AT404992B - Sensor zur bestimmung eines enzymsubstrates - Google Patents
Sensor zur bestimmung eines enzymsubstrates Download PDFInfo
- Publication number
- AT404992B AT404992B AT0066497A AT66497A AT404992B AT 404992 B AT404992 B AT 404992B AT 0066497 A AT0066497 A AT 0066497A AT 66497 A AT66497 A AT 66497A AT 404992 B AT404992 B AT 404992B
- Authority
- AT
- Austria
- Prior art keywords
- layer
- sensor
- enzyme
- sensor according
- copolymer
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title claims description 51
- 108090000790 Enzymes Proteins 0.000 title claims description 51
- 239000000758 substrate Substances 0.000 title claims description 13
- 229940088598 enzyme Drugs 0.000 claims description 50
- 239000012528 membrane Substances 0.000 claims description 41
- 239000004800 polyvinyl chloride Substances 0.000 claims description 19
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
- 229920001577 copolymer Polymers 0.000 claims description 9
- 239000008103 glucose Substances 0.000 claims description 9
- 239000004014 plasticizer Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 8
- 230000003287 optical effect Effects 0.000 claims description 7
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims description 6
- 230000004888 barrier function Effects 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 6
- 239000000178 monomer Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 239000001301 oxygen Substances 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 108010015776 Glucose oxidase Proteins 0.000 claims description 4
- 239000004366 Glucose oxidase Substances 0.000 claims description 4
- 229940116332 glucose oxidase Drugs 0.000 claims description 4
- 235000019420 glucose oxidase Nutrition 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 239000011976 maleic acid Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 230000003647 oxidation Effects 0.000 claims description 4
- 238000007254 oxidation reaction Methods 0.000 claims description 4
- 229920002307 Dextran Polymers 0.000 claims description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical group CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims description 2
- 150000002334 glycols Chemical class 0.000 claims description 2
- 229920001567 vinyl ester resin Polymers 0.000 claims description 2
- -1 vinyl hydroxy esters Chemical class 0.000 claims description 2
- 230000005284 excitation Effects 0.000 claims 2
- 230000027734 detection of oxygen Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 8
- 230000035699 permeability Effects 0.000 description 8
- 229920002554 vinyl polymer Polymers 0.000 description 7
- 239000002904 solvent Substances 0.000 description 5
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 229920002301 cellulose acetate Polymers 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 229920012485 Plasticized Polyvinyl chloride Polymers 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 108010073450 Lactate 2-monooxygenase Proteins 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229960005489 paracetamol Drugs 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 1
- NQBXSWAWVZHKBZ-UHFFFAOYSA-N 2-butoxyethyl acetate Chemical compound CCCCOCCOC(C)=O NQBXSWAWVZHKBZ-UHFFFAOYSA-N 0.000 description 1
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108010060059 Sarcosine Oxidase Proteins 0.000 description 1
- 102000008118 Sarcosine oxidase Human genes 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 229920005603 alternating copolymer Polymers 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 229920001480 hydrophilic copolymer Polymers 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0066497A AT404992B (de) | 1997-04-17 | 1997-04-17 | Sensor zur bestimmung eines enzymsubstrates |
| EP98890110A EP0872729B2 (de) | 1997-04-17 | 1998-04-16 | Biosensor mit permeabler Deckmembran aus Polyvinylchlorid-Copolymer |
| US09/061,524 US6214185B1 (en) | 1997-04-17 | 1998-04-16 | Sensor with PVC cover membrane |
| DE59812949T DE59812949D1 (de) | 1997-04-17 | 1998-04-16 | Biosensor mit permeabler Deckmembran aus Polyvinylchlorid-Copolymer |
| JP10754398A JP4087496B2 (ja) | 1997-04-17 | 1998-04-17 | センサ、液体試料中の酵素基質の濃度決定及び検出方法、ならびにポリ塩化ビニル共重合体の使用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0066497A AT404992B (de) | 1997-04-17 | 1997-04-17 | Sensor zur bestimmung eines enzymsubstrates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA66497A ATA66497A (de) | 1998-04-15 |
| AT404992B true AT404992B (de) | 1999-04-26 |
Family
ID=3496573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0066497A AT404992B (de) | 1997-04-17 | 1997-04-17 | Sensor zur bestimmung eines enzymsubstrates |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6214185B1 (enExample) |
| EP (1) | EP0872729B2 (enExample) |
| JP (1) | JP4087496B2 (enExample) |
| AT (1) | AT404992B (enExample) |
| DE (1) | DE59812949D1 (enExample) |
Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
| US7657297B2 (en) * | 2004-05-03 | 2010-02-02 | Dexcom, Inc. | Implantable analyte sensor |
| US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
| US7899511B2 (en) | 2004-07-13 | 2011-03-01 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| DE59814359D1 (de) | 1997-09-26 | 2009-05-28 | Sphere Medical Ltd | Mikrostrukturierter biosensor, verwendung des biosensors und verfahren zur immobilisierung von biokatalysatoren |
| US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
| US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| KR100349000B1 (ko) * | 1998-07-09 | 2003-03-26 | 주식회사 아이센스 | 친수성폴리우레탄을사용한바이오센서의제조방법 |
| AT409798B (de) * | 1998-11-19 | 2002-11-25 | Hoffmann La Roche | Elektrodensystem |
| GB9916522D0 (en) * | 1999-07-15 | 1999-09-15 | Univ Manchester | Polymeric compositions and sensor devices |
| WO2001090733A1 (en) | 2000-05-23 | 2001-11-29 | Radiometer Medical A/S | A sensor membrane, a method for the preparation thereof, a sensor and a layered membrane structure for such sensor |
| US6793789B2 (en) * | 2000-09-30 | 2004-09-21 | Geun Sig Cha | Reference electrode with a polymeric reference electrode membrane |
| US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| AU2002309528A1 (en) | 2001-04-02 | 2002-10-15 | Therasense, Inc. | Blood glucose tracking apparatus and methods |
| US6652720B1 (en) * | 2001-05-31 | 2003-11-25 | Instrumentation Laboratory Company | Analytical instruments, biosensors and methods thereof |
| US6960466B2 (en) * | 2001-05-31 | 2005-11-01 | Instrumentation Laboratory Company | Composite membrane containing a cross-linked enzyme matrix for a biosensor |
| US6872297B2 (en) * | 2001-05-31 | 2005-03-29 | Instrumentation Laboratory Company | Analytical instruments, biosensors and methods thereof |
| CN1300578C (zh) * | 2001-07-27 | 2007-02-14 | 爱科来株式会社 | 分析用具 |
| US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
| US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
| US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
| US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US9282925B2 (en) | 2002-02-12 | 2016-03-15 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
| WO2004053483A2 (en) * | 2002-12-11 | 2004-06-24 | Instrumentation Laboratory Company | Multi-analyte reference solutions |
| US20040256227A1 (en) * | 2003-02-11 | 2004-12-23 | Jungwon Shin | Electrochemical urea sensors and methods of making the same |
| US20040154933A1 (en) * | 2003-02-11 | 2004-08-12 | Instrumentation Laboratory Company | Polymeric membranes for use in electrochemical sensors |
| US7875293B2 (en) | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
| EP1502957B1 (en) * | 2003-07-11 | 2008-08-27 | F. Hoffmann-La Roche Ag | Castable diffusion membrane for enzyme-based sensor application |
| CA2473069C (en) * | 2003-07-11 | 2014-03-18 | F. Hoffmann-La Roche Ag | Castable diffusion membrane for enzyme-based sensor application |
| US7651596B2 (en) | 2005-04-08 | 2010-01-26 | Dexcom, Inc. | Cellulosic-based interference domain for an analyte sensor |
| US7366556B2 (en) | 2003-12-05 | 2008-04-29 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7467003B2 (en) * | 2003-12-05 | 2008-12-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US20050056552A1 (en) * | 2003-07-25 | 2005-03-17 | Simpson Peter C. | Increasing bias for oxygen production in an electrode system |
| US7460898B2 (en) * | 2003-12-05 | 2008-12-02 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7424318B2 (en) | 2003-12-05 | 2008-09-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7761130B2 (en) * | 2003-07-25 | 2010-07-20 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US20050176136A1 (en) * | 2003-11-19 | 2005-08-11 | Dexcom, Inc. | Afinity domain for analyte sensor |
| US8332008B2 (en) | 2003-08-01 | 2012-12-11 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| US8275437B2 (en) | 2003-08-01 | 2012-09-25 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| US7519408B2 (en) | 2003-11-19 | 2009-04-14 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
| US8160669B2 (en) | 2003-08-01 | 2012-04-17 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8788006B2 (en) | 2003-08-01 | 2014-07-22 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US8845536B2 (en) | 2003-08-01 | 2014-09-30 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
| US7774145B2 (en) | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7276029B2 (en) | 2003-08-01 | 2007-10-02 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US9135402B2 (en) | 2007-12-17 | 2015-09-15 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8369919B2 (en) | 2003-08-01 | 2013-02-05 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8761856B2 (en) | 2003-08-01 | 2014-06-24 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US8233959B2 (en) | 2003-08-22 | 2012-07-31 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US20050090607A1 (en) * | 2003-10-28 | 2005-04-28 | Dexcom, Inc. | Silicone composition for biocompatible membrane |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| EP2256493B1 (en) | 2003-12-05 | 2014-02-26 | DexCom, Inc. | Calibration techniques for a continuous analyte sensor |
| US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| EP2228642B1 (en) * | 2003-12-08 | 2017-07-19 | DexCom, Inc. | Systems and methods for improving electrochemical analyte sensors |
| EP2301428B1 (en) | 2003-12-09 | 2016-11-30 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
| US7637868B2 (en) | 2004-01-12 | 2009-12-29 | Dexcom, Inc. | Composite material for implantable device |
| US20050182451A1 (en) * | 2004-01-12 | 2005-08-18 | Adam Griffin | Implantable device with improved radio frequency capabilities |
| US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US8277713B2 (en) | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
| US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8886272B2 (en) | 2004-07-13 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| US7946984B2 (en) | 2004-07-13 | 2011-05-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8565848B2 (en) | 2004-07-13 | 2013-10-22 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20060016700A1 (en) | 2004-07-13 | 2006-01-26 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20060121547A1 (en) * | 2004-12-03 | 2006-06-08 | Mcintire Mark | Diffusion layer for an enzyme-based sensor application |
| US8097725B2 (en) * | 2004-12-03 | 2012-01-17 | Roche Diagnostics Operations, Inc. | Luminescent indicator dye and optical sensor |
| US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
| US20060249381A1 (en) * | 2005-05-05 | 2006-11-09 | Petisce James R | Cellulosic-based resistance domain for an analyte sensor |
| RU2423073C2 (ru) * | 2005-07-14 | 2011-07-10 | Нано-Дайтек Корпорейшн | Микрофлюидные устройства и способы их подготовки и применения |
| US9757061B2 (en) | 2006-01-17 | 2017-09-12 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| EP2004796B1 (en) * | 2006-01-18 | 2015-04-08 | DexCom, Inc. | Membranes for an analyte sensor |
| PL3756537T3 (pl) | 2006-02-22 | 2024-02-19 | Dexcom, Inc. | Czujnik analitów |
| EP4218548A1 (en) | 2006-03-09 | 2023-08-02 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US7920907B2 (en) | 2006-06-07 | 2011-04-05 | Abbott Diabetes Care Inc. | Analyte monitoring system and method |
| US7831287B2 (en) * | 2006-10-04 | 2010-11-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| EP2081587A2 (en) * | 2006-10-18 | 2009-07-29 | Research Development Foundation | Alpha-msh therapies for treatment of autoimmune disease |
| EP2129285B1 (en) | 2007-03-26 | 2014-07-23 | Dexcom, Inc. | Analyte sensor |
| US20200037874A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US20080306434A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| EP4159114B1 (en) | 2007-10-09 | 2024-04-10 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
| US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US9839395B2 (en) | 2007-12-17 | 2017-12-12 | Dexcom, Inc. | Systems and methods for processing sensor data |
| CA2715628A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
| US8241616B2 (en) * | 2008-04-03 | 2012-08-14 | Rohm And Haas Company | Hair styling composition |
| WO2010033724A2 (en) | 2008-09-19 | 2010-03-25 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
| EP4029444A1 (en) | 2009-07-02 | 2022-07-20 | Dexcom, Inc. | Analyte sensor |
| US20120283537A1 (en) * | 2009-10-30 | 2012-11-08 | Petisce James R | Analyte sensor layers and methods related thereto |
| EP4324399A3 (en) | 2011-04-15 | 2024-05-15 | DexCom, Inc. | Advanced analyte sensor calibration and error detection |
| JP5599012B1 (ja) | 2014-06-23 | 2014-10-01 | 国立大学法人 東京大学 | 採取部及びバイオセンサ |
| ES2856174T3 (es) * | 2016-09-07 | 2021-09-27 | Hoffmann La Roche | Procedimientos para someter a prueba sensores electroquímicos basados en enzimas |
| CN110418605A (zh) | 2017-01-19 | 2019-11-05 | 德克斯康公司 | 柔性分析物传感器 |
| DK3700416T3 (da) | 2017-10-24 | 2024-09-30 | Dexcom Inc | På forhånd forbundne analytsensorer |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| CN112240900B (zh) * | 2020-10-21 | 2022-05-06 | 南京工业大学 | 一种乳酸生物传感器的制备方法 |
| JP2022067884A (ja) * | 2020-10-21 | 2022-05-09 | 株式会社アドバンテスト | バイオセンサおよびバイオセンサ用リアクター、リアクターの製造方法 |
| WO2022197982A1 (en) | 2021-03-19 | 2022-09-22 | Dexcom, Inc. | Drug releasing membrane for analyte sensor |
| CN116997292A (zh) | 2021-04-02 | 2023-11-03 | 德克斯康公司 | 受个体化传感器特性和个体化生理特性影响的对血糖浓度的个性化建模 |
| EP4401634A1 (en) | 2021-09-15 | 2024-07-24 | Dexcom, Inc. | Bioactive releasing membrane for analyte sensor |
| CA3253956A1 (en) | 2022-03-18 | 2023-09-21 | Dexcom, Inc. | CONTINUOUS MULTI-ANALYTICAL SENSOR SYSTEMS |
| CA3264975A1 (en) | 2022-09-02 | 2024-03-07 | Dexcom, Inc. | CONTINUOUS ANALYTE SENSOR DEVICES AND METHODS |
| AU2023415722A1 (en) | 2022-12-30 | 2025-07-31 | Dexcom, Inc. | Sensing systems and methods for hybrid glucose and ketone monitoring |
| WO2024192181A1 (en) | 2023-03-16 | 2024-09-19 | Dexcom, Inc. | Continuous multi- analyte sensor systems |
| WO2025147486A1 (en) | 2024-01-05 | 2025-07-10 | Dexcom, Inc. | Polymers with dual functionality |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2476125A1 (fr) * | 1980-02-19 | 1981-08-21 | Kuraray Co | Supports pour l'immobilisation de substances biologiques actives et adsorbants selectifs, electrodes selectives et colonnes d'analyse utilisant lesdits supports |
| JPS59109175A (ja) * | 1982-12-14 | 1984-06-23 | Mitsubishi Petrochem Co Ltd | 固定化酵素およびその製造方法 |
| GB2146029A (en) * | 1983-09-02 | 1985-04-11 | Univ Ramot | Membranes and films |
| JPS61274682A (ja) * | 1985-05-31 | 1986-12-04 | Nok Corp | 酵素固定化膜の製造法 |
| US4894253A (en) * | 1986-08-12 | 1990-01-16 | University Of Cincinnati | Method for production of coated electrode |
| JPH03158750A (ja) * | 1989-11-15 | 1991-07-08 | Nikkiso Co Ltd | 酵素センサー |
| DD294729A5 (de) * | 1990-05-28 | 1991-10-10 | Zentralinstitut Fuer Molekularbiologie,De | Verfahren zur herstellung von immobilisaten mit biologisch aktiven, makromolekularen verbindungen |
| JPH04301759A (ja) * | 1991-03-29 | 1992-10-26 | Nok Corp | グルコ−スバイオセンサ |
| JPH0599882A (ja) * | 1991-10-09 | 1993-04-23 | Nok Corp | グルコ−スバイオセンサ |
| WO1994002584A1 (en) * | 1992-07-28 | 1994-02-03 | The Victoria University Of Manchester | Sensor devices |
| WO1994002585A1 (en) * | 1992-07-28 | 1994-02-03 | The Victoria University Of Manchester | Sensor devices |
| JPH09168855A (ja) * | 1995-12-21 | 1997-06-30 | Honda Motor Co Ltd | 樹脂成形用金型の製造方法および装置 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795316A (fr) * | 1972-02-11 | 1973-05-29 | Nat Patent Dev Corp | Systeme catalytique presentant une activite enzymatique durable et de stabilite augmentee |
| US4214968A (en) † | 1978-04-05 | 1980-07-29 | Eastman Kodak Company | Ion-selective electrode |
| JPS5911183A (ja) * | 1983-06-25 | 1984-01-20 | Nippon Paint Co Ltd | 酵素固定化物およびその製造方法 |
| GB8526902D0 (en) * | 1985-10-31 | 1985-12-04 | Unilever Plc | Electrochemical analysis |
| US4757022A (en) * | 1986-04-15 | 1988-07-12 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
| EP0333862A4 (en) * | 1986-12-10 | 1992-01-02 | Terumo Kabushiki Kaisha | Ion carrier membrane and ion sensor provided with same |
| US4900449A (en) † | 1987-05-20 | 1990-02-13 | Gelman Sciences | Filtration membranes and method of making the same |
| US5540828A (en) | 1987-06-08 | 1996-07-30 | Yacynych; Alexander | Method for making electrochemical sensors and biosensors having a polymer modified surface |
| US5417835A (en) * | 1989-06-23 | 1995-05-23 | The Board Of Regents Of The University Of Michigan | Solid state ion sensor with polyimide membrane |
| GB8916633D0 (en) * | 1989-07-20 | 1989-09-06 | Health Lab Service Board | Electrochemical cell and reference electrode |
| WO1992013271A1 (en) | 1991-01-25 | 1992-08-06 | Markwell Medical Institute, Inc. | Implantable biological fluid measuring device |
| GB9105406D0 (en) † | 1991-03-14 | 1991-05-01 | Ici Plc | Sensor devices |
| JP2995927B2 (ja) † | 1991-06-20 | 1999-12-27 | エヌオーケー株式会社 | グルコ−スバイオセンサ |
| US5607567A (en) * | 1992-03-10 | 1997-03-04 | The Board Of Regents Acting For And On Behalf Of University Of Michigan | Protamine-responsive polymeric membrane electrode |
| AT397513B (de) | 1992-12-15 | 1994-04-25 | Avl Verbrennungskraft Messtech | Amperometrische enzymelektrode |
| AT401653B (de) * | 1994-10-05 | 1996-11-25 | Avl Verbrennungskraft Messtech | Verfahren zur immobilisierung biologischer komponenten in einer polymermatrix sowie biosensoren unter verwendung derartiger immobilisate |
| US5522977A (en) * | 1994-10-07 | 1996-06-04 | Biomedix, Inc. | Glucose sensor |
| US5840168A (en) * | 1995-06-16 | 1998-11-24 | Orion Research, Inc. | Solid contact ion-selective electrode |
-
1997
- 1997-04-17 AT AT0066497A patent/AT404992B/de not_active IP Right Cessation
-
1998
- 1998-04-16 EP EP98890110A patent/EP0872729B2/de not_active Expired - Lifetime
- 1998-04-16 DE DE59812949T patent/DE59812949D1/de not_active Expired - Lifetime
- 1998-04-16 US US09/061,524 patent/US6214185B1/en not_active Expired - Lifetime
- 1998-04-17 JP JP10754398A patent/JP4087496B2/ja not_active Expired - Fee Related
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2476125A1 (fr) * | 1980-02-19 | 1981-08-21 | Kuraray Co | Supports pour l'immobilisation de substances biologiques actives et adsorbants selectifs, electrodes selectives et colonnes d'analyse utilisant lesdits supports |
| JPS59109175A (ja) * | 1982-12-14 | 1984-06-23 | Mitsubishi Petrochem Co Ltd | 固定化酵素およびその製造方法 |
| GB2146029A (en) * | 1983-09-02 | 1985-04-11 | Univ Ramot | Membranes and films |
| JPS61274682A (ja) * | 1985-05-31 | 1986-12-04 | Nok Corp | 酵素固定化膜の製造法 |
| US4894253A (en) * | 1986-08-12 | 1990-01-16 | University Of Cincinnati | Method for production of coated electrode |
| JPH03158750A (ja) * | 1989-11-15 | 1991-07-08 | Nikkiso Co Ltd | 酵素センサー |
| DD294729A5 (de) * | 1990-05-28 | 1991-10-10 | Zentralinstitut Fuer Molekularbiologie,De | Verfahren zur herstellung von immobilisaten mit biologisch aktiven, makromolekularen verbindungen |
| JPH04301759A (ja) * | 1991-03-29 | 1992-10-26 | Nok Corp | グルコ−スバイオセンサ |
| JPH0599882A (ja) * | 1991-10-09 | 1993-04-23 | Nok Corp | グルコ−スバイオセンサ |
| WO1994002584A1 (en) * | 1992-07-28 | 1994-02-03 | The Victoria University Of Manchester | Sensor devices |
| WO1994002585A1 (en) * | 1992-07-28 | 1994-02-03 | The Victoria University Of Manchester | Sensor devices |
| JPH09168855A (ja) * | 1995-12-21 | 1997-06-30 | Honda Motor Co Ltd | 樹脂成形用金型の製造方法および装置 |
Non-Patent Citations (3)
| Title |
|---|
| C.A. 116(4) 1992 : 33655J, C.A. 107(17) 1987 : 150483B, * |
| C.A. 124(18) 1996 : 242449Z, C.A. 123(1) 1995 : 4063D, * |
| C.A. 96(5) 1982 : 30960N, * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0872729B2 (de) | 2012-08-29 |
| JP4087496B2 (ja) | 2008-05-21 |
| EP0872729A1 (de) | 1998-10-21 |
| US6214185B1 (en) | 2001-04-10 |
| DE59812949D1 (de) | 2005-09-01 |
| JPH1151894A (ja) | 1999-02-26 |
| ATA66497A (de) | 1998-04-15 |
| EP0872729B1 (de) | 2005-07-27 |
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