JP4087496B2 - センサ、液体試料中の酵素基質の濃度決定及び検出方法、ならびにポリ塩化ビニル共重合体の使用 - Google Patents
センサ、液体試料中の酵素基質の濃度決定及び検出方法、ならびにポリ塩化ビニル共重合体の使用 Download PDFInfo
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- JP4087496B2 JP4087496B2 JP10754398A JP10754398A JP4087496B2 JP 4087496 B2 JP4087496 B2 JP 4087496B2 JP 10754398 A JP10754398 A JP 10754398A JP 10754398 A JP10754398 A JP 10754398A JP 4087496 B2 JP4087496 B2 JP 4087496B2
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- Prior art keywords
- enzyme
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- coating film
- enzyme substrate
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT664/97 | 1997-04-17 | ||
| AT0066497A AT404992B (de) | 1997-04-17 | 1997-04-17 | Sensor zur bestimmung eines enzymsubstrates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH1151894A JPH1151894A (ja) | 1999-02-26 |
| JPH1151894A5 JPH1151894A5 (enExample) | 2005-09-22 |
| JP4087496B2 true JP4087496B2 (ja) | 2008-05-21 |
Family
ID=3496573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10754398A Expired - Fee Related JP4087496B2 (ja) | 1997-04-17 | 1998-04-17 | センサ、液体試料中の酵素基質の濃度決定及び検出方法、ならびにポリ塩化ビニル共重合体の使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6214185B1 (enExample) |
| EP (1) | EP0872729B2 (enExample) |
| JP (1) | JP4087496B2 (enExample) |
| AT (1) | AT404992B (enExample) |
| DE (1) | DE59812949D1 (enExample) |
Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
| US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US7657297B2 (en) * | 2004-05-03 | 2010-02-02 | Dexcom, Inc. | Implantable analyte sensor |
| US7899511B2 (en) | 2004-07-13 | 2011-03-01 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
| DE59814359D1 (de) | 1997-09-26 | 2009-05-28 | Sphere Medical Ltd | Mikrostrukturierter biosensor, verwendung des biosensors und verfahren zur immobilisierung von biokatalysatoren |
| US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| KR100349000B1 (ko) * | 1998-07-09 | 2003-03-26 | 주식회사 아이센스 | 친수성폴리우레탄을사용한바이오센서의제조방법 |
| AT409798B (de) * | 1998-11-19 | 2002-11-25 | Hoffmann La Roche | Elektrodensystem |
| GB9916522D0 (en) * | 1999-07-15 | 1999-09-15 | Univ Manchester | Polymeric compositions and sensor devices |
| EP1292823A1 (en) | 2000-05-23 | 2003-03-19 | Radiometer Medical A/S | A sensor membrane, a method for the preparation thereof, a sensor and a layered membrane structure for such sensor |
| US6793789B2 (en) * | 2000-09-30 | 2004-09-21 | Geun Sig Cha | Reference electrode with a polymeric reference electrode membrane |
| US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US7041468B2 (en) | 2001-04-02 | 2006-05-09 | Therasense, Inc. | Blood glucose tracking apparatus and methods |
| US6652720B1 (en) * | 2001-05-31 | 2003-11-25 | Instrumentation Laboratory Company | Analytical instruments, biosensors and methods thereof |
| US6872297B2 (en) * | 2001-05-31 | 2005-03-29 | Instrumentation Laboratory Company | Analytical instruments, biosensors and methods thereof |
| US6960466B2 (en) * | 2001-05-31 | 2005-11-01 | Instrumentation Laboratory Company | Composite membrane containing a cross-linked enzyme matrix for a biosensor |
| CN1300578C (zh) | 2001-07-27 | 2007-02-14 | 爱科来株式会社 | 分析用具 |
| US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
| US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
| US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
| US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
| US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US9282925B2 (en) | 2002-02-12 | 2016-03-15 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US8010174B2 (en) * | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US7422903B2 (en) * | 2002-12-11 | 2008-09-09 | Instrumentation Laboratory Company | Multi-analyte reference solutions |
| US20040154933A1 (en) * | 2003-02-11 | 2004-08-12 | Instrumentation Laboratory Company | Polymeric membranes for use in electrochemical sensors |
| US20040256227A1 (en) * | 2003-02-11 | 2004-12-23 | Jungwon Shin | Electrochemical urea sensors and methods of making the same |
| US7875293B2 (en) | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
| EP1502957B1 (en) * | 2003-07-11 | 2008-08-27 | F. Hoffmann-La Roche Ag | Castable diffusion membrane for enzyme-based sensor application |
| CA2473069C (en) * | 2003-07-11 | 2014-03-18 | F. Hoffmann-La Roche Ag | Castable diffusion membrane for enzyme-based sensor application |
| US8282549B2 (en) | 2003-12-09 | 2012-10-09 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
| WO2007120442A2 (en) * | 2003-07-25 | 2007-10-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7460898B2 (en) * | 2003-12-05 | 2008-12-02 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US20050176136A1 (en) * | 2003-11-19 | 2005-08-11 | Dexcom, Inc. | Afinity domain for analyte sensor |
| US7424318B2 (en) | 2003-12-05 | 2008-09-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7366556B2 (en) | 2003-12-05 | 2008-04-29 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7467003B2 (en) * | 2003-12-05 | 2008-12-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US20070173710A1 (en) * | 2005-04-08 | 2007-07-26 | Petisce James R | Membranes for an analyte sensor |
| WO2005012871A2 (en) * | 2003-07-25 | 2005-02-10 | Dexcom, Inc. | Increasing bias for oxygen production in an electrode system |
| US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| US8788006B2 (en) | 2003-08-01 | 2014-07-22 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US6931327B2 (en) | 2003-08-01 | 2005-08-16 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| US8160669B2 (en) | 2003-08-01 | 2012-04-17 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7955261B2 (en) | 2003-08-01 | 2011-06-07 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US8761856B2 (en) | 2003-08-01 | 2014-06-24 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US8275437B2 (en) | 2003-08-01 | 2012-09-25 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8845536B2 (en) | 2003-08-01 | 2014-09-30 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7774145B2 (en) | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| US7519408B2 (en) | 2003-11-19 | 2009-04-14 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
| US9135402B2 (en) | 2007-12-17 | 2015-09-15 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8369919B2 (en) | 2003-08-01 | 2013-02-05 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US8233959B2 (en) | 2003-08-22 | 2012-07-31 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US20050090607A1 (en) * | 2003-10-28 | 2005-04-28 | Dexcom, Inc. | Silicone composition for biocompatible membrane |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| EP2256493B1 (en) | 2003-12-05 | 2014-02-26 | DexCom, Inc. | Calibration techniques for a continuous analyte sensor |
| ATE474219T1 (de) * | 2003-12-08 | 2010-07-15 | Dexcom Inc | Systeme und verfahren zur verbesserung elektrochemischer analytsensoren |
| US7637868B2 (en) | 2004-01-12 | 2009-12-29 | Dexcom, Inc. | Composite material for implantable device |
| US20050182451A1 (en) * | 2004-01-12 | 2005-08-18 | Adam Griffin | Implantable device with improved radio frequency capabilities |
| US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8277713B2 (en) | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
| US7946984B2 (en) | 2004-07-13 | 2011-05-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8886272B2 (en) | 2004-07-13 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| US8565848B2 (en) | 2004-07-13 | 2013-10-22 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7905833B2 (en) | 2004-07-13 | 2011-03-15 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8097725B2 (en) * | 2004-12-03 | 2012-01-17 | Roche Diagnostics Operations, Inc. | Luminescent indicator dye and optical sensor |
| US20060121547A1 (en) * | 2004-12-03 | 2006-06-08 | Mcintire Mark | Diffusion layer for an enzyme-based sensor application |
| WO2006110193A2 (en) | 2005-04-08 | 2006-10-19 | Dexcom, Inc. | Cellulosic-based interference domain for an analyte sensor |
| US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
| WO2006121661A2 (en) * | 2005-05-05 | 2006-11-16 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
| RU2423073C2 (ru) * | 2005-07-14 | 2011-07-10 | Нано-Дайтек Корпорейшн | Микрофлюидные устройства и способы их подготовки и применения |
| US9757061B2 (en) | 2006-01-17 | 2017-09-12 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| ES2871822T3 (es) | 2006-02-22 | 2021-11-02 | Dexcom Inc | Sensor de analito |
| EP4218548A1 (en) | 2006-03-09 | 2023-08-02 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US20080071158A1 (en) | 2006-06-07 | 2008-03-20 | Abbott Diabetes Care, Inc. | Analyte monitoring system and method |
| US7831287B2 (en) * | 2006-10-04 | 2010-11-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7807143B2 (en) * | 2006-10-18 | 2010-10-05 | Research Development Foundation | Alpha-MSH therapies for treatment of autoimmune disease |
| EP2129285B1 (en) | 2007-03-26 | 2014-07-23 | Dexcom, Inc. | Analyte sensor |
| US20200037875A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| EP2152350A4 (en) | 2007-06-08 | 2013-03-27 | Dexcom Inc | INTEGRATED MEDICATION RELEASE DEVICE WITH CONTINUOUS ANALYTICAL SENSOR |
| EP2227132B1 (en) | 2007-10-09 | 2023-03-08 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
| US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8290559B2 (en) | 2007-12-17 | 2012-10-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8229535B2 (en) | 2008-02-21 | 2012-07-24 | Dexcom, Inc. | Systems and methods for blood glucose monitoring and alert delivery |
| EP2106784B1 (en) * | 2008-04-03 | 2015-04-22 | Rohm and Haas Company | Hair styling composition |
| WO2010033724A2 (en) | 2008-09-19 | 2010-03-25 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
| US9149220B2 (en) | 2011-04-15 | 2015-10-06 | Dexcom, Inc. | Advanced analyte sensor calibration and error detection |
| EP2448486B1 (en) | 2009-07-02 | 2021-08-25 | Dexcom, Inc. | Analyte sensors and methods of manufacturing same |
| WO2011053715A2 (en) * | 2009-10-30 | 2011-05-05 | Edwards Lifesciences Corporation | Analyte sensor layers and methods |
| JP5599012B1 (ja) | 2014-06-23 | 2014-10-01 | 国立大学法人 東京大学 | 採取部及びバイオセンサ |
| CN109790562B (zh) * | 2016-09-07 | 2023-08-15 | 豪夫迈·罗氏有限公司 | 用于测试基于酶的电化学传感器的方法 |
| EP4365912A3 (en) | 2017-01-19 | 2024-07-17 | DexCom, Inc. | Flexible analyte sensors |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| EP3700416B1 (en) | 2017-10-24 | 2024-06-26 | Dexcom, Inc. | Pre-connected analyte sensors |
| CN112240900B (zh) * | 2020-10-21 | 2022-05-06 | 南京工业大学 | 一种乳酸生物传感器的制备方法 |
| JP2022067884A (ja) * | 2020-10-21 | 2022-05-09 | 株式会社アドバンテスト | バイオセンサおよびバイオセンサ用リアクター、リアクターの製造方法 |
| AU2022238919A1 (en) | 2021-03-19 | 2023-10-19 | Dexcom, Inc. | Drug releasing membrane for analyte sensor |
| AU2022249389A1 (en) | 2021-04-02 | 2023-11-02 | Dexcom, Inc. | Personalized modeling of blood glucose concentration impacted by individualized sensor characteristics and individualized physiological characteristics |
| EP4401634A1 (en) | 2021-09-15 | 2024-07-24 | Dexcom, Inc. | Bioactive releasing membrane for analyte sensor |
| CN120936291A (zh) | 2022-03-18 | 2025-11-11 | 德克斯康公司 | 连续多分析物传感器系统 |
| US20240090802A1 (en) | 2022-09-02 | 2024-03-21 | Dexcom, Inc. | Continuous analyte sensor devices and methods |
| EP4642327A1 (en) | 2022-12-30 | 2025-11-05 | Dexcom, Inc. | Sensing systems and methods for hybrid glucose and ketone monitoring |
| US20240306956A1 (en) | 2023-03-16 | 2024-09-19 | Dexcom, Inc. | Continuous multi-analyte sensor systems |
| WO2025147486A1 (en) | 2024-01-05 | 2025-07-10 | Dexcom, Inc. | Polymers with dual functionality |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795316A (fr) | 1972-02-11 | 1973-05-29 | Nat Patent Dev Corp | Systeme catalytique presentant une activite enzymatique durable et de stabilite augmentee |
| US4214968A (en) † | 1978-04-05 | 1980-07-29 | Eastman Kodak Company | Ion-selective electrode |
| JPS56115727A (en) * | 1980-02-19 | 1981-09-11 | Kuraray Co Ltd | Carrier for immobilizing physiologically active substance |
| JPS59109175A (ja) * | 1982-12-14 | 1984-06-23 | Mitsubishi Petrochem Co Ltd | 固定化酵素およびその製造方法 |
| JPS5911183A (ja) * | 1983-06-25 | 1984-01-20 | Nippon Paint Co Ltd | 酵素固定化物およびその製造方法 |
| IL69644A (en) * | 1983-09-02 | 1986-11-30 | Univ Ramot | Enzyme electrodes and their preparation |
| JPS61274682A (ja) * | 1985-05-31 | 1986-12-04 | Nok Corp | 酵素固定化膜の製造法 |
| GB8526902D0 (en) * | 1985-10-31 | 1985-12-04 | Unilever Plc | Electrochemical analysis |
| US4757022A (en) * | 1986-04-15 | 1988-07-12 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
| US4894253A (en) * | 1986-08-12 | 1990-01-16 | University Of Cincinnati | Method for production of coated electrode |
| CA1315927C (en) * | 1986-12-10 | 1993-04-13 | Terumo Kabushiki Kaisha | Ion carrier membrane, and ion sensor having same |
| US4900449A (en) † | 1987-05-20 | 1990-02-13 | Gelman Sciences | Filtration membranes and method of making the same |
| US5540828A (en) | 1987-06-08 | 1996-07-30 | Yacynych; Alexander | Method for making electrochemical sensors and biosensors having a polymer modified surface |
| US5417835A (en) * | 1989-06-23 | 1995-05-23 | The Board Of Regents Of The University Of Michigan | Solid state ion sensor with polyimide membrane |
| GB8916633D0 (en) * | 1989-07-20 | 1989-09-06 | Health Lab Service Board | Electrochemical cell and reference electrode |
| JP2615220B2 (ja) * | 1989-11-15 | 1997-05-28 | 日機装株式会社 | 酵素センサー |
| DD294729A5 (de) * | 1990-05-28 | 1991-10-10 | Zentralinstitut Fuer Molekularbiologie,De | Verfahren zur herstellung von immobilisaten mit biologisch aktiven, makromolekularen verbindungen |
| WO1992013271A1 (en) | 1991-01-25 | 1992-08-06 | Markwell Medical Institute, Inc. | Implantable biological fluid measuring device |
| GB9105406D0 (en) * | 1991-03-14 | 1991-05-01 | Ici Plc | Sensor devices |
| JPH04301759A (ja) * | 1991-03-29 | 1992-10-26 | Nok Corp | グルコ−スバイオセンサ |
| JP2995927B2 (ja) † | 1991-06-20 | 1999-12-27 | エヌオーケー株式会社 | グルコ−スバイオセンサ |
| JP3016290B2 (ja) * | 1991-10-09 | 2000-03-06 | エヌオーケー株式会社 | グルコ−スバイオセンサ |
| US5607567A (en) * | 1992-03-10 | 1997-03-04 | The Board Of Regents Acting For And On Behalf Of University Of Michigan | Protamine-responsive polymeric membrane electrode |
| GB9215973D0 (en) * | 1992-07-28 | 1992-09-09 | Univ Manchester | Sensor devices |
| GB9215971D0 (en) * | 1992-07-28 | 1992-09-09 | Univ Manchester | Sensor devices |
| AT397513B (de) | 1992-12-15 | 1994-04-25 | Avl Verbrennungskraft Messtech | Amperometrische enzymelektrode |
| AT401653B (de) | 1994-10-05 | 1996-11-25 | Avl Verbrennungskraft Messtech | Verfahren zur immobilisierung biologischer komponenten in einer polymermatrix sowie biosensoren unter verwendung derartiger immobilisate |
| US5522977A (en) * | 1994-10-07 | 1996-06-04 | Biomedix, Inc. | Glucose sensor |
| US5840168A (en) * | 1995-06-16 | 1998-11-24 | Orion Research, Inc. | Solid contact ion-selective electrode |
| JPH09168855A (ja) * | 1995-12-21 | 1997-06-30 | Honda Motor Co Ltd | 樹脂成形用金型の製造方法および装置 |
-
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- 1998-04-16 DE DE59812949T patent/DE59812949D1/de not_active Expired - Lifetime
- 1998-04-16 US US09/061,524 patent/US6214185B1/en not_active Expired - Lifetime
- 1998-04-17 JP JP10754398A patent/JP4087496B2/ja not_active Expired - Fee Related
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|---|---|
| EP0872729A1 (de) | 1998-10-21 |
| DE59812949D1 (de) | 2005-09-01 |
| US6214185B1 (en) | 2001-04-10 |
| EP0872729B1 (de) | 2005-07-27 |
| AT404992B (de) | 1999-04-26 |
| EP0872729B2 (de) | 2012-08-29 |
| JPH1151894A (ja) | 1999-02-26 |
| ATA66497A (de) | 1998-04-15 |
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