JP4220673B2 - 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド - Google Patents

遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド Download PDF

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JP4220673B2
JP4220673B2 JP2000561339A JP2000561339A JP4220673B2 JP 4220673 B2 JP4220673 B2 JP 4220673B2 JP 2000561339 A JP2000561339 A JP 2000561339A JP 2000561339 A JP2000561339 A JP 2000561339A JP 4220673 B2 JP4220673 B2 JP 4220673B2
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gene
expression
sequence
vector
promoter
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JP2002522027A5 (https=
JP2002522027A (ja
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マイケル アントニオ，
ロバート クロンビー，
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EMD Millipore Corp
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Millipore Corp
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Priority claimed from GBGB9815879.3A external-priority patent/GB9815879D0/en
Priority claimed from GBGB9906712.6A external-priority patent/GB9906712D0/en
Priority claimed from GBGB9909494.8A external-priority patent/GB9909494D0/en
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

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  • Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2000561339A 1998-07-21 1999-07-21 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド Expired - Lifetime JP4220673B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
GBGB9815879.3A GB9815879D0 (en) 1998-07-21 1998-07-21 A polynucleotide
US10768898P 1998-11-09 1998-11-09
US60/107,688 1998-11-09
GBGB9906712.6A GB9906712D0 (en) 1999-03-23 1999-03-23 A polynucleotide
US12741099P 1999-04-01 1999-04-01
US60/127,410 1999-04-01
GBGB9909494.8A GB9909494D0 (en) 1999-04-23 1999-04-23 A plasmid
US13401699P 1999-05-12 1999-05-12
US9909494.8 1999-05-12
US9815879.3 1999-05-12
US60/134,016 1999-05-12
US9906712.6 1999-05-12
PCT/GB1999/002357 WO2000005393A2 (en) 1998-07-21 1999-07-21 A polynucleotide comprising a ubiquitous chromatin opening element (ucoe)

Related Child Applications (1)

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JP2004293969A Division JP2005052149A (ja) 1998-07-21 2004-10-06 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

Publications (3)

Publication Number Publication Date
JP2002522027A JP2002522027A (ja) 2002-07-23
JP2002522027A5 JP2002522027A5 (https=) 2005-11-17
JP4220673B2 true JP4220673B2 (ja) 2009-02-04

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JP2000561339A Expired - Lifetime JP4220673B2 (ja) 1998-07-21 1999-07-21 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2004293969A Pending JP2005052149A (ja) 1998-07-21 2004-10-06 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2007285560A Withdrawn JP2008109931A (ja) 1998-07-21 2007-11-01 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2008305611A Withdrawn JP2009102331A (ja) 1998-07-21 2008-11-28 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

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JP2004293969A Pending JP2005052149A (ja) 1998-07-21 2004-10-06 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2007285560A Withdrawn JP2008109931A (ja) 1998-07-21 2007-11-01 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド
JP2008305611A Withdrawn JP2009102331A (ja) 1998-07-21 2008-11-28 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド

Country Status (8)

Country Link
EP (2) EP2348118A1 (https=)
JP (4) JP4220673B2 (https=)
KR (3) KR100795626B1 (https=)
CN (1) CN100365127C (https=)
AU (1) AU771111B2 (https=)
CA (1) CA2333852C (https=)
MX (1) MXPA01000830A (https=)
WO (1) WO2000005393A2 (https=)

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KR100955756B1 (ko) * 2001-04-05 2010-04-30 밀리포어 코포레이션 개량된 유전자 발현
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ATE354645T1 (de) * 2002-12-20 2007-03-15 Chromagenics Bv Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können
WO2004067701A2 (en) * 2003-02-01 2004-08-12 Innovata Plc Improved genetic elements providing high levels of expression
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US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
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JP2010525789A (ja) * 2007-01-08 2010-07-29 ミリポア・コーポレイション １つ又はそれ以上のきょう雑物の低下したレベルの存在下で組換えタンパク質を生産するための細胞培養法
CN104531699B (zh) * 2014-10-09 2017-03-15 河南农业大学 一种增强外源基因表达的猪的ucoe调控元件片段
KR102893385B1 (ko) * 2014-12-16 2025-12-02 가반 인스티튜트 오브 메디컬 리서치 시퀀싱 컨트롤
WO2018175153A1 (en) 2017-03-19 2018-09-27 Applied Stemcell, Inc. Novel integration sites and uses thereof
CN110799643B (zh) 2017-04-03 2023-12-22 小利兰·斯坦福大学托管委员会 用于细胞谱系的多重定量分析的组合物和方法
US20200385754A1 (en) * 2017-12-07 2020-12-10 Integrity Biosolutions, Llc Engineered ubiquitous chromatin opening elements and uses thereof
CN112135909A (zh) * 2018-05-24 2020-12-25 国立大学法人北海道大学 新载体及其应用
AU2019320771B2 (en) * 2018-08-15 2025-12-18 Illumina Cambridge Limited Compositions and methods for improving library enrichment
AU2019354390A1 (en) * 2018-10-02 2021-04-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for multiplexed quantitative analysis of cell lineages
WO2020223160A1 (en) * 2019-04-30 2020-11-05 Chan Zuckerberg Biohub, Inc. A novel chromatin-opening element for stable long term gene expression
CN112575031B (zh) * 2019-09-29 2023-04-07 新乡医学院 一种遍在染色质开放表达元件、重组表达载体、表达系统及其制备方法、应用
CN116574735B (zh) * 2023-07-03 2023-11-10 艾米能斯(苏州)生物科技有限公司 一种多核苷酸及其应用

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AU5053499A (en) 2000-02-14
EP1098986A2 (en) 2001-05-16
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WO2000005393A3 (en) 2000-08-17
KR100795626B1 (ko) 2008-01-17
CA2333852C (en) 2007-05-29
JP2008109931A (ja) 2008-05-15
KR20070108336A (ko) 2007-11-09
CN1334878A (zh) 2002-02-06
JP2002522027A (ja) 2002-07-23
KR20010083131A (ko) 2001-08-31
JP2005052149A (ja) 2005-03-03
KR20090117675A (ko) 2009-11-12
CA2333852A1 (en) 2000-02-03
JP2009102331A (ja) 2009-05-14
EP2348118A1 (en) 2011-07-27
AU771111B2 (en) 2004-03-11
CN100365127C (zh) 2008-01-30
MXPA01000830A (es) 2002-06-04
EP1098986B1 (en) 2011-12-28
HK1035740A1 (en) 2001-12-07

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