JP3579345B2 - ４−カルボキシアミノ−２−置換−１，２，３，４−テトラヒドロキノリンの製造方法 - Google Patents

４−カルボキシアミノ−２−置換−１，２，３，４−テトラヒドロキノリンの製造方法 Download PDF

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Publication number
JP3579345B2
JP3579345B2 JP2000362153A JP2000362153A JP3579345B2 JP 3579345 B2 JP3579345 B2 JP 3579345B2 JP 2000362153 A JP2000362153 A JP 2000362153A JP 2000362153 A JP2000362153 A JP 2000362153A JP 3579345 B2 JP3579345 B2 JP 3579345B2
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Prior art keywords
trifluoromethyl
quinoline
dihydro
ethyl
carboxylic acid
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Japanese (ja)
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JP2001163859A (ja
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バーンズ デイモン デビッド
ウェイン ダッガー ロバート
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ファイザー・プロダクツ・インク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2000362153A 1999-11-30 2000-11-29 ４−カルボキシアミノ−２−置換−１，２，３，４−テトラヒドロキノリンの製造方法 Expired - Fee Related JP3579345B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30
US60/167967 1999-11-30

Publications (2)

Publication Number Publication Date
JP2001163859A JP2001163859A (ja) 2001-06-19
JP3579345B2 true JP3579345B2 (ja) 2004-10-20

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JP2000362153A Expired - Fee Related JP3579345B2 (ja) 1999-11-30 2000-11-29 ４−カルボキシアミノ−２−置換−１，２，３，４−テトラヒドロキノリンの製造方法

Country Status (44)

Country Link
US (1) US6313142B1 (https=)
EP (1) EP1125929B1 (https=)
JP (1) JP3579345B2 (https=)
KR (1) KR100408177B1 (https=)
CN (1) CN1173953C (https=)
AP (1) AP2000002011A0 (https=)
AR (1) AR029775A1 (https=)
AT (1) ATE315028T1 (https=)
AU (1) AU784694B2 (https=)
BG (1) BG105009A (https=)
BR (1) BR0005636A (https=)
CA (1) CA2327029C (https=)
CO (1) CO5261552A1 (https=)
CY (1) CY1104989T1 (https=)
CZ (1) CZ20004407A3 (https=)
DE (1) DE60025317T2 (https=)
DK (1) DK1125929T3 (https=)
DZ (1) DZ3079A1 (https=)
EA (1) EA003668B1 (https=)
EE (1) EE200000659A (https=)
ES (1) ES2254109T3 (https=)
GE (1) GEP20022798B (https=)
GT (1) GT200000190A (https=)
HN (1) HN2000000203A (https=)
HR (1) HRP20000804A2 (https=)
HU (1) HUP0004747A3 (https=)
ID (1) ID28489A (https=)
IL (1) IL139849A (https=)
IS (1) IS5715A (https=)
MA (1) MA25223A1 (https=)
NO (1) NO20006039L (https=)
NZ (1) NZ508509A (https=)
OA (1) OA11494A (https=)
PA (1) PA8503801A1 (https=)
PE (1) PE20010913A1 (https=)
PL (1) PL344208A1 (https=)
SG (1) SG102603A1 (https=)
SK (1) SK17792000A3 (https=)
TN (1) TNSN00230A1 (https=)
TW (1) TW591016B (https=)
UA (1) UA65615C2 (https=)
UY (1) UY26451A1 (https=)
YU (1) YU71500A (https=)
ZA (1) ZA200006947B (https=)

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AU2002361811A1 (en) 2001-12-19 2003-07-09 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
CN1596240A (zh) * 2001-12-19 2005-03-16 阿特罗吉尼克斯公司 查耳酮衍生物及其治疗疾病的用途
ATE410521T1 (de) * 2002-04-11 2008-10-15 Roar Holding Llc Ex-vivo-verfahren zur bestimmung der cetp- aktivität und der wirksamkeit der behandlung von herzerkrankungen
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
AU2003277285B2 (en) * 2002-10-04 2007-12-13 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7223870B2 (en) 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
US20040181075A1 (en) * 2002-12-19 2004-09-16 Weingarten M. David Process of making chalcone derivatives
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
EP1961419B1 (en) 2002-12-20 2010-03-24 Pfizer Products Inc. Dosage forms comprising a CETP inhibitor and an HMG-CoA reductase inhibitor
JP2006523218A (ja) * 2003-03-04 2006-10-12 高砂香料工業株式会社 光学活性アミン類の製造方法
WO2004082675A1 (en) * 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of s-[2- ([[1- (2-ethylbutyl) cyclohexyl] carbonyl] amino) phenyl] 2-methylpropanethioate
MXPA05009848A (es) * 2003-03-17 2005-12-06 Japan Tobacco Inc Composiciones farmaceuticas de inhibidores de la proteina de transferencia del ester de colesterilo.
TWI494102B (zh) * 2003-05-02 2015-08-01 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
WO2005037796A1 (en) * 2003-10-08 2005-04-28 Eli Lilly And Company Compounds and methods for treating dyslipidemia
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
AU2005267436A1 (en) * 2004-06-24 2006-02-02 Eli Lilly And Company Compounds and methods for treating dyslipidemia
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
WO2006069162A1 (en) * 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
UA90706C2 (ru) * 2005-02-24 2010-05-25 Милленниум Фармасьютикалз, Инк. Антагонисты рецептора pgd2 для лечения воспалительных заболеваний
TW200808731A (en) 2006-03-30 2008-02-16 Tanabe Seiyaku Co A process for preparing tetrahydroquinoline derivatives
AR065670A1 (es) 2007-03-09 2009-06-24 Indigene Pharmaceuticals Inc Combinacion de metformina r-(+) lipoato y agentes antihiperlipidemicos para el tratamiento de hiperglucemia diabetica y complicaciones diabeticas
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
AR077208A1 (es) * 2009-06-30 2011-08-10 Lilly Co Eli Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam
CU20250001A7 (es) 2022-07-05 2025-10-17 Newamsterdam Pharma B V Sales de obicetrapib y procesos para su fabricación y productos intermedios de estos

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FR7870M (https=) * 1968-11-08 1970-04-27
US3971789A (en) 1972-10-21 1976-07-27 John Wyeth & Brother Limited O-(4-Quinolylamino)benzamides
GB8432091D0 (en) 1984-12-19 1985-01-30 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
US4839368A (en) 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
GB8804444D0 (en) 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5231102A (en) 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US6140342A (en) 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Also Published As

Publication number Publication date
DK1125929T3 (da) 2006-04-03
IL139849A (en) 2006-10-31
DE60025317T2 (de) 2006-08-03
EP1125929B1 (en) 2006-01-04
SG102603A1 (en) 2004-03-26
ATE315028T1 (de) 2006-02-15
CY1104989T1 (el) 2010-03-03
PL344208A1 (en) 2001-06-04
TW591016B (en) 2004-06-11
CZ20004407A3 (cs) 2002-06-12
NO20006039D0 (no) 2000-11-29
CO5261552A1 (es) 2003-03-31
IL139849A0 (en) 2002-02-10
GT200000190A (es) 2002-04-27
OA11494A (en) 2004-05-07
ZA200006947B (en) 2002-05-27
JP2001163859A (ja) 2001-06-19
YU71500A (sh) 2003-02-28
AR029775A1 (es) 2003-07-16
HK1038007A1 (en) 2002-03-01
SK17792000A3 (sk) 2002-10-08
GEP20022798B (en) 2002-09-25
UY26451A1 (es) 2001-06-29
DE60025317D1 (de) 2006-03-30
EE200000659A (et) 2001-08-15
EP1125929A1 (en) 2001-08-22
CN1302800A (zh) 2001-07-11
UA65615C2 (uk) 2004-04-15
PE20010913A1 (es) 2001-09-10
HUP0004747A2 (hu) 2001-10-28
AU784694B2 (en) 2006-06-01
AU7178900A (en) 2001-05-31
HN2000000203A (es) 2001-06-13
ID28489A (id) 2001-05-31
HUP0004747A3 (en) 2002-12-28
CN1173953C (zh) 2004-11-03
PA8503801A1 (es) 2002-07-30
AP2000002011A0 (en) 2000-12-31
DZ3079A1 (fr) 2004-10-24
NZ508509A (en) 2001-06-29
HRP20000804A2 (en) 2001-06-30
CA2327029C (en) 2005-08-09
EA200001129A3 (ru) 2001-10-22
EA003668B1 (ru) 2003-08-28
TNSN00230A1 (fr) 2005-11-10
BG105009A (en) 2001-11-30
IS5715A (is) 2001-05-31
CA2327029A1 (en) 2001-05-30
MA25223A1 (fr) 2001-07-02
BR0005636A (pt) 2001-07-17
US6313142B1 (en) 2001-11-06
ES2254109T3 (es) 2006-06-16
HU0004747D0 (https=) 2001-02-28
NO20006039L (no) 2001-05-31
EA200001129A2 (ru) 2001-06-25
KR100408177B1 (ko) 2003-12-01
KR20010052012A (ko) 2001-06-25

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