JP4190586B2 - 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 - Google Patents
抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 Download PDFInfo
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- JP4190586B2 JP4190586B2 JP51087698A JP51087698A JP4190586B2 JP 4190586 B2 JP4190586 B2 JP 4190586B2 JP 51087698 A JP51087698 A JP 51087698A JP 51087698 A JP51087698 A JP 51087698A JP 4190586 B2 JP4190586 B2 JP 4190586B2
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- Prior art keywords
- calcium
- phosphate
- dental composition
- gel
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000000499 gel Substances 0.000 title claims abstract description 62
- 239000000606 toothpaste Substances 0.000 title claims abstract description 47
- 239000000551 dentifrice Substances 0.000 title claims abstract description 43
- 229940034610 toothpaste Drugs 0.000 title claims description 34
- 235000009508 confectionery Nutrition 0.000 title abstract description 91
- 235000015218 chewing gum Nutrition 0.000 title abstract description 37
- 230000000675 anti-caries Effects 0.000 title abstract 2
- 229940112822 chewing gum Drugs 0.000 title description 28
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 82
- 239000011575 calcium Substances 0.000 claims abstract description 65
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 53
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 53
- 239000000203 mixture Substances 0.000 claims abstract description 51
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 12
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 12
- 229910019142 PO4 Inorganic materials 0.000 claims description 52
- 229940043430 calcium compound Drugs 0.000 claims description 50
- 239000010452 phosphate Substances 0.000 claims description 50
- 150000001674 calcium compounds Chemical class 0.000 claims description 49
- 150000001875 compounds Chemical class 0.000 claims description 28
- 210000003296 saliva Anatomy 0.000 claims description 27
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 25
- 229910001424 calcium ion Inorganic materials 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 19
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 18
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 18
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 18
- 230000007935 neutral effect Effects 0.000 claims description 18
- 159000000007 calcium salts Chemical class 0.000 claims description 14
- 239000011734 sodium Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Chemical class OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 9
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 9
- 239000011737 fluorine Substances 0.000 claims description 9
- 229910052731 fluorine Inorganic materials 0.000 claims description 9
- 239000001530 fumaric acid Chemical class 0.000 claims description 9
- 235000011087 fumaric acid Nutrition 0.000 claims description 9
- 239000000174 gluconic acid Chemical class 0.000 claims description 9
- 235000012208 gluconic acid Nutrition 0.000 claims description 9
- 239000004310 lactic acid Chemical class 0.000 claims description 9
- 235000014655 lactic acid Nutrition 0.000 claims description 9
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical class OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 9
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Chemical class OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 9
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 8
- 239000013078 crystal Substances 0.000 claims description 7
- 239000003966 growth inhibitor Substances 0.000 claims description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 3
- 235000010980 cellulose Nutrition 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 238000013268 sustained release Methods 0.000 claims description 3
- 239000012730 sustained-release form Substances 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 2
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229910004261 CaF 2 Inorganic materials 0.000 claims 1
- 229910008449 SnF 2 Inorganic materials 0.000 claims 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract description 76
- 239000001506 calcium phosphate Substances 0.000 abstract description 56
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract description 48
- 235000011010 calcium phosphates Nutrition 0.000 abstract description 48
- 208000002925 dental caries Diseases 0.000 abstract description 29
- 239000000654 additive Substances 0.000 abstract description 22
- 238000009472 formulation Methods 0.000 abstract description 13
- 239000003795 chemical substances by application Substances 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 9
- 210000000214 mouth Anatomy 0.000 abstract description 9
- 229930006000 Sucrose Natural products 0.000 abstract description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract description 7
- 230000003902 lesion Effects 0.000 abstract description 7
- 239000005720 sucrose Substances 0.000 abstract description 7
- 210000004268 dentin Anatomy 0.000 abstract description 6
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract description 4
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract description 4
- 208000002064 Dental Plaque Diseases 0.000 abstract description 3
- 210000003298 dental enamel Anatomy 0.000 abstract description 3
- 210000005239 tubule Anatomy 0.000 abstract description 3
- 230000008439 repair process Effects 0.000 abstract description 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 230000001013 cariogenic effect Effects 0.000 abstract 1
- 229920000591 gum Polymers 0.000 description 62
- 229960005069 calcium Drugs 0.000 description 49
- 235000021317 phosphate Nutrition 0.000 description 43
- 229910052500 inorganic mineral Inorganic materials 0.000 description 32
- 235000010755 mineral Nutrition 0.000 description 32
- 239000011707 mineral Substances 0.000 description 32
- 230000002378 acidificating effect Effects 0.000 description 18
- ZBZJARSYCHAEND-UHFFFAOYSA-L calcium;dihydrogen phosphate;hydrate Chemical compound O.[Ca+2].OP(O)([O-])=O.OP(O)([O-])=O ZBZJARSYCHAEND-UHFFFAOYSA-L 0.000 description 16
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 14
- 230000000694 effects Effects 0.000 description 12
- -1 calcium phosphate compound Chemical class 0.000 description 9
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 9
- 230000000996 additive effect Effects 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 7
- 230000001055 chewing effect Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000003449 preventive effect Effects 0.000 description 7
- LFULEKSKNZEWOE-UHFFFAOYSA-N propanil Chemical compound CCC(=O)NC1=CC=C(Cl)C(Cl)=C1 LFULEKSKNZEWOE-UHFFFAOYSA-N 0.000 description 7
- 230000009469 supplementation Effects 0.000 description 7
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- 235000003599 food sweetener Nutrition 0.000 description 6
- 239000003349 gelling agent Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 6
- 239000003765 sweetening agent Substances 0.000 description 6
- 239000001736 Calcium glycerylphosphate Substances 0.000 description 5
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 5
- 229940095618 calcium glycerophosphate Drugs 0.000 description 5
- 235000019299 calcium glycerylphosphate Nutrition 0.000 description 5
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 5
- 238000000151 deposition Methods 0.000 description 5
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium phosphate dihydrate Substances O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 5
- 239000006072 paste Substances 0.000 description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 4
- 101000801619 Homo sapiens Long-chain-fatty-acid-CoA ligase ACSBG1 Proteins 0.000 description 4
- 102100033564 Long-chain-fatty-acid-CoA ligase ACSBG1 Human genes 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 235000010634 bubble gum Nutrition 0.000 description 4
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 4
- 239000001639 calcium acetate Substances 0.000 description 4
- 235000011092 calcium acetate Nutrition 0.000 description 4
- 229960005147 calcium acetate Drugs 0.000 description 4
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 4
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 4
- 229940038472 dicalcium phosphate Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 238000005755 formation reaction Methods 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 235000019691 monocalcium phosphate Nutrition 0.000 description 4
- 229910000150 monocalcium phosphate Inorganic materials 0.000 description 4
- 229940085991 phosphate ion Drugs 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 244000246386 Mentha pulegium Species 0.000 description 3
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- 235000004357 Mentha x piperita Nutrition 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 235000010216 calcium carbonate Nutrition 0.000 description 3
- 239000004227 calcium gluconate Substances 0.000 description 3
- 235000013927 calcium gluconate Nutrition 0.000 description 3
- 229960004494 calcium gluconate Drugs 0.000 description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 description 3
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- 239000007844 bleaching agent Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 229940041131 calcium lactate gluconate Drugs 0.000 description 1
- 235000011035 calcium tartrate Nutrition 0.000 description 1
- 239000001427 calcium tartrate Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000015111 chews Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000037123 dental health Effects 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052587 fluorapatite Inorganic materials 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- XVNVFKZODWAQKN-UHFFFAOYSA-N phosphoric acid;heptahydrate Chemical group O.O.O.O.O.O.O.OP(O)(O)=O XVNVFKZODWAQKN-UHFFFAOYSA-N 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 235000015260 sugar-free gum Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/362—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Cosmetics (AREA)
- Confectionery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/704,420 US5833954A (en) | 1996-08-20 | 1996-08-20 | Anti-carious chewing gums, candies, gels, toothpastes and dentifrices |
| US08/704,420 | 1996-08-20 | ||
| PCT/US1997/014519 WO1998007448A1 (en) | 1996-08-20 | 1997-08-19 | Anti-carious chewing gums, candies, gels, toothpastes and dentifrices |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006334369A Division JP2007145847A (ja) | 1996-08-20 | 2006-12-12 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002500504A JP2002500504A (ja) | 2002-01-08 |
| JP2002500504A5 JP2002500504A5 (enExample) | 2005-05-12 |
| JP4190586B2 true JP4190586B2 (ja) | 2008-12-03 |
Family
ID=24829402
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51087698A Expired - Lifetime JP4190586B2 (ja) | 1996-08-20 | 1997-08-19 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
| JP2006334369A Pending JP2007145847A (ja) | 1996-08-20 | 2006-12-12 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
| JP2009215669A Expired - Lifetime JP5121800B2 (ja) | 1996-08-20 | 2009-09-17 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006334369A Pending JP2007145847A (ja) | 1996-08-20 | 2006-12-12 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
| JP2009215669A Expired - Lifetime JP5121800B2 (ja) | 1996-08-20 | 2009-09-17 | 抗カリエスチューインガム、キャンディー、ゲル、練り歯磨および歯磨剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5833954A (enExample) |
| EP (1) | EP0952851B1 (enExample) |
| JP (3) | JP4190586B2 (enExample) |
| CN (1) | CN1137728C (enExample) |
| AT (1) | ATE507843T1 (enExample) |
| AU (1) | AU735193B2 (enExample) |
| BR (1) | BR9711339A (enExample) |
| DE (1) | DE69740186D1 (enExample) |
| WO (1) | WO1998007448A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8648529B2 (en) | 2009-10-29 | 2014-02-11 | Lintec Corporation | Light-emitting composition, electroluminescent sheet, and method for producing same |
| US8723410B2 (en) | 2008-05-22 | 2014-05-13 | Lintec Corporation | Luminescent composition, electroluminescent sheet using the luminescent composition, and process for producing the electroluminescent sheet |
| US8764505B2 (en) | 2008-05-22 | 2014-07-01 | Lintec Corporation | Process for producing an inorganic electroluminescent sheet |
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| US6036944A (en) * | 1995-08-08 | 2000-03-14 | Enamelon, Inc. | Processes for the remineralization and mineralization of teeth |
| US6491900B2 (en) * | 1996-08-20 | 2002-12-10 | American Dental Association Health Foundation | Anti-carious candies and confections |
| WO1998013013A1 (en) * | 1996-09-27 | 1998-04-02 | Enamelon, Inc. | Improved products and methods for the remineralization and prevention of demineralization of teeth |
| US6673380B2 (en) | 1998-11-17 | 2004-01-06 | Mcneil-Ppc, Inc. | Fortified confectionery delivery systems and methods of preparation thereof |
| AUPP494798A0 (en) * | 1998-07-29 | 1998-08-20 | Pacific Biolink Pty Limited | Protective protein formulation |
| US6582731B1 (en) * | 1998-11-25 | 2003-06-24 | Konrad Kaufmann | Hard candy with plaque-neutralizing effect comprising alkali metal monophosphate |
| AU2004201045B2 (en) * | 1999-01-26 | 2005-12-15 | Wm. Wrigley Jr. Company | Chewing Gum with Dental Health Benefits Employing Calcium Lactate |
| WO2000042861A1 (en) * | 1999-01-26 | 2000-07-27 | Wm. Wrigley Jr. Company | Chewing gum with dental health benefits employing calcium lactate |
| EP1173154A4 (en) * | 1999-04-15 | 2003-07-23 | Wrigley W M Jun Co | CHEWING GUM FOR DENTAL CARE, WHICH CONTAINS CALCIUM IN A PLEASANT ACID |
| US6482395B1 (en) * | 1999-06-01 | 2002-11-19 | Church & Dwight Co. Inc. | Remineralizing-mineralizing oral products containing discrete cationic and anionic agglomerate components and method of use |
| US6440394B2 (en) * | 1999-06-01 | 2002-08-27 | Church & Dwight, Co., Inc. | Remineralizing-mineralizing oral products containing discrete cationic and anionic agglomerate components and method of use |
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| WO2005030146A2 (en) * | 2003-09-26 | 2005-04-07 | Mc Veigh, Kevin, E. | Calcium dietary supplement |
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| BR112015032853B1 (pt) | 2013-07-19 | 2020-12-01 | Unilever Nv | produto de tratamento oral e método de remineralização de dente |
| CA2929016C (en) | 2013-11-22 | 2018-06-05 | The Procter & Gamble Company | Regimen for controlling or reducing dentine hypersensitivity |
| ITMI20132003A1 (it) * | 2013-11-29 | 2015-05-30 | Perfetti Van Melle Spa | Prodotti di confetteria con calcio fosfato |
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| AU2016282207B2 (en) * | 2015-06-26 | 2021-02-18 | Eikonic R&D Pty Ltd | Composition for the prevention of microbial growth |
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| EA038664B1 (ru) * | 2016-09-23 | 2021-09-30 | ЮНИЛЕВЕР АйПи ХОЛДИНГС Б.В. | Композиция для ухода за полостью рта |
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| CN113100323A (zh) * | 2021-04-07 | 2021-07-13 | 佛山市安齿生物科技有限公司 | 一种可变色、护齿的口香糖及其制备方法 |
| CN116023679B (zh) * | 2022-12-01 | 2024-04-23 | 中山大学附属口腔医院 | 一种温敏性缓释钙磷抗菌纳米水凝胶及其制备方法与应用 |
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-
1996
- 1996-08-20 US US08/704,420 patent/US5833954A/en not_active Expired - Lifetime
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1997
- 1997-08-19 CN CNB971988986A patent/CN1137728C/zh not_active Expired - Lifetime
- 1997-08-19 JP JP51087698A patent/JP4190586B2/ja not_active Expired - Lifetime
- 1997-08-19 DE DE69740186T patent/DE69740186D1/de not_active Expired - Lifetime
- 1997-08-19 WO PCT/US1997/014519 patent/WO1998007448A1/en not_active Ceased
- 1997-08-19 BR BR9711339-5A patent/BR9711339A/pt not_active IP Right Cessation
- 1997-08-19 AU AU40730/97A patent/AU735193B2/en not_active Expired
- 1997-08-19 AT AT97938396T patent/ATE507843T1/de not_active IP Right Cessation
- 1997-08-19 EP EP97938396A patent/EP0952851B1/en not_active Expired - Lifetime
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1998
- 1998-06-02 US US09/088,869 patent/US5993786A/en not_active Expired - Lifetime
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2006
- 2006-12-12 JP JP2006334369A patent/JP2007145847A/ja active Pending
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- 2009-09-17 JP JP2009215669A patent/JP5121800B2/ja not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8723410B2 (en) | 2008-05-22 | 2014-05-13 | Lintec Corporation | Luminescent composition, electroluminescent sheet using the luminescent composition, and process for producing the electroluminescent sheet |
| US8764505B2 (en) | 2008-05-22 | 2014-07-01 | Lintec Corporation | Process for producing an inorganic electroluminescent sheet |
| US8648529B2 (en) | 2009-10-29 | 2014-02-11 | Lintec Corporation | Light-emitting composition, electroluminescent sheet, and method for producing same |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010047575A (ja) | 2010-03-04 |
| AU4073097A (en) | 1998-03-06 |
| WO1998007448A1 (en) | 1998-02-26 |
| EP0952851B1 (en) | 2011-05-04 |
| JP5121800B2 (ja) | 2013-01-16 |
| JP2002500504A (ja) | 2002-01-08 |
| EP0952851A1 (en) | 1999-11-03 |
| CN1233964A (zh) | 1999-11-03 |
| ATE507843T1 (de) | 2011-05-15 |
| US5993786A (en) | 1999-11-30 |
| EP0952851A4 (en) | 2002-11-13 |
| CN1137728C (zh) | 2004-02-11 |
| BR9711339A (pt) | 2000-10-24 |
| US5833954A (en) | 1998-11-10 |
| JP2007145847A (ja) | 2007-06-14 |
| AU735193B2 (en) | 2001-07-05 |
| DE69740186D1 (de) | 2011-06-16 |
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