JP4290003B2 - 質量標識体 - Google Patents

質量標識体 Download PDF

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Publication number
JP4290003B2
JP4290003B2 JP2003529154A JP2003529154A JP4290003B2 JP 4290003 B2 JP4290003 B2 JP 4290003B2 JP 2003529154 A JP2003529154 A JP 2003529154A JP 2003529154 A JP2003529154 A JP 2003529154A JP 4290003 B2 JP4290003 B2 JP 4290003B2
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JP
Japan
Prior art keywords
mass
label
peptide
analysis
tag
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2003529154A
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English (en)
Japanese (ja)
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JP2005503557A (ja
JP2005503557A5 (enExample
Inventor
アンドリュー・フギン・トンプソン
クリスチャン・ハモン
ユルゲン・シャファー
カルステン・クーン
ヨゼフ・シュワルツ
トーマス・ノイマン
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Proteome Sciences PLC
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Electrophoretics Ltd
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Publication date
Application filed by Electrophoretics Ltd filed Critical Electrophoretics Ltd
Publication of JP2005503557A publication Critical patent/JP2005503557A/ja
Publication of JP2005503557A5 publication Critical patent/JP2005503557A5/ja
Application granted granted Critical
Publication of JP4290003B2 publication Critical patent/JP4290003B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • G01N33/6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/15Non-radioactive isotope labels, e.g. for detection by mass spectrometry

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
JP2003529154A 2001-09-14 2002-09-16 質量標識体 Expired - Lifetime JP4290003B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01307830 2001-09-14
PCT/GB2002/004240 WO2003025576A2 (en) 2001-09-14 2002-09-16 Mass labels

Publications (3)

Publication Number Publication Date
JP2005503557A JP2005503557A (ja) 2005-02-03
JP2005503557A5 JP2005503557A5 (enExample) 2005-12-22
JP4290003B2 true JP4290003B2 (ja) 2009-07-01

Family

ID=8182269

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003529154A Expired - Lifetime JP4290003B2 (ja) 2001-09-14 2002-09-16 質量標識体

Country Status (9)

Country Link
US (1) US7732378B2 (enExample)
EP (1) EP1425586B1 (enExample)
JP (1) JP4290003B2 (enExample)
CA (1) CA2460131C (enExample)
DE (1) DE60223696T2 (enExample)
DK (1) DK1425586T3 (enExample)
ES (1) ES2296996T3 (enExample)
PT (1) PT1425586E (enExample)
WO (1) WO2003025576A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009503485A (ja) * 2005-07-26 2009-01-29 エレクトロフォレティクス リミテッド 質量標識体
JP2009508135A (ja) * 2005-09-12 2009-02-26 エレクトロフォレティクス リミテッド 質量標識体

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US7556969B2 (en) 2002-12-19 2009-07-07 Northeastern University Intensified neutral loss tags and use thereof in mass spectrometry
JP4613299B2 (ja) 2003-01-30 2011-01-12 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 分析物分析に関する方法、混合物、キット、および組成物
GB0306756D0 (en) * 2003-03-24 2003-04-30 Xzillion Gmbh & Co Kg Mass labels
JP2005140755A (ja) * 2003-11-10 2005-06-02 Japan Science & Technology Agency 質量分析用プローブ及びそれを用いた質量分析方法
DE602004009824T2 (de) * 2003-11-26 2008-03-06 Applera Corp., Framingham Analyse von massenspektraldaten in den ruhigen gebieten
EP1916527A1 (en) * 2003-11-26 2008-04-30 Applera Corporation Analysis of mass spectral data in the quiet zones
US7105806B2 (en) * 2003-11-26 2006-09-12 Applera Corporation Method and apparatus for de-convoluting a convoluted spectrum
US7307169B2 (en) 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
US7355045B2 (en) 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
JP2007519910A (ja) 2004-01-28 2007-07-19 イマティクス バイオテクノロジーズ ゲーエムベーハー 腫瘍関連ペプチドの同定および定量方法
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
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US7618780B2 (en) 2004-05-20 2009-11-17 Trillion Genomics Limited Use of mass labelled probes to detect target nucleic acids using mass spectrometry
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WO2007013699A1 (ja) * 2005-07-29 2007-02-01 Eisai R & D Management Co., Ltd. 化合物に対するタンパク質の結合力を解析する方法
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GB0704764D0 (en) 2007-03-12 2007-04-18 Electrophoretics Ltd Isobarically labelled reagents and methods of their use
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GB0809488D0 (en) 2008-05-23 2008-07-02 Electrophoretics Ltd Mass spectrometric analysis
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KR101081053B1 (ko) * 2008-07-18 2011-11-07 포항공과대학교 산학협력단 가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법
GB0916881D0 (en) * 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
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US8617898B2 (en) * 2010-01-25 2013-12-31 Dh Technologies Development Pte. Ltd. Quantitative analysis of vitamin D3, vitamin D2, and metabolites thereof
US8455818B2 (en) 2010-04-14 2013-06-04 Wisconsin Alumni Research Foundation Mass spectrometry data acquisition mode for obtaining more reliable protein quantitation
GB201006360D0 (en) 2010-04-16 2010-06-02 Immatics Biotechnologies Gmbh Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development
ES2676183T3 (es) 2010-07-02 2018-07-17 Ventana Medical Systems, Inc. Detección de dianas usando marcas de masa y espectrometría de masas
US8589084B2 (en) * 2010-10-08 2013-11-19 Massachusetts Institute Of Technology Detection of ethanol emission from a spark ignition engine operating on gasohols
EP2651961A1 (en) * 2010-12-13 2013-10-23 De Staat Der Nederlanden, Vert. Door De Minister Van VWS Protein affinity tag and uses thereof
DE102012102875B4 (de) 2011-04-04 2024-04-18 Wisconsin Alumni Research Foundation Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben
US9388132B2 (en) 2011-09-15 2016-07-12 Wisconsin Alumni Research Foundation Isobaric tandem mass tags for quantitative proteomics and peptidomics
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CN110047729B (zh) * 2014-02-21 2021-10-01 普度研究基金会 使用不混溶的提取溶剂分析所提取的样品
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DK3213056T3 (da) 2014-10-30 2020-09-28 Waters Technologies Corp Fremgangsmåder til hurtig forberedelse af mærkede glycosylaminer og til analyse af glykosylerede biomolekyler, som giver samme baggrund
CN107108465B (zh) 2014-11-13 2020-08-04 沃特世科技公司 快速标记的n-聚糖的液相色谱校准方法
GB201423361D0 (en) 2014-12-30 2015-02-11 Immatics Biotechnologies Gmbh Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides
US11061023B2 (en) 2016-06-21 2021-07-13 Waters Technologies Corporation Fluorescence tagging of glycans and other biomolecules through reductive amination for enhanced MS signals
CN109642906A (zh) 2016-06-21 2019-04-16 沃特世科技公司 对用两亲强碱性部分改性的聚糖进行电喷雾电离的方法
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CN110609103A (zh) * 2018-06-15 2019-12-24 中国科学院大连化学物理研究所 基于化学标记和质谱的蛋白与材料相互作用结构分析方法
KR102362170B1 (ko) 2019-04-08 2022-02-11 주식회사 엘지화학 Maldi 질량분석을 이용한 고분자의 상대적 정량분석방법
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009503485A (ja) * 2005-07-26 2009-01-29 エレクトロフォレティクス リミテッド 質量標識体
JP2009508135A (ja) * 2005-09-12 2009-02-26 エレクトロフォレティクス リミテッド 質量標識体

Also Published As

Publication number Publication date
PT1425586E (pt) 2007-12-31
WO2003025576A3 (en) 2003-07-31
DK1425586T3 (da) 2008-02-11
CA2460131C (en) 2006-11-21
EP1425586A2 (en) 2004-06-09
JP2005503557A (ja) 2005-02-03
DE60223696T2 (de) 2009-01-29
ES2296996T3 (es) 2008-05-01
US7732378B2 (en) 2010-06-08
DE60223696D1 (de) 2008-01-03
EP1425586B1 (en) 2007-11-21
CA2460131A1 (en) 2003-03-27
WO2003025576A2 (en) 2003-03-27
US20050048489A1 (en) 2005-03-03

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