JP4080534B2 - 低温保存システムのためのアイスシーディング装置 - Google Patents
低温保存システムのためのアイスシーディング装置 Download PDFInfo
- Publication number
- JP4080534B2 JP4080534B2 JP52786597A JP52786597A JP4080534B2 JP 4080534 B2 JP4080534 B2 JP 4080534B2 JP 52786597 A JP52786597 A JP 52786597A JP 52786597 A JP52786597 A JP 52786597A JP 4080534 B2 JP4080534 B2 JP 4080534B2
- Authority
- JP
- Japan
- Prior art keywords
- ice
- chamber
- liquefied
- container
- rack
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000010899 nucleation Methods 0.000 title claims abstract description 49
- 238000005138 cryopreservation Methods 0.000 title abstract description 28
- 239000012472 biological sample Substances 0.000 claims abstract description 13
- 238000007599 discharging Methods 0.000 claims abstract description 3
- 239000007921 spray Substances 0.000 claims description 60
- 239000007789 gas Substances 0.000 claims description 54
- 239000000112 cooling gas Substances 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 230000001276 controlling effect Effects 0.000 claims description 2
- 230000008014 freezing Effects 0.000 abstract description 29
- 238000007710 freezing Methods 0.000 abstract description 29
- 230000015572 biosynthetic process Effects 0.000 abstract description 26
- 238000001816 cooling Methods 0.000 abstract description 21
- 239000007788 liquid Substances 0.000 abstract description 16
- 230000002338 cryopreservative effect Effects 0.000 abstract description 5
- 230000001413 cellular effect Effects 0.000 abstract description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 110
- 210000004027 cell Anatomy 0.000 description 58
- 210000001519 tissue Anatomy 0.000 description 46
- 238000000034 method Methods 0.000 description 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 24
- 239000000243 solution Substances 0.000 description 24
- 239000013078 crystal Substances 0.000 description 19
- 239000002577 cryoprotective agent Substances 0.000 description 16
- 239000002609 medium Substances 0.000 description 13
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 12
- 230000008569 process Effects 0.000 description 10
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 9
- 238000003860 storage Methods 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 230000000959 cryoprotective effect Effects 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 238000005057 refrigeration Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000012595 freezing medium Substances 0.000 description 6
- 230000003834 intracellular effect Effects 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 230000035899 viability Effects 0.000 description 6
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 5
- 230000005779 cell damage Effects 0.000 description 5
- 230000003833 cell viability Effects 0.000 description 5
- AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 5
- 238000004017 vitrification Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 230000018044 dehydration Effects 0.000 description 4
- 238000006297 dehydration reaction Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000009434 installation Methods 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000006911 nucleation Effects 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 230000000451 tissue damage Effects 0.000 description 3
- 231100000827 tissue damage Toxicity 0.000 description 3
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 2
- -1 IDMEM Substances 0.000 description 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 208000037887 cell injury Diseases 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000007373 indentation Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 238000004781 supercooling Methods 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000005280 amorphization Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- UMNKXPULIDJLSU-UHFFFAOYSA-N dichlorofluoromethane Chemical compound FC(Cl)Cl UMNKXPULIDJLSU-UHFFFAOYSA-N 0.000 description 1
- 229940099364 dichlorofluoromethane Drugs 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229940027278 hetastarch Drugs 0.000 description 1
- 229940050526 hydroxyethylstarch Drugs 0.000 description 1
- 238000010874 in vitro model Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000001172 liquid--solid extraction Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000010587 phase diagram Methods 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- CMDGQTVYVAKDNA-UHFFFAOYSA-N propane-1,2,3-triol;hydrate Chemical compound O.OCC(O)CO CMDGQTVYVAKDNA-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/42—Low-temperature sample treatment, e.g. cryofixation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/144—Apparatus for temperature control, e.g. refrigerators or freeze-drying apparatus
- A01N1/145—Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D25/00—Charging, supporting, and discharging the articles to be cooled
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D29/00—Arrangement or mounting of control or safety devices
- F25D29/001—Arrangement or mounting of control or safety devices for cryogenic fluid systems
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
- F25D3/102—Stationary cabinets
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Thermal Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Combustion & Propulsion (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Hydroponics (AREA)
- Devices That Are Associated With Refrigeration Equipment (AREA)
- Liquid Crystal (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/593,587 US5689961A (en) | 1996-01-30 | 1996-01-30 | Ice seeding apparatus for cryopreservation systems |
| US08/593,587 | 1996-01-30 | ||
| PCT/US1997/001619 WO1997028402A1 (en) | 1996-01-30 | 1997-01-30 | Ice seeding apparatus for cryopreservation systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007314892A Division JP4693834B2 (ja) | 1996-01-30 | 2007-12-05 | 低温保存システムのためのアイスシーディング装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000505872A JP2000505872A (ja) | 2000-05-16 |
| JP2000505872A5 JP2000505872A5 (https=) | 2004-11-11 |
| JP4080534B2 true JP4080534B2 (ja) | 2008-04-23 |
Family
ID=24375320
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52786597A Expired - Fee Related JP4080534B2 (ja) | 1996-01-30 | 1997-01-30 | 低温保存システムのためのアイスシーディング装置 |
| JP2007314892A Expired - Fee Related JP4693834B2 (ja) | 1996-01-30 | 2007-12-05 | 低温保存システムのためのアイスシーディング装置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007314892A Expired - Fee Related JP4693834B2 (ja) | 1996-01-30 | 2007-12-05 | 低温保存システムのためのアイスシーディング装置 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5689961A (https=) |
| EP (2) | EP1763997A3 (https=) |
| JP (2) | JP4080534B2 (https=) |
| AT (1) | ATE348289T1 (https=) |
| AU (1) | AU1852097A (https=) |
| DE (1) | DE69737109T2 (https=) |
| ES (1) | ES2276419T3 (https=) |
| WO (1) | WO1997028402A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5891617A (en) * | 1993-09-15 | 1999-04-06 | Organogenesis Inc. | Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing |
| TW333451B (en) * | 1996-05-21 | 1998-06-11 | Kulpa Kk | Method and apparatus for embalming a dead body |
| US6337205B1 (en) | 1998-01-06 | 2002-01-08 | Integrated Biosystems, Inc | Cryopreservation vial apparatus and methods |
| EP2295540A1 (en) | 1998-11-19 | 2011-03-16 | Organogenesis, Inc. | Bioengineered tissue constructs and methods for producing and using them |
| US20010036665A1 (en) * | 1999-03-18 | 2001-11-01 | Susan M. Young | Method of preparing cryogenically preserved adherent cell containing plate for tissue culture applications |
| US7144729B2 (en) | 2000-09-01 | 2006-12-05 | Dfb Pharmaceuticals, Inc. | Methods and compositions for tissue regeneration |
| US6684646B2 (en) * | 2001-05-22 | 2004-02-03 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical material |
| US6945056B2 (en) * | 2001-11-01 | 2005-09-20 | Integrated Biosystems, Inc. | Systems and methods for freezing, mixing and thawing biopharmaceutical material |
| US6698213B2 (en) * | 2001-05-22 | 2004-03-02 | Integrated Biosystems, Inc. | Systems and methods for freezing and storing biopharmaceutical material |
| WO2003006989A1 (fr) * | 2001-07-12 | 2003-01-23 | Kyowa Medex Co., Ltd. | Procede de quantification de lipoproteines denaturees, reactifs pour la quantification de lipoproteines denaturees, procede de detection de maladies du systeme circulatoire et reactifs pour la detection de maladies du systeme circulatoire |
| US7104074B2 (en) | 2001-11-01 | 2006-09-12 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing, transporting and thawing biopharmaceutical material |
| UA46673C2 (en) * | 2002-01-14 | 2005-04-15 | Halyna Stepanivna Lobintseva | Method of cryopreservation of human hemopoietic cells |
| WO2004010780A2 (en) * | 2002-07-30 | 2004-02-05 | General Biotechnology, Llc | Innocuous intracellular ice |
| WO2004055456A1 (en) * | 2002-12-13 | 2004-07-01 | Integrated Biosystems, Inc. | Scaled down freezing and thawing system for bioparmaceuticals and biologics |
| WO2004069156A2 (en) * | 2003-01-30 | 2004-08-19 | The Regents Of The University Of California | Inactivated probiotic bacteria and methods of use thereof |
| US7278278B2 (en) * | 2003-06-12 | 2007-10-09 | 21St Century Medicine, Inc. | Cryogenic storage system |
| US20050241333A1 (en) * | 2003-12-03 | 2005-11-03 | Hamilton Robert W | Rate-controlled freezer and cooling methods thereof |
| EP1634496A1 (en) * | 2004-09-14 | 2006-03-15 | The Automation Partnership (Cambridge) Limited | Ultra-low temperature storage system |
| EP1639892B1 (en) * | 2004-09-14 | 2013-01-23 | The Automation Partnership (Cambridge) Limited | Ultra-low temperature storage system |
| CA2584203A1 (en) * | 2004-10-14 | 2006-04-20 | James Hardie International Finance B.V. | Cavity wall system |
| DE102005009065A1 (de) * | 2005-02-22 | 2006-08-24 | Eberhard-Karls-Universität Tübingen | Kryokonservierung von definierten Zellverbänden |
| WO2007103917A2 (en) | 2006-03-06 | 2007-09-13 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| US7540168B2 (en) * | 2006-10-20 | 2009-06-02 | Custom Biogenic Systems | Cryogenic storage container system |
| AU2010242985B2 (en) | 2009-04-29 | 2015-06-18 | Biolife Solutions, Inc. | Apparatuses and compositions for cryopreservation of cellular monolayers |
| US20140328766A1 (en) * | 2010-08-24 | 2014-11-06 | Ge Healthcare Limited | Composition and method for generating a metabolic profile using 13c-mr detection |
| JP5867893B2 (ja) * | 2010-09-14 | 2016-02-24 | 株式会社ミツヤコーポレーション | 凍結方法 |
| WO2012138944A1 (en) * | 2011-04-06 | 2012-10-11 | Celltronix | Method and scalable devices for hyper-fast cooling |
| US9534992B2 (en) * | 2011-05-18 | 2017-01-03 | Biocision, Llc | Ventilation assisted passive cell freezing device |
| DE102011108251A1 (de) * | 2011-07-22 | 2013-01-24 | Gottfried Wilhelm Leibniz Universität Hannover, Körperschaft des öffentlichen Rechts | Verfahren zum Induzieren der Nukleation in einer Probe und System hierfür |
| WO2014160000A1 (en) * | 2013-03-13 | 2014-10-02 | Stratatech Corporation | Cryopreservation of viable human skin substitutes |
| US10544387B2 (en) * | 2013-03-27 | 2020-01-28 | Biostage, Inc. | Bioreactors and uses thereof |
| JP6573363B2 (ja) * | 2015-03-27 | 2019-09-11 | 国立大学法人東北大学 | 凍結装置、凍結方法 |
| RU2650888C1 (ru) * | 2017-04-23 | 2018-04-18 | Федеральное государственное автономное образовательное учреждение высшего образования "Северо-Восточный федеральный университет имени М.К.Аммосова" | Способ криогенной обработки семян растений |
| GB201716729D0 (en) | 2017-10-12 | 2017-11-29 | Asymptote Ltd | Cryopreservation method and apparatus |
| US11352262B2 (en) | 2017-12-18 | 2022-06-07 | Praxair Technology, Inc. | Methods for automatic filling, charging and dispensing carbon dioxide snow block |
| EP3846634B1 (en) * | 2018-09-06 | 2023-12-20 | The Coca-Cola Company | Supercooled beverage nucleation and ice crystal formation using a high-pressure gas |
| CN110596227B (zh) * | 2019-08-08 | 2021-11-23 | 河北省食品检验研究院(国家果类及农副加工产品质量监督检验中心、河北省食品安全实验室) | 飞行时间质谱即用型斯坦利沙门氏菌定性标准样品的制备方法 |
| WO2021083648A1 (en) | 2019-10-30 | 2021-05-06 | Liconic Ag | High-efficiency low-temperature storage device |
| FI129124B (en) * | 2020-01-23 | 2021-07-30 | Acoustic Extra Freezing Oy | Device and method for controllable growth of crystals in a process of freezing |
| WO2022066192A1 (en) * | 2020-09-24 | 2022-03-31 | TMRW Life Sciences, Inc. | Cryogenic storage system with sensors to measure one or more parameters therewithin |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1751315A1 (de) * | 1968-05-10 | 1971-07-08 | Kueleg Gmbh Kuehlmoebel Und Em | Tiefkuehlgeraet |
| DE1751316A1 (de) * | 1968-05-10 | 1971-07-22 | Kueleg Gmbh Kuehlmoebel Und Em | Tiefkuehlgeraet zum Gefrieren von Lebensmitteln u.dgl. |
| US3842831A (en) | 1972-10-27 | 1974-10-22 | Genetic Labor Inc | Cellular skin patch |
| CA1005250A (en) * | 1974-03-22 | 1977-02-15 | Kuleg Kuhlmobelfabrik And Apparatebau G.M.B.H. | Refrigeration apparatus |
| FR2271521A1 (en) * | 1974-05-15 | 1975-12-12 | Anhydride Carbonique Ind | Small batches of food frozen with dry ice - sprayed on as ten or more successive layers |
| DE2557870A1 (de) * | 1975-12-22 | 1977-06-23 | Linde Ag | Verfahren und vorrichtung zum tiefgefrieren von biologischen substanzen |
| DE2929278A1 (de) * | 1979-07-19 | 1981-01-29 | Forschungsgesellschaft Fuer Bi | Verfahren zum eingefrieren von zellsuspensionen |
| US4344291A (en) * | 1980-04-28 | 1982-08-17 | Liquid Carbonic Corporation | Cryogenic cabinet freezer |
| FR2498429A1 (fr) * | 1981-01-27 | 1982-07-30 | Carboxyque Francaise | Enceinte de refrigeration perfectionnee |
| US4539716A (en) | 1981-03-19 | 1985-09-10 | Massachusetts Institute Of Technology | Fabrication of living blood vessels and glandular tissues |
| US4546500A (en) | 1981-05-08 | 1985-10-15 | Massachusetts Institute Of Technology | Fabrication of living blood vessels and glandular tissues |
| US4416380A (en) * | 1981-05-11 | 1983-11-22 | Paul Flum Ideas, Inc. | Product merchandising rack |
| US4485096A (en) | 1982-02-26 | 1984-11-27 | Massachusetts Institute Of Technology | Tissue-equivalent and method for preparation thereof |
| US4485097A (en) | 1982-05-26 | 1984-11-27 | Massachusetts Institute Of Technology | Bone-equivalent and method for preparation thereof |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US4865871A (en) | 1983-08-23 | 1989-09-12 | Board Of Regents The University Of Texas System | Method for cryopreparing biological tissue |
| US5024830A (en) | 1983-08-23 | 1991-06-18 | The Board Of Regents, The University Of Texas | Method for cryopreparing biological tissue for ultrastructural analysis |
| US4676070A (en) | 1984-11-30 | 1987-06-30 | The Board Of Regents, The University Of Texas | Apparatus and method for cryopreparing biological tissue |
| US4799361A (en) | 1983-08-23 | 1989-01-24 | Board Of Regents, The University Of Texas System | Method for cryopreparing biological tissue for ultrastructural analysis |
| DE3342489C2 (de) * | 1983-11-24 | 1986-10-23 | Messer Griesheim Gmbh, 6000 Frankfurt | Vorrichtung zur tiefkalten Lagerung von biologischen oder pharmazeutischen Proben |
| FR2558337B1 (fr) | 1984-01-19 | 1986-05-02 | Air Liquide | Dispositif de congelation de produits biologiques conditionnes en paillettes |
| US5084377A (en) | 1984-09-19 | 1992-01-28 | Larry Rowan | Cryogenic suspension method |
| US4604346A (en) | 1984-10-09 | 1986-08-05 | Massachusetts Institute Of Technology | Skin-equivalent prepared by the use of punch biopsy |
| JPS61255655A (ja) * | 1985-05-09 | 1986-11-13 | 畜産試験場長 | 胚の凍結保存におけるヨウ化銀による植氷の方法 |
| US4688387A (en) | 1985-11-12 | 1987-08-25 | Vital Force, Inc. | Method for preservation and storage of viable biological materials at cryogenic temperatures |
| DE3610563A1 (de) * | 1986-03-27 | 1987-10-01 | Messer Griesheim Gmbh | Vorrichtung zum gefrieren von auf einem hordewagen befindlichen lebensmitteln |
| JPH07111292B2 (ja) * | 1986-11-10 | 1995-11-29 | 株式会社コルポ | 保冷コンテナ輸送保管装置 |
| US4807442A (en) | 1986-12-03 | 1989-02-28 | Board Of Regents The University Of Texas System | Cryo-slamming apparatus and method for ultrarapid cooling of biological samples |
| US5044165A (en) | 1986-12-03 | 1991-09-03 | Board Of Regents, The University Of Texas | Cryo-slammer |
| US4890457A (en) | 1987-01-02 | 1990-01-02 | Cryolife, Inc. | Method for cryopreserving heart valves |
| IT1207525B (it) | 1987-06-23 | 1989-05-25 | Ist Naz Ric Sul Cancro | Metodo per la preservazione difogli trapiantabili di epitelio coltivato in vitro vitale. |
| JPS6423078A (en) * | 1987-07-16 | 1989-01-25 | Ekika Carbon Dioxide Co | Cooler/refrigerating chamber |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| JPH01150775A (ja) * | 1987-12-07 | 1989-06-13 | Hitachi Ltd | 極低温冷媒供給装置 |
| US5194269A (en) | 1988-01-20 | 1993-03-16 | Lee Tung Ching | Production of frozen foods and other products |
| US5071741A (en) | 1988-04-18 | 1991-12-10 | Cryolife, Inc. | Cryoprotective agent and its use in cryopreservation of cellular matter |
| US4837379A (en) | 1988-06-02 | 1989-06-06 | Organogenesis Inc. | Fibrin-collagen tissue equivalents and methods for preparation thereof |
| US5001047A (en) | 1988-07-14 | 1991-03-19 | Barnet L. Liberman | Method of preserving organs |
| CA2000181A1 (en) | 1988-10-14 | 1990-04-14 | Chung-Faye Chao | Process for producing cultured epidermal sheet, product and method of use |
| ATE84196T1 (de) * | 1989-10-13 | 1993-01-15 | Sauerstoffwerk Guttroff F Gmbh | Verfahren und einrichtung zum kuehlen und gefrieren von wasserhaltigen lebensmitteln. |
| US5131850A (en) | 1989-11-03 | 1992-07-21 | Cryolife, Inc. | Method for cryopreserving musculoskeletal tissues |
| US5118512A (en) | 1990-01-23 | 1992-06-02 | Osteotech, Inc. (A Delaware Corp.) | Process for cryopreserving biological materials and materials prepared thereby |
| US5100676A (en) | 1990-02-02 | 1992-03-31 | Biosurface Technology, Inc. | Cool storage of cultured epithelial sheets |
| US5145770A (en) | 1990-06-04 | 1992-09-08 | Biosurface Technology, Inc. | Cryopreservation of cultured epithelial sheets |
| US5233844A (en) * | 1991-08-15 | 1993-08-10 | Cryo-Cell International, Inc. | Storage apparatus, particularly with automatic insertion and retrieval |
| US5205135A (en) * | 1991-11-13 | 1993-04-27 | Liquid Carbonic Corporation | Helical conveyor freezer |
| US5309722A (en) * | 1992-11-06 | 1994-05-10 | Harsco Corporation | Temperature control system for liquid nitrogen refrigerator |
| US5410886A (en) * | 1992-12-08 | 1995-05-02 | American Cryogas Industries, Inc. | Method and apparatus for supplementing mechanical refrigeration by the controlled introduction of a cryogen |
| JP3126869B2 (ja) * | 1993-06-29 | 2001-01-22 | 株式会社神戸製鋼所 | 被処理物の加圧処理方法および加圧処理装置 |
| US5891617A (en) | 1993-09-15 | 1999-04-06 | Organogenesis Inc. | Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing |
| US5518878A (en) | 1993-09-15 | 1996-05-21 | Organogenesis Inc. | Cryopreservation of cultured skin or cornea equivalents with agitation |
| US5417072A (en) | 1993-11-08 | 1995-05-23 | Trw Inc. | Controlling the temperature in a cryogenic vessel |
| WO1996001882A1 (fr) * | 1994-07-11 | 1996-01-25 | Solvay (Societe Anonyme) | Refrigerants |
| IT1277696B1 (it) | 1995-12-22 | 1997-11-11 | Enichem Spa | Catalizzatori per la polimerizzazione di alfa-olefine |
| MX9705540A (es) | 1996-01-30 | 1997-10-31 | Organogenesis Inc | Metodo y diseño de empaque para la crioconservacion y almacenamiento de equivalentes de tejido cultivado. |
| US5813537A (en) * | 1997-07-16 | 1998-09-29 | Illinois Tool Works Inc. | Edge protector having relieved apex-G board |
-
1996
- 1996-01-30 US US08/593,587 patent/US5689961A/en not_active Expired - Lifetime
-
1997
- 1997-01-30 JP JP52786597A patent/JP4080534B2/ja not_active Expired - Fee Related
- 1997-01-30 ES ES97904153T patent/ES2276419T3/es not_active Expired - Lifetime
- 1997-01-30 DE DE69737109T patent/DE69737109T2/de not_active Expired - Lifetime
- 1997-01-30 EP EP06025552A patent/EP1763997A3/en not_active Withdrawn
- 1997-01-30 AU AU18520/97A patent/AU1852097A/en not_active Abandoned
- 1997-01-30 WO PCT/US1997/001619 patent/WO1997028402A1/en not_active Ceased
- 1997-01-30 US US09/117,412 patent/US6167710B1/en not_active Expired - Fee Related
- 1997-01-30 AT AT97904153T patent/ATE348289T1/de not_active IP Right Cessation
- 1997-01-30 EP EP97904153A patent/EP1012499B1/en not_active Expired - Lifetime
-
2001
- 2001-01-02 US US09/753,168 patent/US6347525B2/en not_active Expired - Fee Related
-
2007
- 2007-12-05 JP JP2007314892A patent/JP4693834B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1012499A4 (en) | 2000-07-05 |
| EP1763997A2 (en) | 2007-03-21 |
| US6347525B2 (en) | 2002-02-19 |
| JP2000505872A (ja) | 2000-05-16 |
| US20010000848A1 (en) | 2001-05-10 |
| ATE348289T1 (de) | 2007-01-15 |
| AU1852097A (en) | 1997-08-22 |
| JP2008067719A (ja) | 2008-03-27 |
| DE69737109T2 (de) | 2007-07-12 |
| US5689961A (en) | 1997-11-25 |
| ES2276419T3 (es) | 2007-06-16 |
| EP1012499A1 (en) | 2000-06-28 |
| EP1012499B1 (en) | 2006-12-13 |
| EP1763997A3 (en) | 2007-04-04 |
| WO1997028402A1 (en) | 1997-08-07 |
| DE69737109D1 (de) | 2007-01-25 |
| JP4693834B2 (ja) | 2011-06-01 |
| US6167710B1 (en) | 2001-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4080534B2 (ja) | 低温保存システムのためのアイスシーディング装置 | |
| US8794013B2 (en) | Method and system for nucleation control in a controlled rate freezer (CRF) | |
| Ozkavukcu et al. | Cryopreservation: basic knowledge and biophysical effects | |
| ES2748911T3 (es) | Método de Liofilización | |
| KR101265382B1 (ko) | 물질의 핵생성을 유도하는 방법 | |
| SCHACHAR et al. | Investigations of low-temperature storage of articular cartilage for transplantation. | |
| NO20025851D0 (no) | Kryogen preservering av biologisk aktivt materiale ved å benytte höytemperaturfrysing | |
| Gavish et al. | Cryopreservation of whole murine and porcine livers | |
| US3940943A (en) | Multistage freezing system for preservation of biological materials | |
| EP1028623B1 (en) | Method for cryopreservation | |
| CN101379356A (zh) | 诱导材料成核的方法 | |
| US8820097B2 (en) | Method and system for regulating the mixture of cryogen liquid and warm gas for a controlled rate cryogenic chiller or freezing system | |
| CA2245004C (en) | Ice seeding apparatus for cryopreservation systems | |
| Nannou et al. | Cryopreservation: Methods, equipment and critical concerns | |
| Seki | 4 Importance of cooling versus warming rates in vitrification | |
| Trounson et al. | Embryo cryopreservation | |
| Lindstrom et al. | Injury to potato leaves exposed to subzero temperatures in the absence of freezing | |
| Sareen et al. | Overview of Cryobiology in ART | |
| Talwar | Overview of Cryobiology in Assisted Reproductive Technology | |
| Coger et al. | Preservation Techniques | |
| MX2008009384A (en) | Method of inducing nucleation of a material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040114 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040114 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060425 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20060720 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20060904 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20061025 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20061219 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070316 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070507 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070618 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20070814 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071205 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20071220 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20080108 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20080207 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110215 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110215 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120215 Year of fee payment: 4 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130215 Year of fee payment: 5 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140215 Year of fee payment: 6 |
|
| LAPS | Cancellation because of no payment of annual fees |