JP2002522027A5 - - Google Patents
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- JP2002522027A5 JP2002522027A5 JP2000561339A JP2000561339A JP2002522027A5 JP 2002522027 A5 JP2002522027 A5 JP 2002522027A5 JP 2000561339 A JP2000561339 A JP 2000561339A JP 2000561339 A JP2000561339 A JP 2000561339A JP 2002522027 A5 JP2002522027 A5 JP 2002522027A5
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- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9815879.3A GB9815879D0 (en) | 1998-07-21 | 1998-07-21 | A polynucleotide |
| US10768898P | 1998-11-09 | 1998-11-09 | |
| US60/107,688 | 1998-11-09 | ||
| GBGB9906712.6A GB9906712D0 (en) | 1999-03-23 | 1999-03-23 | A polynucleotide |
| US12741099P | 1999-04-01 | 1999-04-01 | |
| US60/127,410 | 1999-04-01 | ||
| GBGB9909494.8A GB9909494D0 (en) | 1999-04-23 | 1999-04-23 | A plasmid |
| US13401699P | 1999-05-12 | 1999-05-12 | |
| US60/134,016 | 1999-05-12 | ||
| US9815879.3 | 1999-05-12 | ||
| US9909494.8 | 1999-05-12 | ||
| US9906712.6 | 1999-05-12 | ||
| PCT/GB1999/002357 WO2000005393A2 (en) | 1998-07-21 | 1999-07-21 | A polynucleotide comprising a ubiquitous chromatin opening element (ucoe) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004293969A Division JP2005052149A (ja) | 1998-07-21 | 2004-10-06 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002522027A JP2002522027A (ja) | 2002-07-23 |
| JP2002522027A5 true JP2002522027A5 (https=) | 2005-11-17 |
| JP4220673B2 JP4220673B2 (ja) | 2009-02-04 |
Family
ID=27547316
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000561339A Expired - Lifetime JP4220673B2 (ja) | 1998-07-21 | 1999-07-21 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
| JP2004293969A Pending JP2005052149A (ja) | 1998-07-21 | 2004-10-06 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
| JP2007285560A Withdrawn JP2008109931A (ja) | 1998-07-21 | 2007-11-01 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
| JP2008305611A Withdrawn JP2009102331A (ja) | 1998-07-21 | 2008-11-28 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004293969A Pending JP2005052149A (ja) | 1998-07-21 | 2004-10-06 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
| JP2007285560A Withdrawn JP2008109931A (ja) | 1998-07-21 | 2007-11-01 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
| JP2008305611A Withdrawn JP2009102331A (ja) | 1998-07-21 | 2008-11-28 | 遍在性クロマチンオープニングエレメント（ｕｃｏｅ）を含むポリヌクレオチド |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1098986B1 (https=) |
| JP (4) | JP4220673B2 (https=) |
| KR (3) | KR100795626B1 (https=) |
| CN (1) | CN100365127C (https=) |
| AU (1) | AU771111B2 (https=) |
| CA (1) | CA2333852C (https=) |
| MX (1) | MXPA01000830A (https=) |
| WO (1) | WO2000005393A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100996016B1 (ko) | 2000-09-20 | 2010-11-22 | 밀리포어 코포레이션 | 폴리뉴클레오티드 |
| DK1395669T3 (da) | 2001-01-26 | 2009-11-16 | Selexis Sa | Matriks bindingsregioner og fremgangsmåder til anvendelse af disse |
| ES2387951T3 (es) * | 2001-04-05 | 2012-10-04 | Emd Millipore Corporation | Expresión génica mejorada |
| JP2005500019A (ja) * | 2001-04-05 | 2005-01-06 | エムエル ラボラトリーズ ピーエルシー | 改良された遺伝子発現 |
| US7812148B2 (en) | 2001-04-05 | 2010-10-12 | Millipore Corporation | Vectors comprising CpG islands without position effect varigation and having increased expression |
| HUP0402659A3 (en) | 2001-05-30 | 2008-07-28 | Glaxo Group Ltd | Chromosome-based platforms |
| KR20040032105A (ko) * | 2001-06-04 | 2004-04-14 | 엠엘 래보러토리즈 피엘씨 | 재조합 단백질의 조성물 및 재조합 단백질의 고수준대규모 생산방법 |
| PT1600510E (pt) | 2001-07-04 | 2007-06-25 | Chromagenics Bv | Sequências de adn com actividade anti-repressora. |
| DE60329366D1 (de) | 2002-01-09 | 2009-11-05 | Univ Erasmus Medical Ct | Induktierbare transposition beim transgenen organismus mit transposon-vektor |
| CA2489475C (en) | 2002-06-14 | 2011-03-29 | Chromagenics B.V. | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
| WO2003106674A2 (en) | 2002-06-14 | 2003-12-24 | Chromagenics B.V. | Means and methods for regulating gene expression |
| ATE524559T1 (de) | 2002-12-18 | 2011-09-15 | Chromagenics Bv | Methode zur verbesserung der proteinproduktion |
| ATE354645T1 (de) | 2002-12-20 | 2007-03-15 | Chromagenics Bv | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
| US9057079B2 (en) | 2003-02-01 | 2015-06-16 | Emd Millipore Corporation | Expression elements |
| KR101269656B1 (ko) | 2003-10-24 | 2013-05-30 | 셀렉시스 에스. 에이. | Ｍａｒ 서열의 복합 트랜스펙션 방법에 의한 포유동물 세포에서의 고효율 유전자 전달 및 발현 |
| WO2005065348A2 (en) | 2003-12-31 | 2005-07-21 | Kalobios, Inc. | Transactivation system for mammalian cells |
| EA014182B1 (ru) | 2004-07-20 | 2010-10-29 | Симфоген А/С | КОМПОЗИЦИЯ ПОЛИКЛОНАЛЬНЫХ АНТИ-RhD АНТИТЕЛ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ КОМПОЗИЦИИ |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| KR101271884B1 (ko) | 2004-11-08 | 2013-06-05 | 크로마제닉스 비.브이. | 고수준으로 단백질을 발현하는 숙주세포의 선택 |
| ES2384391T3 (es) | 2004-11-08 | 2012-07-04 | Chromagenics B.V. | Selección de células hospedantes que expresan proteína a altos niveles |
| GB0504587D0 (en) | 2005-03-05 | 2005-04-13 | Ml Lab Plc | Vectors comprising guinea pig CMV regulatory elements |
| GB0509965D0 (en) | 2005-05-17 | 2005-06-22 | Ml Lab Plc | Improved expression elements |
| WO2007081336A1 (en) * | 2006-01-13 | 2007-07-19 | Five Prime Therapeutics, Inc. | Mammalian vectors for high-level expression of recombinant proteins |
| US7968700B2 (en) | 2006-03-20 | 2011-06-28 | Chromagenics B.V. | Expression augmenting DNA fragments, use thereof, and methods for finding thereof |
| JP2010525789A (ja) * | 2007-01-08 | 2010-07-29 | ミリポア・コーポレイション | １つ又はそれ以上のきょう雑物の低下したレベルの存在下で組換えタンパク質を生産するための細胞培養法 |
| CN104531699B (zh) * | 2014-10-09 | 2017-03-15 | 河南农业大学 | 一种增强外源基因表达的猪的ucoe调控元件片段 |
| AU2015367290A1 (en) * | 2014-12-16 | 2017-05-11 | Garvan Institute Of Medical Research | Sequencing controls |
| EP3601542A4 (en) * | 2017-03-19 | 2021-01-13 | Applied Stemcell, Inc. | NEW INTEGRATION SITES AND THEIR USES |
| CA3056796A1 (en) | 2017-04-03 | 2018-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for multiplexed quantitative analysis of cell lineages |
| US20200385754A1 (en) * | 2017-12-07 | 2020-12-10 | Integrity Biosolutions, Llc | Engineered ubiquitous chromatin opening elements and uses thereof |
| US11781146B2 (en) * | 2018-05-24 | 2023-10-10 | National University Corporation Hokkaido University | Vector including a translation-impaired dihydrofolate reductase gene cassette and ubiquitously acting chromatin opening element |
| SG11202100765UA (en) | 2018-08-15 | 2021-03-30 | Illumina Inc | Compositions and methods for improving library enrichment |
| GB2592776B (en) * | 2018-10-02 | 2023-08-16 | Univ Leland Stanford Junior | Compositions and methods for multiplexed quantitative analysis of cell lineages |
| WO2020223160A1 (en) * | 2019-04-30 | 2020-11-05 | Chan Zuckerberg Biohub, Inc. | A novel chromatin-opening element for stable long term gene expression |
| CN112575031B (zh) * | 2019-09-29 | 2023-04-07 | 新乡医学院 | 一种遍在染色质开放表达元件、重组表达载体、表达系统及其制备方法、应用 |
| CN116574735B (zh) * | 2023-07-03 | 2023-11-10 | 艾米能斯(苏州)生物科技有限公司 | 一种多核苷酸及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| GB8718779D0 (en) | 1987-08-07 | 1987-09-16 | Grosveld F G | Dna sequence & expression vector |
| EP0945515A3 (en) | 1989-11-06 | 2002-08-21 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
| EP0532525B1 (de) | 1990-05-18 | 1995-08-16 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Neue protein-polykation-konjugate |
| WO1991018088A1 (en) | 1990-05-23 | 1991-11-28 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Adeno-associated virus (aav)-based eucaryotic vectors |
| GB9109928D0 (en) | 1991-05-08 | 1991-07-03 | Interox Chemicals Ltd | Thickened compositions |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| CA2131620A1 (en) | 1992-03-20 | 1993-09-30 | Louis C. Smith | A dna transporter system and method of use |
| US5583009A (en) | 1992-12-08 | 1996-12-10 | University Of Washington | Method of preparing recombinant proteins in transgenic animals containing metallothionein gene elements that bestow tissue-independent copy number-dependent, position-indepedent gene expression |
| US5578475A (en) | 1993-07-12 | 1996-11-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
| EP0831922A2 (en) | 1995-06-08 | 1998-04-01 | Therexsys Limited | Improved pharmaceutical compositions for gene therapy |
| JP2000516472A (ja) | 1996-08-16 | 2000-12-12 | メディカル リサーチ カウンシル | 組織特異的遺伝子発現を与える自己複製型エピソーム性発現ベクター |
| DE19651443A1 (de) * | 1996-12-11 | 1998-06-18 | Hoechst Ag | Selbstverstärkende, pharmakologisch kontrollierbare Expressionssysteme |
| AU749113B2 (en) | 1997-02-12 | 2002-06-20 | Innovata Plc | Compositions and methods for highly efficient transfection |
-
1999
- 1999-07-21 AU AU50534/99A patent/AU771111B2/en not_active Expired
- 1999-07-21 MX MXPA01000830A patent/MXPA01000830A/es not_active IP Right Cessation
- 1999-07-21 EP EP99934910A patent/EP1098986B1/en not_active Expired - Lifetime
- 1999-07-21 CN CNB998111554A patent/CN100365127C/zh not_active Expired - Lifetime
- 1999-07-21 CA CA002333852A patent/CA2333852C/en not_active Expired - Lifetime
- 1999-07-21 JP JP2000561339A patent/JP4220673B2/ja not_active Expired - Lifetime
- 1999-07-21 WO PCT/GB1999/002357 patent/WO2000005393A2/en not_active Ceased
- 1999-07-21 EP EP10183981A patent/EP2348118A1/en not_active Withdrawn
- 1999-07-21 KR KR1020017000883A patent/KR100795626B1/ko not_active Expired - Lifetime
-
2004
- 2004-10-06 JP JP2004293969A patent/JP2005052149A/ja active Pending
-
2007
- 2007-10-15 KR KR1020070103583A patent/KR20070108336A/ko not_active Ceased
- 2007-11-01 JP JP2007285560A patent/JP2008109931A/ja not_active Withdrawn
-
2008
- 2008-11-28 JP JP2008305611A patent/JP2009102331A/ja not_active Withdrawn
-
2009
- 2009-09-30 KR KR1020090093097A patent/KR20090117675A/ko not_active Ceased