JP4065554B2 - 抗体の調製 - Google Patents

抗体の調製 Download PDF

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Publication number
JP4065554B2
JP4065554B2 JP51633993A JP51633993A JP4065554B2 JP 4065554 B2 JP4065554 B2 JP 4065554B2 JP 51633993 A JP51633993 A JP 51633993A JP 51633993 A JP51633993 A JP 51633993A JP 4065554 B2 JP4065554 B2 JP 4065554B2
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JP
Japan
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ser
gly
thr
antibody
val
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Expired - Lifetime
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JP51633993A
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English (en)
Japanese (ja)
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JPH07500017A (ja
Inventor
ボルト，サラ・ルイーズ
クラーク，マイケル・ロナルド
ゴーマン，スコット・デヴィッド
ルートリッジ，エドワード・グラハム
ウォルドマン，ハーマン
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BTG International Ltd
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BTG International Ltd
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Publication of JPH07500017A publication Critical patent/JPH07500017A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP51633993A 1992-03-24 1992-10-21 抗体の調製 Expired - Lifetime JP4065554B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9206422.9 1992-03-24
GB929206422A GB9206422D0 (en) 1992-03-24 1992-03-24 Antibody preparation
PCT/GB1992/001933 WO1993019196A1 (en) 1992-03-24 1992-10-21 ANTI-CD3 AGLYCOSYLATED IgG ANTIBODY

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2003270135A Division JP4113467B2 (ja) 1992-03-24 2003-07-01 抗体の調製

Publications (2)

Publication Number Publication Date
JPH07500017A JPH07500017A (ja) 1995-01-05
JP4065554B2 true JP4065554B2 (ja) 2008-03-26

Family

ID=10712757

Family Applications (3)

Application Number Title Priority Date Filing Date
JP51633993A Expired - Lifetime JP4065554B2 (ja) 1992-03-24 1992-10-21 抗体の調製
JP2003270135A Expired - Fee Related JP4113467B2 (ja) 1992-03-24 2003-07-01 抗体の調製
JP2005351160A Expired - Fee Related JP4113890B2 (ja) 1992-03-24 2005-12-05 抗体の調製

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2003270135A Expired - Fee Related JP4113467B2 (ja) 1992-03-24 2003-07-01 抗体の調製
JP2005351160A Expired - Fee Related JP4113890B2 (ja) 1992-03-24 2005-12-05 抗体の調製

Country Status (12)

Country Link
US (11) US5585097A (Direct)
EP (1) EP0586617B1 (Direct)
JP (3) JP4065554B2 (Direct)
KR (1) KR100238497B1 (Direct)
AT (1) ATE155818T1 (Direct)
AU (1) AU671085B2 (Direct)
CA (1) CA2109815C (Direct)
DE (1) DE69221147T2 (Direct)
ES (1) ES2106195T3 (Direct)
GB (1) GB9206422D0 (Direct)
GR (1) GR3024489T3 (Direct)
WO (1) WO1993019196A1 (Direct)

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