JP3391796B2 - 新規化合物、その製法および抗腫瘍剤 - Google Patents

新規化合物、その製法および抗腫瘍剤

Info

Publication number
JP3391796B2
JP3391796B2 JP50192396A JP50192396A JP3391796B2 JP 3391796 B2 JP3391796 B2 JP 3391796B2 JP 50192396 A JP50192396 A JP 50192396A JP 50192396 A JP50192396 A JP 50192396A JP 3391796 B2 JP3391796 B2 JP 3391796B2
Authority
JP
Japan
Prior art keywords
group
compound
hydrogen atom
halogen atom
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP50192396A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO1995034559A1 (ja
Inventor
恭司 冨田
勝巳 千葉
茂樹 柏本
厚一郎 柴森
保知 筑木
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of JPWO1995034559A1 publication Critical patent/JPWO1995034559A1/ja
Application granted granted Critical
Publication of JP3391796B2 publication Critical patent/JP3391796B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP50192396A 1994-06-14 1995-06-06 新規化合物、その製法および抗腫瘍剤 Expired - Lifetime JP3391796B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
JP15657894 1994-06-14
JP6-156578 1994-06-14
JP19792194 1994-07-28
JP6-197921 1994-07-28
JP6-306914 1994-11-15
JP30691494 1994-11-15
JP6-339956 1994-12-28
JP33995694 1994-12-28
JP8170595 1995-03-13
JP7-81705 1995-03-13
PCT/JP1995/001110 WO1995034559A1 (en) 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent

Publications (2)

Publication Number Publication Date
JPWO1995034559A1 JPWO1995034559A1 (ja) 1997-01-28
JP3391796B2 true JP3391796B2 (ja) 2003-03-31

Family

ID=27524935

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50192396A Expired - Lifetime JP3391796B2 (ja) 1994-06-14 1995-06-06 新規化合物、その製法および抗腫瘍剤

Country Status (27)

Country Link
US (1) US5817669A (OSRAM)
EP (1) EP0787726B1 (OSRAM)
JP (1) JP3391796B2 (OSRAM)
KR (1) KR100350921B1 (OSRAM)
CN (1) CN1053668C (OSRAM)
AT (1) ATE209645T1 (OSRAM)
AU (1) AU679859B2 (OSRAM)
BR (1) BR9508037A (OSRAM)
CA (1) CA2192824C (OSRAM)
CZ (1) CZ292631B6 (OSRAM)
DE (1) DE69524251T2 (OSRAM)
DK (1) DK0787726T3 (OSRAM)
ES (1) ES2163512T3 (OSRAM)
FI (1) FI112485B (OSRAM)
HK (1) HK1000495A1 (OSRAM)
HU (1) HU220072B (OSRAM)
MX (1) MX9606331A (OSRAM)
NO (1) NO307255B1 (OSRAM)
NZ (1) NZ287139A (OSRAM)
PL (1) PL181867B1 (OSRAM)
PT (1) PT787726E (OSRAM)
RO (1) RO117793B1 (OSRAM)
RU (1) RU2151770C1 (OSRAM)
SI (1) SI0787726T1 (OSRAM)
SK (1) SK281341B6 (OSRAM)
TW (1) TW319769B (OSRAM)
WO (1) WO1995034559A1 (OSRAM)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20040309A2 (en) 2001-09-26 2006-05-31 Bayer Pharmaceuticals Corporation 1,6-nafthyridine derivatives as antidiabetics
US6802423B2 (en) * 2002-02-20 2004-10-12 Trans Global Foods, Inc. Disposable food delivery apparatus
US7163948B2 (en) * 2003-04-07 2007-01-16 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs
CA2536429C (en) * 2003-09-10 2012-02-14 Kyorin Pharmaceutical Co., Ltd. 7-(4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl) quinolonecarboxylic acid derivative
DE10352979A1 (de) * 2003-11-13 2005-06-09 Merck Patent Gmbh Pyridopyrimidinone
AU2013201203C1 (en) * 2004-03-15 2015-04-23 Sumitomo Dainippon Pharma Co., Ltd. Sns-595 and methods of using the same
DE602005025738D1 (de) * 2004-03-15 2011-02-17 Dainippon Sumitomo Pharma Co Pharmazeutische zusammensetzung enthaltend sns-595 und deren verwendungen
RU2405782C2 (ru) * 2004-10-14 2010-12-10 Ф.Хоффманн-Ля Рош Аг Хиназолинилметилентиазолиноны в качестве cdk-1 ингибиторов
US7268231B2 (en) * 2004-10-14 2007-09-11 Hoffmann-La Roche Inc. 1,5-Naphthyridine azolinone
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
CA2619663A1 (en) * 2005-08-19 2007-02-22 Cylene Pharmaceuticals, Inc. Human ribosomal dna(rdna) and ribosomal rna (rrna) nucleic acids and uses thereof
RU2428983C2 (ru) * 2005-09-02 2011-09-20 Санесис Фармасьютикалз, Инк. Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака
CN104873502A (zh) * 2005-09-02 2015-09-02 逊尼希思制药公司 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法
EP1931339B1 (en) * 2005-09-02 2018-05-16 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
KR20170118936A (ko) * 2005-09-02 2017-10-25 선에시스 파마슈티컬스 인코포레이티드 암 치료를 위한 (＋)-1,4-디히드로-7-［(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐］-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법
AU2013219242C1 (en) * 2005-09-02 2016-09-22 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
WO2007033232A1 (en) * 2005-09-14 2007-03-22 Janssen Pharmaceutica, N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase
EP2354138A1 (en) * 2006-06-12 2011-08-10 Sunesis Pharmaceuticals, Inc. Compounds and compositions for treatment of cancer
WO2008016678A2 (en) * 2006-08-01 2008-02-07 Sunesis Pharmaceuticals, Inc. Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
MX344865B (es) * 2006-08-02 2016-12-19 Sunesis Pharmaceuticals Inc Metodos para usar acido (+)-1,4-dihidro-7-[(3s,4s)-3-metoxi-4-(met ilamino)-1-pirrolidinil]-4-oxo-1(2-tiazolil)-1,8-naftiridina-3-ca rboxilico para el tratamiento de ciertos padecimientos hematologicos.
JP6029808B2 (ja) * 2007-10-22 2016-11-24 サネシス ファーマシューティカルズ， インコーポレイテッド 併用療法における（＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の使用方法
EP2249831A2 (en) * 2007-12-10 2010-11-17 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-ý(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl¨-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
KR20170090535A (ko) 2008-12-31 2017-08-07 선에시스 파마슈티컬스 인코포레이티드 (＋)-1,4-다이하이드로-7-［(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리딘일］-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카복실산의 제조 방법
SG173855A1 (en) 2009-02-27 2011-09-29 Sunesis Pharmaceuticals Inc Methods of using sns-595 for treatment of cancer subjects with reduced brca2 activity
UA110465C2 (en) 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
TW201120037A (en) * 2009-10-26 2011-06-16 Sunesis Pharmaceuticals Inc Compounds and methods for treatment of cancer
CN108329246B (zh) * 2011-05-13 2021-02-26 阵列生物制药公司 作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物
CN103497186B (zh) * 2013-09-24 2015-02-25 浙江司太立制药股份有限公司 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法
CN110520422B (zh) * 2017-03-24 2023-09-05 涌永制药株式会社 新型吡啶酮羧酸衍生物或其盐

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988463A (en) * 1974-05-06 1976-10-26 Merck & Co., Inc. Method of preventing metastasis of H. Ep. No. 3
US4384001A (en) * 1978-12-21 1983-05-17 Gosalvez Mario Treatment of tumors with thiazolidine-4-carboxylic acid
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
DE3577089D1 (de) * 1984-01-26 1990-05-17 Abbott Lab Antibakterielle chinolinderivate.
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
JPS61152682A (ja) * 1984-12-27 1986-07-11 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体、そのエステルおよびその塩
JPS61251667A (ja) * 1985-04-30 1986-11-08 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
IL79110A0 (en) * 1985-06-13 1986-09-30 Schering Corp Polycyclic quinoline,naphthyridine and pyrazinopyridine derivatives
US4851425A (en) * 1985-06-14 1989-07-25 The Upjohn Company Cyclopentapyrazole and tetrahydroindazole compounds and their use as anti-inflammatory and anti-allergic agents
JPS6233176A (ja) * 1985-08-05 1987-02-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
JP2704428B2 (ja) * 1988-06-15 1998-01-26 富山化学工業株式会社 キノロンカルボン酸誘導体またはその塩
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
JPH06233176A (ja) * 1993-01-29 1994-08-19 Sony Corp ビデオカメラ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ｙｏｓｈｉｎｏｒｉ Ｙａｍａｓｈｉｔａ，ｅｔ ａｌ．，Ａｎｔｉｔｕｍｏｒ ｑｕｉｎｏｌｏｎｅｓ ｗｉｔｈ ｍａｍｍａｌｉａｎ ｔｏｐｏｉ ｓｏｍｅｒａｓｅ ▲ＩＩ▼ ｍｅｄｉａｔｅｄ ＤＮＡ ｃｌｅａｖａｇｅ ａｃｔｉｖｉｔｙ，Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ，Ｖｏｌ．５２，ｐ．２８１８−２８２２，１９９２

Also Published As

Publication number Publication date
NO307255B1 (no) 2000-03-06
KR100350921B1 (ko) 2002-11-18
PL181867B1 (pl) 2001-09-28
HU9603455D0 (en) 1997-02-28
ATE209645T1 (de) 2001-12-15
CA2192824A1 (en) 1995-12-21
SK157496A3 (en) 1997-08-06
NZ287139A (en) 1997-07-27
MX9606331A (es) 1997-03-29
EP0787726A1 (en) 1997-08-06
FI965020A0 (fi) 1996-12-13
CA2192824C (en) 2006-11-07
PL317726A1 (en) 1997-04-28
TW319769B (OSRAM) 1997-11-11
HU220072B (hu) 2001-10-28
SI0787726T1 (en) 2002-04-30
DE69524251D1 (de) 2002-01-10
AU2576795A (en) 1996-01-05
NO965305D0 (no) 1996-12-11
CN1053668C (zh) 2000-06-21
US5817669A (en) 1998-10-06
CZ292631B6 (cs) 2003-11-12
CZ364396A3 (en) 1997-06-11
ES2163512T3 (es) 2002-02-01
NO965305L (no) 1997-02-04
RO117793B1 (ro) 2002-07-30
SK281341B6 (sk) 2001-02-12
WO1995034559A1 (en) 1995-12-21
AU679859B2 (en) 1997-07-10
EP0787726B1 (en) 2001-11-28
RU2151770C1 (ru) 2000-06-27
HK1000495A1 (en) 2002-07-19
BR9508037A (pt) 1997-09-16
DE69524251T2 (de) 2002-07-11
EP0787726A4 (OSRAM) 1997-08-06
PT787726E (pt) 2002-04-29
HUT75777A (en) 1997-05-28
CN1158614A (zh) 1997-09-03
FI112485B (fi) 2003-12-15
FI965020A7 (fi) 1996-12-16
DK0787726T3 (da) 2002-02-11

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