ATE209645T1 - Neue verbindung, verfahren zu ihrer herstellung und antitumormittel - Google Patents

Neue verbindung, verfahren zu ihrer herstellung und antitumormittel

Info

Publication number
ATE209645T1
ATE209645T1 AT95920265T AT95920265T ATE209645T1 AT E209645 T1 ATE209645 T1 AT E209645T1 AT 95920265 T AT95920265 T AT 95920265T AT 95920265 T AT95920265 T AT 95920265T AT E209645 T1 ATE209645 T1 AT E209645T1
Authority
AT
Austria
Prior art keywords
hydrogen atom
group
lower alkyl
production
alkyl group
Prior art date
Application number
AT95920265T
Other languages
German (de)
English (en)
Inventor
Kyoji Tomita
Katsumi Chiba
Shigeki Kashimoto
Koh-Ichiro Shibamori
Yasunori Tsuzuki
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Application granted granted Critical
Publication of ATE209645T1 publication Critical patent/ATE209645T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95920265T 1994-06-14 1995-06-06 Neue verbindung, verfahren zu ihrer herstellung und antitumormittel ATE209645T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP15657894 1994-06-14
JP19792194 1994-07-28
JP30691494 1994-11-15
JP33995694 1994-12-28
JP8170595 1995-03-13
PCT/JP1995/001110 WO1995034559A1 (en) 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent

Publications (1)

Publication Number Publication Date
ATE209645T1 true ATE209645T1 (de) 2001-12-15

Family

ID=27524935

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95920265T ATE209645T1 (de) 1994-06-14 1995-06-06 Neue verbindung, verfahren zu ihrer herstellung und antitumormittel

Country Status (27)

Country Link
US (1) US5817669A (OSRAM)
EP (1) EP0787726B1 (OSRAM)
JP (1) JP3391796B2 (OSRAM)
KR (1) KR100350921B1 (OSRAM)
CN (1) CN1053668C (OSRAM)
AT (1) ATE209645T1 (OSRAM)
AU (1) AU679859B2 (OSRAM)
BR (1) BR9508037A (OSRAM)
CA (1) CA2192824C (OSRAM)
CZ (1) CZ292631B6 (OSRAM)
DE (1) DE69524251T2 (OSRAM)
DK (1) DK0787726T3 (OSRAM)
ES (1) ES2163512T3 (OSRAM)
FI (1) FI112485B (OSRAM)
HK (1) HK1000495A1 (OSRAM)
HU (1) HU220072B (OSRAM)
MX (1) MX9606331A (OSRAM)
NO (1) NO307255B1 (OSRAM)
NZ (1) NZ287139A (OSRAM)
PL (1) PL181867B1 (OSRAM)
PT (1) PT787726E (OSRAM)
RO (1) RO117793B1 (OSRAM)
RU (1) RU2151770C1 (OSRAM)
SI (1) SI0787726T1 (OSRAM)
SK (1) SK281341B6 (OSRAM)
TW (1) TW319769B (OSRAM)
WO (1) WO1995034559A1 (OSRAM)

Families Citing this family (33)

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CN1578781A (zh) * 2001-09-26 2005-02-09 拜尔药品公司 用作抗糖尿病药物的1,8－萘啶衍生物
US6802423B2 (en) * 2002-02-20 2004-10-12 Trans Global Foods, Inc. Disposable food delivery apparatus
WO2004091627A2 (en) * 2003-04-07 2004-10-28 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs
BRPI0413964B8 (pt) * 2003-09-10 2021-05-25 Kyorin Seiyaku Kk ácido derivado do ácido carboxílico quinolona, sua composição e agente antibacterial
DE10352979A1 (de) * 2003-11-13 2005-06-09 Merck Patent Gmbh Pyridopyrimidinone
AU2013201203C1 (en) * 2004-03-15 2015-04-23 Sumitomo Dainippon Pharma Co., Ltd. Sns-595 and methods of using the same
JP5317472B2 (ja) * 2004-03-15 2013-10-16 サネシス ファーマシューティカルズ， インコーポレイテッド Ｓｎｓ−５９５、及びその使用方法
US7268231B2 (en) * 2004-10-14 2007-09-11 Hoffmann-La Roche Inc. 1,5-Naphthyridine azolinone
BRPI0518164A (pt) * 2004-10-14 2008-11-04 Hoffmann La Roche quinazolinilmetilenotiazolinonas como inibidores de cdk1
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
WO2007022474A2 (en) * 2005-08-19 2007-02-22 Cylene Pharmaceuticals, Inc. HUMAN RIBOSOMAL DNA(rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF
KR20080041298A (ko) * 2005-09-02 2008-05-09 선에시스 파마슈티컬스 인코포레이티드 암 치료를 위한(＋)-1,4-디히드로-7-[(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐]-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법
RU2428983C2 (ru) * 2005-09-02 2011-09-20 Санесис Фармасьютикалз, Инк. Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака
CA2620915C (en) * 2005-09-02 2014-03-25 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
CN104873502A (zh) * 2005-09-02 2015-09-02 逊尼希思制药公司 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
AU2013219242C1 (en) * 2005-09-02 2016-09-22 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
AU2006291007A1 (en) * 2005-09-14 2007-03-22 Janssen Pharmaceutica, N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
EP2354138A1 (en) 2006-06-12 2011-08-10 Sunesis Pharmaceuticals, Inc. Compounds and compositions for treatment of cancer
WO2008016678A2 (en) * 2006-08-01 2008-02-07 Sunesis Pharmaceuticals, Inc. Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
JP2009545601A (ja) * 2006-08-02 2009-12-24 サネシス ファーマシューティカルズ， インコーポレイテッド （＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸の組合せ使用
CN103720701A (zh) * 2007-10-22 2014-04-16 逊尼希思制药公司 在联合治疗中使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸的方法
CA2708264C (en) * 2007-12-10 2018-07-03 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
AU2009335159B2 (en) * 2008-12-31 2015-07-23 Sunesis Pharmaceuticals, Inc. Method of preparing (+)-1,4-dihydro-7-[(3S,4S)-3methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
AU2010217796B2 (en) 2009-02-27 2015-04-30 Sunesis Pharmaceuticals, Inc. Methods of using SNS-595 for treatment of cancer subjects with reduced BRCA2 activity
UA110465C2 (en) * 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
WO2011056566A2 (en) * 2009-10-26 2011-05-12 Sunesis Pharmaceuticals, Inc. Compounds and methods for treatment of cancer
CA2835835C (en) * 2011-05-13 2019-04-02 Array Biopharma Inc. Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors
CN103497186B (zh) * 2013-09-24 2015-02-25 浙江司太立制药股份有限公司 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法
AU2018238079B2 (en) * 2017-03-24 2022-03-03 Wakunaga Pharmaceutical Co., Ltd. Novel pyridone carboxylic acid derivative or salt thereof

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US4384001A (en) * 1978-12-21 1983-05-17 Gosalvez Mario Treatment of tumors with thiazolidine-4-carboxylic acid
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
EP0154780B1 (en) * 1984-01-26 1990-04-11 Abbott Laboratories Quinoline antibacterial compounds
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
JPS61152682A (ja) * 1984-12-27 1986-07-11 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体、そのエステルおよびその塩
JPS61251667A (ja) * 1985-04-30 1986-11-08 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
IE60420B1 (en) * 1985-06-13 1994-07-13 Schering Corp Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives
US4851425A (en) * 1985-06-14 1989-07-25 The Upjohn Company Cyclopentapyrazole and tetrahydroindazole compounds and their use as anti-inflammatory and anti-allergic agents
JPS6233176A (ja) * 1985-08-05 1987-02-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
JP2704428B2 (ja) * 1988-06-15 1998-01-26 富山化学工業株式会社 キノロンカルボン酸誘導体またはその塩
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
JPH06233176A (ja) * 1993-01-29 1994-08-19 Sony Corp ビデオカメラ

Also Published As

Publication number Publication date
HU9603455D0 (en) 1997-02-28
FI965020A7 (fi) 1996-12-16
FI965020A0 (fi) 1996-12-13
AU2576795A (en) 1996-01-05
NO965305D0 (no) 1996-12-11
EP0787726B1 (en) 2001-11-28
CA2192824A1 (en) 1995-12-21
FI112485B (fi) 2003-12-15
US5817669A (en) 1998-10-06
SK281341B6 (sk) 2001-02-12
KR100350921B1 (ko) 2002-11-18
CN1053668C (zh) 2000-06-21
EP0787726A4 (OSRAM) 1997-08-06
PL181867B1 (pl) 2001-09-28
ES2163512T3 (es) 2002-02-01
JP3391796B2 (ja) 2003-03-31
CN1158614A (zh) 1997-09-03
SK157496A3 (en) 1997-08-06
EP0787726A1 (en) 1997-08-06
RO117793B1 (ro) 2002-07-30
WO1995034559A1 (en) 1995-12-21
NO307255B1 (no) 2000-03-06
DE69524251T2 (de) 2002-07-11
CZ292631B6 (cs) 2003-11-12
NZ287139A (en) 1997-07-27
HU220072B (hu) 2001-10-28
HK1000495A1 (en) 2002-07-19
PT787726E (pt) 2002-04-29
CZ364396A3 (en) 1997-06-11
MX9606331A (es) 1997-03-29
DE69524251D1 (de) 2002-01-10
DK0787726T3 (da) 2002-02-11
NO965305L (no) 1997-02-04
HUT75777A (en) 1997-05-28
BR9508037A (pt) 1997-09-16
AU679859B2 (en) 1997-07-10
PL317726A1 (en) 1997-04-28
SI0787726T1 (en) 2002-04-30
CA2192824C (en) 2006-11-07
TW319769B (OSRAM) 1997-11-11
RU2151770C1 (ru) 2000-06-27

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Legal Events

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UEP Publication of translation of european patent specification