) * | 2001-03-08 | 2008-05-20 | Emory University | pH-dependent NMDA receptor antagonists |
| DK1243262T3 (da) * | 2001-03-20 | 2006-10-02 | Sanol Arznei Schwarz Gmbh | Hidtil ukendt anvendelse af en peptidklasse af forbindelser til behandling af ikke-neuropatiske, inflammatoriske smerter |
| ES2185606T3 (es) * | 2001-03-21 | 2003-05-01 | Sanol Arznei Schwarz Gmbh | Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma. |
| US7790404B2 (en) * | 2001-08-20 | 2010-09-07 | Sanford-Burnham Medical Research Institute | Excitatory glycine receptors and methods |
| AUPR731901A0 (en) * | 2001-08-28 | 2001-09-20 | Goodchild, Colin Stanley | Method of treatment |
| FR2850023B1 (fr) * | 2003-01-17 | 2007-04-06 | Mapreg | Medicaments pour le systeme nerveux |
| IL154318A (en) | 2003-02-06 | 2010-05-31 | Sarah Herzog Memorial Hospital | Pharmaceutical compositions for the treatment of movement disorders |
| EP1621199B8 (en) * | 2003-04-18 | 2011-01-19 | Advanced Medicine Research Institute | Remedies for diseases to be applied to eye |
| JP4664924B2 (ja) * | 2003-12-02 | 2011-04-06 | ウーツェーベー ファルマ ゲーエムベーハー | 中枢神経因性疼痛の治療のためのペプチド化合物の新規使用 |
| WO2005070950A1 (en) * | 2004-01-15 | 2005-08-04 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of ethinyl estradiol |
| JP2007517877A (ja) * | 2004-01-15 | 2007-07-05 | ワーナー・チルコット・カンパニー・インコーポレーテッド | エストラジオールのジ−ステロイド型プロドラッグ |
| US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
| US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
| KR20070007931A (ko) | 2004-04-16 | 2007-01-16 | 쉬바르츠파르마에이지 | 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도 |
| EP1604655A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| EP1604656A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
| PL1781276T3 (pl) * | 2004-08-27 | 2010-11-30 | Ucb Pharma Gmbh | Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy |
| US20060252749A1 (en) * | 2005-01-28 | 2006-11-09 | Srz Properties, Inc. | Lacosamide for add-on therapy of psychosis |
| CA2610481A1 (en) * | 2005-07-12 | 2007-01-18 | Warner Chilcott Company, Inc. | 3-ester prodrugs of estradiol |
| CN101218245B (zh) * | 2005-07-12 | 2011-08-17 | 沃纳奇尔科特有限责任公司 | 炔雌醇的3-酯前药 |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| JP4382735B2 (ja) * | 2005-10-06 | 2009-12-16 | 独立行政法人科学技術振興機構 | 神経因性疼痛治療剤 |
| CA2623838A1 (en) * | 2005-10-28 | 2007-05-03 | Sun-Yeou Kim | Extract of the family dioscoreaceae and composition for preventing or treating peripheral neuropathy comprising the same |
| WO2007144195A2 (en) | 2006-06-15 | 2007-12-21 | Schwarz Pharma Ag | Pharmaceutical composition with synergistic anticonvulsant effect |
| CN101466390B (zh) * | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
| US20090203658A1 (en) * | 2007-01-08 | 2009-08-13 | Duke University | Neuroactive steroid compositions and methods of use therefor |
| EA201070077A1 (ru) * | 2007-06-29 | 2010-08-30 | Эмори Юниверсити | Антагонисты nmda-рецепторов с нейропротективным действием |
| WO2010077292A1 (en) * | 2008-12-09 | 2010-07-08 | King Faisal Specialist Hospital & Research Center | Pregnenolone sulfate for the treatment of neurologic disorders |
| CA2848212C (en) * | 2011-09-08 | 2022-03-29 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| WO2013043985A1 (en) | 2011-09-23 | 2013-03-28 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
| EP2806877B2 (en) | 2012-01-23 | 2025-01-29 | Sage Therapeutics, Inc. | Neuroactive steroid formulations comprising a complex of allopregnanolone and sulfobutyl ether beta-cyclodextrin |
| FR2992645B1 (fr) * | 2012-07-02 | 2014-08-01 | Univ Claude Bernard Lyon | Nouveaux derives de pyrrolidine |
| CA2882708A1 (en) | 2012-08-21 | 2014-02-27 | Sage Therapeutics, Inc. | Methods of treating epilepsy or status epilepticus |
| AU2013352141B2 (en) | 2012-11-30 | 2018-04-05 | The Regents Of The University Of California | Anticonvulsant activity of steroids |
| PT2968369T (pt) | 2013-03-13 | 2018-12-05 | Sage Therapeutics Inc | Esteroides neuroativos e métodos para o seu uso |
| US10259840B2 (en) | 2014-06-18 | 2019-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| CZ2014575A3 (cs) | 2014-08-26 | 2016-02-24 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | Amfifilní sloučeniny s neuroprotektivními účinky |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| EP3828194B1 (en) | 2015-07-06 | 2025-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| HUE071964T2 (hu) | 2015-07-06 | 2025-10-28 | Sage Therapeutics Inc | Oxiszterolok és alkalmazási eljárásaik |
| KR20240157128A (ko) | 2016-03-08 | 2024-10-31 | 세이지 테라퓨틱스, 인크. | 신경활성 스테로이드, 조성물, 및 그의 용도 |
| SMT202200300T1 (it) | 2016-04-01 | 2022-09-14 | Sage Therapeutics Inc | Ossisteroli e relativi metodi d'uso |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| ES2884071T3 (es) * | 2016-07-07 | 2021-12-10 | Sage Therapeutics Inc | 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA |
| ES2935057T3 (es) | 2016-09-30 | 2023-03-01 | Sage Therapeutics Inc | C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA |
| RU2019115113A (ru) | 2016-10-18 | 2020-11-24 | Сейдж Терапьютикс, Инк. | Оксистеролы и способы их применения |
| KR20230051723A (ko) | 2016-10-18 | 2023-04-18 | 세이지 테라퓨틱스, 인크. | 옥시스테롤 및 그의 사용 방법 |
| EP3988096A1 (en) * | 2020-10-26 | 2022-04-27 | Universidad Pablo de Olavide OTRI | Sulfated c19 steroid hormones to treat and/or prevent proteotoxicity in protein-aggregation diseases |
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|---|---|---|---|---|
| US5212167A (en) * | 1991-09-12 | 1993-05-18 | Trustees Of Boston University | Modulation of receptor-mediated ion transport |
| EP0603312A4 (en) * | 1991-09-13 | 1995-06-07 | Cocensys Inc | NEW GABA A RECEPTOR WITH STEROID BINDING POINTS. |
| DE69435286D1 (de) * | 1993-05-24 | 2010-05-20 | Purdue Pharma Ltd | Verfahren und zusammensetzungen zum hervorrufen von schlaf |
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- 1996-07-24 WO PCT/US1996/012198 patent/WO1997003677A1/en not_active Ceased
- 1996-07-24 JP JP50696497A patent/JP4313435B2/ja not_active Expired - Fee Related
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1998
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|---|---|
| EP0840612A1 (en) | 1998-05-13 |
| US6083941A (en) | 2000-07-04 |
| JPH11509844A (ja) | 1999-08-31 |
| WO1997003677A1 (en) | 1997-02-06 |
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