JP2005503557A5 - - Google Patents
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- JP2005503557A5 JP2005503557A5 JP2003529154A JP2003529154A JP2005503557A5 JP 2005503557 A5 JP2005503557 A5 JP 2005503557A5 JP 2003529154 A JP2003529154 A JP 2003529154A JP 2003529154 A JP2003529154 A JP 2003529154A JP 2005503557 A5 JP2005503557 A5 JP 2005503557A5
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- JP
- Japan
- Prior art keywords
- mass
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- marker
- analysis method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000004458 analytical method Methods 0.000 claims 35
- 239000003550 marker Substances 0.000 claims 19
- 239000000523 sample Substances 0.000 claims 14
- 239000012491 analyte Substances 0.000 claims 11
- 238000010606 normalization Methods 0.000 claims 10
- 239000013076 target substance Substances 0.000 claims 10
- 238000004949 mass spectrometry Methods 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 150000002500 ions Chemical class 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000001360 collision-induced dissociation Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000010195 expression analysis Methods 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 238000011223 gene expression profiling Methods 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01307830 | 2001-09-14 | ||
| PCT/GB2002/004240 WO2003025576A2 (en) | 2001-09-14 | 2002-09-16 | Mass labels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503557A JP2005503557A (ja) | 2005-02-03 |
| JP2005503557A5 true JP2005503557A5 (enExample) | 2005-12-22 |
| JP4290003B2 JP4290003B2 (ja) | 2009-07-01 |
Family
ID=8182269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003529154A Expired - Lifetime JP4290003B2 (ja) | 2001-09-14 | 2002-09-16 | 質量標識体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7732378B2 (enExample) |
| EP (1) | EP1425586B1 (enExample) |
| JP (1) | JP4290003B2 (enExample) |
| CA (1) | CA2460131C (enExample) |
| DE (1) | DE60223696T2 (enExample) |
| DK (1) | DK1425586T3 (enExample) |
| ES (1) | ES2296996T3 (enExample) |
| PT (1) | PT1425586E (enExample) |
| WO (1) | WO2003025576A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002014867A2 (en) | 2000-08-11 | 2002-02-21 | Agilix Corporation | Ultra-sensitive detection systems |
| AU2002365271B2 (en) * | 2001-11-06 | 2008-12-11 | Agilix Corporation | Sensitive coded detection systems |
| US7556969B2 (en) | 2002-12-19 | 2009-07-07 | Northeastern University | Intensified neutral loss tags and use thereof in mass spectrometry |
| JP4613299B2 (ja) | 2003-01-30 | 2011-01-12 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 分析物分析に関する方法、混合物、キット、および組成物 |
| GB0306756D0 (en) * | 2003-03-24 | 2003-04-30 | Xzillion Gmbh & Co Kg | Mass labels |
| JP2005140755A (ja) * | 2003-11-10 | 2005-06-02 | Japan Science & Technology Agency | 質量分析用プローブ及びそれを用いた質量分析方法 |
| DE602004009824T2 (de) * | 2003-11-26 | 2008-03-06 | Applera Corp., Framingham | Analyse von massenspektraldaten in den ruhigen gebieten |
| EP1916527A1 (en) * | 2003-11-26 | 2008-04-30 | Applera Corporation | Analysis of mass spectral data in the quiet zones |
| US7105806B2 (en) * | 2003-11-26 | 2006-09-12 | Applera Corporation | Method and apparatus for de-convoluting a convoluted spectrum |
| US7307169B2 (en) | 2004-01-05 | 2007-12-11 | Applera Corporation | Isotopically enriched N-substituted piperazines and methods for the preparation thereof |
| US7355045B2 (en) | 2004-01-05 | 2008-04-08 | Applera Corporation | Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof |
| JP2007519910A (ja) | 2004-01-28 | 2007-07-19 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 腫瘍関連ペプチドの同定および定量方法 |
| US20080206737A1 (en) * | 2004-05-19 | 2008-08-28 | Hunter Christie L | Expression quantification using mass spectrometry |
| US20070054345A1 (en) * | 2004-05-19 | 2007-03-08 | Hunter Christie L | Expression quantification using mass spectrometry |
| US7618780B2 (en) | 2004-05-20 | 2009-11-17 | Trillion Genomics Limited | Use of mass labelled probes to detect target nucleic acids using mass spectrometry |
| EP1776588A1 (en) * | 2004-07-12 | 2007-04-25 | Applera Corporation | Mass tags for quantitative analyses |
| US20070048752A1 (en) | 2004-07-12 | 2007-03-01 | Applera Corporation | Mass tags for quantitative analyses |
| WO2006023398A2 (en) * | 2004-08-16 | 2006-03-02 | Ludwig Institute For Cancer Research | Modular isotope labelled mass spectrometry reagents and methods for quantitation of amino acids, peptides and proteins |
| US20060134710A1 (en) * | 2004-10-30 | 2006-06-22 | Viorica Lopez-Avila | WDR11 protein assay |
| AU2006210551A1 (en) * | 2005-02-03 | 2006-08-10 | Perkinelmer Las, Inc. | Ultra-sensitive detection systems using multidimension signals |
| US20060183238A1 (en) | 2005-02-09 | 2006-08-17 | Applera Corporation | Amine-containing compound analysis methods |
| US20070134802A1 (en) * | 2005-06-30 | 2007-06-14 | Heinz Doebeli | Ionization modifier for mass spectrometry |
| GB0515323D0 (en) * | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
| WO2007013699A1 (ja) * | 2005-07-29 | 2007-02-01 | Eisai R & D Management Co., Ltd. | 化合物に対するタンパク質の結合力を解析する方法 |
| GB0518585D0 (en) * | 2005-09-12 | 2005-10-19 | Electrophoretics Ltd | Mass labels |
| EP1921081A1 (en) * | 2006-11-06 | 2008-05-14 | Koninklijke Philips Electronics N.V. | Use of arylboronic acids in protein labelling |
| GB0704764D0 (en) | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
| WO2008142579A2 (en) * | 2007-05-23 | 2008-11-27 | Williamson Nicholas A | Method of mass analysis of target molecules in complex mixtures |
| GB0809488D0 (en) | 2008-05-23 | 2008-07-02 | Electrophoretics Ltd | Mass spectrometric analysis |
| GB0811574D0 (en) * | 2008-06-24 | 2008-07-30 | Trillion Genomics Ltd | Characterising planar samples by mass spectrometry |
| KR101081053B1 (ko) * | 2008-07-18 | 2011-11-07 | 포항공과대학교 산학협력단 | 가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법 |
| GB0916881D0 (en) * | 2009-09-25 | 2009-11-11 | Electrophoretics Ltd | Mass labels |
| GB0921665D0 (en) | 2009-12-10 | 2010-01-27 | Trillion Genomics Ltd | Phobes |
| US8617898B2 (en) * | 2010-01-25 | 2013-12-31 | Dh Technologies Development Pte. Ltd. | Quantitative analysis of vitamin D3, vitamin D2, and metabolites thereof |
| US8455818B2 (en) | 2010-04-14 | 2013-06-04 | Wisconsin Alumni Research Foundation | Mass spectrometry data acquisition mode for obtaining more reliable protein quantitation |
| GB201006360D0 (en) | 2010-04-16 | 2010-06-02 | Immatics Biotechnologies Gmbh | Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development |
| ES2676183T3 (es) | 2010-07-02 | 2018-07-17 | Ventana Medical Systems, Inc. | Detección de dianas usando marcas de masa y espectrometría de masas |
| US8589084B2 (en) * | 2010-10-08 | 2013-11-19 | Massachusetts Institute Of Technology | Detection of ethanol emission from a spark ignition engine operating on gasohols |
| EP2651961A1 (en) * | 2010-12-13 | 2013-10-23 | De Staat Der Nederlanden, Vert. Door De Minister Van VWS | Protein affinity tag and uses thereof |
| DE102012102875B4 (de) | 2011-04-04 | 2024-04-18 | Wisconsin Alumni Research Foundation | Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben |
| US9388132B2 (en) | 2011-09-15 | 2016-07-12 | Wisconsin Alumni Research Foundation | Isobaric tandem mass tags for quantitative proteomics and peptidomics |
| US10436790B2 (en) | 2011-09-28 | 2019-10-08 | Waters Technologies Corporation | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals |
| EP2847594B1 (en) * | 2012-05-10 | 2016-06-22 | Thermo Finnigan LLC | Method for highly multiplexed quantitation of peptides by mass spectrometry and labeling reagent sets therefor |
| WO2013177293A1 (en) | 2012-05-22 | 2013-11-28 | Biogen Idec Ma Inc. | Trapping reagents for reactive metabolites screening |
| GB201322567D0 (en) | 2013-12-19 | 2014-02-05 | Electrophoretics Ltd | Mass labels |
| CN110047729B (zh) * | 2014-02-21 | 2021-10-01 | 普度研究基金会 | 使用不混溶的提取溶剂分析所提取的样品 |
| US10269550B2 (en) | 2014-02-21 | 2019-04-23 | Purdue Research Foundation | Systems and methods for quantifying an analyte extracted from a sample |
| US11495448B2 (en) | 2014-02-21 | 2022-11-08 | Purdue Research Foundation | Systems and methods for quantifying an analyte extracted from a sample |
| DK3213056T3 (da) | 2014-10-30 | 2020-09-28 | Waters Technologies Corp | Fremgangsmåder til hurtig forberedelse af mærkede glycosylaminer og til analyse af glykosylerede biomolekyler, som giver samme baggrund |
| CN107108465B (zh) | 2014-11-13 | 2020-08-04 | 沃特世科技公司 | 快速标记的n-聚糖的液相色谱校准方法 |
| GB201423361D0 (en) | 2014-12-30 | 2015-02-11 | Immatics Biotechnologies Gmbh | Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides |
| US11061023B2 (en) | 2016-06-21 | 2021-07-13 | Waters Technologies Corporation | Fluorescence tagging of glycans and other biomolecules through reductive amination for enhanced MS signals |
| CN109642906A (zh) | 2016-06-21 | 2019-04-16 | 沃特世科技公司 | 对用两亲强碱性部分改性的聚糖进行电喷雾电离的方法 |
| EP3479103B1 (en) | 2016-07-01 | 2022-04-20 | Waters Technologies Corporation | Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation |
| CN110609103A (zh) * | 2018-06-15 | 2019-12-24 | 中国科学院大连化学物理研究所 | 基于化学标记和质谱的蛋白与材料相互作用结构分析方法 |
| KR102362170B1 (ko) | 2019-04-08 | 2022-02-11 | 주식회사 엘지화학 | Maldi 질량분석을 이용한 고분자의 상대적 정량분석방법 |
| EP4096694A4 (en) | 2020-01-30 | 2024-01-24 | Prognomiq Inc | LUNG BIOMARKERS AND METHODS OF USE THEREOF |
| WO2021163467A1 (en) * | 2020-02-14 | 2021-08-19 | Temple University-Of The Commonwealth System Of Higher Education | Linking amino acid sequences, manufacturing method thereof, and use thereof |
| US20220328134A1 (en) | 2021-03-31 | 2022-10-13 | PrognomIQ, Inc. | Multi-omic assessment |
| WO2023019148A1 (en) * | 2021-08-10 | 2023-02-16 | PrognomIQ, Inc. | Macromolecule enrichment |
| WO2023039479A1 (en) | 2021-09-10 | 2023-03-16 | PrognomIQ, Inc. | Direct classification of raw biomolecule measurement data |
| CN118215845A (zh) | 2021-09-13 | 2024-06-18 | 普罗科技有限公司 | 增强的对生物分子的检测和定量 |
| WO2024133457A2 (en) * | 2022-12-21 | 2024-06-27 | Roche Diagnostics Gmbh | (poly)label signal enhancer |
| EP4667939A1 (en) | 2024-06-21 | 2025-12-24 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Multiplex cancer cell profiling using ms-tagged probes containing an iminosydnone cleavable linker |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| AU717435B2 (en) * | 1996-01-23 | 2000-03-23 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
| US6027890A (en) * | 1996-01-23 | 2000-02-22 | Rapigene, Inc. | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
| HUP9901560A3 (en) | 1996-04-08 | 2000-09-28 | Glaxo Group Ltd | Mass-based encoding and qualitative analysis of combinatorial libraries |
| JP2001524808A (ja) | 1996-12-10 | 2001-12-04 | ジーントレイス・システムズ・インコーポレイテッド | 放出可能な不揮発性の質量標識分子 |
| EP1400599B1 (en) * | 1997-01-15 | 2007-10-03 | Xzillion GmbH & CO.KG | Mass label linked hybridisation probes |
| EP1002128A1 (en) * | 1997-07-11 | 2000-05-24 | Brax Genomics Limited | Characterising nucleic acids |
| AU746443B2 (en) | 1997-09-15 | 2002-05-02 | Xzillion Gmbh & Co. Kg | Characterising nucleic acid by mass spectrometry |
| GB9823646D0 (en) | 1997-12-19 | 1998-12-23 | Brax Genomics Ltd | Compounds for mass spectrometry |
| GB0006141D0 (en) | 2000-03-14 | 2000-05-03 | Brax Group Ltd | Mass labels |
| WO2002014867A2 (en) | 2000-08-11 | 2002-02-21 | Agilix Corporation | Ultra-sensitive detection systems |
-
2002
- 2002-09-16 DE DE60223696T patent/DE60223696T2/de not_active Expired - Lifetime
- 2002-09-16 DK DK02767650T patent/DK1425586T3/da active
- 2002-09-16 ES ES02767650T patent/ES2296996T3/es not_active Expired - Lifetime
- 2002-09-16 EP EP02767650A patent/EP1425586B1/en not_active Expired - Lifetime
- 2002-09-16 PT PT02767650T patent/PT1425586E/pt unknown
- 2002-09-16 CA CA002460131A patent/CA2460131C/en not_active Expired - Lifetime
- 2002-09-16 WO PCT/GB2002/004240 patent/WO2003025576A2/en not_active Ceased
- 2002-09-16 JP JP2003529154A patent/JP4290003B2/ja not_active Expired - Lifetime
- 2002-09-16 US US10/489,341 patent/US7732378B2/en not_active Expired - Lifetime
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