AU679859B2 - Novel compound, process for producing the same, and antitumor agent - Google Patents

Novel compound, process for producing the same, and antitumor agent

Info

Publication number
AU679859B2
AU679859B2 AU25767/95A AU2576795A AU679859B2 AU 679859 B2 AU679859 B2 AU 679859B2 AU 25767/95 A AU25767/95 A AU 25767/95A AU 2576795 A AU2576795 A AU 2576795A AU 679859 B2 AU679859 B2 AU 679859B2
Authority
AU
Australia
Prior art keywords
hydrogen atom
producing
same
group
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU25767/95A
Other languages
English (en)
Other versions
AU2576795A (en
Inventor
Katsumi Chiba
Shigeki Kashimoto
Koh-Ichiro Shibamori
Kyoji Tomita
Yasunori Tsuzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of AU2576795A publication Critical patent/AU2576795A/en
Application granted granted Critical
Publication of AU679859B2 publication Critical patent/AU679859B2/en
Assigned to DAINIPPON SUMITOMO PHARMA CO., LTD. reassignment DAINIPPON SUMITOMO PHARMA CO., LTD. Request to Amend Deed and Register Assignors: DAINIPPON PHARMACEUTICAL CO. LTD.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU25767/95A 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent Expired AU679859B2 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
JP15657894 1994-06-14
JP6-156578 1994-06-14
JP6-197921 1994-07-28
JP19792194 1994-07-28
JP30691494 1994-11-15
JP6-306914 1994-11-15
JP33995694 1994-12-28
JP6-339956 1994-12-28
JP7-81705 1995-03-13
JP8170595 1995-03-13
PCT/JP1995/001110 WO1995034559A1 (en) 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent

Publications (2)

Publication Number Publication Date
AU2576795A AU2576795A (en) 1996-01-05
AU679859B2 true AU679859B2 (en) 1997-07-10

Family

ID=27524935

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25767/95A Expired AU679859B2 (en) 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent

Country Status (26)

Country Link
US (1) US5817669A (OSRAM)
EP (1) EP0787726B1 (OSRAM)
JP (1) JP3391796B2 (OSRAM)
KR (1) KR100350921B1 (OSRAM)
CN (1) CN1053668C (OSRAM)
AT (1) ATE209645T1 (OSRAM)
AU (1) AU679859B2 (OSRAM)
BR (1) BR9508037A (OSRAM)
CA (1) CA2192824C (OSRAM)
CZ (1) CZ292631B6 (OSRAM)
DE (1) DE69524251T2 (OSRAM)
DK (1) DK0787726T3 (OSRAM)
ES (1) ES2163512T3 (OSRAM)
FI (1) FI112485B (OSRAM)
HU (1) HU220072B (OSRAM)
MX (1) MX9606331A (OSRAM)
NO (1) NO307255B1 (OSRAM)
NZ (1) NZ287139A (OSRAM)
PL (1) PL181867B1 (OSRAM)
PT (1) PT787726E (OSRAM)
RO (1) RO117793B1 (OSRAM)
RU (1) RU2151770C1 (OSRAM)
SI (1) SI0787726T1 (OSRAM)
SK (1) SK281341B6 (OSRAM)
TW (1) TW319769B (OSRAM)
WO (1) WO1995034559A1 (OSRAM)

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HUP0402310A2 (hu) * 2001-09-26 2005-02-28 Bayer Pharmaceuticals Corporation 1,6-Naftiridin-származékok mint antidiabetikumok és ezeket tartalmazó gyógyszerkészítmények
US6802423B2 (en) * 2002-02-20 2004-10-12 Trans Global Foods, Inc. Disposable food delivery apparatus
EP1610795A4 (en) * 2003-04-07 2007-10-24 Cylene Pharmaceuticals Inc SUBSTITUTED 1,4-DIHYDRO-4-OXO-1,8-NAPHTHPYRIDINE HETEROCYCLIC ANALOGUES
DK1666477T3 (da) * 2003-09-10 2013-07-29 Kyorin Seiyaku Kk 7-(4-trisubstitueret 3-cyclopropylaminomethyl-1- pyrrolidinyl)-quinoloncarboxylsyre-derivat
DE10352979A1 (de) * 2003-11-13 2005-06-09 Merck Patent Gmbh Pyridopyrimidinone
JP5317472B2 (ja) 2004-03-15 2013-10-16 サネシス ファーマシューティカルズ， インコーポレイテッド Ｓｎｓ−５９５、及びその使用方法
AU2013201203C1 (en) * 2004-03-15 2015-04-23 Sumitomo Dainippon Pharma Co., Ltd. Sns-595 and methods of using the same
KR100875408B1 (ko) * 2004-10-14 2008-12-23 에프. 호프만-라 로슈 아게 Ｃｄｋ1 항증식성 활성을 갖는 1,5-나프티리딘 아졸리디논
CA2583311A1 (en) * 2004-10-14 2006-04-20 F. Hoffmann-La Roche Ag Quinazolinylmethylenethiazolinones as cdk1 inhibitors
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
CA2619663A1 (en) * 2005-08-19 2007-02-22 Cylene Pharmaceuticals, Inc. Human ribosomal dna(rdna) and ribosomal rna (rrna) nucleic acids and uses thereof
AU2013219242C1 (en) * 2005-09-02 2016-09-22 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
RU2428983C2 (ru) * 2005-09-02 2011-09-20 Санесис Фармасьютикалз, Инк. Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
CN104873502A (zh) * 2005-09-02 2015-09-02 逊尼希思制药公司 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法
KR20080041298A (ko) * 2005-09-02 2008-05-09 선에시스 파마슈티컬스 인코포레이티드 암 치료를 위한(＋)-1,4-디히드로-7-[(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐]-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법
JP5374153B2 (ja) * 2005-09-02 2013-12-25 サネシス ファーマシューティカルズ， インコーポレイテッド 癌の治療のための（＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸を使用する方法
WO2007033232A1 (en) * 2005-09-14 2007-03-22 Janssen Pharmaceutica, N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
CA2654876A1 (en) * 2006-06-12 2007-12-21 Sunesis Pharmaceuticals, Inc. 1-8-naphthyridine compounds for the treatment of cancer
US20100048609A1 (en) * 2006-08-01 2010-02-25 Jacobs Jeffrey W Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
HUE026693T2 (hu) 2006-08-02 2016-07-28 Sunesis Pharmaceuticals Inc (+)-1,4-dihidro-7-[(3S,4S)-3-metoxi-4-(metilamino)-1-pirrolidinil]-4-oxo-1-(2-tiazolil) -1,8-naftiridin-3-karbonsav és cytarabin (Ara-C) kombinált alkalmazása leukémia kezelésére
AU2008317400B2 (en) * 2007-10-22 2014-10-02 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino) -1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3- carboxylic acid in combination therapy
CA2708264C (en) * 2007-12-10 2018-07-03 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
RU2548031C2 (ru) * 2008-12-31 2015-04-10 Санесис Фармасьютикалз, Инк. Способ получения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты
RU2558835C2 (ru) 2009-02-27 2015-08-10 Санесис Фармасьютикалз, Инк. Способы применения sns-595 для лечения субъектов с онкологическими заболеваниями, имеющих сниженную активность brca2
UA110465C2 (en) * 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
US8470817B2 (en) * 2009-10-26 2013-06-25 Sunesis Pharmaceuticals, Inc. Compounds and methods for treatment of cancer
CN105130967B (zh) * 2011-05-13 2018-04-17 阵列生物制药公司 作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物
CN103497186B (zh) * 2013-09-24 2015-02-25 浙江司太立制药股份有限公司 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法
EP3604305B1 (en) * 2017-03-24 2024-08-28 Wakunaga Pharmaceutical Co., Ltd. Novel pyridone carboxylic acid derivative or salt thereof

Citations (2)

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JPS63500518A (ja) * 1985-06-13 1988-02-25 シェリング・コ−ポレ−ション 多環式キノリン、ナフチリジンおよびピラジノピリジン誘導体
JPH06233176A (ja) * 1993-01-29 1994-08-19 Sony Corp ビデオカメラ

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US3988463A (en) * 1974-05-06 1976-10-26 Merck & Co., Inc. Method of preventing metastasis of H. Ep. No. 3
US4384001A (en) * 1978-12-21 1983-05-17 Gosalvez Mario Treatment of tumors with thiazolidine-4-carboxylic acid
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
DE3577089D1 (de) * 1984-01-26 1990-05-17 Abbott Lab Antibakterielle chinolinderivate.
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
JPS61152682A (ja) * 1984-12-27 1986-07-11 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体、そのエステルおよびその塩
JPS61251667A (ja) * 1985-04-30 1986-11-08 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
US4851425A (en) * 1985-06-14 1989-07-25 The Upjohn Company Cyclopentapyrazole and tetrahydroindazole compounds and their use as anti-inflammatory and anti-allergic agents
JPS6233176A (ja) * 1985-08-05 1987-02-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
JP2704428B2 (ja) * 1988-06-15 1998-01-26 富山化学工業株式会社 キノロンカルボン酸誘導体またはその塩
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe

Patent Citations (2)

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JPS63500518A (ja) * 1985-06-13 1988-02-25 シェリング・コ−ポレ−ション 多環式キノリン、ナフチリジンおよびピラジノピリジン誘導体
JPH06233176A (ja) * 1993-01-29 1994-08-19 Sony Corp ビデオカメラ

Also Published As

Publication number Publication date
CN1158614A (zh) 1997-09-03
NZ287139A (en) 1997-07-27
HU9603455D0 (en) 1997-02-28
NO965305L (no) 1997-02-04
DE69524251D1 (de) 2002-01-10
CA2192824A1 (en) 1995-12-21
CA2192824C (en) 2006-11-07
NO307255B1 (no) 2000-03-06
EP0787726A1 (en) 1997-08-06
HUT75777A (en) 1997-05-28
HU220072B (hu) 2001-10-28
CN1053668C (zh) 2000-06-21
US5817669A (en) 1998-10-06
RU2151770C1 (ru) 2000-06-27
FI965020A7 (fi) 1996-12-16
BR9508037A (pt) 1997-09-16
ES2163512T3 (es) 2002-02-01
DE69524251T2 (de) 2002-07-11
SK281341B6 (sk) 2001-02-12
TW319769B (OSRAM) 1997-11-11
CZ292631B6 (cs) 2003-11-12
PL181867B1 (pl) 2001-09-28
KR100350921B1 (ko) 2002-11-18
HK1000495A1 (en) 2002-07-19
RO117793B1 (ro) 2002-07-30
NO965305D0 (no) 1996-12-11
FI965020A0 (fi) 1996-12-13
EP0787726A4 (OSRAM) 1997-08-06
AU2576795A (en) 1996-01-05
DK0787726T3 (da) 2002-02-11
CZ364396A3 (en) 1997-06-11
EP0787726B1 (en) 2001-11-28
SI0787726T1 (en) 2002-04-30
ATE209645T1 (de) 2001-12-15
JP3391796B2 (ja) 2003-03-31
MX9606331A (es) 1997-03-29
SK157496A3 (en) 1997-08-06
FI112485B (fi) 2003-12-15
WO1995034559A1 (en) 1995-12-21
PT787726E (pt) 2002-04-29
PL317726A1 (en) 1997-04-28

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