JP4294732B2 - アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出 - Google Patents

アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出 Download PDF

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Publication number
JP4294732B2
JP4294732B2 JP53016497A JP53016497A JP4294732B2 JP 4294732 B2 JP4294732 B2 JP 4294732B2 JP 53016497 A JP53016497 A JP 53016497A JP 53016497 A JP53016497 A JP 53016497A JP 4294732 B2 JP4294732 B2 JP 4294732B2
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Japan
Prior art keywords
oligonucleotide
oligonucleotide probe
target
sequence
capture
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Expired - Lifetime
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JP53016497A
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Japanese (ja)
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JP2001519648A (ja
JP2001519648A5 (enExample
Inventor
バラニー，フランシス
バラニー，ジョージ
ハマー，ロバート・ピー
ケンプ，マリア
ブロック，ヘルマン
ザービ，モニブ
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Cornell Research Foundation Inc
Louisiana State University
University of Minnesota System
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Cornell Research Foundation Inc
University of Minnesota Twin Cities
Louisiana State University
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/02—Identifying library members by their fixed physical location on a support or substrate
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00277—Apparatus
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
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  • Materials Engineering (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP53016497A 1996-02-09 1997-02-05 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出 Expired - Lifetime JP4294732B2 (ja)

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Application Number Priority Date Filing Date Title
US1135996P 1996-02-09 1996-02-09
US60/011,359 1996-02-09
PCT/US1997/001535 WO1997031256A2 (en) 1996-02-09 1997-02-05 Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays

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JP2007260054A Division JP4890411B2 (ja) 1996-02-09 2007-10-03 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出

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JP2001519648A JP2001519648A (ja) 2001-10-23
JP2001519648A5 JP2001519648A5 (enExample) 2004-11-25
JP4294732B2 true JP4294732B2 (ja) 2009-07-15

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JP53016497A Expired - Lifetime JP4294732B2 (ja) 1996-02-09 1997-02-05 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出
JP2007260054A Expired - Lifetime JP4890411B2 (ja) 1996-02-09 2007-10-03 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出
JP2011098299A Expired - Lifetime JP5634937B2 (ja) 1996-02-09 2011-04-26 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出
JP2014185507A Expired - Lifetime JP5855195B2 (ja) 1996-02-09 2014-09-11 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出

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JP2007260054A Expired - Lifetime JP4890411B2 (ja) 1996-02-09 2007-10-03 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出
JP2011098299A Expired - Lifetime JP5634937B2 (ja) 1996-02-09 2011-04-26 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出
JP2014185507A Expired - Lifetime JP5855195B2 (ja) 1996-02-09 2014-09-11 アドレス可能アレイでのリガーゼ検出反応を用いた核酸配列の相違の検出

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EP (7) EP2368897B1 (enExample)
JP (4) JP4294732B2 (enExample)
AU (1) AU735440B2 (enExample)
CA (1) CA2244891C (enExample)
WO (1) WO1997031256A2 (enExample)

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US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5846719A (en) * 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US6280935B1 (en) 1994-10-13 2001-08-28 Lynx Therapeutics, Inc. Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags
HUP9900910A2 (hu) * 1995-06-07 1999-07-28 Lynx Therapeutics, Inc. Oligonukleotid jelzések osztályozáshoz és azonosításhoz
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
EP0912761A4 (en) 1996-05-29 2004-06-09 Cornell Res Foundation Inc DETERMINATION OF DIFFERENCES IN THE NUCLEIC ACID SEQUENCE BY MEANS OF A COMBINATION OF LIGASE DETERMINATION AND POLYMERASE CHAIN REACTION
US6312892B1 (en) * 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
US6225056B1 (en) * 1996-09-13 2001-05-01 Laboratory Of Molecular Biophotonics Solid phases for target nucleic acid detection, process for production thereof, and method of target nucleic acid detection
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
EP1249705A3 (en) 1996-12-31 2003-11-05 Genometrix Genomics Incorporated Multiplexed molecular analysis apparatus and its fabrication method
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