JP4136017B2 - 粒子分析装置 - Google Patents
粒子分析装置 Download PDFInfo
- Publication number
- JP4136017B2 JP4136017B2 JP24758796A JP24758796A JP4136017B2 JP 4136017 B2 JP4136017 B2 JP 4136017B2 JP 24758796 A JP24758796 A JP 24758796A JP 24758796 A JP24758796 A JP 24758796A JP 4136017 B2 JP4136017 B2 JP 4136017B2
- Authority
- JP
- Japan
- Prior art keywords
- unit
- particles
- reference pattern
- output
- distribution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 title claims description 43
- 238000010586 diagram Methods 0.000 claims description 102
- 230000002159 abnormal effect Effects 0.000 claims description 21
- 238000001514 detection method Methods 0.000 claims description 13
- 210000000601 blood cell Anatomy 0.000 description 29
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- 210000000265 leukocyte Anatomy 0.000 description 14
- 238000005259 measurement Methods 0.000 description 13
- 210000003714 granulocyte Anatomy 0.000 description 10
- 239000011148 porous material Substances 0.000 description 9
- 210000003651 basophil Anatomy 0.000 description 8
- 210000003743 erythrocyte Anatomy 0.000 description 8
- 210000004698 lymphocyte Anatomy 0.000 description 8
- 210000001616 monocyte Anatomy 0.000 description 7
- 210000000805 cytoplasm Anatomy 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000001772 blood platelet Anatomy 0.000 description 2
- 210000003979 eosinophil Anatomy 0.000 description 2
- 238000013139 quantization Methods 0.000 description 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003219 hemolytic agent Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24758796A JP4136017B2 (ja) | 1996-09-19 | 1996-09-19 | 粒子分析装置 |
| US08/932,601 US6246786B1 (en) | 1996-09-19 | 1997-09-17 | Particle analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24758796A JP4136017B2 (ja) | 1996-09-19 | 1996-09-19 | 粒子分析装置 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006102590A Division JP4448831B2 (ja) | 2006-04-03 | 2006-04-03 | 粒子分析装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH1090156A JPH1090156A (ja) | 1998-04-10 |
| JPH1090156A5 JPH1090156A5 (enExample) | 2004-09-16 |
| JP4136017B2 true JP4136017B2 (ja) | 2008-08-20 |
Family
ID=17165731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24758796A Expired - Lifetime JP4136017B2 (ja) | 1996-09-19 | 1996-09-19 | 粒子分析装置 |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US6246786B1 (enExample) |
| JP (1) | JP4136017B2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6592822B1 (en) * | 1998-05-14 | 2003-07-15 | Luminex Corporation | Multi-analyte diagnostic system and computer implemented process for same |
| JP4708605B2 (ja) * | 2000-07-24 | 2011-06-22 | シスメックス株式会社 | 粒子分析装置とその粒子分画方法 |
| US6535836B1 (en) * | 2000-09-29 | 2003-03-18 | Coulter International Corp. | Method for the analysis of abnormal particle populations |
| US6979570B2 (en) * | 2001-07-26 | 2005-12-27 | Sysmex Corporation | Particle analyzer and particle analyzing method |
| JP4751535B2 (ja) * | 2001-07-26 | 2011-08-17 | シスメックス株式会社 | 分画方法とそれを用いた血液分析装置 |
| US6916658B2 (en) * | 2001-07-27 | 2005-07-12 | Beckman Coulter, Inc. | Method for measurement of immature granulocytes |
| US20050058330A1 (en) * | 2003-09-16 | 2005-03-17 | Sysmex Corporation | Method of displaying smear image and retrieving method employing the same, surveillance method, system of displaying smear image, program for displaying smear image and recording medium recording the program |
| US7352900B2 (en) * | 2003-10-22 | 2008-04-01 | Sysmex Corporation | Apparatus and method for processing particle images and program product for same |
| US7697764B2 (en) * | 2003-11-21 | 2010-04-13 | National University Corporation Kochi University | Similar pattern searching apparatus, method of similar pattern searching, program for similar pattern searching, and fractionation apparatus |
| US7792611B2 (en) * | 2004-10-01 | 2010-09-07 | Ingo Werner Scheer | Spray pattern characterization and monitoring method and system |
| US20070248943A1 (en) * | 2006-04-21 | 2007-10-25 | Beckman Coulter, Inc. | Displaying cellular analysis result data using a template |
| US8217943B2 (en) * | 2006-04-21 | 2012-07-10 | Beckman Coulter, Inc. | Displaying cellular analysis result data using a template |
| US20070250548A1 (en) * | 2006-04-21 | 2007-10-25 | Beckman Coulter, Inc. | Systems and methods for displaying a cellular abnormality |
| US9322834B2 (en) | 2007-05-30 | 2016-04-26 | Sysmex Corporation | Sample analyzer, blood analyzer and displaying method |
| JP5006107B2 (ja) * | 2007-05-30 | 2012-08-22 | シスメックス株式会社 | 表示方法および血液分析装置 |
| JP5350611B2 (ja) * | 2007-06-28 | 2013-11-27 | シスメックス株式会社 | 表示方法および試料分析装置 |
| US20100220315A1 (en) * | 2009-02-27 | 2010-09-02 | Beckman Coulter, Inc. | Stabilized Optical System for Flow Cytometry |
| JP2011075340A (ja) * | 2009-09-29 | 2011-04-14 | Sysmex Corp | 粒子分析装置およびコンピュータプログラム |
| JP2014106161A (ja) * | 2012-11-28 | 2014-06-09 | Horiba Ltd | 血液細胞に関するスキャッターグラムの表示装置、表示方法、および、該表示装置を有する血液分析装置 |
| US9939453B2 (en) | 2012-12-31 | 2018-04-10 | Beckman Coulter, Inc. | Immature platelet enumeration systems and methods |
| CN103926187B (zh) * | 2014-03-20 | 2016-04-06 | 深圳市帝迈生物技术有限公司 | 基于参数截断的参数输出方法和系统及血液细胞分析仪 |
| CN105424560A (zh) * | 2015-11-24 | 2016-03-23 | 苏州创继生物科技有限公司 | 流式颗粒仪数据自动化定量分析方法 |
| JP6762494B2 (ja) * | 2016-02-29 | 2020-09-30 | 国立大学法人大阪大学 | エクソソームの形状分布の解析装置、がん検査装置、エクソソームの形状分布の解析方法、及びがん検査方法 |
| US11244452B2 (en) | 2017-10-16 | 2022-02-08 | Massachusetts Institute Of Technology | Systems, devices and methods for non-invasive hematological measurements |
| WO2021015843A1 (en) | 2019-07-24 | 2021-01-28 | Massachusetts Institute Of Technology | Finger inserts for a nailfold imaging device |
| CN115699108A (zh) | 2020-05-28 | 2023-02-03 | 露科实验室股份有限公司 | 一种从无创性毛细血管视频中检测白细胞和/或白细胞亚型的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3520316A (en) * | 1963-12-12 | 1970-07-14 | Bowles Eng Corp | Pressure-to-pressure transducer |
| US3502974A (en) * | 1966-05-23 | 1970-03-24 | Coulter Electronics | Signal modulated apparatus for generating and detecting resistive and reactive changes in a modulated current path for particle classification and analysis |
| US4485175A (en) * | 1983-01-03 | 1984-11-27 | Coulter Electronics, Inc. | Method for three-volume differential determination of lymphocyte, monocyte and granulocyte populations of leukocytes |
| US4661913A (en) * | 1984-09-11 | 1987-04-28 | Becton, Dickinson And Company | Apparatus and method for the detection and classification of articles using flow cytometry techniques |
| US5134662A (en) * | 1985-11-04 | 1992-07-28 | Cell Analysis Systems, Inc. | Dual color camera microscope and methodology for cell staining and analysis |
| US4741043B1 (en) * | 1985-11-04 | 1994-08-09 | Cell Analysis Systems Inc | Method of and apparatus for image analyses of biological specimens |
| US5260192A (en) * | 1987-03-13 | 1993-11-09 | Coulter Corporation | Method and apparatus for screening cells or formed bodies with populations expressing selected characteristics utilizing at least one sensing parameter |
| US5155044A (en) * | 1987-03-13 | 1992-10-13 | Coulter Electronics, Inc. | Lysing reagent system for isolation, identification and/or analysis of leukocytes from whole blood samples |
| KR970007077B1 (ko) * | 1987-03-13 | 1997-05-02 | 코울터 일렉트로닉스 인커퍼레이티드 | 광산란 기술을 이용한 다중-부분식별 분석 방법 |
| IL85532A (en) * | 1987-03-13 | 1992-03-29 | Coulter Electronics | Method and lytic reagent system for isolation,identification and/or analysis of leukocytes from whole blood samples |
| US5047930A (en) * | 1987-06-26 | 1991-09-10 | Nicolet Instrument Corporation | Method and system for analysis of long term physiological polygraphic recordings |
| US5123055A (en) * | 1989-08-10 | 1992-06-16 | International Remote Imaging Systems, Inc. | Method and an apparatus for differentiating a sample of biological cells |
| JP3076118B2 (ja) * | 1991-11-27 | 2000-08-14 | シスメックス株式会社 | 粒子計数方法 |
| JPH06186156A (ja) * | 1992-10-21 | 1994-07-08 | Toa Medical Electronics Co Ltd | 粒子分析装置 |
| JP3213097B2 (ja) * | 1992-12-28 | 2001-09-25 | シスメックス株式会社 | 粒子分析装置及び方法 |
| CA2166464C (en) * | 1993-07-09 | 2002-01-01 | Louis A. Kamentsky | Computerized microscope specimen encoder |
| JPH0785168A (ja) | 1993-09-10 | 1995-03-31 | Toa Medical Electronics Co Ltd | 臨床検査結果用表示装置 |
| JP3411112B2 (ja) * | 1994-11-04 | 2003-05-26 | シスメックス株式会社 | 粒子画像分析装置 |
| DE69530367T2 (de) * | 1995-03-06 | 2004-02-19 | Perkin-Elmer Ltd., Beaconsfield | Kontrolle eines Mikroskopprobenträgers |
| JP3504029B2 (ja) * | 1995-07-04 | 2004-03-08 | シスメックス株式会社 | 粒子分析装置 |
| JP3308441B2 (ja) * | 1995-12-19 | 2002-07-29 | シスメックス株式会社 | 尿中有形成分分析装置 |
-
1996
- 1996-09-19 JP JP24758796A patent/JP4136017B2/ja not_active Expired - Lifetime
-
1997
- 1997-09-17 US US08/932,601 patent/US6246786B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH1090156A (ja) | 1998-04-10 |
| US6246786B1 (en) | 2001-06-12 |
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